ライフサイエンスコーパス: large molecule

1 fall between traditional small molecules and large molecules).

2 formational, discontinuous epitope on a very large molecule.

3 nic transitions from a specific nucleus in a large molecule.

4 ltered, and the nucleus becomes permeable to large molecules.

5 that require fast mass transfer or deal with large molecules.

6 accessible to small apatite crystals but not large molecules.

7 s for the separation of small molecules from large molecules.

8 escribed for calculating the total energy of large molecules.

9 gulates the inward permeability of P2X7Rs to large molecules.

10 litate rather than hinder diffusion even for large molecules.

11 arily regulates the outward P2X7R current of large molecules.

12 he transdermal delivery of several small and large molecules.

13 raction speed and in their inability to load large molecules.

14 ydrophobicity of protein molecules and other large molecules.

15 used to enhance the ionization efficiency of large molecules.

16 sistance and increased flux of small but not large molecules.

17 nsitivity and signal stability for small and large molecules.

18 rophoresis and has comparable resolution for large molecules.

19 pulmonary microvascular barrier function to large molecules.

20 catalysis and adsorption processes involving large molecules.

21 molar mass determinations for both small and large molecules.

22 ates and are inherently multidimensional for large molecules.

23 viate these issues but are too expensive for large molecules.

24 e of following proton transfer (PT) in these large molecules.

25 rties in between that enable the building of large molecules.

26 hat hinder desorption/ionization by trapping large molecules.

27 e to a membrane pore allowing the passage of large molecules.

28 pletion increased epithelial permeability to large molecules.

29 e selective uptake or exclusion of small and large molecules.

30 fers from limited selectivity when analyzing large molecules.

31 is explanation seems to be true for cationic large molecules.

32 tent of cytoplasmic membrane permeability to large molecules.

33 the permeabilization of the cell membrane to large molecules.

34 terms of speed and memory, particularly for large molecules.

35 al ergodicity breaking in an unprecedentedly large molecule, (12)C(60), determined from its icosahedr

36 ne accessibility mutagenesis, the relatively large molecule [2-(trimethylammonium)] methanethiosulfon

37 us multicomponent analysis of both small and large molecules across a wide polarity range in single e

38 Vesicular transport enables the export of large molecules across the cell wall, and vesicles conta

39 t of fluid, solutes, hormones, and small and large molecules across the microvascular endothelium.

40 ifferences control the movement of fluid and large molecules across the microvascular wall of normal

41 otein family that facilitates the passage of large molecules across the periplasm.

42 n machineries for the successful delivery of large molecules across their cell envelopes.

43 rstanding of the dissociation mechanisms for large molecules adsorbed on surfaces is still a challeng

44 normalization of microvascular integrity to large molecules after 24 h.

45 the brain parenchyma, and of both small and large molecule agents into the perivascular space from t

46 reated kidney value) clearance of small- and large-molecule agents and the urine flow rates that resu

47 o a constantly changing mixture of small and large molecules, along with an abundance of bacteria, vi

48 nanowires, nanotubes, nanoribbons, or other large molecules; among these complex materials, networks

49 lar components are necessary for adhesion: a large molecule and a small (9 kD) protein.

50 urpose-built for targeted delivery of modern large molecule and temperature-sensitive therapeutics to

51 ine various biophysical characteristics of a large molecule and the biomechanical properties of human

52 ave a 6-fold higher sensitivity in detecting large molecules and a 33% improvement in detecting small

53 ons as a selectivity filter for transport of large molecules and a sieve-like filter for diffusion of

54 utilization of maximal quantum coherence in large molecules and biopolymers.

55 neurofilaments was detected by exclusion of large molecules and by direct force measurements with at

56 cular beds regulate the passage of small and large molecules and cells.

57 rogen, water, and metals and the presence of large molecules and grains.

58 liminate or attenuate the broad signals from large molecules and improve spectral resolution.

59 lenging target given its innate exclusion of large molecules and its defenses against bacterial invas

60 accurately predicting the whole spectrum of large molecules and materials.

