ライフサイエンスコーパス: lactam

1 iotics that inhibit PG synthases (e.g., beta-lactams).

2 by replacement with an alpha-methylene-gamma-lactam.

3 ases, thereby restoring activity of the beta-lactam.

4 ylation of an N-alkyl-alpha,beta-unsaturated lactam.

5 ation of N-protected 5,5-disubstituted gamma-lactam.

6 nn condensation, to form the quinolone-gamma-lactam.

7 ertiary amines, or their corresponding gamma-lactams.

8 able to hydrolyze nearly all available beta-lactams.

9 h delayed hypersensitivity reactions to beta-lactams.

10 vants that preserve the efficacy of the beta-lactams.

11 kly quantify the pathogen's response to beta-lactams.

12 compare them with related nonplanar bridged lactams.

13 able gamma-lactams, gamma-lactones and delta-lactams.

14 tion provides enol- or enamine-derived gamma-lactams.

15 ntial for synthesizing eight-membered biaryl lactams.

16 s enzymes and not merely the targets of beta-lactam acylation.

17 (DBO) scaffold restore the activity of beta-lactams against pathogenic bacteria, including those pro

18 Initial beta-lactam agent administered as either IV push or IV piggyb

19 opulation has reported allergies to the beta-lactam agent penicillin, with higher rates reported by o

20 the addition of SAARs for narrow-spectrum B-lactam agents, antifungals predominantly used for invasi

21 Like other beta-lactam agents, the principal bactericidal activity of ce

22 e widespread, and algorithms to clarify beta-lactam allergy and optimize antibiotic use were describe

23 sessment tool in patients with reported beta-lactam allergy resulted in a pronounced and sustained in

24 A beta-lactam allergy was the second most common reason.

25 tion of patients reporting a penicillin/beta-lactam allergy.

26 generality of our approach, we use the beta-lactam ampicillin to predict target molecule occupancy a

27 tion of three representative classes of beta-lactams (ampicillin, cefotaxime, and meropenem) and at t

28 structure, and antibiotic activity assay of lactam analogues of teixobactin and explores ring-expand

29 Lactam analogues of teixobactin containing all four ster

30 with the La antigen protein demonstrate that lactam analogues with muted nonspecific thiol reactiviti

31 Upon cyclization of the Barbier product to lactam and enolate methylation, the third ring is annula

32 provides a widespread advantage across beta-lactam and non beta-lactam antibiotics, non-antibiotic d

33 These monomers included various lactones, lactams and a thiolactone, which varied markedly in thei

34 ing us to investigate synergism between beta-lactams and DCS.

35 bstrates will suffer from the fact that beta-lactams and fluoroquinolones coselect resistance to thes

36 isconnection for the assembly of substituted lactams and pyrrolidines with its potential demonstrated

37 ncreased accessibility upon exposure to beta-lactams and that a judiciously chosen surfactant permeab

38 The role of other broad-spectrum beta-lactams and the likelihood of ampC induction by other En

39 beta-lactamases and the potentiation of beta-lactam antibacterial activity, indicating that DBO funct

40 an be co-regulated with production of a beta-lactam antibiotic (carbapenem carboxylate) and a linear

41 Bacteria are known to evade beta-lactam antibiotic action by producing beta-lactamases (B

42 Patients with reported beta-lactam antibiotic allergies (BLAs) are more likely to re

43 BLA was associated with greater use of beta-lactam antibiotic alternatives.

44 reveals weak binding events between the beta-lactam antibiotic ampicillin and the porin PorB from the

45 al antienterococcal antibiotic and/or a beta-lactam antibiotic at any time during treatment were excl

46 The beta-lactam antibiotic ceftazidime is one of the handful of d

47 rmine therapeutic versus subtherapeutic beta-lactam antibiotic exposure.

