ライフサイエンスコーパス: lactam ring

1 o-fused to a thiazole-containing 18-membered lactam ring.

2 o-fused to a thiazole-containing 18-membered lactam ring.

3 arbapenems is anticipated as all have a beta lactam ring.

4 by release of the inhibitor with opened beta-lactam ring.

5 the leaving group after opening of the beta-lactam ring.

6 irst-generation inhibitors containing a beta-lactam ring.

7 idly hydrolyzing the amide group of the beta-lactam ring.

8 lic hydroxide for the hydrolysis of the beta-lactam ring.

9 volved in the formation of the critical beta-lactam ring.

10 the hydrolysis of the amide bond in the beta-lactam ring.

11 idues of a side-chain cystine or [i-(i + 4)] lactam ring.

12 gested a unique and stabilizing role for the lactam ring.

13 e featuring non-canonical lactone as well as lactam rings.

14 idue to form five-, six-, and seven-membered lactam rings.

15 sporin antibiotics by hydrolysis of the beta-lactam ring and are an important mechanism of resistance

16 y buried ethylene glycol molecule mimics the lactam ring and, thus, serves as a surrogate ligand.

17 o-S-CCys,beta-H bond for closure of the beta-lactam ring, and the CVal,beta-H bond for installation o

18 cylation of Ser-70 by TZB and opening of the lactam ring are followed by one of several different eve

19 Although the phenols with a seven-membered lactam ring are harder to oxidize, the sterically nonhin

20 When the alkyl substituents of the lactam ring are lengthened from ethyl to decyl, sulfoglo

21 yze the amide bond of the four-membered beta-lactam ring are the primary resistance mechanism, with m

22 Lactam rings are found in many biologically active natur

23 e elaboration of the requisite nine-membered lactam ring as the key step are described.

24 ception stems from the size of a "bystander" lactam ring at the benzylic position.

25 uncated pancratistatin analogues lacking the lactam ring B, but retaining the crucial C10a-C10b bond

26 of two oxidative cyclizations, with the beta-lactam ring being installed first and the thiazolidine r

27 coordinate that involves ring opening of the lactam ring by an internal carboxylic acid group to form

28 llowed by reductive ring opening of the beta-lactam ring by LiEt(3)BH to provide an entry into the cl

29 ese findings raise the possibility that beta-lactam rings can be regio- and stereospecifically integr

30 uaternary stereocenter at C3 position of the lactam ring, can act as effective reverse-turn mimics an

31 g opens prior to enamine formation since the lactam ring carbonyl (C=O) peak disappears prior to the

32 uoro substitution is positioned alpha to the lactam ring carbonyl and results in KMN-159's fivefold i

33 esence of various heterocycles followed by a lactam ring closure of the free amine on the ester.

34 d a mild TBD/ethyl trifluoroacetate mediated lactam ring closure to afford a representative GSM in hi

35 ene unit to C5 of L-proline followed by beta-lactam ring closure.

36 biosynthetic route to the production of beta-lactam-ring-containing antibiotics.

37 racteristic electrochemical signals of the B-lactam ring disappeared upon hydrolysis.

38 Lewis acid-promoted Boyer-Schmidt-Aube lactam ring expansions using an azidoalkylboronate enabl

39 Lewis acid-promoted Boyer-Schmidt-Aube lactam ring expansions using an azidoalkylboronate enabl

40 rriers, resulting in the closure of the beta-lactam ring for the oxidase activity (ACV) or formation

41 probably carries out both deacetylation and lactam ring formation and requires the product of CwlD a

42 as achieved through side chain-to-side chain lactam ring formation between Lys(i) and Asp(i+4) residu

43 nism in which the rate-limiting step is beta-lactam ring formation coupled to a protein conformationa

44 ollowed by deacetylation of muramic acid and lactam ring formation.

45 joint discovery to an apparently common beta-lactam ring-forming enzyme, are now being revealed.

46 as been proposed that the four-membered beta-lactam ring forms initially, associated with a highly ox

47 metallo-beta-lactamase enzymes to hydrolyse lactam rings found in many antibiotics, rendering them i

48 specialized C domain prepares the embedded B-lactam ring from a serine residue.

49 carbapenem bicyclic core consists of a beta-lactam ring fused to a pyrroline ring.

50 Installation of the lactam ring has been achieved through several pathways a

51 , as well as the extra amide NH group of the lactam ring, hydrogen bond to the chloride anion.

52 enzyme that catalyzes formation of the beta-lactam ring in (5R)-carbapenem-3-carboxylic acid biosynt

53 catalyzes the formation of a monocyclic beta-lactam ring in a similar ATP/Mg2+-dependent reaction, im

54 BlaM cleaves the beta-lactam ring in CCF2, changing its fluorescence emission

55 and clavulanic acid, the positioning of the lactam ring in the active site in the correct orientatio

56 med CPS) catalyzes the formation of the beta-lactam ring in the biosynthetic pathway to (5R)-carbapen

57 preinstalling the beta configuration of the lactam ring in the monomer via the stereospecific [2+2]

58 s of beta-lactamases that hydrolyze the beta-lactam ring, inactivating the antimicrobial agent.

