ライフサイエンスコーパス: lamellipodia

1 een the long-axis direction of two different lamellipodia).

2 ot of filopodia capable of emanating without lamellipodia.

3 lting in FAK activation and the formation of lamellipodia.

4 logy of their tips, which lack filopodia and lamellipodia.

5 ells increased F-actin and Arp2/3 complex in lamellipodia.

6 s templates for formation and orientation of lamellipodia.

7 ated by the Arp2/3 complex, forming ruffling lamellipodia.

8 (Arp2/3) complex in the membrane ruffles and lamellipodia.

9 and filopodial spike-based protrusions, not lamellipodia.

10 luding protrusions ranging from filopodia to lamellipodia.

11 activity and drives its localization within lamellipodia.

12 MRCKalpha colocalize at the cell membrane in lamellipodia.

13 y compressed axial cell length and collapsed lamellipodia.

14 d is required for Rac1-mediated formation of lamellipodia.

15 cells, where it colocalizes with F-actin in lamellipodia.

16 number and disturbed orientation of cellular lamellipodia.

17 unction in live fibroblasts with established lamellipodia.

18 tion between cells is mediated by protruding lamellipodia.

19 ited elongated cellular tails and diminished lamellipodia.

20 axillin-based focal adhesion within the same lamellipodia.

21 play growth cones with significantly smaller lamellipodia.

22 protein accumulation at the leading edge of lamellipodia.

23 e line depleted of Arp2/3 complex that lacks lamellipodia.

24 of SMN and actin at the leading edge at the lamellipodia.

25 e projection and retraction of filopodia and lamellipodia.

26 n inactive conformation and localizes to the lamellipodia.

27 ed in process extension and the formation of lamellipodia.

28 s rapid rearrangement, forming filopodia and lamellipodia.

29 d the organization of actin filaments within lamellipodia.

30 leton in the apical cortex and in protruding lamellipodia.

31 es, which are essentially stand-alone motile lamellipodia.

32 y the generation of persistent and polarized lamellipodia.

33 location to and efficient incorporation into lamellipodia.

34 wth factor-stimulated membrane protrusion at lamellipodia.

35 ovarian cancer cells with PI3KC2beta-driven lamellipodia.

36 zed HGF-mediated effects on the formation of lamellipodia, a pre-requisite for migration using human

37 on two-dimensional (2D) surfaces by forming lamellipodia-actin-rich extensions at the leading edge o

38 bsence of INF2 led to defective formation of lamellipodia and abnormal SD trafficking.

39 KAI1/CD82, consistent with the diminution of lamellipodia and actin cortical network; while the growt

40 riphery and a decrease in the persistence of lamellipodia and cell motility, a phenotype consistent w

41 ion of SphK1/p-SphK1 with actin/cortactin in lamellipodia and down-regulation or inhibition of SphK1

42 lls along the edge of a wound still extended lamellipodia and elongated toward the wound but were inh

43 filament networks required for formation of lamellipodia and endocytic actin structures.

44 CLAMP accumulated in lamellipodia and filopodia at the leading edge of migrat

45 well as p21-activated kinase (PAK)-mediated lamellipodia and filopodia formation following bradykini

46 imulation, but does not affect PAK-meditated lamellipodia and filopodia formation following PDGF and

47 nteraction is essential for the formation of lamellipodia and filopodia in migrating cells.

48 rc2 and one of its substrates, cortactin, in lamellipodia and filopodia of Aplysia growth cones.

49 ting actin organization and dynamics in both lamellipodia and filopodia of Aplysia growth cones.

50 In lamellipodia and filopodia, actin polymerization directl

51 trated specifically at the tips of extending lamellipodia and filopodia, instead of endosomes as in o

52 , observed as cytoskeleton protrusions-i.e., lamellipodia and filopodia-were reduced after treatment.

53 nt manner and induced the retraction of MVEC lamellipodia and filopodia.

54 actin-rich cell surface projections such as lamellipodia and filopodia.

55 ed, in neuronal cells alpha-COP localizes to lamellipodia and growth cones and moves within the axon,

56 Actinin-4 associates with lamellipodia and has been implicated in regulating lamel

57 actuated retraction of macrophage front end lamellipodia and induced loss of cell polarity.

58 romoted nascent FA formation and turnover in lamellipodia and inhibited the frequency and rate of FA

59 that did not diffuse rapidly enough to enter lamellipodia and instead stably bound adhesion complexes

60 and kinetics of cell protrusions, including lamellipodia and invadopodia.

