ライフサイエンスコーパス: lactic acidosis

1 brain damage during ischemia due to enhanced lactic acidosis.

2 and catecholamines were responsible for the lactic acidosis.

3 t rate and systemic vascular resistance, and lactic acidosis.

4 elay, lethargy, severe hypotonia, and modest lactic acidosis.

5 ctate, making them specialized for detecting lactic acidosis.

6 in body fat distribution, dyslipidemia, and lactic acidosis.

7 es, branched-chain ketoaciduria, and primary lactic acidosis.

8 e, global neurodevelopmental regression, and lactic acidosis.

9 rdynamic, tachycardic state with progressive lactic acidosis.

10 dead space ventilation and exercise-induced lactic acidosis.

11 ed to hypovolemia, tissue hypoperfusion, and lactic acidosis.

12 erature, heart rate, oxygen consumption, and lactic acidosis.

13 ive to treatment and causing oxygen debt and lactic acidosis.

14 PDH worsens exercise performance and induces lactic acidosis.

15 minal pain and metabolic decompensation with lactic acidosis.

16 ety events of interest were hypoglycemia and lactic acidosis.

17 DG metabolism, were relatively unaffected by lactic acidosis.

18 ed lifespan of Ndufs4-KO mice and attenuated lactic acidosis.

19 mplex II deficiency, were found to have mild lactic acidosis.

20 ab work was significant for leukocytosis and lactic acidosis.

21 was strongly associated with the presence of lactic acidosis.

22 aprevir-ritonavir-dasabuvir may cause type B lactic acidosis.

23 epatic metabolism, intestinal infarction and lactic acidosis.

24 and CotH expression, an effect not seen with lactic acidosis.

25 gram, marked elevation of serum enzymes, and lactic acidosis.

26 year-old man who died with linezolid-induced lactic acidosis.

27 and serologic evidence of liver failure and lactic acidosis.

28 not been associated with increased rates of lactic acidosis.

29 genase enzyme activity but most did not have lactic acidosis.

30 aired kidney function because of concerns of lactic acidosis.

31 in was not associated with increased risk of lactic acidosis.

32 vival of cells after exposure to hypoxia and lactic acidosis.

33 lls is abolished by simultaneous exposure to lactic acidosis.

34 ng the origins and treatment of pathological lactic acidosis.

35 nd hyperglycemia, possibly mediated by brain lactic acidosis.

36 e molecule used by sensory neurons to detect lactic acidosis.

37 35%), mixed venous saturation (by 65%), and lactic acidosis (5.5-6.0 mM).

38 In particular, lactic acidosis abolished stabilization of HIF-1alpha pr

39 ondrial inner membrane to undergo fusion and lactic acidosis after the loss of outer membrane fusion.

40 mino acid supplies, glucose deprivation, and lactic acidosis, all of which pose challenges for protei

41 rine metabolite studies showed hypoglycemia, lactic acidosis, altered Krebs cycle function and dysreg

42 e characterized by fetal growth retardation, lactic acidosis, aminoaciduria, cholestasis, and abnorma

43 An infant presented with fatal infantile lactic acidosis and cardiomyopathy, and was found to hav

44 , aminoaciduria, cholestasis, iron overload, lactic acidosis and early death (GRACILE syndrome), and

45 drome patients in having intermittent severe lactic acidosis and early-onset neurodevelopmental probl

46 ion who were taking stavudine presented with lactic acidosis and elevated levels of aminotransferases

47 Both affected individuals presented with lactic acidosis and evidence of multiple mitochondrial r

48 three families with children suffering from lactic acidosis and hyperpyruvatemia revealed a causal l

49 C) and can present with severe hypoglycemia, lactic acidosis and hypertriglyceridemia.

50 ses up to 100-fold, possibly contributing to lactic acidosis and hypoglycemia in patients with severe

51 ative epidermis but rapidly died of systemic lactic acidosis and hypoglycemia, indicating excessive g

52 In patients with acute lactic acidosis and ketoacidosis, lactate and ketone bod

53 Q(10) deficiency who presented with neonatal lactic acidosis and later developed multisytem disease i

54 Symptoms of affected family members include lactic acidosis and low serum methionine levels.

55 Routine blood tests showed lactic acidosis and mild elevation of the creatine kinas

56 All case subjects presented with lactic acidosis and nine developed hypertrophic cardiomy

57 senting with fatal infantile cardiomyopathy, lactic acidosis and respiratory failure.