61 escriptions of mobility within structures of large molecules and membranes as well as in free space.

62 ectron dynamics and ionisation mechanisms of large molecules and nanoparticles.

63 solution-phase approach to the formation of large molecules and nanostructures by coupling reactions

64 TRAMbio performs well even on large molecules and on discrete time series of protein m

65 in the domain of inception that lies between large molecules and soot particles, we provide a new mec

66 water, the controlled covalent synthesis of large molecules and structures in vivo has remained chal

67 tside the TDA limits such as the analysis of large molecules and the use of high flow-rates.

68 ol levels, capability of analyzing small and large molecules, and good spatial resolution (250 mum).

69 This could be a general route to very large molecules, and is exemplified here by the synthesi

70 ll-cell channels are permeable to relatively large molecules, and it was thought that opening of hemi

71 t, permeable TJs become first restrictive to large molecules, and only later to small molecules, with

72 These NPs themselves can be considered as large molecules, and thus, applying a wet-chemical depro

73 key role in terminating the burst release of large molecules, and to provide a means for novel aqueou

74 ruggability (ligandability), suitability for large-molecule approaches (e.g. antibodies) or new modal

75 has revolutionized the manner by which many large molecules are characterized, the highly variable a

76 cromolecules, spurring investigations of how large molecules are distributed within the crystals with

77 Large molecules are less effective at crowding than wate

78 approaches, especially when medium-sized and large molecules are modeled.

79 These findings challenge the dogma that large molecules are required to disrupt challenging PPIs

80 ethod is especially superior for cases where large molecules are sedimented at faster rotor speeds, d

81 Two fundamental problems for such large molecules are their poor penetration into tissues

82 and catabolism mechanisms and kinetics of a large molecule at the administration site.

83 erred between coupled heteronuclear spins in large molecules at high magnetic fields in the presence

84 s describe vibrational dephasing dynamics in large molecules at intermediate times because of the loc

85 ation and dissociation of bonds between very large molecules at rates that change considerably under

86 As a result, large molecules at the front of the injected sample plug

87 ouble bonds on the self-assembly of discrete large molecules at the liquid/solid interface.

88 is directly linked to permeation of ions and large molecules (ATP and fluorescent dyes) and occurs du

89 demonstrate a novel separation mechanism for large molecules based on their radial migration in capil

90 o reconcile the small nature of DOM with the large-molecule behavior observed in other studies.

91 te is to selectively restrict the passage of large molecules between cells while allowing electrical

92 ompound classes such as macrocycles or other large molecules beyond the rule-of-five limit.

93 Moreover, like other large molecules, bscAbs may be restricted from entry int

94 demand to allow adsorption and processing of large molecules but challenge our synthetic ability.

95 digests tissue HA and facilitates spread of large molecules but is not sufficient to cause subcutane

96 of P2X7R outward and inward permeability to large molecules by Cl-(o) and Na+(o), respectively, may

97 Na+ (Na+(o)) regulates the inward current of large molecules by P2X7Rs.

98 a of the slowly diffusing species (generally large molecules) by diffusion editing, the slowly relaxi

99 Surprisingly, such heavy and large molecules can be deposited on any substrate by thi

100 Large molecules can be generically separated from small

101 Today, very large molecules can be manipulated at will, with the res

102 Individual large molecules can be positioned on surfaces, and atoms

103 ules to traverse by passive diffusion, while large molecules can only translocate with the help of nu

104 on protein and shown that, in resting cells, large molecules can rapidly diffuse across the cell with

105 mers) because the degradation mechanisms for large molecules can result in hundreds of thousands to e

106 Catalysis, in particular, biomass and large molecule catalysis, is one of the important areas

107 method for transporting colloidal particles, large molecules, cells, and other materials across surfa

108 ant polymer is beta-(1,6)-glucans, which are large molecules composed of a linear beta-(1,6)-glucan c

109 veraged to identify catalysts for converting large molecules computationally.

