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1  a similar structure of 16-membered aglycone lactone ring.
2 educed level of intramolecular attack at the lactone ring.
3 he ether-like moieties within the artesunate lactone ring.
4  compounds by cleaving the amide bond or the lactone ring.
5 dditional hydrogen bond to the oxygen of the lactone ring.
6 of GVIA iPLA(2) inhibitors based on the beta-lactone ring.
7  sn-2 carbonyl of DAG was constrained into a lactone ring.
8 he alkyl chain between the THF rings and the lactone ring.
9 he alkyl chain between the THF rings and the lactone ring.
10  required for the synthesis of a 16-membered lactone ring.
11  thiolactone ring in place of the homoserine lactone ring.
12 mediated hydrolysis of the natural products' lactone rings.
13                  Subsequent reduction of the lactone ring and cyclization of the resulting diols 27 a
14  particular attention to modification of the lactone ring and methylenedioxy group, were synthesized
15           Furthermore, steric bulk about the lactone ring and the alpha sugar may be critical for dru
16 ractions between its polarized five-membered lactone ring and the Mg(2+).
17 ral and functional features of digoxin are a lactone ring and three digitoxose sugars attached to a s
18  B, which have an epoxide in the macrocyclic lactone ring, and C and D, which have a double bond inst
19 ching a compensating lipophilic chain to the lactone ring as an alpha-alkylidene moiety produced comp
20 xist between DLIF and digoxin at or near the lactone ring as well as in the nature of the sugars.
21 ches to vinigrol based on the involvement of lactone rings as tools for the conformational rigidifica
22 dies revealed a shift in the position of the lactone ring associated with removal of the C2-methyl an
23 ) difference in the strains of the generated lactone rings; (b) difference in the strengths of the et
24 ene flanked by a 7-membered and a 6-membered lactone ring based on spectroscopic analysis.
25 nonfluorescent; however, upon opening of the lactone ring by the formation of the ethyl ester derivat
26 generate the tert-butyl group and one of the lactone rings, characteristic of all G. biloba trilacton
27 formation of 3a from EB, CO, and 1 is rapid, lactone ring closing is rate-determining.
28 h alkylation/cyclization and an Ullmann-type lactone ring closure into the pentacyclic lamellarin ske
29 d a linear propyl group at position-4 of the lactone ring confers excellent potency.
30  sugar, steroid, and five-member unsaturated lactone ring, contribute to Ab recognition.
31                                Moreover, the lactone ring could not be opened hydrolytically without
32 pal pharmacophores of DAG constrained into a lactone ring (DAG-lactones).
33                   Sirtinol, a cell-permeable lactone ring derived from naphthol, is a dual Sirt1/Sirt
34 mpounds with substitutions in the homoserine lactone ring did not show evidence of binding to LuxR.
35 ously unknown function of the pro-drug, beta-lactone ring form of lovastatin to inhibit the proteasom
36 ermedius is a nonapeptide (RIPTSTGFF) with a lactone ring formed through condensation of the serine s
37 ization (DP), in which the maximum number of lactone rings formed equals DP minus 2.
38 by the inwardly pointing cyclic pentapeptide lactone rings from adjacent bound ActD molecules should
39 (PMMBL), an acrylic polymer bearing a cyclic lactone ring, has attracted increasing interest because
40                                              Lactone ring hydrolysis was another important biotransfo
41 ardly pointing benzenoid cyclic pentapeptide lactone rings in the complex.
42 uble bond, rearrangement of the six-membered lactone ring into a beta-lactam moiety, and final deprot
43 fore, we propose that initial opening of the lactone ring is promoted by Cys-47 through thioester for
44 a chiral pilocarpine analogue 3 in which the lactone ring is replaced by an oxazolidinone and the bri
45 e center of the acetogenin molecules and the lactone ring is terminal to a long alkyl chain, these ob
46 o each ring; an alpha,beta-unsaturated gamma-lactone ring is terminal to one of the alkyl chains.
47                         The main 12-membered lactone ring is very flexible; as a result, there exist
48 one (BTF), bearing three symmetry-equivalent lactone rings, is unique in its ability to undergo highl
49 nteractions primarily at the alpha-sugar and lactone ring moieties of the cardiac glycosides.
50 ditionally, some orthologs yielded two novel lactone ring moieties.
51 s, requiring the structural integrity of the lactone ring motif and its natural stereochemistry.