48 These inhibitors compete with the beta-lactam antibiotic for the same binding site on the beta-

49 ing agent for use in combination with a beta-lactam antibiotic for the treatment of a wide range of m

50 Combining standard therapy with a beta-lactam antibiotic has been associated with reduced morta

51 opening of the active site, whereby the beta-lactam antibiotic now is enabled to bind to the active s

52 brane-bound protein marker that confers beta-lactam antibiotic resistance.

53 Metampicillin is a beta-lactam antibiotic that is prepared by the reaction of am

54 istance (AMR) facilitated by widespread beta-lactam antibiotic use.

55 sepsis diagnosis to administration of a beta-lactam antibiotic was 48 minutes (19-96 min) versus 72 m

56 ntibacterials, namely, cefadroxil (CFD, beta-lactam antibiotic) and doxycycline (DXC, tetracycline an

57 n the nanomolar range for ampicillin, a beta-lactam antibiotic, used as biorecognition elements in se

58 tion, a high-quality genome sequence of beta-lactam antibiotic-producing Streptomyces clavuligerus AT

59 tember to November 2017 and 2) received beta-lactam antibiotic.

60 ntibiotic resistance upon exposure to a beta-lactam antibiotic.

61 icillin-based sulfones 1-7 to repurpose beta-lactam antibiotics activity with bacterial species that

62 hese are able to rescue the activity of beta-lactam antibiotics against carbapenem-resistant Acinetob

63 trated that 20 restored the activity of beta-lactam antibiotics against carbapenem-resistant Pseudomo

64 veral important drug classes, including beta-lactam antibiotics and antiviral and antineoplastic agen

65 e resistant to penicillin and all other beta-lactam antibiotics and describe a novel mechanism of ind

66 facilitate more rapid administration of beta-lactam antibiotics and may allow for better compliance w

67 We found that critical frontline beta-lactam antibiotics antagonize fluconazole activity.

68 beta-Lactam antibiotics are among the safest and most effecti

69 beta-lactam antibiotics are associated with a variety of immu

70 Intravenous beta-lactam antibiotics are considered to confer a high risk

71 s diagnosis to first-dose completion of beta-lactam antibiotics between IV push and IV piggyback admi

72 t these 2-AI molecules also potentiated beta-lactam antibiotics by affecting mycobacterial protein se

73 play a key role in the biosynthesis of beta-lactam antibiotics by isopenicillin N-synthase (IPNS).

74 has remained universally susceptible to beta-lactam antibiotics for 70 years.

75 significantly reduced susceptibility to beta-lactam antibiotics have been recently described.

76 romise of such a biosensor to determine beta-lactam antibiotics in aqueous solutions by using ampicil

77 Resistance to beta-lactam antibiotics in Gram-negative bacteria is commonly

78 g protein 2X (PBP2X), a major target of beta-lactam antibiotics in pathogenic bacteria.

79 deciding not to use penicillin or other beta-lactam antibiotics is an important tool for antimicrobia

80 MRSA resistance to beta-lactam antibiotics is mediated by two divergons that con

81 An important mechanism of resistance to beta-lactam antibiotics is via their beta-lactamase-catalyzed

82 Combinations of beta-lactam antibiotics show promise in overcoming MDR P. aer

83 s infection has been accomplished using beta-lactam antibiotics such as the penicillins and the cepha

84 Penicillin refers to a group of beta-lactam antibiotics that are the first-line treatment for

85 henotypic resistance profile, including beta-lactam antibiotics that were used to treat ESBL-positive

86 l efforts to preserve the future of the beta-lactam antibiotics through a better understanding of how

87 e active-site beta-lactamases hydrolyze beta-lactam antibiotics through the formation of a covalent a

88 s designed to be given with intravenous beta-lactam antibiotics to degrade excess antibiotics in the

89 can be administered in combination with beta-lactam antibiotics to negate the action of the beta-lact

90 formed by l,d-transpeptidases with some beta-lactam antibiotics undergo non-hydrolytic fragmentation.