61 Scar/WAVE complex is absolutely required for lamellipodia and is a key effector in cell migration, bu

62 c-nucleotide-gated cation channel located in lamellipodia and is essential for rapid cell migration i

63 Abi1 localized at the tip of lamellipodia and its protrusion coordinated with F-actin

64 rotein is abundantly expressed in microglial lamellipodia and maintains alkaline pHi in response to B

65 tworks and bundles of actin filaments termed lamellipodia and microspikes or filopodia, respectively,

66 Arpc2(-/-) cells lack lamellipodia and migrate more slowly than WT cells but h

67 the newly accessible free space by extending lamellipodia and migrating into the gap.

68 inct F-actin-rich membrane structures called lamellipodia and phagocytic cups.

69 rotein known to organize the cytoskeleton of lamellipodia and podosomes, and thus modulating cell mot

70 ncentrations inhibited filopodia and favored lamellipodia and pre-filopodia bundles.

71 f small, mobile M1-AQP4-enriched arrays into lamellipodia and preferential interaction of large, M23-

72 generated branched actin networks comprising lamellipodia and pseudopodia by virtue of its ability to

73 ed p47(phox)/Cortactin/Rac1 translocation to lamellipodia and ROS generation.

74 , which is essential for AbpG to localize to lamellipodia and to rescue the phenotype of abpG(-) cell

75 ed geometries exhibit polarized extension of lamellipodia and upon release, migrate preferentially al

76 cells trigger cycles of retraction of local lamellipodia and, concomitantly, strengthen local adhesi

77 types, including actin polymerization-driven lamellipodia, and contractility-driven blebs.

78 The activity of Rac, formation of stable lamellipodia, and directed migration are restored in bet

79 morphology, the development of filopodia and lamellipodia, and phagocytosis of WNV-infected cells and

80 ocal adhesions, as well as from the front of lamellipodia, and strongly reduced cell invasion.

81 EGF led to cell polarization in the form of lamellipodia, and this occurred through a mechanism invo

82 Protrusion and retraction of lamellipodia are common features of eukaryotic cell moti

83 Lamellipodia are dynamic actin-rich cellular extensions

84 r order structures such as stress fibers and lamellipodia are fundamental for cell migration and adhe

85 However, the mechanisms by which new lamellipodia are initiated and directed are unknown.

86 milar effects on superficial and deep cells: lamellipodia are lost, blebs appear instead, and collect

87 Lamellipodia are networks of actin filaments generated a

88 However, recent reports indicate that lamellipodia are not required for cell movement, suggest

89 o shallow gradients of PDGF, indicating that lamellipodia are not required for fibroblast chemotaxis.

90 One implication is that lamellipodia are only marginally important for cell migr

91 embedded in Matrigel, basal and superficial lamellipodia are recovered; however, only the directiona

92 Lamellipodia are sheet-like protrusions formed during mi

93 Lamellipodia are sheet-like, leading edge protrusions in

94 Although lamellipodia are widely believed to be critical for dire

95 unction formation in endothelial cells using lamellipodia as the initial protrusive contact, subseque

96 to larger cell size and remarkably developed lamellipodia as well as accumulation of filamentous acti

97 equirements of transitions between blebs and lamellipodia, as well as the time scales on which they o

98 he Scar/WAVE regulatory complex (WRC) drives lamellipodia assembly via the Arp2/3 complex, whereas th

99 vestigated the possible role of INF2 in both lamellipodia-associated actin dynamics and actin-depende

100 adhesion sites via intermittently appearing lamellipodia at established cell junctions.

101 thesis that the principal role of cofilin in lamellipodia at steady state is to break down F-actin, c

102 a stationary cell, the cell polarizes, forms lamellipodia at the leading edge (LE), and triggers the

103 cell migration by securing the formation of lamellipodia at the leading edge of the cell.

104 ment of front-rear polarity and formation of lamellipodia at the leading edge.

105 nificantly reduced percentages of cells with lamellipodia at the wound edge in patients with CRSwNP c

106 y, tumor cells overexpressing Dyn2 protruded lamellipodia at twice the rate, migrated faster (180%) a

107 or myosin II activity switched the cells to lamellipodia-based 3D migration.

