ライフサイエンスコーパス: lag

1 nserved genes, Caenorhabditis elegans mpk-1, lag-1, and lag-3/sel-8, which encode homologs of ERK/MAP

2 dicators (18 leading, 30 coincidental, and 9 lagging) and 5 other trade/money indexes.

3 A lag phase was observed prior to O(2) evolution, suggesti

4 ses in breeding probability observed after a lag period following highest rabbit numbers.

5 earching for temporal patterns by applying a lag penalty.

6 Among the latter, 33.2% had a lag period of 1.3 years before insulin was initiated.

7 indicator on PDMP mandate implementation, a lag indicator, and alternative policy implementation dat

8 rrupted time series analyses incorporating a lag period to allow for potential policy-associated chan

9 the direct sprayed dried samples revealed a lag time for 2 h in acidic media followed by rapid relea

10 lated forms of both conformers, leading to a lag phase in activity until the more active phosphorylat

11 rrelates positively with host density with a lag of 1-4 months.

12 Second, and with a lag of 190 (+/- 44) y, an increase in the detrital K/Ti

13 th stimulation will, inevitably, result in a lagged increase in canopy tree mortality, as is indeed w

14 Significantly larger accommodative lags were measured with MFCLs compared to SV.

15 oveal involvement, the loss of visual acuity lagged behind central RPE atrophy in AF images.

16 al conditions because their ability to adapt lags behind the rate of habitat alteration.

17 al information available to the brain always lags behind the timing of events in the present moment.

18 es, Caenorhabditis elegans mpk-1, lag-1, and lag-3/sel-8, which encode homologs of ERK/MAPK and core

19 angle showed a shear-dependent occlusion and lag time for both PRP and WB.

20 e often followed by plateaus, shoulders, and lag-driven oscillations.

21 ly correlated, and depending on the sign and lag between the time series, either shallow sealing or m

22 ng annual incidence rates from 2002-2011 and lagged moving averages of annual estimates for PM2.5 wer

23 dissolved gas concentrations are damped and lagged with respect to equilibrium concentrations, being

24 patial heterogeneity of flux footprints, and lagged influence of biophysical drivers.

25 T was treated as a time-varying variable and lagged by 1 year to account for cancer latency, with non

26 y, we demonstrate that some coincidental and lagging indicators actually show leading indicator chara

27 incorporated nucleotides during leading and lagging strand syntheses.

28 delta (Poldelta) synthesize the leading and lagging strands, respectively.

29 e analysis of BrdU uptake during leading and lagging-strand telomere replication shows preferential u

30 mental speciation has been underutilised and lags behind other contributions to speciation research.

31 Whether this apparent lag reflects taphonomic biases or behavioral distinction

32 id interfaces into predesigned architectures lags the progress made in bulk solution both in practice

33 for analyzing single-cell methylome data are lagging far behind.

34 results suggest that terrestrial species are lagging behind shifting isotherms more than marine speci

35 Effective therapies are lagging behind because most drugs cannot reach their tar

36 misalignment at metaphase plates as well as lagging chromosomes at anaphase.

37 ased FeNO (4.35 [-0.1, 8.7] ppb) and also at lag 2.

38 ng a sharp rise in motion autocorrelation at lag-1 and a sharp rise in the autocorrelation decay time

39 dence interval (CI): 0.76, 3.93] increase at lag 0 and 3.99% (95% CI: 0.08, 8.06) increase at lag 3,

40 0 and 3.99% (95% CI: 0.08, 8.06) increase at lag 3, respectively.

41 ory disease, asthma, and pneumonia peaked at lag 3 by 8.85% (95% CI: 0.80, 17.55), 14.55% (95% CI: 6.

42 l lag days 0-6, and for 3-d moving averages (lag 0-2).

43 ort from plant molecular biologists has been lagging behind, but recent work in Arabidopsis (Arabidop

44 to obtain, and they have, as a result, been lagging behind the congeneric Plasmodium species infecti

45 creased levels of grass pollen a day before (lag 1) were associated with increased FeNO (4.35 [-0.1,

46 mbient levels of grass pollen 2 days before (lag 2) were associated with lower mid-forced expiratory

47 03] %, respectively) and also 3 days before (lag 3).