91 Proteins related to the degradation of beta-lactam antibiotics were abundant in EVs released from th

92 ed penicillin allergies who receive non-beta-lactam antibiotics when compared to their non-penicillin

93 oup was less likely to fail the goal of beta-lactam antibiotics within 1 hour (44.6% vs 57.3%; odds r

94 ide resistance, including resistance to beta-lactam antibiotics, an antibiotic class prescribed frequ

95 ng as the first line of defense against beta-lactam antibiotics, and antibiotic stress leads to relea

96 ases (MBLs) degrade a broad spectrum of beta-lactam antibiotics, and are a major disseminating source

97 ble bacteria in the presence of several beta-lactam antibiotics, and directly degrade the antibiotics

98 on in patients treated with intravenous beta-lactam antibiotics, and our findings support continued c

99 tudies will aid in the synthesis of new beta-lactam antibiotics, beta-lactamase inhibitors, and bicyc

100 ad advantage across beta-lactam and non beta-lactam antibiotics, non-antibiotic drugs and even divers

101 llin-binding protein poorly acylated by beta-lactam antibiotics, PBP2a.

102 High-dose drugs, especially beta-lactam antibiotics, RCM and clindamycin, are common elic

103 ll wall, or blocking its synthesis with beta-lactam antibiotics, results in an increased flux through

104 combinations of avibactam and different beta-lactam antibiotics, suggest that it may be possible to i

105 the hypothesis that upon treatment with beta-lactam antibiotics, susceptible Enterobacteriaceae isola

106 and zidebactam) potentiate activity of beta-lactam antibiotics, to various extents, against carbapen

107 sing factors for immediate reactions to beta-lactam antibiotics.

108 sistant Staphylococcus aureus (MRSA) to beta-lactam antibiotics.

109 sed susceptibility in vitro to multiple beta-lactam antibiotics.

110 o enhance the susceptibility of MRSA to beta-lactam antibiotics.

111 due to their ability to inactivate all beta-lactam antibiotics.

112 rst described as inactivators of common beta-lactam antibiotics.

113 stance, rendering bacteria resistant to beta-lactam antibiotics.

114 aten the clinical utility of almost all beta-lactam antibiotics.

115 ions, or hypersensitivities to multiple beta-lactam antibiotics.

116 L-form growth and non-lytic killing by beta-lactam antibiotics.

117 due to rapidly rising resistance toward beta-lactam antibiotics.

118 e mecA gene, confers resistance to many beta-lactam antibiotics.

119 inactivating most of the commonly used beta-lactam antibiotics.

120 ence in improving DPT protocols, after BL (B-lactam) antibiotics.

121 udes vancomycin plus an antipseudomonal beta-lactam (AP-BL).

122 ct drug synergies; for example, certain beta-lactams appear to work cooperatively due to their prefer

123 Desired delta-lactams are achieved in yields as high as 99% and enanti

124 olide analogues having alpha-methylene-gamma-lactams are synthesized using the allenic Pauson-Khand r

125 ysis indicated a wide variety of mobile beta-lactam ARGs associated with pathogens downstream of WWTP

126 f ARGs in general (85.4 versus <2%) and beta-lactam ARGs in particular.

127 ta-unsaturated enones, esters, lactones, and lactams as well as alkenylboronic esters.

128 d to explore what effects administering beta-lactam-avibactam combinations have on treating MRSA infe

129 By dissecting the structure of beta-lactam-based ligands, a new series of compounds was desi

130 Avibactam is a non-beta-lactam beta-lactamase inhibitor for treating complicated

131 approximately 32-minute time savings to beta-lactam (beta = -0.60; 95% CI, -0.91 to -0.29) and approx

132 Piperacillin-tazobactam (P/T) is a beta-lactam-beta-lactamase inhibitor combination frequently u

133 ycin, ceftaroline, ertapenem, and novel beta-lactam-beta-lactamase inhibitor combinations from Januar

134 ould identify susceptibility to 2 newer beta-lactam/beta-lactamase inhibitor (BL-BLI) combinations, c

135 ment implications, particularly for new beta-lactam/beta-lactamase inhibitor combinations.