108 A second lamellipodia-based function-cell spreading-was also defe

109 Arp2/3 complex is also crucial to lamellipodia-based migration of keratocytes.

110 ablished that nonlinear elasticity supported lamellipodia-based migration, whereas linear elasticity

111 argeted to the leading edge, consistent with lamellipodia-based migration.

112 by implicating CP in filopodia as well as in lamellipodia, both of which are important for locomotion

113 ARPC3(-/-) fibroblasts were unable to extend lamellipodia but generated dynamic leading edges compose

114 bolished the BK-triggered dynamic changes of lamellipodia, but also reduced microglial motility and m

115 ormation of microspikes normally embedded in lamellipodia, but not of filopodia capable of emanating

116 etwork density and protrusion persistence of lamellipodia by controlling the state of actin-driven pr

117 They also regulate lamellipodia, can promote actin nucleation, and are requ

118 embrane protrusions, such as multiple blebs, lamellipodia, combinations of both, or absence of any su

119 animal cells initiate crawling by protruding lamellipodia, consisting of a dense network of actin fil

120 hermore, rapid transitions between blebs and lamellipodia could also be triggered upon changes in sub

121 In lamellipodia, CP dissociates from the actin cytoskeleton

122 y associated with the protrusive activity of lamellipodia, depends on the barbed ends of actin filame

123 cells, showing the cytoskeleton dynamics in lamellipodia during protrusion and mitochondria displace

124 ortant in vivo as well, for the formation of lamellipodia during the ventral enclosure event of Caeno

125 cell types, coronins exert their effects on lamellipodia dynamics by an inhibitory interaction with

126 Capping protein in regulating filopodia and lamellipodia dynamics in Drosophila melanogaster cells a

127 ulated in breast cancer, is localized at the lamellipodia edges of aggressive breast cancer cells.

128 f polarity, as evidenced by the formation of lamellipodia encircling the entire cell, as well as redu

129 First, polarized lamellipodia extend mediolaterally and make new C-cadher

130 Polarization of lamellipodia extended by both superficial and deeper pro

131 s into the Arp2/3 complex's critical role in lamellipodia extension and directional fibroblast migrat

132 inant-negative (DN) tail-tip expression lack lamellipodia, fail to migrate into the wound, and form s

133 ical motif detector that automatically finds lamellipodia, filopodia, blebs and other motifs.

134 f actin filament-based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs

135 inking proteins, such as filopodia (fascin), lamellipodia (fimbrin), and stress fibers (alpha-actinin

136 ed colonic epithelial cells showed defective lamellipodia, focal adhesions, and repair after wounding

137 followed by relocalization to the actin-rich lamellipodia for dynamic forward protrusion of the cells

138 he observed dynamic: (1) competition between lamellipodia for shared pools of Rac and Rho, (2) activa

139 calize actin monomers to the leading edge of lamellipodia for their motility.

140 These extended lamellipodia form a signaling microdomain that sequester

141 t and retraction from the cell surface where lamellipodia form.

142 dependent effect, coupled with filopodia and lamellipodia formation and an enrichment of a pool of th

143 tive mutant of ARF6 attenuates inhibition of lamellipodia formation and cell migration by PITs, confi

144 The SCAR/WAVE complex is the major driver of lamellipodia formation and cell migration downstream of

145 ation of kindlin-2 binding to Arp2/3 impairs lamellipodia formation and cell spreading.

146 ine triphosphate synthesis inhibitor reduced lamellipodia formation and decreased breast cancer cell

147 t, PI3k, and Akt phosphorylation, suppressed lamellipodia formation and endothelial cell migration.

148 Thr-308 and phospho-Ser-473) and potentiated lamellipodia formation and HLMVEC migration.

149 as aberrant and associated with dysregulated lamellipodia formation and impaired persistence of migra

150 Strikingly, lamellipodia formation and in vivo ENCC chain migration

151 Exo70 on the Arp2/3 complex is required for lamellipodia formation and maintaining directional persi

152 30(Cas)-deficient murine fibroblasts induced lamellipodia formation and membrane ruffling, which was

153 e in the cellular membrane are essential for lamellipodia formation and metastasis.

154 Moreover, cortistatin impaired lamellipodia formation and migration of human aortic SMC

155 uing turning behavior of T cells mediated by lamellipodia formation and MLCK activity may be importan

156 have previously reported that HGF stimulates lamellipodia formation and motility of human lung microv

157 kt signaling and NADPH oxidase activation in lamellipodia formation and motility of lung endothelial

158 trate that WAVE1 and WAVE2 are redundant for lamellipodia formation and motility.