59 by binding of moxalactam and the intact beta-lactam ring is observed for 100 ms after photolysis.

60 art of the catalytic cycle, wherein the beta-lactam ring is opened and an acyl-enzyme intermediate fo

61 The R-group side chain of the B-lactam ring is responsible for allergic cross-reactivity

62 the conformation of the strained 9-membered lactam ring, is described.

63 chloride upon allylic alcohols containing a lactam ring leads mainly to epoxy alkyl peroxides with h

64 hile to the carbonyl carbon in the substrate lactam ring leads to a metastable intermediate via a dom

65 To test the hypothesis that such lactam rings may also be modulating activation of the re

66 Furthermore, increasing the 23-membered lactam ring of 1 by one carbon atom (succinyl --> glutar

67 ctamase catalyzes the hydrolysis of the beta-lactam ring of ampicillin.

68 lly compatible with the highly unstable beta-lactam ring of carbapenems and that the triazole ring ge

69 eptide to isopenicillin N, the critical beta-lactam ring of clavulanic acid is demonstrated to form b

70 The carboxylate attached to the beta-lactam ring of doripenem is stabilized by a salt bridge

71 1) with two methoxy beta-substituents on the lactam ring of each dipyrrinone was synthesized and exam

72 al enzyme beta-lactamase hydrolyzes the beta-lactam ring of penicillin and chemically related antibio

73 ybenzyl) group and the C6 substituent in the lactam ring of the free-radical intermediate.

74 ediates its cyclization to the critical beta-lactam ring of the nocardicin family of antibiotics.

75 te Ser70 for nucleophilic attack on the beta-lactam ring of the substrate.

76 The side chains attached to the cleaved beta-lactam rings of benzylpenicillin and cephaloridine are l

77 r time scales, the Raman data show that beta-lactam ring opening eventually leads to a complex mixtur

78 ach, involving a cyanide-initiated acyl-beta-lactam ring opening followed by cyclization, was success

79 c catalytic process in which hydrolytic beta-lactam ring opening is induced via nucleophilic attacks

80 ents with cefoxitin revealed a burst of beta-lactam ring opening with associated SKIE values of 1.6 o

81 o group in the C7 side chain, undergoes beta-lactam ring opening with intramolecular aminolysis by a

82 ma-lactams and gamma-lactones via N1-C2 beta-lactam ring opening/cyclization under acidic or basic co

83 The Raman data also demonstrate that the lactam ring opens prior to enamine formation since the l

84 gen atom to provide the cis-substituted beta-lactam ring preferentially.

85 olysis and aminolysis of the four membered B-lactam ring present.

86 We hypothesized that the lactam ring promoted conformational stability to yield a

87 including altered nitrogen hybridization and lactam ring puckering, that may drive the observed diflu

88 The beta-lactam ring represents a valuable moiety that can induce

89 n of the side chain upon opening of the beta-lactam ring retained antibacterial activity while safely

90 an acyl enzyme formed between Ser70 and the lactam ring's C=O group.

91 natures characteristic of the unreacted beta-lactam ring show that in both phases the inhibitor binds

92 the biological results reveals that smaller lactam ring substituents enable intercalation into both

93 n strategies [in particular, introduction of lactam rings such as that of cyclo(Glu30,Lys33)], and de

94 designed based on the pyrrolidine-5,5-trans-lactam ring system.

95 at changing the size of the thiazolidine and lactam ring systems would have on the ability of these s

96 800CW, with a quencher connected through the lactam ring that is hydrolyzed by the enzyme BlaC (beta-

97 After acylation of the beta-lactam ring, the dihydrothiazine dioxide ring opened wit

98 te a water molecule that hydrolyzes the beta-lactam ring through a proton shuttle.

99 s that attaching a hydrophobic moiety to the lactam ring to mimic the isobutyl side chain of the leuc

100 The diastereomeric analogues use a lactam ring to restrict two of the six free torsional an

101 he bulky side chain substituents of the beta-lactam ring typical of these compounds can be accommodat

102 This beta-lactam ring was further elaborated into the azetidine of

103 While enzymatic hydrolysis of the B-lactam ring was observed, it was not accompanied by inhi

104 othesis that the Glu20-Lys23 and Glu30-Lys33 lactam rings were favoring an alpha-helical conformation

105 five-, six-, and seven-membered lactone and lactam rings were synthesized in one-pot conditions by u

106 determined prior to the cleavage of the beta-lactam ring, when the rigid fused rings of benzylpenicil

107 hat catalyzes formation of a monocyclic beta-lactam ring with concomitant ATP hydrolysis.

108 ent, but reversible, interaction of the beta-lactam ring with the catalytic serine, followed by relea

109 constraints such as side-chain to side-chain lactam rings would stabilize an alpha-helical conformati

110 constraints such as side-chain-to-side-chain lactam rings would stabilize an alpha-helical conformati