110 Mechanistic understanding of large molecule conversion and the discovery of suitable

111 sors to haloacetonitriles and other emerging large-molecule DBPs with the expected toxicity.

112 esolution mass spectrometry revealed several large-molecule DBPs, including chloroanilines, (chloro)h

113 Embryonic large molecule derived from yolk sac (ELYS) is a constit

114 duction potential of a factor of up to 5 for large molecules (dextran) under unretained conditions.

115 However, for large molecules, distant constraints might affect reacti

116 he first-time, buccal delivery of dry coated large molecule drug, vancomycin, through controlled depo

117 ped as new drugs for the brain because these large molecule drugs do not cross the brain capillary wa

118 But it can also reduce the efficacy of large-molecule drugs by triggering an anti-drug response

119 filters are advantageous for the analysis of large molecules due to the ability to perform ion isolat

120 e made it possible to quantify expression of large molecules during embryogenesis, little information

121 preventing waste of expensive biologics and large molecules during proof-of-concept and pre-clinical

122 fter radiosynoviorthesis or extravasation of large molecules (e.g., [(90)Y]Y-ibritumomab tiuxetan).

123 rt decreases with increasing molecular size, large molecules (e.g., albumin) are nevertheless removed

124 between the separated channels but prevents large molecules, e.g., DNA, from traversing the membrane

125 ergence of new data, it became apparent that large molecules enter the cell directly through the pore

126 without template replication or assembly of large molecules; exhibits selection both without and wit

127 type G protein-coupled receptors (aGPCRs), a large molecule family with over 30 members in humans, op

128 Without fluid or in large molecule fluids (e.g., isopropanol, ethanol, or fl

129 2 diabetes mellitus, exclusively focusing on large-molecule formats (notably enteroendocrine peptides

130 me the highly charged, barrier-like layer of large molecules forming a target cell's glycocalyx.

131 to prevent the migration of cells and other large molecules from the blood into the CNS.

132 den typical of GBM tumors, plus exclusion of large molecules from the brain parenchyma.

133 ding of fluorescein-labeled Ficoll and other large molecules from the SE/CC complex showed an irregul

134 It is a common knowledge that large molecules have small diffusion coefficients.

135 ' cage, making their replacement by a single large molecule (here adamantane or ferrocene) entropical

136 molecule guests are completely surrounded by large molecule hosts.

137 opportunities for probing atomic motion in a large molecule in a typical pump-probe measurement.

138 We have prepared a large molecule in which four perylene-3,4:9,10-tetracarb

139 ble biochemical monitoring of both small and large molecules in a variety of body fluids, such as swe

140 eed for more benchmarks on the mechanisms of large molecules in complex reactions.

141 The multiple charging of large molecules in electrospray ionization provides key

142 we can detect interactions between small and large molecules in human blood serum and quantify the si

143 TNF increased paracellular flux of large molecules in occludin-sufficient, but not occludin

144 zation of adhered brain endothelial cells to large molecules in response to applied pulsed electric f

145 s a new approach for ionizing both small and large molecules in solids or liquid solvents with high s

146 es a separate pathway that permeates anionic large molecules in some cell types.

147 If proteins or other large molecules in the sample bind the fluorescent probe

148 eening method for examining the diffusion of large molecules in tissues, and for studying the effects

149 and aging (18 month) males and females using large-molecule in vivo microdialysis.

150 Recently, large molecules incorporating phenyl rings have been sho

151 picomolar range were obtained for small- and large-molecule interactions in both synthetic and cell-d

152 ion is obtained by mathematically breaking a large molecule into smaller parts, called kernels.

153 e delivery of neurotrophic factors and other large molecules into the brain.

154 Given the potential to deliver large molecules into the CNS via this technique, we prop

155 Mechanistically, we found that the uptake of large molecules is a receptor-independent, fluid-phase p

156 ctrometry (CDMS) for measuring the masses of large molecules, macromolecular complexes, and synthetic

157 s found in nonribosomal peptide synthetases, large molecule mass spectrometry is shown to be a new, u

158 e studies indicate that intranasally applied large molecules may enter the brain and cerebrospinal fl

159 d current and an increase in permeability to large molecules, mediated by the opening of pannexin-1 h

160 at the interface between small molecule and large molecule medicinal chemistry.