159 MEK inhibition was sufficient to promote lamellipodia formation and oppose filopodial actin-spike

160 omolog 2 (Spns2), and S1P receptor, S1P1, in lamellipodia formation and perhaps motility of HLMVECs.

161 MYH9(E1841K/E1841K) mice exhibited increased lamellipodia formation and reorganization of F-actin str

162 ibit growth factor-induced actin remodeling, lamellipodia formation and, ultimately, cell migration a

163 Here we identify Arp2/3-dependent lamellipodia formation as a prominent morphological feat

164 arboring melanoma cells massively upregulate lamellipodia formation by dendritic actin polymerization

165 breast cancer cells and reduces Rac-directed lamellipodia formation in both cell lines.

166 r inhibition of SphK1 attenuated HGF-induced lamellipodia formation in HLMVECs.

167 Pharmacological study revealed that lamellipodia formation mediated by arp2/3 and contractil

168 the predominant isoform of PI3K involved in lamellipodia formation of ovarian cancer cells.

169 factor for the recruitment of modulators of lamellipodia formation such as capping protein or cofili

170 he increase in endocytosis and the defect in lamellipodia formation were associated with reduced chem

171 and decreased the frequency of RAC1-positive lamellipodia formation while CERS6 overexpression promot

172 enriched at the cell periphery to facilitate lamellipodia formation while Rho kinase exhibited a sign

173 ing Drp1 or overexpression of Mfn1 inhibited lamellipodia formation, a key step for cancer metastasis

174 e precise coordination of cell polarization, lamellipodia formation, adhesion, and force generation.

175 n dynamics associated with barrier function, lamellipodia formation, and cell migration via modulatio

176 ells and was also required for polarization, lamellipodia formation, and chemotaxis.

177 mbrane, as well as promoting cell spreading, lamellipodia formation, and membrane ruffling, cell morp

178 hese results suggest that HGF/c-Met-mediated lamellipodia formation, and perhaps motility is dependen

179 moting Arp2/3-dependent actin nucleation and lamellipodia formation, but distinct roles in controllin

180 proteins resulted in more cell spreading and lamellipodia formation, causing accumulation of more mit

181 First, ARPC1B is required for lamellipodia formation, cell migration, and actin reorga

182 Drosophila macrophages results in defects in lamellipodia formation, cell spreading, and redistributi

183 Crk-associated substrate (p130Cas)-mediated lamellipodia formation, countering the invasive phenotyp

184 prove the key role of this Ca(2+) channel on lamellipodia formation, lamellipodial persistence, and c

185 o reduced ENS precursor migration as well as lamellipodia formation, proliferation, and survival in c

186 is and NADPH oxidase attenuated HGF- induced lamellipodia formation, ROS generation and cell migratio

187 ulation of Spns2 also suppressed HGF-induced lamellipodia formation, suggesting a key role for inside

188 tion in 3D collagen, but was dispensable for lamellipodia formation, suggesting that vinculin-mediate

189 ssion of wild type Nanog increased filopodia/lamellipodia formation, whereas mutant Y35F and Y174F Na

190 sion of Schwann cell processes and disrupted lamellipodia formation.

191 Slit2- and VEGF-induced Rac1 activation and lamellipodia formation.

192 and Ser-473) phosphorylation and suppressed lamellipodia formation.

193 c-Met signaling in HGF-induced sprouting and lamellipodia formation.

194 shed TWEAK activation of Rac1 and subsequent lamellipodia formation.

195 ely elevates Rac-GTP levels to induce radial lamellipodia formation.

196 decreased cell-matrix adhesion and enhanced lamellipodia formation.

197 , with specific siRNA attenuated HGF-induced lamellipodia formation.

198 dothelia and epithelia suggests that ventral lamellipodia formed as a response to force imbalance and

199 ide and cyclodextrin on the force exerted by lamellipodia from developing growth cones (GCs) of isola

200 ACF), is similar to retrograde actin flow in lamellipodia, growth cones, immunological synapses, dend

201 The presence of Tpm in lamellipodia, however, is disputed in the literature [9-

202 t STRADalpha depletion results in misaligned lamellipodia, improper Golgi positioning, and reduced in

203 focal adhesions (FAs) assemble in protruding lamellipodia in association with rapid filamentous actin

204 y and decreased the percentage of cells with lamellipodia in both groups.