136 n (benzylpenicillin MIC >= 256 mug/ml), beta-lactam/beta-lactamase inhibitors and cephalosporins (amo

137 llin-binding protein (PBP) 5 (PBP5) and beta-lactam binding affinity in HOU503 versus R497.

138 penicillin derivative, showed increased beta-lactam binding affinity of PBP5 of HOU503 compared with

139 azabicyclo[3.3.1]nonan-2-one skeleton with a lactam binding site and that has been used in superstoic

140 MecR1, which both have an extracellular beta-lactam-binding sensor domain.

141 primary transcriptome landscape of the beta-lactam biosynthetic pathway is analyzed, suggesting temp

142 An accurate diagnosis of beta-lactam (BL) allergy can reduce patient morbidity and mor

143 European allergy specialists deal with beta-lactam (BL) hypersensitivity demonstrated a significant

144 ing evidence suggests the addition of a beta-lactam (BL) to daptomycin (DAP) results in synergistic i

145 beta-lactams (BLCs) are the most widely used antibiotics and

146 nhibitor (BLI) drugs, including the non-beta-lactam BLI avibactam (AVI).

147 However, some beta-lactam-BLI combinations have lost their effectiveness ag

148 ed understanding of the biochemistry of beta-lactam breakdown.

149 as demonstrated to produce the corresponding lactams by employing engineered biocatalysts.

150 lective synthesis of highly substituted beta-lactams by intramolecular Tsuji-Trost allylation is repo

151 ction bias make inferences on effective beta-lactam choices problematic.

152 tures along with new, and improved, PBP-beta-lactam co-structures.

153 e and the efficacy of twenty-eight dual beta-lactam combination therapies were compared to their cons

154 y was to determine the efficacy of dual beta-lactam combination treatments derived from eight approve

155 Five of the dual beta-lactam combinations resulted in greater than 70% surviva

156 vergently construct beta-, gamma-, and delta-lactams, completely overruling the inherent reactivities

157 f crystal structures, in particular for beta-lactam complexes, and methods such as neutron diffractio

158 ction of omega-amino acids and corresponding lactam compounds.

159 entified mutations that allow growth at beta-lactam concentrations far exceeding those inhibiting gro

160 Depending on the relative beta-lactam configuration, the reactions occur under kinetic

161 at the three and seven position of the beta-lactam core structure on the electrochemical fingerprint

162 ver, several synthetic applications of gamma-lactam derivatives are presented including some examples

163 of phosphorus and fluorine substituted gamma-lactam derivatives is presented.

164 ng to the efficient formation of chiral beta-lactam derivatives.

165 The resulting epsilon-caprolactam- and gamma-lactam-derived imines were obtained in moderate to excel

166 -mediated allylations of aldehydes with beta-lactam-derived organoindiums.

167 mented with subinhibitory levels of the beta-lactam drug cefoxitin, we find that mecA provides a wide

168 and some combinations of avibactam with beta-lactam drugs appear to prevent such escape phenotypes.

169 ases can now confer resistance to other beta-lactam drugs, including both cephalosporins and carbapen

170 y, we explored di- and tripeptides with beta-lactam electrophilic warheads as inhibitors of dengue an

171 opic and solid-state structural proof of the lactam-embedded smallest ever metal-free stable Huckel a

172 This breaks the dogma that beta-lactams enter Gram-negative bacteria only by passive dif

173 y macrolide but with high prevalence of beta-lactam, fluoroquinolone, and tetracycline resistance gen

174 Patients treated with daptomycin plus a beta-lactam for MRSA bloodstream infection had lower odds of

175 reoselectivity and the use of Bosch's chiral lactam for preparation of enantioenriched cyclic imine.

