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1 the prepeptide LctA and export of the mature lantibiotic.
2 ution of the biosynthesis of a two-component lantibiotic.
3 illus plantarum strain of dairy origin, is a lantibiotic.
4 hat sublancin is a dehydroalanine-containing lantibiotic.
5 equired for the production of the mutacin II lantibiotic.
6 fers protection against Smb, a two-component lantibiotic.
7 at display antimicrobial activity are called lantibiotics.
8 ifferences compared with other two-component lantibiotics.
9 ly precluded its use in the synthesis of the lantibiotics.
10 ed empirical force-field parameters to model lantibiotics.
11 rapidly growing class of bacteriocins termed lantibiotics.
12 ceptor proteins have been identified for any lantibiotics.
13 n that displays a receptor-like function for lantibiotics.
14 igma(X) all contribute to resistance against lantibiotics.
15 tection against Smb and structurally similar lantibiotics.
16 in producing more stable, medically relevant lantibiotics.
17 I proteins) for protection against their own lantibiotics.
18 alogue of cystine, is a key component of the lantibiotics, a family of modified peptides bearing mult
20 ding a sortase, putative sortase substrates, lantibiotic ABC transporters and a putative siderophore
22 ses, and that the PE-specific cyclic peptide lantibiotic agent Duramycin efficiently inhibits the ent
26 (a nonlantibiotic), nisin (a single peptide lantibiotics), and three peptide antibiotics (bacitracin
27 NA in the formation of dehydroamino acids in lantibiotics, and serve as a basis for the functional ch
34 to gain insight into the mechanism by which lantibiotics are biosynthesized, the cyclase enzymes inv
47 ng topology different than that of any known lantibiotic as determined by tandem mass spectrometry.
49 f mutacin 1140 to epidermin and an S. mutans lantibiotic, B-Ny266, but it appears to have significant
51 peptide transporter, a purine repressor, and lantibiotic biosynthesis had no substantial impact on th
53 resumably ensuring synchronous and concerted lantibiotic biosynthesis in the wider population and, th
62 blancin leader was similar to known type AII lantibiotics, containing a double-glycine motif that is
63 , another residue that is fully conserved in lantibiotic cyclases, to Asn resulted in a protein that
68 ns resulted in two large deletions, one in a lantibiotic encoding region, analogous to a predicted de
70 was used to produce analogues of the potent lantibiotic epilancin 15X, in order to assess the import
71 ly to impact colonization resistance through lantibiotic expression or intestinal acidification, infl
75 in but not against structurally very similar lantibiotics from other species such as subtilin from Ba
76 in which subinhibitory concentrations of the lantibiotic function in a feed-forward mechanism to elic
77 TprA/PhrA) that controls the expression of a lantibiotic gene cluster in the Gram-positive human path
78 risk of VRE infection, high abundance of the lantibiotic gene is associated with reduced density of E
81 ipeptide sequences, some overlapped with the lantibiotic genes of Blautia pseudococcoides SCSK (BpSCS
82 found that it induces the expression of the lantibiotic genes when pneumococcal cells are at high de
86 single compound (the Halbeta subunit of the lantibiotic haloduracin), catalyzes reactions with highe
87 c data instead of isolation, a two-component lantibiotic, haloduracin, was identified in the genome o
92 laborate post-translational modifications of lantibiotics have revealed that these enzymes have relax
98 also showcases the ability to prepare other lantibiotics in the class II lacticin 481 family, includ
100 ring that appears conserved in many class II lantibiotics, including those not belonging to the lacti
101 ctivity spectrum of sublancin was like other lantibiotics, inhibiting Gram-positive bacteria but not
102 e structural and functional diversity of the lantibiotics is much broader than previously imagined.