205 ng, cell-cell junctions and the formation of lamellipodia in breast cancer (BC), implicating a centra

206 to advance the development of filopodia and lamellipodia in Chinese hamster ovary cells, stimulate t

207 em, we tested the role of Arp2/3 complex and lamellipodia in directional cell migration.

208 ectively concentrated at the leading edge of lamellipodia in migrating cells and axonal growth cones.

209 s to immediate transitions between blebs and lamellipodia in migrating cells.

210 own of Shroom3 caused defective formation of lamellipodia in podocyte, which would lead to the disrup

211 miR-196a also reduces the formation of lamellipodia in response to VEGF suggesting that ANXA1 r

212 Ral GTPases were localized to the leading lamellipodia in SCs and were required for the formation

213 g edges of leader cells, but also in cryptic lamellipodia in submarginal cell rows NHE1 expression di

214 edges of leader cells, as well as to cryptic lamellipodia in submarginal cell rows.

215 sial data have been published on the role of lamellipodia in thrombus formation and stability.

216 f Erg-deficient HUVECs showed a reduction in lamellipodia, in line with decreased motility.

217 in generated several profound effects on the lamellipodia, including an increase of F-actin, a rearwa

218 udies have suggested that structures besides lamellipodia, including lamella and filopodia, may have

219 us and the leading edge of the cell to drive lamellipodia-independent 3D cell migration.

220 Likewise, the retraction phase of lamellipodia is controlled by PDK1 through an MRCKalpha-

221 at their tips, the protrusion efficiency of lamellipodia is determined by a finely tuned balance bet

222 The generation of lamellipodia is supported by actin dynamics at the leadi

223 s, suggesting that one principle function of lamellipodia is to organize cell-matrix adhesions in a s

224 al exerted force and maximal velocity during lamellipodia leading-edge protrusion.

225 r structures, to the plasma membrane, and to lamellipodia-like membrane protrusions.

226 During development, Schwann cells extend lamellipodia-like processes to segregate large- and smal

227 We find that lamellipodia-like protrusions and retrograde actin flow

228 Directed apical lamellipodia-like protrusions propel the cells.

229 malian cells lacking CARMIL1 have defects in lamellipodia, macropinocytosis, cell migration, and Rac1

230 about the architecture and dynamics of thin lamellipodia made by slow-moving cells on flat surfaces,

231 Consistent with lamellipodia-mediated contacts, latrunculin-B decreases

232 partial retraction of the nearby protruding lamellipodia membrane and a strengthening of paxillin-ba

233 ions of actin-rich processes like filopodia, lamellipodia, microvilli, and stereocilia requires the c

234 ho-Elmo and ITSN1 co-localize with GPR124 at lamellipodia of adhering endothelial cells, where GPR124

235 rom sparsely distributed algal cells and the lamellipodia of human hepatocytes.

236 FM force-distance (f-d) curves obtained from lamellipodia of live cells often exhibit a signal from w

237 localized with cytoskeletal protein ezrin in lamellipodia of microglia and maintained its more alkali

238 riven condensation of actin filaments in the lamellipodia of migrating cells and exerts significant f

239 dependent on Tn-bearing proteins present in lamellipodia of migrating cells.

240 o9b localizes to the extreme leading edge of lamellipodia of migrating cells.

241 at the leading edge including filopodia and lamellipodia of migrating cells.

242 in the organization of actin bundles within lamellipodia of migrating IECs.

243 PC1 and Pacsin 2 co-localize on the lamellipodia of migrating kidney epithelial cells.

244 ctin filament nucleation and assembly in the lamellipodia of moving cells.

245 paired localization of LPL to the actin-rich lamellipodia of T cells.

246 dynamic, mainly owing to the edge dynamics (lamellipodia) of the myofibroblasts.

247 s and a reduction in the number of polarized lamellipodia on intercalating cells.

248 We imaged XTC cells that exhibit flat lamellipodia on poly-L-lysine-coated coverslips.

249 In these contexts, protrusions adopt lamellipodia or an amoeboid morphology.

250 ation of different actin structures, such as lamellipodia or filopodia, by altering the balance of th

251 ized, random, or oscillatory, with competing lamellipodia oscillating out of phase.

