ライフサイエンスコーパス: lactone

1 dihydro-6-pentyl-2H-pyran-2-one (C10 massoia lactone).

2 between the C-9 amine and the Fukuyama-type lactone.

3 argets are functionally impaired by the beta-lactone.

4 with CO to give an O-[Zr] bonded borata-beta-lactone.

5 ylation of the diastereomeric tricyclic beta-lactone.

6 ished by their high content of a hydrophobic lactone.

7 lization reaction, leading to a triterpenoid lactone.

8 lysates with a model probe of threonine beta-lactone.

9 ovides an additional stereocenter within the lactone.

10 t was subsequently gelled with glucono delta-lactone.

11 the corresponding unreported unsaturated 1,7-lactones.

12 pective enantiopure, fused six-five bicyclic lactones.

13 opening reactions and reduction to saturated lactones.

14 um's acid derivatives and alkynes into delta-lactones.

15 transcriptional networks between PMA and DAG-lactones.

16 ted epoxides to beta,beta-disubstituted beta-lactones.

17 arboxylic acids to form diverse six-membered lactones.

18 tent activator of LasR than other homoserine lactones.

19 nes can lead to important four-membered beta-lactones.

20 a Kulinkovich reaction of the corresponding lactones.

21 e aliphatic polyesters from cyclic esters or lactones.

22 are typically difficult to achieve by ROP of lactones.

23 d into diastereomerically pure five-membered lactones.

24 s are easily turned into corresponding delta-lactones.

25 s (SBLs) with carbapenems also produces beta-lactones.

26 clic ethers to esters, and terminal diols to lactones.

27 for the enantioselective synthesis of gamma-lactones.

28 lides with other competing synthons of gamma-lactones.

29 e potency of 3OC(12)HSL and other homoserine lactones.

30 Ten antifouling 14-membered resorcylic acid lactones 1-10 were isolated previously with low or trace

31 ealtime detection of N-hexanoyl-L-homoserine lactone (199 Da), a gram-negative bacterial infection bi

32 ylbutanoylquinic acid, and the corresponding lactone 3-O-caffeoyl-4-O-3-methylbutanoyl-1,5-quinide, a

33 el system composed of (3-caffeoylquinic acid lactone (3-CQAL), 4- caffeoyl quinic acid lactone (4-CQA

34 s, such as N-(3-oxo-dodecanoyl)-l-homoserine lactone (3O-C12-HSL), that promote biofilm formation and

35 The cognate autoinducer, 3OC(12) homoserine lactone (3OC(12)HSL), is a more potent activator of LasR

36 12-HSL) and N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL).

37 ally to N-(3-hydroxydodecanoyl)-l-homoserine lactone (3OHC12-HSL) and N-(3-oxododecanoyl)-l-homoserin

38 id lactone (3-CQAL), 4- caffeoyl quinic acid lactone (4-CQAL), and 4-feruloylquinic acid lactone (4-F

39 lactone (4-CQAL), and 4-feruloylquinic acid lactone (4-FQAL)) was used for the screening of enzymes

40 sphaerides E-H (1-4) together with one gamma-lactone (5) and the methyl ester of compound 2 (11).

41 umber of variables (14 compounds), including lactones (6-pentyl-alpha-pyrone, gamma-decalactone, gamm

42 d with high monomer content of a hydrophobic lactone-accumulated in the liver and, to a lesser extent

43 of des-hydroxybilobalide is found to rely on lactone acidification through lone-pair delocalization,

44 common signaling molecule N-acyl-homoserine lactone (AHL) at concentrations 100-fold lower than the

45 which is mediated by an N-acyl L-homoserine lactone (AHL) signal (C(8)-AHL) and its cognate LuxR-typ

46 exchange of signals such as acyl-homoserine lactones (AHL) enables communication within and between

47 catalyze the biosynthesis of acyl-homoserine lactones (AHL) signals using S-adenosyl-l-methionine and

48 the homoserine lactone of N-acyl homoserine lactone (AHLs).