176 nsideration that the adjunctive role of beta-lactams for MRSA in select patients helps elicit favorab

177 These data underscore the importance of beta-lactams for SaB, including consideration that the adjunc

178 s to efficient and high yielding fused gamma-lactam formation across a range of substituted heterocyc

179 e C-9/C-10 olefin, followed by reduction and lactam formation between the C-9 amine and the Fukuyama-

180 omplex was not a competent catalyst for beta-lactam formation.

181 isocyanate cycloaddition method affords beta-lactams from glycals with high regio- and stereoselectiv

182 o- and diastereoselective synthesis of delta-lactams from readily available acrylamide derivatives an

183 unactivated alkenes provides valuable gamma-lactams, gamma-lactones and delta-lactams.

184 Patients treated with beta-lactam had higher IL-1beta on days 3 (median +5.6 pg/mL;

185 nce, penicillin and the wider family of beta-lactams have remained the single most important family o

186 ompared with acyl-enzyme complexes with beta-lactams, hindering its function to deprotonate Glu166 an

187 gal alkaloids that feature a quinolone-gamma-lactam hybrid, which is a potential pharmacophore for th

188 ations between exposure to antibiotics (beta-lactam, imidazole, macrolide, nitrofurantoin, quinolone,

189 We compared the efficacies of a beta-lactam in combination with daptomycin (BL/D-C) and beta-

190 rocess allows for the partial reduction of a lactam in the presence of Cp(2)ZrHCl (Schwartz's reagent

191 ion of three such indolines gave tetracyclic lactams in 89, 90, and 61% yields.

192 ides a rapid route to a diverse set of delta-lactams in good yield and stereoselectivity, which serve

193 on of 1,4,2-dioxazol-5-ones to furnish gamma-lactams in up to 97% yield and 98% ee via intramolecular

194 DCS resensitized MRSA to beta-lactams in vitro and significantly enhanced MRSA eradica

195 arly for MBLs; the likely impact of new beta-lactam:inhibitor combinations and the continuing clinica

196 ry experiments revealed that tripeptide-beta-lactam inhibitors bind to the protease in two distinct b

197 A key bicyclic beta-lactam intermediate not only serves as the key controlli

198 daptomycin) plus an antistaphylococcal beta-lactam (intravenous flucloxacillin, cloxacillin, or cefa

199 d for the synthesis of seven-membered biaryl lactams involving Pd-catalyzed, native amine-directed, o

200 nctionalization of tertiary carboxamides and lactams is described.

201 hydrolyzes carbapenems, the most potent beta-lactams; known KPC variants differ in turnover of expand

202 macrocyclization has traditionally relied on lactam, lactone and disulfide bond-forming reactions tha

203 The key lactam linkage introduced in alpha-RgIA fixed the favore

204 esidue for site-specific conjugation to beta-lactam linker-functionalized siRNA.

205 interest in whether the superiority of beta-lactams links to key cytokine pathways.

206 knowing whether the superior performance of -lactams may be linked to key cytokine signaling pathways

207 d the continuing clinical importance of beta-lactams mean that this remains a rewarding research area

208 Tripeptides with a (3S)-beta-lactam moiety displayed the highest activity, with IC(50

209 addition of a 2-aminoethyl side chain onto a lactam moiety.

210 e inhibitors, and bicyclic carbohydrate-beta-lactam monomers prepared by the alkene-isocyanate method

211 ombination with daptomycin (BL/D-C) and beta-lactam monotherapy (BL-M) in improving clinical outcomes

212 h P. aeruginosa bacteremia treated with beta-lactam monotherapy during 2009-2015.

213 Although beta-lactam monotherapy is common, data to guide the choice b

214 rs, patients were treated with either a beta-lactam (n = 24), including oxacillin, cefazolin, or ceft

215 digm for the biosynthesis of quinolone-gamma-lactam natural products via Dieckmann condensation.

