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1 the prepeptide LctA and export of the mature lantibiotic.
2 ution of the biosynthesis of a two-component lantibiotic.
3 illus plantarum strain of dairy origin, is a lantibiotic.
4 hat sublancin is a dehydroalanine-containing lantibiotic.
5 equired for the production of the mutacin II lantibiotic.
6 fers protection against Smb, a two-component lantibiotic.
7 at display antimicrobial activity are called lantibiotics.
8 ifferences compared with other two-component lantibiotics.
9 ly precluded its use in the synthesis of the lantibiotics.
10 ed empirical force-field parameters to model lantibiotics.
11 rapidly growing class of bacteriocins termed lantibiotics.
12 ceptor proteins have been identified for any lantibiotics.
13 n that displays a receptor-like function for lantibiotics.
14 igma(X) all contribute to resistance against lantibiotics.
15 tection against Smb and structurally similar lantibiotics.
16 in producing more stable, medically relevant lantibiotics.
17 I proteins) for protection against their own lantibiotics.
18 alogue of cystine, is a key component of the lantibiotics, a family of modified peptides bearing mult
19                  Synthetic approaches to the lantibiotics, a family of thioether-bridged antimicrobia
20 ding a sortase, putative sortase substrates, lantibiotic ABC transporters and a putative siderophore
21       The biosynthetic pathway of the type B lantibiotic actagardine (formerly gardimycin), produced
22 ses, and that the PE-specific cyclic peptide lantibiotic agent Duramycin efficiently inhibits the ent
23  phase synthesis of macrocyclic peptides and lantibiotic analogues.
24 dental pathogen, secretes different kinds of lantibiotic and nonlantibiotic bacteriocins.
25                    In particular, and unlike lantibiotics and other defensins, the third position of
26  (a nonlantibiotic), nisin (a single peptide lantibiotics), and three peptide antibiotics (bacitracin
27 NA in the formation of dehydroamino acids in lantibiotics, and serve as a basis for the functional ch
28                                              Lantibiotics are a class of peptide antibiotics that con
29                                              Lantibiotics are a family of antibacterial peptide natur
30                                              Lantibiotics are a group of highly post-translationally
31                                              Lantibiotics are a group of ribosomally synthesized and
32                                              Lantibiotics are a large family of antibacterial peptide
33                                              Lantibiotics are a unique class of peptide antibiotics.
34  to gain insight into the mechanism by which lantibiotics are biosynthesized, the cyclase enzymes inv
35                                   Type A (I) lantibiotics are cationic antimicrobial peptides that ha
36                                              Lantibiotics are complex polycyclic molecules formed by
37                                              Lantibiotics are highly modified peptides that are part
38                                              Lantibiotics are peptide-derived antibiotics that inhibi
39                                              Lantibiotics are peptide-derived antimicrobial agents th
40                                              Lantibiotics are post-translationally modified peptide a
41                                              Lantibiotics are ribosomally synthesized and post-transl
42                                              Lantibiotics are ribosomally synthesized and post-transl
43                                              Lantibiotics are ribosomally synthesized and posttransla
44                                              Lantibiotics are ribosomally synthesized antimicrobial p
45                                              Lantibiotics are ribosomally synthesized peptides that u
46                                              Lantibiotics are ribosomally synthesized, posttranslatio
47 ng topology different than that of any known lantibiotic as determined by tandem mass spectrometry.
48 lly good model for studying the potential of lantibiotics as sources of novel biomaterials.
49 f mutacin 1140 to epidermin and an S. mutans lantibiotic, B-Ny266, but it appears to have significant
50           This mutacin (mutacin IV) is a non-lantibiotic bacteriocin which kills closely related Stre
51 peptide transporter, a purine repressor, and lantibiotic biosynthesis had no substantial impact on th
52            The role of the leader peptide in lantibiotic biosynthesis has been subject to much specul
53 resumably ensuring synchronous and concerted lantibiotic biosynthesis in the wider population and, th
54 upon the role of these conserved residues in lantibiotic biosynthesis.
55 enitrificans NG80-2 also contains a class II lantibiotic biosynthetic gene cluster.
56                                              Lantibiotic bovicin HJ50 is produced by Streptococcus bo
57 ry networks that govern the synthesis of the lantibiotics by the producing organisms.