58 with failure to thrive, developmental delay, lactic acidosis and severe encephalopathy suggestive of

59 Mitochondrial myopathy with lactic acidosis and sideroblastic anemia (MLASA) is an o

60 en use in five severely septic patients with lactic acidosis and six healthy volunteers before and af

61 ds harboring mitochondrial encephalomyopathy lactic acidosis and stroke A3243G tRNA((Leu)UUR) gene mu

62 her the mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (A3243G MELAS)

63 such as mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) and myo

64 of the mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) phenoty

65 suggestive of mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrom

66 osis (ALS), mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), dermat

67 romes including mitochondrial encephalopathy lactic acidosis and stroke-like episodes (MELAS), matern

68 ses, notably mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS).

69 tation causing mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS); the tR

70 tients with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome (MELAS

71 are part of the mitochondrial encephalopathy lactic acidosis and stroke-like episodes syndrome.

72 MELAS (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) and MIDD syndr

73 Melas (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) is one of a gr

74 (Mitochondrial Myopathy, Encephalopathy with Lactic Acidosis and Stroke-like episodes) syndrome, the

75 ease MELAS (mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes) syndrome.

76 ssociated with mitochondrial encephalopathy, lactic acidosis and stroke-like episodes, but were docum

77 me, and mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes.

78 d deafness and mitochondrial encephalopathy, lactic acidosis and stroke-like episodes.

79 muscle and, therefore, is proposed to detect lactic acidosis and to transduce angina and muscle ische

80 erum fibrinogen, elevated prothrombin time), lactic acidosis, and hepatic steatosis were characterist

81 ere metabolic crises including hypoglycemia, lactic acidosis, and hyperammonemia.

82 riorated with respiratory and renal failure, lactic acidosis, and hypotension.

83 Within solid tumor microenvironments, lactic acidosis, and hypoxia each have powerful effects

84 d Ca accumulation, attenuated sepsis-related lactic acidosis, and improved left ventricular function.

85 d vision, promoted feeding behavior, reduced lactic acidosis, and increased survival.

86 e-threatening syndrome of hepatic steatosis, lactic acidosis, and myopathy has been reported.

87 cs, increased glycolysis, glutaminolysis and lactic acidosis, and neurotransmitter imbalances.

88 , an increase in pulse and respiratory rate, lactic acidosis, and renal failure.

89 hildren present with a fatal encephalopathy, lactic acidosis, and severe mtDNA depletion in muscle.

90 nd drugs interacting with metformin to cause lactic acidosis, and showed both to induce effects on th

91 ssociated with a clinical triad of myopathy, lactic acidosis, and sideroblastic anemia in predominant

92 h as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke (MELAS), neuropathy, ataxia,

93 experiment to mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS)-associa

94 tient carrying the myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) A3243G

95 the mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndro

96 underlying mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndro

97 Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), a mat

98 LAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes).

99 dy the elusive mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes-associated A32

100 tients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes.

101 tion causes mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms (MELAS) and 2%

102 n in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS).

103 , including mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS).

104 -associated mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes.

105 Metformin poisoning with lactic acidosis appears to be amenable to extracorporeal

106 Since Coffin-Lowry syndrome and neonatal lactic acidosis are associated with mutations in the hum

107 ver toxicity, hypersensitivity reactions and lactic acidosis are recognized as acute events with pote

108 a has many manifestations, of which coma and lactic acidosis are the best independent predictors of a

109 opathy, peripheral neuropathy, myopathy, and lactic acidosis associated with deficiencies of multiple

110 who presented with exercise intolerance and lactic acidosis associated with severe deficiency of com

111 The first presented with acute lactic acidosis at 3 weeks of age and developed severe d

112 at 32 degrees C attenuated the shock-related lactic acidosis but caused metabolic acidosis, most like

113 ndrial toxicity (i.e., neuropathy, myopathy, lactic acidosis), but these side effects are rarely repo

114 fever, tachycardia, oxygen consumption, and lactic acidosis, but it does not prevent the development

115 Severe symptoms include seizures, lactic acidosis, cardiac arrhythmia, and death within da

116 ever, the dominant theory in the field, that lactic acidosis causes muscle fatigue, is unlikely to te

117 to occur in a variety of diseases including lactic acidosis, Cowden Syndrome, and several cancers.

118 Eighty-seven patients (44.8%) had lactic acidosis defined as an arterial blood pH less tha

119 Lactic acidosis developed during continuous infusion of

120 In both groups, a significant lactic acidosis developed during exercise and the magnit

121 or patients with critical tissue hypoxia and lactic acidosis due to anemia.

122 I suggest that lactic acidosis due to malaria can be explained primaril

123 Among children with lactic acidosis due to severe anemia, transfusion of lon

124 No patients developed metformin-associated lactic acidosis during follow-up.

125 nly has been assumed that the development of lactic acidosis during sepsis results from a deficit in

126 sive myocardial thickening, hyperalaninemia, lactic acidosis, exercise intolerance, and persistent ad

127 mia, while one had fatal cardiomyopathy with lactic acidosis following a febrile illness.