49 eleases variable chain length acylhomoserine lactones (AHLs) and acyl-oxohomoserine lactones (AOHLs)

50 biofilm communities using N-acyl homoserine lactones (AHLs) as one type of signaling molecule.

51 nge, such as the exchange of acyl-homoserine lactones (AHLs) by Gram-negative bacteria.

52 es able to degrade or modify acyl-homoserine lactones (AHLs) have drawn considerable interest for the

53 by auto-inducers, like the N-acyl homoserine lactones (AHLs) in numerous Gram-negative bacteria.

54 m-negative bacteria are the N-acylhomoserine lactones (AHLs), which are known to affect the growth an

55 transformations include DABAL-Me(3)-mediated lactone aminolysis and a mild TBD/ethyl trifluoroacetate

56 evealed that in the case of the six-membered lactone an energetically favorable conformer adopts a ne

57 etrahydrofurans including aryl-Hagen's gland lactone analogues via intramolecular iodoetherification.

58 of horseradish roots, like (3S,3aS,7aR)-wine lactone and 3-isopropyl-2-methoxypyrazine.

59 oducts; a tricyclic N-heterocycle-fused beta-lactone and a bicyclic enamine derived from in situ deca

60 e intact under conditions that hydrolyze the lactone and allows the ester group to be recovered when

61 s structure-activity analyses identified the lactone and diene as moieties conferring anticancer acti

62 lization has traditionally relied on lactam, lactone and disulfide bond-forming reactions that aim at

63 kenes provides valuable gamma-lactams, gamma-lactones and delta-lactams.

64 ering) impact on the relative levels of beta-lactones and hydrolysis products formed.

65 ernary stereocenters on structurally similar lactones and ketones, where it exhibits excellent regios

66 A strategy for the synthesis of medium-sized lactones and lactams from linear precursors is described

67 The generic statement that sesquiterpene lactones and phenolic compounds are determinants of bitt

68 bolites that included sugars, sesquiterpenes lactones and phenolics in the leaf and stem parts, which

69 ption of these sensory traits in relation to lactones and phenolics were brought out.

70 , selected plant-derived five-membered gamma-lactones and six-membered delta-lactones that occur with

71 nsformations, including conversions to gamma-lactones and tetrazoles.

72 Naturally occurring terpenoid lactones and their synthetic derivatives have attracted

73 tion of the QS molecule 3-O-C(12)-homoserine lactone, and QS-regulated virulence factors pyocyanin an

74 sible signal factors (DSFs), acyl-homoserine lactones, and autoinducer-2 systems.

75 ch as alpha,beta-unsaturated enones, esters, lactones, and lactams as well as alkenylboronic esters.

76 and 2,3-dihydroxy acids, beta-hydroxy-omega-lactones, and omega-1-methyl alcohols.

77 Enantiomerically enriched azetidines, gamma-lactones, and tetrahydroquinolines were obtained via a t

78 is involved in formation of the unsaturated lactone; and the ferric-reductase-like enzyme RbtH, whic

79 ntities of the anti-inflammatory diterpenoid lactones andrographolide and neoandrographolide, and the

80 pure bicyclo[2.2.2]octenones, including the lactone-annulated system 26, has been prepared by engagi

81 f the biosynthetic gene cluster for the beta-lactone antibiotic obafluorin and delineate its biosynth

82 erine lactones (AHLs) and acyl-oxohomoserine lactones (AOHLs) as signaling molecules during quorum se

83 These lactones are closely related to the monoterpene-limonene

84 The functionalized beta-lactones are formed under mild conditions in high yields

85 The heterocycle-fused lactones are obtained in moderate to good yield.

86 alpha-Methylene-gamma-lactones are present in ~3% of known natural products, a

87 sults, including the formation of a bicyclic lactone arising from oxidative termination of the photor

88 nes with acrylates or alpha,beta-unsaturated lactones as carbon electrophiles.