216 Substitution of the lactam nitrogen with electronically different groups aff

217 n with vs without an antistaphylococcal beta-lactam on mortality, bacteremia, relapse, or treatment f

218 on of the most widely used antibiotics, beta-lactams (penicillins, cephalosporines, carbapenems, and

219 Double antibiotic therapy (beta-lactam plus either an aminoglycoside or a fluoroquinolon

220 thod from the same nine-membered unsaturated lactam precursor, we developed conditions for stereo- an

221 ion at 140 degrees C in DMF to afford a beta-lactam product.

222 Here, we report a novel gamma-lactam pyrazolidinone that targets penicillin-binding pr

223 titution (S(N)2) reaction to give spiro-beta-lactam-pyrroloquinoline scaffolds 6a-t.

224 as developed for the synthesis of spiro-beta-lactam-pyrroloquinolines.

225 d ring is annulated by a one-pot sequence of lactam reduction and aza-Prins cyclization to directly s

226 tly belonging to the aminoglycoside and beta-lactam resistance classes.

227 stances between isolates with different beta-lactam resistance determinants suggests that the propens

228 wide and rapid spread of large spectrum beta-lactam resistance genes such as carbapenemases is detrim

229 imum inhibitory concentration (MIC) and beta-lactam resistance genes with mortality in the MERINO tri

230 ive method for detecting PBP2a-mediated beta-lactam resistance in clinically relevant non-SASS for th

231 The development of beta-lactam resistance in non-SASS through acquisition and ex

232 Overcoming beta-lactam resistance in pathogens such as Pseudomonas aerug

233 ly reliable for detecting mecA-mediated beta-lactam resistance in S. epidermidis isolates.

234 oints reliably identified mecA-mediated beta-lactam resistance in S. epidermidis Using mecA PCR as th

235 notypic methods to detect mecA-mediated beta-lactam resistance in staphylococci is becoming more comp

236 ce to erythromycin has been recognised, beta-lactam resistance in toxigenic diphtheria has not been d

237 s in the dacB-defective background, the beta-lactam resistance phenotype was abolished, disabling the

238 olates with characterized mechanisms of beta-lactam resistance, 180 clinical isolates from the Mayo C

239 sistent with a first step in developing beta-lactam resistance.

240 sistent with a first-step in developing beta-lactam resistance.

241 of C. diphtheriae BQ11 and mechanism of beta-lactam resistance.

242 Methicillin (beta-lactam) resistance in Staphylococcus epidermidis is medi

243 out in both types of EVs to investigate beta-lactam resistant determinants.

244 ituted cyclopentenes, derived from (+)-vince lactam, resulted in 5-exo cyclizations which furnished a

245 The beta-lactams retain a central place in the antibacterial arma

246 yze the amide bond of the four-membered beta-lactam ring are the primary resistance mechanism, with m

247 uoro substitution is positioned alpha to the lactam ring carbonyl and results in KMN-159's fivefold i

248 carbapenem bicyclic core consists of a beta-lactam ring fused to a pyrroline ring.

249 The beta-lactam ring represents a valuable moiety that can induce

250 ent, but reversible, interaction of the beta-lactam ring with the catalytic serine, followed by relea

251 , as well as the extra amide NH group of the lactam ring, hydrogen bond to the chloride anion.

252 by release of the inhibitor with opened beta-lactam ring.

253 irst-generation inhibitors containing a beta-lactam ring.

254 Three n-type fused lactam semiconducting polymers were synthesized for ther

255 fficient synthesis of bicyclic N-unprotected lactams similar to those in many useful drugs.

256 ts and lactone moieties with cyclopropyl and lactam structural motifs, respectively, were found to be

257 sis for the formation of the quinolone-gamma-lactam structure.

258 re then countered by new generations of beta-lactam structure.

259 ng-opening polymerization of a bicyclic beta-lactam sugar monomer.