128 were significantly (P < 0.05) protected from lactic acidosis, glutamate buildup, and diminished HCO(3

129 severe neurological dysfunction, congenital lactic acidosis, growth retardation, and early death.

130 d multi-organ derangement with leukocytosis, lactic acidosis, haemolytic anaemia and hyperbilirubinem

131 ated individuals who presented at birth with lactic acidosis, hypotonia, feeding difficulties, and de

132 al MCT1 may contribute to the development of lactic acidosis in brain pathologies, and suggest target

133 However, metformin can lead to lactic acidosis in diabetic patients with advanced chron

134 pertaining to metformin, kidney disease, and lactic acidosis in humans between 1950 and June 2014.

135 Lactic acidosis in malaria can be treated safely with di

136 The overall incidence of lactic acidosis in metformin users varies across studies

137 Data suggesting an increased risk of lactic acidosis in metformin-treated patients with chron

138 e role played by the tumor microenvironment, lactic acidosis in particular, on the uptake by tumor ce

139 on is central to the development of coma and lactic acidosis in severe falciparum malaria.

140 Interstitial lactic acidosis in the donor allograft is associated wit

141 e patients with severe exercise intolerance, lactic acidosis in the resting state (in four patients),

142 e finishing diets to alleviate acute ruminal lactic acidosis in vitro.

143 cultures with concurrent vasopressors and/or lactic acidosis increased (P < .001 for all methods), wh

144 Lactic acidosis, induced by the addition of 25 mm lactic

145 pplied pharmacokinetic modeling to show that lactic acidosis inhibits FDG uptake by cancer cells in v

146 ing brain diseases, such as stroke, in which lactic acidosis is a key component.

147 Linezolid-induced lactic acidosis is associated with diminished global oxy

148 Lactic acidosis is being re-evaluated as a factor in mus

149 Lactic acidosis is common in solid tumors because of the

150 The widely prevalent idea that lactic acidosis is responsible for hyperglycemia-enhance

151 Lactic acidosis (LA) frequently occurs after heart trans

152 , it is known to induce metformin-associated lactic acidosis (MALA), a severe medical condition with

153 Indeed, the outcome of lactic acidosis might depend on the prompt initiation of

154 <1%) patient in the doxorubicin alone group (lactic acidosis [n=1]).

155 ghei malaria, (ii) respiratory distress with lactic acidosis occurs during P. berghei malaria, and (i

156 logies, anaerobic glycolysis produces severe lactic acidosis of brain tissue leading to brain cell da

157 at express ASICs an extra sensitivity to the lactic acidosis of local ischemia compared to acidity ca

158 ith serious metabolic complications, such as lactic acidosis, pancreatitis, and peripheral neuropathy

159 Among lactic acidosis-positive patients, however, in-ICU death

160 Our findings reveal that the condition of lactic acidosis present in solid tumors inhibits canonic

161 In particular, features such as lactic acidosis, pyruvate dehydrogenase (PDH) deficiency

162 Blood data were consistent with extreme lactic acidosis, reduced glomerular filtration, and stre

163 trovirals are well characterized and include lactic acidosis related to nucleoside reverse transcript

164 cultures with concurrent vasopressors and/or lactic acidosis remained stable (P = .098).

165 fection who all presented with severe type B lactic acidosis shortly after starting treatment with om

166 nificantly associated with the occurrence of lactic acidosis (specificity: 92.9%; sensitivity: 67.1%;

167 ome (mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes) is a rare, multis

168 In contrast, lactic acidosis strongly synergized with hypoxia to acti

169 cytochrome c oxidase deficiency and hepatic lactic acidosis that accompanies this disorder is unknow

170 We therefore conclude that lactic acidosis-the combination of lactate ion buildup a

171 Lactic acidosis--the strongest prognostic indicator in a

172 desaturation when performing work above the lactic acidosis threshold (LAT), but not below it.

173 h a clinical spectrum ranging from infantile lactic acidosis to childhood (cardio)myopathy and late-o

174 bit rapid weight loss and suffer from severe lactic acidosis, ultimately leading to early mortality u

175 alpha alpha Hb (n = 6) resulted in hypoxia, lactic acidosis, ventricular arrhythmias, and decreased

176 Lactic acidosis was no more common in metformin recipien

177 No cases of lactic acidosis were observed.

178 s associated with hemodynamic depression and lactic acidosis, which appeared (illustrative echocardio

179 mitochondrial myopathy, encephalopathy, and lactic acidosis with stroke-like episodes (MELAS) and Pa

180 hold causes mitochondrial encephalomyopathy, lactic acidosis with stroke-like episodes (MELAS) syndro