89 nspired by this mechanism, we exploited beta-lactones as putative mycolic acid mimics to block serine

90 approach to construct a wide range of amino lactones as well as 1,2-amino alcohol derivatives.

91 steps, provides a general access to 4-alkyl lactones as well as a robust access to the target sex ph

92 of the diastereoisomers of these p-menthane lactones, as well as their common precursor, menthofuran

93 -carbon quaternary stereocenter and the beta-lactone at an early stage.

94 ensing inhibitor (QSI) - a N-acyl homoserine lactone autoinducer antagonist - and then dosed onto hea

95 ulted in 2,3-difunctionalized benzofuran and lactone bearing indoline-2-one scaffolds under same cond

96 ce factors, by N-3-oxododecanolyl homoserine lactone binding to the quorum sensing receptor, LasR.

97 sferases potentially involved in diterpenoid lactone biosynthesis.

98 , were proposed to contain a C3-C14 ether or lactone bridge, similar to asbestinins.

99 types containing either a C14-C11 or C14-C12 lactone bridge.

100 ited greater amounts of vanillin and whiskey-lactones but lower concentrations of fruity aroma compou

101 ctions not only led to enantioenriched gamma-lactones, but also various other heterocycles and acycli

102 lectrophilicity of the alpha-methylene-gamma-lactone by replacement with an alpha-methylene-gamma-lac

103 idation sequence for annulation of the delta-lactone (C ring).

104 t-chain AHLs, N-3-(oxododecanoyl)-homoserine lactone (C12-HSL) and N-butyryl homoserine lactone (C4-H

105 e lactone (C12-HSL) and N-butyryl homoserine lactone (C4-HSL), on cell viability and mucus secretion

106 ition of the RhlI product butyryl-homoserine lactone (C4-HSL), or bacteria that produce C4-HSL, to La

107 The enzymatically produced cyclopropyl-gamma-lactones can be further elaborated to furnish a variety

108 gent C-glycosidation of carbohydrate-derived lactones can be mediated by the protecting groups and ap

109 However, other homoserine lactones can elicit LasR-dependent quorum-sensing respon

110 ion of various heterocyclic monomers such as lactones, carbonates, or epoxides but also to trigger th

111 vs 17 kcal mol(-1) for BTP) include its high lactone carbonyl stretching energy (1821 cm(-1) in aceto

112 egy is demonstrated with a cyclobutane-fused lactone (CBL) polymer.

113 n P. aeruginosa involves two acyl-homoserine-lactone circuits, LasI-LasR and RhlI-RhlR.

114 face selectivity of both chlorine attack and lactone closure.

115 imeric, trimeric, and tetrameric macrocyclic lactones consisting of units of this prostaglandin.

116 the production of the bioactive diterpenoid lactone constituents of the important medicinal herb A.

117 The p-menthane lactones constitute a family of powerful odorants, inclu

118 Lactones containing five-, six-, and seven-membered ring

119 tudied in regard to its bitter sesquiterpene lactones content.

120 This compound has a furyl-delta-lactone core similar to that of Salvinorin A (Sal A), an

121 analytical approach we identified a fragrant lactone corresponding to an odorant zone reminiscent of

122 c acids (CQAs, FQAs) and their corresponding lactones (CQALs, FQALs) in a non-selective way.

123 r esterase (HLE) hydrolyzed chlorogenic acid lactones (CQALs, FQALs) selectively, while chlorogenate

124 UVC activated the L-galactono-1,4-lactone dehydrogenase (GalDH), a key enzyme for vitamin

125 y active synthesis of the beta-hydroxy-gamma-lactone derivative with high enantiomeric purity using S

126 ion of isochroman provided the corresponding lactone derivative.

127 retofore unidentified alpha,beta-unsaturated lactone derived from dioxygenation of pyrene at an apica

128 building block starting from a d-gulono-1,4-lactone-derived intermediate in the current Halaven manu

129 sing two sets of chemical properties (set 1: lactone, diastase activity, sucrose - 100%) (set 2: free

130 The alpha-angelica lactone displays unusual regioselectivity in this reacti

131 mnolipids, lipopeptides, and acyl-homoserine-lactones-do not trigger LORE-dependent responses.