58              Thus, with these new techniques lantibiotics can be rapidly characterized.
59 trum bacteriocin nisin, which belongs to the lantibiotic class of antimicrobial peptides.
60  galolacticin, both of which are two-peptide lantibiotics closely related to Smb.
61            Paenicidin A is a highly cyclized lantibiotic, containing six lanthionine and methyllanthi
62 blancin leader was similar to known type AII lantibiotics, containing a double-glycine motif that is
63 , another residue that is fully conserved in lantibiotic cyclases, to Asn resulted in a protein that
64 tients are present in greater abundance than lantibiotic-deficient strains of the same species.
65  formed by the dehydration of Ser/Thr by the lantibiotic dehydratase NisB.
66 vides insights into substrate recognition by lantibiotic dehydratases.
67                                          The lantibiotic efficiently interfered with late stages of c
68 ns resulted in two large deletions, one in a lantibiotic encoding region, analogous to a predicted de
69 g enzyme gene (epiB) for biosynthesis of the lantibiotic epidermin, respectively.
70  was used to produce analogues of the potent lantibiotic epilancin 15X, in order to assess the import
71 ly to impact colonization resistance through lantibiotic expression or intestinal acidification, infl
72 A are peptide antibiotics that belong to the lantibiotic family.
73 fied and characterized mutacin II, the first lantibiotic found in S. mutans.
74              Here, we report a two-component lantibiotic from Bacillus cereus SJ1 with unusual struct
75 in but not against structurally very similar lantibiotics from other species such as subtilin from Ba
76 in which subinhibitory concentrations of the lantibiotic function in a feed-forward mechanism to elic
77 TprA/PhrA) that controls the expression of a lantibiotic gene cluster in the Gram-positive human path
78 risk of VRE infection, high abundance of the lantibiotic gene is associated with reduced density of E
79 olonization correlates with abundance of the lantibiotic gene.
80                                    Thus, the lantibiotic genes are expressed under the control of bot
81 ipeptide sequences, some overlapped with the lantibiotic genes of Blautia pseudococcoides SCSK (BpSCS
82  found that it induces the expression of the lantibiotic genes when pneumococcal cells are at high de
83          Many Gram-positive bacteria produce lantibiotics, genetically encoded and posttranslationall
84 of a thioether ring B mimetic of the natural lantibiotic haloduracin beta was performed.
85 tion of both components of the two-component lantibiotic haloduracin was demonstrated.
86  single compound (the Halbeta subunit of the lantibiotic haloduracin), catalyzes reactions with highe
87 c data instead of isolation, a two-component lantibiotic, haloduracin, was identified in the genome o
88       In comparison to nisin-A, the BP(SCSK) lantibiotic has reduced activity against intestinal comm
89 e a synthetic lanthionine ring analogue of a lantibiotic has retained natural activity levels.
90                               Nisin, a model lantibiotic, has a dual mode of action: it inhibits cell
91                                              Lantibiotics have been extensively engineered by either
92 laborate post-translational modifications of lantibiotics have revealed that these enzymes have relax
93 icum C2 was found to produce a two-component lantibiotic homologous to enterococcal cytolysin.
94                  Additionally, SpaI-mediated lantibiotic immunity depends on the presence of a basic
95 ural and mechanistic basis for LanI-mediated lantibiotic immunity is not yet understood.
96 potential to encode other functions, such as lantibiotic immunity.
97 ht on the structural basis for LanI mediated lantibiotic immunity.
98  also showcases the ability to prepare other lantibiotics in the class II lacticin 481 family, includ
99                The antimicrobial spectrum of lantibiotics includes pathogens, offering a potential th
100 ring that appears conserved in many class II lantibiotics, including those not belonging to the lacti
101 ctivity spectrum of sublancin was like other lantibiotics, inhibiting Gram-positive bacteria but not
102 e structural and functional diversity of the lantibiotics is much broader than previously imagined.
103 to other modifying enzymes of class I and II lantibiotics, LabKC has a C- to N-terminal processing mo
104 n order during the biosynthesis of class III lantibiotic labyrinthopeptin A2.