48 we define novel features that segregate both lagging and paired chromosomes for optimal sperm product

49 in the prevalence of antibiotic tolerance by lag and demonstrate that the benefits of phenotypic hete

50 Challenges causing lagging drug innovation include the duration and expense

51 We quantify the distribution of single-cell lag times of populations of starved Escherichia coli and

52 uctural and pharmacological characterization lags considerably behind.

53 show that thermophilization and the climatic lag in forest plant communities are primarily controlled

54 rrelated with the observed increase in CNSC (lag = 0 years; R (2) = 0.660).

55 on, which together result in the complicated lagging strand replication.

56 In conclusion, lag phase is not a reliable measure of stress because le

57 over multiple consecutive or non-consecutive lags, showing complex, often non-linear associations tha

58 on for transmission to NCHS, with consequent lag in capturing the total number of deaths compared to

59 nd spindles in mPFC, and fired at consistent lags with other thalamic units within spindles, while CA

60 posure and schizophrenia) have, in contrast, lagged behind heritable frameworks of explanation.

61 t-CBT were examined using longitudinal cross-lagged panel modeling.

62 oint transition modeling approach with cross-lagged structure to understand how asthma and obesity in

63 t access should target groups that currently lag in this area.

64 ivation areas for ED visits for anxiety {1-d lag [OR = 1.39 (95% CI: 0.96, 2.01) vs. 0.85 (95% CI: 0.

65 The dataset is updated daily, with a 5-day lag for validity checking.

66 ter adjusting for temporal trends, seven-day lagged analyses showed significant positive associations

67 hanisms that govern germline differentiation lags behind other plant developmental processes.

68 ic simulations of autoregressive distributed lag models to elucidate key drivers of climate and ecolo

69 least squares regression (PLS), distributed lag model (DLM), least absolute shrinkage selector opera

70 used by unwarranted Pif1 interference during lagging strand replication.

71 ropose underlies polymerase recycling during lagging strand synthesis, in analogy to Escherichia coli

72 the major driver of nick translation during lagging strand replication, Pif1-dependent stimulation o

73 30 s intervals revealed three phases (i.e., lag, exponential, and linear) in the development of depo

74 tcome and assessed pooled estimates for each lag when at least three studies were available for a spe

75 ciations were generally positive for earlier lag periods and weaker across later lag periods.

76 n parasites and disease in marine ecosystems lags behind terrestrial systems, increasing the challeng

77 Deletion of the HOT region from endogenous lag-1 reduced LAG-1 levels and abrogated positive autore

78 wever, our understanding of their energetics lags behind that of other taxa.

79 ore did the timing of the phenological event lag behind the timing of the cue.

80 lution obtained from single shot experiments lags averaging static experiments.

81 ed a perceptual illusion he called the flash-lag effect (FLE) to argue that the brain's visual system

82 and DIE (ER = 3.9%; 95% CI: 1.1%, 6.8%) for lag days 0-3.

83 species from the growth-phase and rarely for lag-phase species.

84 d = 0.001)], with similar risk estimates for lagged exposure [20-y lag RRIWD Tertile 3 = 3.37 (95% CI

85 to lack of knowledge about BMP functioning, lag times, nonoptimal placement and distribution of BMPs

86 Plasmodium vivax bench research greatly lags behind Plasmodium falciparum because of an inabilit

87 s for an interquartile range increase in 1-h lagged exposures (ranging from 21.3% for PM2.5 to 74.7%

88 h pollutant concentrations at individual 1-h lags (up to 24 h) and with average concentrations at 8 a

89 However, their widespread adoption has lagged behind Cas9-based strategies due to low activity

90 size calculations for mediation analysis has lagged far behind the development of methods.

91 atistical methods to analyze screen data has lagged.

92 ledge of right ventricular (RV) function has lagged behind that of the left ventricle and historicall

93 reasons their large-scale investigation has lagged behind the study of genomes.

94 take among those who can benefit from it has lagged.

95 tion of these countermeasures in nursing has lagged behind other shift work oriented industries.