161 ike studies of the structure and dynamics of large molecules, multispecies trace gas detection and is

162 cell-to-cell communication, via transfer of large molecules, occurs between the cell bodies of injur

163 compact form that allows comparatively very large molecules of DNA to fit inside the cell's nucleus.

164 nt investigations in animal models show that large molecules of neurotherapeutic potential can be con

165 assignments to individual nuclei, which for large molecules often can only be obtained by tedious po

166 However, these large molecules often suffer from poor cell permeability

167 However, the unexpected adsorption of large molecules on ZIF-8 suggests the existence of struc

168 Bacteria need to deliver large molecules out of the cytosol to the extracellular

169 ever, it has long been deemed infeasible for large molecules-particularly polymers, proteins and pept

170 but controversy persists as to whether such large molecules pass directly through the open ion chann

171 Evans blue was used to examine large molecule penetration into the rat TG.

172 uced barrier loss by limiting both small and large molecule permeability but did not affect myosin li

173 -permeable pore that favors flux of anionic, large-molecule permeants (up to ~1 kDa).

174 These results verify large molecule permeation directly through caspase-activ

175 e, there has been no direct demonstration of large molecule permeation via the Panx1 channel itself,

176 fields where the targets of the analyses are large molecules present in a matrix that would otherwise

177 trometry (HRMS) based approach for analyzing large-molecule proteins at the intact level in biologica

178 Large molecule quantitation by LC-MS/MS commonly relies

179 drug development of either small molecule or large molecule (recombinant proteins, gene medicines) ne

180 e intermediate states), and that crowding by large molecules reduces noise more efficiently than crow

181 However, they are highly hydrophobic and large molecules, regarded as difficult targets for in vi

182 ving time-resolved structural information of large molecules reshaped by intense laser fields.

183 sites of high resistance to the diffusion of large molecules, resulting in an REL of 76.5 kDa.

184 strate enhanced paracellular permeability to large molecules, revealing a potential role of JAM-A in

185 In contrast, large molecules show highest signal for the low-porosity

186 For large molecules, site-specific reversible inactivation o

187 These simulation results suggest that even large molecule solutes would be more easily cleared from

188 e signals generated by shape fluctuations of large molecules studied by feedback tracking microscopy.

189 Delivery of large molecules such as antisense inhibitors or mimics t

190 hannels can be a release site for relatively large molecules such as ATP and glutamate, which can ser

191 model predicts the topological seclusion of large molecules such as CD43 from the site of closest co

192 sible dehydrogenation and rehydrogenation of large molecules such as cyclohexane and methylcyclohexan

193 first report of a method for introduction of large molecules such as DNA into amphioxus embryos, open

194 to the device but did not prevent passage of large molecules such as IgG and IgM.

195 ely 12 angstroms) raises questions as to how large molecules such as LF and EF can move through the p

196 ng free Ca2+, with respect to the passage of large molecules such as mannitol and sucrose.

197 P2X7 receptor (P2X7R) expands to accommodate large molecules such as N-methyl-D-glucamine (NMDG+).

198 rotein-protein interactions usually involves large molecules such as peptides and macrocycles.

199 often intractable on classical computers for large molecules such as proteins and for protocols such

200 lar weight cutoff filter cartridge to remove large molecules such as proteins and lipids.

201 ges and slow sensor responses when detecting large molecules such as proteins and nucleic acids.

202 However, it is also common to observe that large molecules such as proteins and polymers often prod

203 ution, the determination of the structure of large molecules such as proteins, which is one of the mo

204 hyper-Raman intensities are now possible for large molecules such as R6G.

205 rgets, from rare atoms and molecules to very large molecules, such as a proteins, protein complexes,

206 ostulated to act as a filtration barrier for large molecules, such as albumin.