105 synthesis enabled the total synthesis of the lantibiotic lacticin 481 and analogues containing cross-
106                                          The lantibiotic lacticin 481 is synthesized on ribosomes as
107  show that fusing the leader peptide for the lantibiotic lacticin 481 to its biosynthetic enzyme LctM
108 to prochlorosins 1.7 and 2.8, as well as the lantibiotics lacticin 481, haloduracin alpha, and halodu
109      The prepeptide showed similarity to the lantibiotics lacticin 481, variacin, salivaricin and str
110            We demonstrate the method for two lantibiotics, lacticin 481 and nukacin ISK-1.
111  testing of diaminopimelate analogues of the lantibiotic lactocin S.
112 ally synthesized peptide bacteriocins called lantibiotics (lanthionine-containing antibiotics) and is
113  the functional characterization of the many lantibiotic-like dehydratases involved in the biosynthes
114     Here, we present evidence that SapB is a lantibiotic-like peptide that is derived by posttranslat
115                                      The sal lantibiotic locus plays an important role in the virulen
116 sent, suggesting that quorum sensing and the lantibiotic machinery may help pneumococcal cells compet
117                                              Lantibiotic-mediated dysbiosis results in sustained loss
118                              For inhibition, lantibiotics must recognize specific receptor molecules
119 rimary structure of the Streptococcus mutans lantibiotic mutacin 1140 was elucidated by NMR spectrosc
120 g A and B structures from nisin, the related lantibiotic mutacin, and synthetic analogues.
121 egulatory mechanisms governing production of lantibiotic mutacins I, II, and III in S. mutans have ne
122  MutRS controls production of three separate lantibiotic mutacins in three different strains of S. mu
123 s of bacteriocins produced by S. mutans, the lantibiotic mutacins, are particularly effective at kill
124                                          The lantibiotic NAI-107 is active against Gram-positive bact
125                                          The lantibiotic nisin and related peptides display unique an
126                        Here we show that the lantibiotic nisin exercises its antibacterial action by
127                                          The lantibiotic nisin has been used as an effective food pre
128                                          The lantibiotic nisin is an antimicrobial peptide produced b
129                                          The lantibiotic nisin is an antimicrobial peptide that is wi
130 verproduction of Fst sensitized cells to the lantibiotic nisin, and Fst-resistant mutants were cross-
131              Lactococcus lactis produces the lantibiotic nisin, which is widely used as a food preser
132 but not Gram-negative bacteria; and like the lantibiotics nisin and subtilin in its ability to inhibi
133                                  As with all lantibiotics, nisin contains a number of dehydro-residue
134 otecting the producer strain against its own lantibiotic on the molecular level.
135            Unlike all previous two-component lantibiotics, only one of the two peptides of bicereucin
136 e occurring during the synthesis of class I (lantibiotic) or some class II bacteriocins.
137 acteria, attributed to the production of the lantibiotic paenibacillin and the colistin peptide polym
138 utacin II is a post-translationally modified lantibiotic peptide secreted by Streptococcus mutans T8,
139                                              Lantibiotic peptides are potent antimicrobial compounds
140 ecule to elicit precocious production of the lantibiotic, presumably ensuring synchronous and concert
141                          Nisin, a 34 residue lantibiotic produced by strains of Lactococcus lactis su
142  an uncharacterized but structurally similar lantibiotic produced by Streptococcus gallolyticus.
143                  Microbisporicin is a potent lantibiotic produced by the actinomycete Microbispora co
144 esized, posttranslationally modified peptide lantibiotic produced by the actinomycete Planomonospora
145           Microbisporicin is a potent type I lantibiotic produced by the rare actinomycete Microbispo
146 ation by CprK-CprR was activated by multiple lantibiotics produced by diverse Gram-positive bacteria.
147 481 is a lanthionine-containing bacteriocin (lantibiotic) produced by Lactococcus lactis subsp. lacti
148                                       Unlike lantibiotic producer regulation, regulation by CprK-CprR
149 sm of B. subtilis in particular and of other lantibiotic producing strains in general.
150 inst E. faecalis through administration of a lantibiotic-producing B. producta strain after allo-HCT.
151 sortium of commensal bacteria containing the lantibiotic-producing B. producta strain prevented intes
152                       However, the impact of lantibiotic-producing bacteria on the microbiome remains
153            Our findings reveal the impact of lantibiotic-producing bacterial species on microbiome re
154                                              Lantibiotic-producing commensal strains of the gastroint
155            These studies advance a model for lantibiotic production where substrate binding via an N-
156 d polyol utilization, arsenic resistance and lantibiotic production.
157 s and is homologous to an operon involved in lantibiotic production.