96 nization and their functional properties has lagged behind that of the thalamocortical systems they c

97 hibitors of other amyloidogenic proteins has lagged behind.

98 However, proteomics has lagged far behind genomic approaches in scalability, sta

99 The research in 3DP of textiles has lagged behind other areas primarily due to the difficult

100 otal sRNA pool; siRNA locus annotations have lagged far behind.

101 deluge are progressing, many biologists have lagged behind due to the fast pace of computational adva

102 rtain its contribution to human disease have lagged far behind our understanding of protein coding va

103 pancreatic ductal adenocarcinoma (PDAC) have lagged behind advances made in the treatment of many oth

104 es for the study of structural variants have lagged behind those for smaller variants.

105 al examination, the child showed marked head lag and did not reach out to objects.

106 wo controlled human exposure studies (1-hour lag: -13.22%; 95% CI: -24.11% to -2.33%).

107 acteria, are often accompanied by multi-hour lags before growth resumes.

108 significant differences for multiple hourly lags.

109 ze LTP responder survival and implementation lag would facilitate resource optimization in glaucoma t

110 ex spectral power increase that decreased in lag time with increasing locomotion speed.

111 -off by evolving phenotypic heterogeneity in lag time.

112 A reduction in lag time exiting stationary phase was linked to L. plant

113 in a decreased growth rate and an increased lag phase duration.

114 Besides a significantly increased lag time and decreased RPA rate for PRP compared to WB (

115 hree indoor exposure metrics, for individual lag days 0-6, and for 3-d moving averages (lag 0-2).

116 This obliquity-induced lag, in turn, makes carbon dioxide a delayed climate amp

117 ted migration to tail wounds with an initial lag in recruitment early after wounding.

118 f mitochondrial DNA transcription initiation lags that of bacterial and nuclear DNA transcription.

119 ad placement demonstrated a mean inspiratory lag for phrenic nerve stimulation of 23.7 ms (p < 0.001

120 the data generated from new instrumentation lags behind.

121 However, recovery of Wnt signaling post-IR lagged behind proliferative recovery.

122 diversity in SER appears strong but there is lag with regard to inclusion.

123 ver, the understanding of RTK ligand bias is lagging behind the knowledge of GPCR ligand bias.

124 cture and properties of metabolomics data is lagging behind.

125 stand and predict Earth's natural systems is lagging behind our ability to monitor and measure change

126 Jet lag is a consequence of the misalignment of the body's i

127 t of intake and had more frequent social jet lag (P < 0.05).

128 sed, presented sleep alterations, social jet lag, obesity and higher metabolic risk.

129 dult, wild-type mice to distinct chronic jet-lag paradigms, which showed that long-term circadian mis

130 earlier lag periods and weaker across later lag periods.

131 composition approaches, we obtain a new lead/lag order of the macroeconomic indicators and perform cl

132 tial allows us to better understand the lead/lag relationships.

133 among the US economic indicators with leads/lags.

134 Study limitations include likely lag time in receipt of completed death certificates rece

135 with antihypertensive medications, and long lag time to clinical outcomes.

136 decades to occur, resulting in decades-long lag times between the time when a land-use activity is i

137 ved include severe local outbreaks with long lag time relative to the aggregate infection curve, and

138 As a consequence, cells with long lag times have no substantial effect on population growt

139 Metabolomic analysis reveals that long lags result from the depletion of key metabolites that f

140 p under irrigated croplands, with SIC losses lagging behind the downward-advancing wetting front by ~

141 Surprisingly, the main lagging-strand polymerase, Pol delta, binds the leading

142 explore how dispersal limitation, migration lags, and competitive exclusion may cause mismatches.

143 our knowledge of other aminergic modulation lags behind.

144 this hypothesis cannot explain the multi-Myr lag between the delta(13)C excursion and global cooling.

145 Analysis of human antibodies to NA lags behind that of antibodies to HA.

146 result in repeat contractions in the nascent lagging strand.

147 that after bypass CMGs encounter the nascent lagging strands of the converging fork and then transloc

148 e and inhibition of T4P formation at the new lagging pole.