207 sma membrane channel permeable to relatively large molecules, such as ATP.

208 Large molecules, such as IgG, diffuse across sclera in a

209 However, even for large molecules, such as monoclonal antibodies, Alexa750

210 ssential technique to characterize small and large molecules, such as organic compounds, metabolites,

211 l units, such as small molecular ligands, or large molecules, such as proteins, can be positioned wit

212 of cancer immunotherapeutic approaches using large molecules, such as T cell bispecific Abs (TCBs).

213 A large body of work on glasses and large molecules suggests that this balancing should be i

214 previously been used to select aptamers for large-molecule targets such as proteins, lipopolysacchar

215 Large molecules that are assisted by transport factors (

216 edly enhanced tight junction permeability to large molecules that could be modeled by size-selective

217 Both the GDNF and the TNFR are large molecules that do not cross the blood-brain barrie

218 een the initiator-coated pore structures and large molecules that hinder desorption/ionization by tra

219 Glycoproteins are biologically significant large molecules that participate in numerous cellular ac

220 mage(2), but it is unclear whether there are large molecules that regulate the integrity of the plasm

221 Many peptidic APIs are large molecules that require considerable effort for int

222 nt of bioengineered RNAs as a novel class of large molecule therapeutic agents.

223 d BBB-targeted procedure for the delivery of large-molecule therapeutic agents to treat neurological

224 a significant obstacle in the development of large molecule therapeutics for CNS disease.

225 Regulatory approval of large molecule therapeutics, including antibody therapie

226 flexibility in the non-invasive delivery of large molecule therapeutics.

227 al for positive interplay between small- and large-molecule therapeutics against HIV entry, which may

228 osis is an attractive pathway for delivering large-molecule therapeutics to the central nervous syste

229 are a possible way out: they scale well for large molecules, they can be parallelized and their accu

230 y bed and enabled extravasation of small and large molecules through the blood-retina barrier.

231 ivity of multidimensional NMR experiments of large molecules through these methods.

232 hat pressure changes impact the retention of large molecules to a much greater degree than small mole

233 rain barrier (BBB), which allows delivery of large molecules to brain tumors.

234 The intrinsic challenge of large molecules to cross the cell membrane and reach int

235 B) presents a major challenge for delivering large molecules to study and treat the central nervous s

236 Large-molecule tracers, such as labeled antibodies, have

237 uires modification for protein secretion and large-molecule transport as well as for bacterial growth

238 s requires conjugation of the PNA to another large molecule, typically a cell-penetrating peptide or

239 re complexes (NPCs), which act a barriers to large molecules unless they are escorted by specific LCD

240 For the same tumor types, diffusion of large molecules was significantly faster in CW than in D

241 Absence of large molecules was verified by atomic force microscopy

242 Similar conductances that are permeable to large molecules were activated by extreme hyperpolarizat

243 The most permeant to large molecules were gap junctions from A-type horizonta

244 spectra remains challenging, especially for large molecules, where the monoisotopic peak is often un

245 face speeding up the gas-phase conversion of large molecules while lessening possible memory effects.

246 as medium-sized biomolecules pass slower and large molecules will be excluded.

247 of the human PKD1 gene, polycystin, shows a large molecule with a unique arrangement of extracellula

248 flagellate-derived polyketides are typically large molecules with complex structures, potent bioactiv

249 Irradiation of nanoscale clusters and large molecules with intense laser pulses transforms the

250 all molecules from salivary mucins and other large molecules with only a 29% reduction of signal comp

251 enables rapid vapor pressure measurements on large molecules with state-of-the-art measurement uncert

252 bling adsorption, activation and reaction of large molecules with sufficient versatility to drive abs

253 rules for renal filtration, given that these large molecules (with aspect ratios ranging from 100:1 t

254 high sensitivity" pH intervals for small and large molecules within a single experiment.

255 Brain penetration of large molecules (zirconium 89-radiolabeled antibodies) w