132 droxy amino acid that cyclizes into the beta-lactone during product release.

133 uct SF226 could be converted to corymbiferan lactone E and a related masked o-QM.

134 e, a novel transport pathway for macrocyclic lactone entry into the environment was identified.

135 functionalized alpha,beta-unsaturated delta-lactones featuring a CF(3)-substituted quaternary stereo

136 ent impact on C6 alcohols, volatile phenols, lactones, fermentation-derived alcohols, acids, or most

137 Monacolin K (acid form), monacolin K (lactone form) and minor monacolin peaks were separated o

138 For the calibration curve of monacolin K (lactone form), a linear correlation in the range 6-119mi

139 orces the molecule to adopt a nonfluorescent lactone form, providing a convenient method to make fluo

140 The observation of increased beta-lactone formation by class D SBL variants, including the

141 port studies on the factors determining beta-lactone formation by class D SBLs.

142 A-23 V128L variants, catalyze increased beta-lactone formation compared with the WT enzymes.

143 iosynthesis, fatty acid activation, and beta-lactone formation.

144 ferred conformations for hydrolysis and beta-lactone formation.

145 arranges the carbon backbone, presumably via lactone-forming Baeyer-Villiger oxidation and subsequent

146 ar alkoxycarbonylation to build the bicyclic lactone framework.

147 es to elaborate the highly substituted delta-lactone framework.

148 of an optically active alpha-methylene-gamma-lactone from p-chlorostyrene has been developed on the b

149 ss D SBL variants catalyze formation of beta-lactones from all clinically relevant carbapenems regard

150 ective synthesis of N-heterocycle-fused-beta-lactones from N-linked ketoacids is described.

151 leading to the formation of endocyclic enol lactones from unsaturated carboxylic acids in an one-pot

152 umarin scaffold in which the carbonyl of the lactone function of the original coumarin dyes has been

153 nctional group in DHM is essential while the lactone functional group tolerates modifications.

154 a catalysts provided access to bicyclic beta-lactone-fused, N-heterocycles in moderate to good yields

155 : guaiacol, cis-whisky lactone, trans-whisky lactone, gamma-nonalactone, eugenol, vanillin, and aceto

156 o use LBA as an alternative to glucono-delta-lactone (GDL) for the production of dairy gels with a co

157 The hydrolysis of glucono-delta-lactone (GdL) provides a slow pH drop that allows for st

158 s possessing the monodiene with a simplified lactone had superior anticancer efficacy relative to tax

159 ctive assembly of five-membered (1-halovinyl)lactones has been developed.

160 ss to trifluoromethylated gamma-amino esters/lactones has been realized through the enantioselective

161 acids, affording gamma-, delta-, or epsilon-lactones, has been achieved for the first time.

162 Chlorogenic acid lactones have been identified as key contributors to cof

163 previously discovered that the sesquiterpene lactone helenalin acetate, a natural compound known to i

164 e functional groups like hydroxyl, ester, or lactone in the resultant products expand the scope of sy

165 s-conformation, and the presence of a labile lactone in this core, many synthetic methodologies commo

166 investigated an approach to decompose these lactones in a selective way without affecting the positi

167 enantiomerically enriched gamma-amino esters/lactones in good to excellent yields from the readily av

168 can overcome these challenges to yield gamma-lactones in high enantiomeric excess (up to 99%) using h

169 ith HCl provides stable gamma-NHC-bora-gamma-lactones in isolated yields ranging from 40% to 73%.

170 The wide abundance of gamma-lactones in natural products and bioactive targets calls

171 Five gamma-lactones, including previously reported rubrynolide and

172 S molecule, N-(3-Oxododecanoyl)-L-homoserine lactone, induces candidal resistance to fluconazole by r

173 Among them, a monooxygenated, seven-membered lactone intermediate as a monodentate ligand of the iron

174 e features the construction of a crystalline lactone intermediate via a selective palladium-catalyzed

175 vel reveals that putative biosynthetic gamma-lactones intermediates are localized in the same cell ty

176 obust and scalable conversion of sugar gamma-lactones into highly valuable glycosides having a quater

177 cifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterparts.