149 patocytes of differing ploidies, we found no lagging chromosomes or micronuclei in mitotic polyploid

150 efined nucleator that reduces the nucleation lag seen in bulk tubulin assembly.

151 and moderate correlations between length of lag and exponential growth-rates; and sometimes none.

152 reliable measure of stress because length of lag and growth-rate inhibition are sometimes highly corr

153 Here, we investigate whether length of lag phase can act as a proxy for stress, using a number

154 ts are compound representations of length of lag, exponential growth-rate, and other factors.

155 st that proper transcriptional regulation of lag-1 confers robustness to somatic reproductive system

156 nings, we identified five core components of lagging-strand synthesis as essential for cccDNA formati

157 However, in the context of lagging strand DNA synthesis, the efficient disruption o

158 Repeats contract in the course of lagging-strand synthesis: The processivity subunit of DN

159 t the midbody in response to the presence of lagging chromatin and functions within the ICB to promot

160 In response to the abnormal presence of lagging chromatin between dividing cells, an evolutionar

161 tion shows preferential under-replication of lagging telomeres.

162 Despite the ubiquity of lags in drought recovery, large uncertainties remain reg

163 Species responses often lag behind climate warming, but the reasons for such lag

164 However, optogenetics lags in plant research because ambient light required fo

165 ions associated with loss of lin-12/Notch or lag-1 activity.

166 ransformed gene is encoded on the leading or lagging strand has limited influence on recombination ef

167 (MMR) and/or leading strand (Polepsilon) or lagging strand (Poldelta) DNA polymerase proofreading.

168 s phospholipids alone extended the oxidation lag time up to 40 h.

169 The pupillary response peaks lagged behind insular activations by several hundreds of

170 at patients exhibit substantially more phase lag.

171 bining optomagnetic readouts of signal phase lag and hydrodynamic size increase of MNPs, NECA-based t

172 nt epoch lengths and numbers, with the phase lag index (PLI) and debiased weighted PLI (dbWPLI), for

173 Once predator phenology lagged behind prey by more than 24 days, rapid extinctio

174 ng to treat in children, with survival rates lagging well behind those observed at initial diagnosis.

175 Results showed reciprocal lags at points of alternation, consistent with behaviora

176 use brain within 72 h, dramatically reducing lag time between viral transduction and imaging, while i

177 one environment, producing greater relative lag load.

178 nuclease-helicase implicated in DNA repair, lagging-strand DNA synthesis, and the recovery of stalle

179 esting that a 'tug of war' reliably resolves lagging.

180 cular reflex-whereas wing steering responses lagged by more than 40 ms.

181 n at the rear exhibits a reproducible 9-15-s lag.

182 cing housing prices, such as the time-series lags of government policy, are tested and analysed in th

183 ception of O(3), were significant at several lags within 7 days.

184 vancomycin by 75%, and resulted in shortened lag-phase and increased colony formation at sub-inhibito

185 ic catchment exhibited significantly shorter lag times and faster rates of net H(2) oxidation and dar

186 marily determined by the cells with shortest lag due to the exponential nature of bacterial populatio

187 e model substrate 7-benzoyl quinoline showed lag phases in several cases, consistent with multiple st

188 frictional resistance exhibits a significant lag in response to such normal stress variations, and id

189 load derived from pathways with significant lag times.

190 A sizeable lag in selecting feature information is seen when stimul

191 ccording to community deprivation, with some lags showing stronger associations among children in hig

192 vement of cancer patient management somewhat lags behind these basic breakthroughs.

193 three studies were available for a specific lag.

194 -regression to combine the location-specific lag-cumulative nonlinear associations across all locatio

195 studies keep increasing in number but still lag behind other medical disciplines, and the quality of

196 er previous methods, we find that they still lag behind parallel-arm cluster-randomized trials and in

197 y led by China's transformations, APAC still lags behind global averages after two decades.

198 sts selectively to specific cell types still lags behind catalyst development.

199 the non-transcribed strand and on the strand lagging during replication.