158                   The in vitro activity of a lantibiotic protease has not yet been characterized.
159 transcription in a manner similar to that by lantibiotic regulatory systems.
160      We also found that nisin, a monopeptide lantibiotic, requires LsrS for its optimum inhibitory ac
161 ple method to reliably identify all modified lantibiotic residues with a minimal amount of material.
162                                              Lantibiotic salivaricins are polycyclic peptides contain
163 tivity, structure, and mode of action of the lantibiotic salivaricins characterized to date.
164 li YebY, which closely resembles that of the lantibiotic self-resistance protein MlbQ.
165 li YebY, which closely resembles that of the lantibiotic self-resistance protein MlbQ.
166 lly used as a food preservative, while other lantibiotics show promising activity against bacterial i
167       Sublancin is an extraordinarily stable lantibiotic, showing no degradation or inactivation afte
168  the enzymes catalyzing the formation of the lantibiotic signature structural motifs, dehydroalanine
169 us mutans strain GS-5 produces a two-peptide lantibiotic, Smb, which displays inhibitory activity aga
170 ntaining morphogenetic peptide suggests that lantibiotic structure and function may be more diverse t
171           The S. tendae peptide, SapT, has a lantibiotic structure and molecular modelling predicts t
172  biosurfactants is conserved, their specific lantibiotic structure is not.
173                          SapB has an unusual lantibiotic structure.
174  mechanisms are also effective against other lantibiotics such as mersacidin, gallidermin and subtili
175 e is in agreement with other closely related lantibiotics, such as epidermin.
176 r to enzymes involved in the biosynthesis of lantibiotics, suggesting that it might be involved in th
177 tected by TIGR04085, significantly outnumber lantibiotic synthases and cyclodehydratases combined in
178 d to serve as alternative substrates for the lantibiotic synthases that dehydrate serine and threonin
179 transporters, oligopeptide transporters, and lantibiotic synthesis.
180                                              Lantibiotic synthetases catalyze the dehydration of Ser
181                                          The lantibiotic synthetases LctM and HalM2 are bifunctional
182 nsporter and its regulators are relatives of lantibiotic systems that evolved to recognize multiple s
183  the similarities between the Cpr system and lantibiotic systems, we propose that the CprABC transpor
184 ins and tridecaptins, in addition to a novel lantibiotic termed paenicidin A.
185 P(SCSK) reduces growth of VRE by secreting a lantibiotic that is similar to the nisin-A produced by L
186 n against haloduracin, another two-component lantibiotic that is structurally similar to Smb; SmbFT i
187                     To date, no analogues of lantibiotics that contain nonproteinogenic amino acids h
188           We identified a motif within these lantibiotics that is likely required for activation of c
189                              However, unlike lantibiotics, the cytolysin is lytic for eukaryotic as w
190      To protect themselves against their own lantibiotics these bacteria express a variety of immunit
191                                  For class I lantibiotics, thiopeptides, and goadsporin, this dehydra
192 anB proteins involved in the biosynthesis of lantibiotics, thiopeptides, and goadsporin.
193 of several bioactive cyclic peptides such as lantibiotics, thiopeptides, and microcystins.
194                    It is unprecedented for a lantibiotic to contain a disulfide bridge.
195  nisin and the most cross-links found in any lantibiotic to date.
196 conserved in the leader sequence of class II lantibiotics to direct other biosynthetic events, such a
197  human microbiome-derived commensals produce lantibiotics to impair pathogens' colonization and promo
198 erial strains secretes bacteriocins, such as lantibiotics, to inhibit or kill neighboring bacteria, t
199  this activity is not due to expression of a lantibiotic-type bacteriocin, but proteolytically proces
200 lational modification enzymes that carry out lantibiotic-type dehydrations of Ser and Thr residues to
201 vant for the biosyntheses of other class III lantibiotics, underlines significant differences of this
202                                Two-component lantibiotics use two peptides that are each posttranslat
203 al diversity of this ribosomally synthesized lantibiotic, we now report the recombinant expression of
204                   The fluorescently modified lantibiotics were added to bacteria, and their cellular
205              The results showed that it is a lantibiotic, which we have named mutacin 1140, and that
206 he structural and functional analysis of the lantibiotics, which are ribosomally synthesized peptides
207                             The discovery of lantibiotics with alternative lanthionine and methyllant

 
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