178 stereoselective synthesis of homocitric acid lactone is described.

179 GC-MS, we show that only the (R)-C10 massoia lactone is found in musts and wines.

180 group to form 2-carboxy-l-lyxonolactone; the lactone is hydrolyzed by a member of the amidohydrolase

181 We show that (R)-C10 massoia lactone is reduced to (R)-delta-decalactone during alcoh

182 alyzed rearrangement of beta-lactams to beta-lactones is important as a resistance mechanism.

183 Formation of delta-lactones is observed when cyclopentanone-2-carboxylates

184 lective synthesis of cyclopentane-fused beta-lactones is presented.

185 l-Ascorbate, a lactone, is oxidized and ring-opened by enzymes in the c

186 n G (4) to the corresponding 5-hydroxy-gamma-lactone isomer myrocin C (1) are also detailed.

187 a ubiquitin-dependent mitophagy inducer, the lactone ivermectin, we have combined genetic and imaging

188 ges were determined for nafithromycin, a new lactone-ketolide, following the completion of a nine-lab

189 These monomers included various lactones, lactams and a thiolactone, which varied marked

190 ation method that is suitable for converting lactones, lactams, and cyclic ketones to their alpha,bet

191 is likely generally applicable to many other lactones, lactides, anhydrides, epoxides, and heterocumu

192 identify mutants that alter which homoserine lactones LasR detects.

193 r woody/toasty, beta-damascenone and massoia lactone, likely with Z-1,5-octadien-3-one for fruit-in-s

194 However, this reactive lactone limits informed structure-activity relationships

195 ols, inulin, oligofructose and sesquiterpene lactones may be considered as potential carriers of food

196 Although these p-menthane lactones may contribute individually to mint and coconut

197 s contributors to the widespread macrocyclic lactone (ML) resistance in several nematode species incl

198 mination of the residues of five macrocyclic lactones (MLs) (abamectin, doramectin, eprinomectin, ive

199 , the substitutions of the epoxide units and lactone moieties with cyclopropyl and lactam structural

200 s of the parent chromophore were replaced by lactone moieties.

201 n established the last stereocenter, and the lactone moiety was formed by ring-closing metathesis.

202 talide Q acid, by functionalizing the cyclic lactone moiety.

203 ion which relies on a disarmed [2.2.2] l-ido lactone motif.

204 n vitro to link the gene cluster to the beta-lactone natural product, nocardiolactone.

205 beta-Lactone natural products occur infrequently in nature bu

206 provide insights into the production of beta-lactone natural products.

207 The antimicrobial beta-lactone obafluorin is produced nonribosomally from dihyd

208 PCET, whereas reduction of a representative lactone occurs through a concerted PCET.

209 hydrolyzes the ester bond of the homoserine lactone of N-acyl homoserine lactone (AHLs).

210 convert the C5 gem-dimethyl group to the C15 lactone of PXN.

211 time, certain fatty amides, gamma- and delta-lactones of high molecular weight, and other aromatic co

212 rgent preparation of fused cyclopropyl-gamma-lactones of high value for medicinal chemistry and the s

213 sensing molecule (N-3-oxohexanoyl-homoserine lactone; OHHL) and PCWDEs.

214 s were prepared by addition of glucono-delta-lactone, once pH of 6 or 5.5 was reached, the suspension

215 ified as alcohols, esters, acids, aldehydes, lactones, phenols, hydrocarbons and ketone.

216 acids to high value chiral hydroxy-acids and lactones poses a number of synthetic challenges: the act

217 The obtained lactone possesses three functionalized sites, which were

218 undergo oxidative cyclization to form gamma-lactones predominantly.