103 to other modifying enzymes of class I and II lantibiotics, LabKC has a C- to N-terminal processing mo
105 synthesis enabled the total synthesis of the lantibiotic lacticin 481 and analogues containing cross-
107 show that fusing the leader peptide for the lantibiotic lacticin 481 to its biosynthetic enzyme LctM
108 to prochlorosins 1.7 and 2.8, as well as the lantibiotics lacticin 481, haloduracin alpha, and halodu
109 The prepeptide showed similarity to the lantibiotics lacticin 481, variacin, salivaricin and str
112 ally synthesized peptide bacteriocins called lantibiotics (lanthionine-containing antibiotics) and is
113 the functional characterization of the many lantibiotic-like dehydratases involved in the biosynthes
114 Here, we present evidence that SapB is a lantibiotic-like peptide that is derived by posttranslat
116 sent, suggesting that quorum sensing and the lantibiotic machinery may help pneumococcal cells compet
119 rimary structure of the Streptococcus mutans lantibiotic mutacin 1140 was elucidated by NMR spectrosc
121 egulatory mechanisms governing production of lantibiotic mutacins I, II, and III in S. mutans have ne
122 MutRS controls production of three separate lantibiotic mutacins in three different strains of S. mu
123 s of bacteriocins produced by S. mutans, the lantibiotic mutacins, are particularly effective at kill
130 verproduction of Fst sensitized cells to the lantibiotic nisin, and Fst-resistant mutants were cross-
132 but not Gram-negative bacteria; and like the lantibiotics nisin and subtilin in its ability to inhibi
137 acteria, attributed to the production of the lantibiotic paenibacillin and the colistin peptide polym
138 utacin II is a post-translationally modified lantibiotic peptide secreted by Streptococcus mutans T8,
140 ecule to elicit precocious production of the lantibiotic, presumably ensuring synchronous and concert
144 esized, posttranslationally modified peptide lantibiotic produced by the actinomycete Planomonospora
146 ation by CprK-CprR was activated by multiple lantibiotics produced by diverse Gram-positive bacteria.
147 481 is a lanthionine-containing bacteriocin (lantibiotic) produced by Lactococcus lactis subsp. lacti
150 inst E. faecalis through administration of a lantibiotic-producing B. producta strain after allo-HCT.
151 sortium of commensal bacteria containing the lantibiotic-producing B. producta strain prevented intes
160 We also found that nisin, a monopeptide lantibiotic, requires LsrS for its optimum inhibitory ac
161 ple method to reliably identify all modified lantibiotic residues with a minimal amount of material.
166 lly used as a food preservative, while other lantibiotics show promising activity against bacterial i
168 the enzymes catalyzing the formation of the lantibiotic signature structural motifs, dehydroalanine
169 us mutans strain GS-5 produces a two-peptide lantibiotic, Smb, which displays inhibitory activity aga
170 ntaining morphogenetic peptide suggests that lantibiotic structure and function may be more diverse t
174 mechanisms are also effective against other lantibiotics such as mersacidin, gallidermin and subtili
176 r to enzymes involved in the biosynthesis of lantibiotics, suggesting that it might be involved in th
177 tected by TIGR04085, significantly outnumber lantibiotic synthases and cyclodehydratases combined in
178 d to serve as alternative substrates for the lantibiotic synthases that dehydrate serine and threonin
182 nsporter and its regulators are relatives of lantibiotic systems that evolved to recognize multiple s
183 the similarities between the Cpr system and lantibiotic systems, we propose that the CprABC transpor
185 P(SCSK) reduces growth of VRE by secreting a lantibiotic that is similar to the nisin-A produced by L
186 n against haloduracin, another two-component lantibiotic that is structurally similar to Smb; SmbFT i
190 To protect themselves against their own lantibiotics these bacteria express a variety of immunit
196 conserved in the leader sequence of class II lantibiotics to direct other biosynthetic events, such a
197 human microbiome-derived commensals produce lantibiotics to impair pathogens' colonization and promo
198 erial strains secretes bacteriocins, such as lantibiotics, to inhibit or kill neighboring bacteria, t
199 this activity is not due to expression of a lantibiotic-type bacteriocin, but proteolytically proces
200 lational modification enzymes that carry out lantibiotic-type dehydrations of Ser and Thr residues to
201 vant for the biosyntheses of other class III lantibiotics, underlines significant differences of this
203 al diversity of this ribosomally synthesized lantibiotic, we now report the recombinant expression of
206 he structural and functional analysis of the lantibiotics, which are ribosomally synthesized peptides