200 h of the panel studies (e.g. Augsburg study, lag 3 hours: -2.26%, 95% confidence interval [CI]: -3.98

201 I]: -3.98% to -0.53%; Rochester panel study, lag 1 hour: -2.69%; 95% CI: -5.13% to -0.26%) and one of

202 climate change, slow responses substantively lag climate forcing, causing disequilibria and reduced f

203 nd climate warming, but the reasons for such lags remain largely unknown.

204 The Makoid-Banakar with T(lag) model was suitable for the efficient simulation of

205 of permissive environments, with a temporal lag.

206 Temporal lags in population- and assemblage-level shifts after fo

207 t conservation has failed; instead, temporal lags in species' responses to conservation action could

208 profiles based on the length of the temporal lags that are introduced.

209 Moreover, the magnitude of temporally lagged, negative HFB coupling between the DAN and DMN (b

210 se to LIN-12/Notch activity, indicating that lag-1 engages in direct positive autoregulation.

211 ubunits, thereby challenging the notion that lagging-strand DNA polymerases frequently dissociate fro

212 The lag phase before lipid oxidation enters the exponential

213 f the RRIs as functions of the scale and the lag.

214 tality should be interpreted cautiously; the lag structure has unclear interpretation and suggests th

215 also bind small aggregates formed during the lag phase and early elongation phase of fibril formation

216 hogenic Abeta seeds already exist during the lag phase of protein aggregation in the brain.

217 (12-19) fragments in interactions during the lag phase, whereas C-terminal fragments (20-32 and 26-32

218 rth's obliquity (axial tilt)-can explain the lag of atmospheric carbon dioxide behind climate during

219 stabilized-emulsions was able to extend the lag phase to 20 days for lipid hydroperoxide and to 14 d

220 man amylin, forms low-order oligomers in the lag phase of amyloid formation.

221 Analysis of the lag phase and exponential slope added important informat

222 training to improve the response (reduce the lag of accommodation) was performed and accommodation re

223 Biofeedback training effectively reduced the lag by >=0.3D in individuals of both groups with SVCL an

224 lipid nanodiscs activate Src by reducing the lag phase in Src autophosphorylation.

225 We explain the lagged climatic response by a shift in the dominant mode

226 tion and show that Pol alpha-primase and the lagging-strand Pol delta can be re-used within the repli

227 indirect inhibition of T4P formation at the lagging pole by MglB due to its MglA GAP activity.

228 ndles in Caenorhabditis elegans, we find the lagging X chromosome, a distinctive feature of anaphase

229 3A) and APOBEC3B, deaminate cytosines in the lagging-strand template during replication.

230 We propose that accumulation of ssDNA in the lagging-strand template fosters the formation of a tripl

231 lation of single-stranded DNA (ssDNA) in the lagging-strand template greatly increases the probabilit

232 oth ahead of the replication fork and on the lagging strand template.

233 2, 5'-flaps are thought to accumulate on the lagging strand, resulting in DNA damage-checkpoint arres

234 and positive regulation also operate on the lagging strand.

235 ase, which can resolve G-quadruplexes on the lagging-strand template.

236 C complex preferentially loads PCNA onto the lagging strand, which is crucial for DNA replication but

237 g cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (

238 A polymerases alpha and delta synthesize the lagging strand.

239 in (GAP) MglB, which localizes mainly to the lagging cell pole, indirectly blocks T4P formation at th

240 at the bottom of the ZF sub-ring, where the lagging strand is blocked and diverted sideways by OB ha

241 vely defined periods of expected therapeutic lag allows insights into the evaluation of treatment res

242 bootstrapped mean differences in therapeutic lag duration between registries.

243 The duration of therapeutic lag for disability progression was calculated for seven

244 The duration of therapeutic lag for relapses was calculated for 10 therapies and ran

245 ctively quantify the duration of therapeutic lag on relapses and disability progression in different

246 t and disease characteristics on therapeutic lag.

247 multiple sclerosis treatments ('therapeutic lag') on clinical disease activity represented by relaps

248 various mechanisms that may contribute these lags in drought recovery could have contrasting implicat

249 Yet this lag is not seen with temporally uncorrelated rapid seria

250 Otus murivorus exhibits a 2-tier "lag behind" phenomenon for cranium and brain evolution,

251 entrations in subjects with SAR, with a time lag between 0 and 13 days depending on the pollen type.