219 lopropanation of the resulting bicyclic beta-lactone produces a strained housane structure that is co

220 roposelective ring opening of Bringmann-type lactones produces a product with one established axis of

221 biF1, highlighting the structure of the beta-lactone-producing thioesterase domain and an interaction

222 The highly strained and reactive beta-lactone products are versatile linchpins for the mono-se

223 The fused bicyclic gamma-lactone products can be easily diversified to other medi

224 n with formation of an alpha-methylene-gamma-lactone proved instrumental, which had not found applica

225 es C and 30 degrees C carry N-acylhomoserine lactone quorum sensing signals, as well as alkaline phos

226 ppears to bind and sequester some homoserine lactone quorum signals, resulting in the inability of P.

227 rs formed as byproducts, the yields of delta-lactones range from moderate to good (up to 74%).

228 Macrocyclic lactones ranging in size from twelve- to seventeen-membe

229 ar Alder-ene (IMAE) reaction and a lactam-to-lactone rearrangement of tetracycle 13, a compound that

230 pulations involving the carbamate formation, lactone reduction and cyclization, afforded cyclopropyl

231 unique members isolated to date, guaianolide lactones represent a particularly prolific class of terp

232 5000 members isolated to date, sesquiterpene lactones represent a prolific source of medicinal agents

233 d pH levels by adding salt and glucono delta-lactone, respectively, to the MCC solutions prior to ren

234 the purees may be allocated to terpene- and lactone-rich ('SH-5'), ester-containing ('Criolla'), and

235 dies revealed a shift in the position of the lactone ring associated with removal of the C2-methyl an

236 ene flanked by a 7-membered and a 6-membered lactone ring based on spectroscopic analysis.

237 nonfluorescent; however, upon opening of the lactone ring by the formation of the ethyl ester derivat

238 d a linear propyl group at position-4 of the lactone ring confers excellent potency.

239 emination of the pathogen by cleavage of the lactone ring of pseudodesmin.

240 ntained within a highly strained 16-membered lactone ring, which also incorporates two trans-2,5-disu

241 ion, epoxide ring-opening polymerization and lactone ring-opening polymerization without requiring an

242 of GVIA iPLA(2) inhibitors based on the beta-lactone ring.

243 cts harboring 14- to 16-membered macrocyclic lactone rings to which various sugars are attached.

244 t sugar units allows the formation of unique lactone rings within the CD framework via a 1,8-HAT-beta

245 one (BTF), bearing three symmetry-equivalent lactone rings, is unique in its ability to undergo highl

246 iosynthetic intermediates of bioactive gamma-lactones rubrynolide and rubrenolide in the Amazonian tr

247 ymmetric construction of a cyclopropyl-delta-lactone scaffold at a gram scale, which could be further

248 This strategy leads to fused heterocyclic lactone scaffolds in a single step with moderate functio

249 602), only 4-vinyl-guaiacol, eugenol and cis-lactone showed odor activity values (OAV's) above 1, wit

250 nolide and a synthetic alpha-methylene-gamma-lactone showing a positive correlation between thiol rea

251 ion of a highly functionalized sesquiterpene lactone skeleton in five steps via an enantioselective k

252 the world, containing bitter sesquiterpenoid lactone (SL) compounds that may negatively affect consum

253 ugars, phenolic acids (PA) and sesquiterpene lactones (SL) in DFC-BE.

254 e saponification of a particularly sensitive lactone substrate.

255 olecular pinacol coupling between ketone and lactone subunits to assemble the complex skeleton of (-)

256 ble molecules, specifically acyl homo serine lactones, such as N-(3-oxo-dodecanoyl)-l-homoserine lact

257 our prediction, we purified a candidate beta-lactone synthetase from Nocardia brasiliensis and recons

258 Our classifier predicted beta-lactone synthetases in uncharacterized biosynthetic gene

259 rd more specialized functions including beta-lactone synthetases.