252 Lamellipodia overlap the VE-cadherin-free adjacent plasm

253 ng diverse actin-based structures, including lamellipodia, podosomes, and endocytic actin networks.

254 ow-curvature areas favored the appearance of lamellipodia, promoting faster closure.

255 loration, with F-actin bundles directing and lamellipodia propagating the process and with signaling

256 er, exhibit retarded migration regardless of lamellipodia protrusion activity.

257 increase in plasma membrane tension stopped lamellipodia protrusion and activated an exocytotic burs

258 the Arp2/3 complex plays a critical role in lamellipodia protrusion and cell motility.

259 Lamellipodin (Lpd) is known to control lamellipodia protrusion by regulating actin filament elo

260 s study, we show that during cell spreading, lamellipodia protrusion flattens plasma membrane folds a

261 cin 1 expression drives faster migration and lamellipodia protrusion in melanocytes in vitro.

262 for cell movement, including actin dynamics, lamellipodia protrusion, and membrane ruffling.

263 Thereby, Lpd supports lamellipodia protrusion, cell migration and endocytosis.

264 causing accumulation of more mitochondria in lamellipodia regions.

265 These biochemically active lamellipodia require cell-substrate attachment but not f

266 rganization to form cell surface extensions (lamellipodia) required for cell migration/invasion durin

267 In contrast, contraction of lamellipodia results in reduced integrin engagement that

268 by confined Ca(2+) pulses that promote local lamellipodia retraction and adhesion cycles along the le

269 clodextrin affected force or velocity during lamellipodia retraction.

270 Moreover, our analysis of the tip cell lamellipodia revealed the diversity in their interaction

271 t and fusing myoblasts, as well as triggered lamellipodia, spreading, and fusion of myoblasts through

272 Rac inhibition negated ICAM-1 mediated lamellipodia, spreading, and fusion of myoblasts.

273 numerous endocytic cups instead of the broad lamellipodia structure characteristic of moving cells.

274 ance between formation of endocytic cups and lamellipodia structures.

275 peptide (2B2) disassemble VIF at sites where lamellipodia subsequently form.

276 s, endothelial cells generate unique ventral lamellipodia that propagate via integrins toward and acr

277 the ECM enforces spatial constraints on the lamellipodia that result in cell shape elongation and en

278 ing the motion of the layer are the force of lamellipodia, the adhesion of cells to the substrate, an

279 interaction is essential for the assembly of lamellipodia, the formation of ruffles, and the process

280 ular fibronectin formed increased numbers of lamellipodia; their random motility and chemotaxis also

281 itochondria actively infiltrate leading edge lamellipodia, thereby increasing local mitochondrial mas

282 ated protein 2/3 complex (ARP2/3)-controlled lamellipodia to appear intermittently at those sites.

283 bilization, and timely turnover of NA within lamellipodia to couple actin-driven protrusion to adhesi

284 ure and switch tumor cells from low-pressure lamellipodia to high-pressure lobopodial protrusions dur

285 er epithelialized cells and extend polarized lamellipodia to migrate apposed to the overlying skin.

286 Platelets use lamellipodia to scan for fibrin(ogen) deposited on the i

287 Moreover, a novel lamellipodia-to-filopodia transition is used in this con

288 Lamellipodia treated with 2.5 mM of cyclodextrin exerted

289 Lamellipodia undergo periodic extension and retraction c

290 phorylation of SphK1 and its localization in lamellipodia was dependent on c-Met and ERK1/2 signaling

291 that can be induced to form either blebs or lamellipodia, we systematically assessed the mechanical

292 Ventral lamellipodia were enriched in the Rac1 effectors cortact

293 in increases the number of ARP2/3-controlled lamellipodia, whereas overexpression of wild-type VE-cad

294 CK2-mediated suppression of Rac1 activity in lamellipodia, whereas RhoC promotes polarized migration

295 ls spontaneously formed protrusions, such as lamellipodia, which are required for generating locomoti

296 We found STIM1 protrusions in lamellipodia, which co-localized with FAs, whereas major

297 olarity by increasing myosin accumulation in lamellipodia, which locally decreases protrusion lifetim

298 CB2 stimulation decreased formation of lamellipodia, which play a key role in monocyte migratio

299 ratinocytes lack polarity, assemble multiple lamellipodia with a 2x increased area over controls, dis

300 gion, formation of cortical actin-rich large lamellipodia with an upregulation of cortactin, and decr