252 We then investigate a time lag in a real biodiversity indicator using empirical dat

253 that purple martins are experiencing a time lag in their distribution.

254 bserve vesicle permeabilization after a time lag that is characterized in relation with the level of

255 ganisms; however, offshore sampling and time lag from sampling to results remain problematic.

256 when they are broadly in phase (i.e. no time lag).

257 urrent antidepressants have significant time lag and efficacy limitations, new rapid-acting agents th

258 eral weeks previously, allowing for the time lag between infection and death.

259 To address this time lag, the isotope dilution mass spectrometry (IDMS) metho

260 e target stimuli presented at different time lags.

261 on fronto-parietal network at different time lags.

262 to understand the mechanisms that drive time lags.

263 Accounting for ecological time lags in biodiversity targets and indicators will greatly

264 is of interacting social and ecological time lags in the transient phase of a shallow lake highlights

265 spective on the influence of ecological time lags on the assessment of conservation success and revie

266 an 10-week study and, when adjusted for time lags, tracked the rise and fall of cases seen in SARS-Co

267 on success and review the principles of time lags and their ecological drivers.

268 Independent analyses-based on time lags, the correlational structure in the data and comput

269 edges (due to non-climate processes or time lags at the warm edge; the biogeography hypothesis or ex

270 ynamics and the interaction with social time lags can be more relevant than solely stable states and

271 ce is developed to demonstrate that the time lags between radiation forcing, air temperature, and rai

272 l change by lake polluters to study the time lags that emerge as a response to the transient, deterio

273 onthly SST anomalies with a three-month time-lag is 0.35, with statistically significant correlations

274 n limitation, source-sink dynamics, and time-lagged local extinction can cause mismatches between nic

275 insight and clinical translation continue to lag the pace of risk variant identification, hindered by

276 Notably, VP infants continued to lag, with overall brain size generally less than that of

277 eld areas prone to water stress are shown to lag as much as 23-33% below the field average during dro

278 forest carbon stocks may be transient due to lagged increases in mortality.

279 gs relative to SWRs, varying from leading to lagging.

280 the contributions of individual nucleases to lagging-strand synthesis nor the structure of the DNA in

281 recipient, early in conjugal transfer, until lagging-strand replication creates the double-stranded f

282 ssociation between total fluoroquinolone use lagged by 1 and 2 months and the proportion of isolates

283 Finally, using lag analyses, we found consistent temporal ordering of f

284 reatly with stressor concentration even when lag remained constant.

285 tly according to average HOMA-IR values when lagged 6-18 h for PM2.5, 15-19 h for BC, and 6-15 h for

286 ndeed essential for stabilizing the ICB when lagging chromatin is present, but not in normal dividing

287 gaps in the nascent leading strand, whereas lagging-strand template R-loops (head-on) had little imp

288 model which shows that bacteria evolve wide lag time distributions when both rapid growth resumption

289 in t1/2, but the number of individuals with lag phase was significantly higher in the AL than in the

290 CT fibrillation kinetics was sigmoidal, with lag, growth, and plateau phases as shown by thioflavin T

291 g seasons was (a) negatively associated with lagged North Atlantic Oscillation for seals at NR and (b

292 ling for potential confounding factors, with lagged and unlagged pesticide exposures.

293 clei arise from cells entering anaphase with lagging chromosomes, cellular mechanisms allowing late-s

294 e decreased in ICBs, and dividing cells with lagging chromatin become binucleated as a consequence of

295 mentation for pregnant and post-partum women lags behind implementation for other high-risk populatio

296 lar risk estimates for lagged exposure [20-y lag RRIWD Tertile 3 = 3.37 (95% CI: 1.83, 6.22; ptrend =

297 In 20-y lagged analyses, we also found exposure-response associa

298 Multi-year lags in tree drought recovery, termed 'drought legacy ef

299 ory variables (from 2009 to 2015) and 1-year-lagged ceftriaxone, cefixime, azithromycin, and ciproflo

300 Also, VPL -> S1 and zero-lag interaction decreased when monkeys were not required