52                               Opening of the lactone ring of 14 and 18 led to seco structures which,
53 clic ring opening at pH > or =8.5, while the lactone ring of 20-O-acyl CPT derivatives remained unaff
54  it was determined by HPLC analysis that the lactone ring of a 20-O-ether derivative of CPT underwent
55 r complementarity about the beta side of the lactone ring of digitalis.
56 titutes a tertiary amine for the macrocyclic lactone ring of ferric enterobactin but maintains an uns
57  contrast with asimicin and parviflorin, the lactone ring of longimicin B, an asimicin analogue with
58  direct in vivo evidence that the homoserine lactone ring of LuxI-family autoinducers is derived from
59                                     The beta-lactone ring of N-(2-oxo-3-oxetanyl)amides, a class of N
60 emination of the pathogen by cleavage of the lactone ring of pseudodesmin.
61 re both the pyrrolidine moiety and the delta-lactone ring of the 3,4-dihydrocoumarin framework are co
62                          Methanolysis of the lactone ring of the N-benzyl-N-methyl derivative 7c foll
63 ects reversible, pH-dependent opening of the lactone ring of wortmannin.
64 1H difference NOE spectra indicated that the lactone rings of asimicin and parviflorin, the latter of
65 nucleophilic serine and that cycloserine and lactone rings of LTV are opened.
66 ly and inwardly pointing cyclic pentapeptide lactone rings of symmetry-related ActD molecules retain
67                                          The lactone rings of the polyketides platenolide and tylacto
68 tments of the transesterification of a delta-lactone ring on retaining a sensitive triethylsilyl prot
69  in alternating epoxide/anhydride ROCOP, and lactone ring opening polymerization, produces amphiphili
70 t lactone resulted in both rearrangement and lactone ring opening, revealing that the farnesyl lacton
71 eral factors, including drug inactivation by lactone ring opening, tumor drug resistance, and toxicit
72 erdisarm iduronate components, reversible by lactone ring opening.
73                         The process includes lactone ring-opening by esterases, stereoselective oxida
74 ion, epoxide ring-opening polymerization and lactone ring-opening polymerization without requiring an
75 cid and exchange with AR-67, which undergoes lactone ring-opening, ionization, and membrane binding i
76                                              Lactone ring or naphthalene (positions 7-9) substituents
77 ither the copolymerization of a hydrolyzable lactone ring or the hydrogel polymer content.
78  benzenoid and quinonoid cyclic pentapeptide lactone rings positioned in the minor groove and directe
79 n on an iminium carbon with formation of the lactone ring present in the lactone-lactam.
80 ics differences due to the type of sugar and lactone ring present in the steroid structure.
81 efficiently catalyze formation of 6-membered lactone ring products from acyl-bound intermediates on D
82 igher DP lactonize more rapidly, but all the lactone rings rapidly open up when exposed to mild alkal
83 tiaromatic destabilization of the alpha-keto-lactone ring rendering the two structures much closer in
84 s aromaticity on enolization, the alpha-keto-lactone ring showed an unexpected and significant antiar
85 oid and quinonoid-linked cyclic pentapeptide lactone rings spanning two base-pairs in opposite direct
86 equired for formation of the core 19,6-gamma-lactone ring structure.
87   However, structures lacking the homoserine lactone ring, structures lacking the l-configuration at
88 ocaenols contain an unusual enolized oxepine lactone ring system that to the best of our knowledge is
89 amma-butyrolactone acrylate (DBA)-containing lactone ring that modulated the lower critical solution
90 othecin (SN-38), have a labile alpha-hydroxy-lactone ring that undergoes pH-dependent reversible hydr
91 rminated by antennal esterases that open the lactone rings to form physiologically inactive hydroxyac
92 cts harboring 14- to 16-membered macrocyclic lactone rings to which various sugars are attached.
93  a series of derivatives in which either the lactone ring was hydrolyzed or the C-9 phosphate ester w
94 the propenoyl-branched carbonyl into a gamma-lactone ring was performed (11-14) not only to derive a
95 ntained within a highly strained 16-membered lactone ring, which also incorporates two trans-2,5-disu
96 isted of lactonization and aminolysis of the lactone ring, which ultimately furnished cyclopropanecar
97 nd to the T. thermophilus ribosome reveals a lactone ring with a conformation similar to that observe
98 e polyketide toxin consists of a 12-membered lactone ring with a lower O-linked polyunsaturated acyl
99                           Replacement of the lactone ring with other cyclic moieties resulted in loss
100        The positions of both the THF and the lactone rings within liposomal membranes were determined
101 t sugar units allows the formation of unique lactone rings within the CD framework via a 1,8-HAT-beta

 
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