260 emical classes, such as aldehydes, alcohols, lactones, terpenoids, fatty aldehydes, fatty acids and h

261 table one, a derivative of the sesquiterpene lactone thapsigargin, is gradually approaching a clinica

262 trifluoroacetic acid-mediated formation of a lactone that is fused to a tetrahydrocarbazole derivativ

263 mbered gamma-lactones and six-membered delta-lactones that occur with terpenoid scaffolds are reviewe

264 logous Pd sigma-complex of the five-membered lactone the smallest Pd/endo-beta-H dihedral angle is ob

265 N-(3-oxo-dodecanoyl) homoserine lactone, the autoinducer of the Pseudomonas aeruginosa L

266 ectively a five-membered ring fused bicyclic lactone, the core structure present in gracilioether F.

267 catalyzing the hydrolysis of acyl-homoserine lactones; these molecules are involved in Gram-negative

268 lization converting a carboxylic acid into a lactone through the oxidation of a tertiary C-H bond und

269 controlled asymmetric synthesis of cis-gamma-lactones through a formal [3 + 2] cycloaddition of enedi

270 iastereoselective addition of alpha-angelica lactone to beta-halo-alpha-ketoesters is reported.

271 osa releases N-(3-oxo-dodecanoyl) homoserine lactone to suppress host immunity for its own better sur

272 tection via acid hydrolysis as well as a key lactone to tetrahydropyran conversion, in order to avoid

273 In addition, we linked the presence of those lactones to interesting odorant zones, reminiscent of mi

274 the structures of briarellin C14-C3 epsilon-lactones to new structural types containing either a C14

275 We present an operationally simple lactone-to-lactam transformation utilizing diverse amine

276 ompounds from oak wood: guaiacol, cis-whisky lactone, trans-whisky lactone, gamma-nonalactone, eugeno

277 Macrocyclic lactone treatments for livestock can have detrimental ef

278 rticularly for the abeo-abietane tri-epoxide lactone triptolide.

279 r tetrahydropyran (THP)-fused bicyclic gamma-lactones, two privileged scaffolds often found in natura

280 s, vinyl ethers, alkenes, cyclic ethers, and lactones) under practical, inexpensive, and environmenta

281 repared from readily available dinorcholanic lactones via their reaction with 4-chlorobutyllithium fo

282 The 16-membered macrocyclic lactone was formed via ring closing metathesis and subse

283 Among a collection of beta-lactones, we found one hit with potent anti-mycobacteria

284 Among volatiles, levels of lactones, well-known key aroma compounds in nectarines,

285 ral, 2-methoxy-4-vinylphenol and cis-whiskey lactone were the compounds that contribute the most to t

286 aled up and the alpha,beta-unsaturated delta-lactones were converted to amino acid derivatives decora

287 bi- and tricyclic, N-heterocycle-fused, beta-lactones were first synthesized in racemic fashion via t

288 of volatile compounds (ketones, esters, and lactones) were observed.

289 nS-generated pheromone N-octanoyl homoserine lactone, which may account for the previously unexplaine

290 ations resulting in cyclopropane-fused gamma-lactones, which are key motifs found in many bioactive m

291 metric synthesis of cyclopropane-fused-delta-lactones, which are key structural motifs found in many

292 ange of epoxides can be carbonylated to beta-lactones, which are subsequently ring-opened to produce

293 situation whereby fragile substrates such as lactone will be hydrolyzed by a stronger base but will n

294 led to the identification of AJH-836, a DAG-lactone with preferential affinity for novel isozymes (n

295 d octanal, 5-methyl furfural and cis-whiskey lactone with the toasting degree.

296 were related to the aging time; cis-whiskey lactone with the type of wood pieces and octanal, 5-meth

297 ogreensporone F, 14-membered resorcylic acid lactones with a cis-2,5-disubstituted tetrahydrofuran ri

298 Macrolactones, macrocyclic lactones with at least twelve atoms within the core ring

299 SQ) or methylquinidine (MeQd)) provided beta-lactones with high enantio- and diastereoselectivities.

300 three major products but with an increasing lactone yield of 33, 49, and 55% on these substrates, re