260 c and phenotypic approaches to identify beta-lactam susceptibility in Escherichia coli, Klebsiella sp

261 placement in PBP2X that confers reduced beta-lactam susceptibility in vitro was more fit, as assessed

262 Decreased beta-lactam susceptibility is geographically widespread in st

263 leic acid quantification to measure the beta-lactam susceptibility phenotype of Ng very rapidly, usin

264 with macrolide resistance and decreased beta-lactam susceptibility was unexpected and is of public he

265 play a crucial role in the survival of beta-lactam susceptible bacteria by acting as the first line

266 e impact of peptidoglycan substrates on beta-lactam targeting of transpeptidation, and (d) demonstrat

267 o exogenous nucleases after exposure to beta-lactams (termed nuclease-accessibility AST [nuc-aAST]).

268 Fourteen compounds from 6 classes (beta-lactams, tetracyclines, sulfonamides, fluoroquinolones,

269 pid, but it has not been successful for beta-lactams (the largest antibiotic class used to treat Ng).

270 beta-lactamase-mediated opening of the beta-lactam, the pyrroline may interconvert between an enamin

271 ol-aAST), a new phenotypic approach for beta-lactams, the major antibiotic class for gram-negative in

272 bacterial cell wall are the targets of beta-lactams, the most clinically successful antibiotics to d

273 proteins (PBPs) are the targets of the beta-lactams, the most successful class of antibiotics ever d

274 reus protects the enzyme targets of the beta-lactams, the penicillin-binding proteins.

275 ws the tremendous advantages offered by beta-lactam therapy and makes a strong case that the debunkin

276 Encephalopathy complicates beta-lactam therapy, particularly with impaired renal functio

277 nt contributors to efficacy of DAP plus beta-lactam therapy.

278 ma-amino amides into 5,5-disubstituted gamma-lactams through a base-mediated new molecular rearrangem

279 enoyl enamines and imines, or (chiral) gamma-lactams through two geminal C-C bond or two C-N bond for

280 emia, addition of an antistaphylococcal beta-lactam to standard antibiotic therapy with vancomycin or

281 class D SBL-catalyzed rearrangement of beta-lactams to beta-lactones is important as a resistance me

282 beta-lactam-treated patients had sharper declines in IL-10 th

283 Therapeutic and subtherapeutic beta-lactam use is associated with different patterns of chan

284 24 but <=72 hours of an antipseudomonal beta-lactam/VAN combination: PTZ/VAN, cefepime (CEF)/VAN, or

285 SBLs neutralize beta-lactams via a hydrolytically labile covalent acyl-enzyme

286 cysteine yields enzymes which fragment beta-lactams via a similar mechanism as the l,d-transpeptidas

287 termined by treating clinicians and the beta-lactam was administered for 7 days.

288 At competing risk analysis, C/EI of beta-lactams was associated with significantly higher rates o

289 llular NF-kappaB inhibition assays for these lactams were benchmarked against parthenolide and a synt

290 Finally, highly substituted gamma-lactams were prepared in one pot from adducts obtained u

291 a wide range of amide substrates, including lactams, which lead to spiro-bicyclic products.

292 rolonging the clinical effectiveness of beta-lactams, which remain first-line antibiotics for many in

293 ity of these enzymes, combinations of a beta-lactam with a beta-lactamase inhibitor (BLI) have been c

294 Among the antimicrobials, B-lactam with B-lactamase inhibitors (OR 3.65; P < .001),

295 containing quinoline, pyrrolidone, and beta-lactam with high bond-forming efficiency.

296 uction to the clinic of combinations of beta-lactams with diazabicyclooctanone and cyclic boronate se

297 livers alpha-alkoxycarbonyl-substituted beta-lactams with outstanding diastereoselectivity.

298 ,4,2-dioxazol-5-ones to provide chiral gamma-lactams with up to 99:1 er and catalyst loadings down to

299 ith I(2) to form either aryl iodides or beta-lactams within minutes at room temperature.

300 The MIC values of gamma-lactam YU253434, 1, are reported along with the finding