ライフサイエンスコーパス: large ribosomal subunit

1 d by eIF5B in concert with components of the large ribosomal subunit.

2 egion of the 28S ribosomal RNA (rRNA) in the large ribosomal subunit.

3 se center, the main antibiotic target in the large ribosomal subunit.

4 primarily by the binding of the drug to its large ribosomal subunit.

5 denosine at position 2503 in 23S rRNA in the large ribosomal subunit.

6 nically relevant antibiotics that target the large ribosomal subunit.

7 in the details of their manipulation of the large ribosomal subunit.

8 A2058 and A749-753 in the exit tunnel of the large ribosomal subunit.

9 part of the GTPase-associated center of the large ribosomal subunit.

10 n is a universal element of the RNA from the large ribosomal subunit.

11 in late-assembly ribosomal proteins into the large ribosomal subunit.

12 ilitate essential steps in biogenesis of the large ribosomal subunit.

13 1, and RpL5 and RpL38 encode proteins of the large ribosomal subunit.

14 a methyl-accepting substrate elutes with the large ribosomal subunit.

15 the peptidyl transferase center (PTC) of the large ribosomal subunit.

16 aryotic Obg proteins are associated with the large ribosomal subunit.

17 form part of the peptide exit tunnel in the large ribosomal subunit.

18 stal structure of the Haloarcula marismortui large ribosomal subunit.

19 AAA-ATPase required for the formation of the large ribosomal subunit.

20 e likely, Mtg1p functions in assembly of the large ribosomal subunit.

21 be cross-linked to Mrp20, a component of the large ribosomal subunit.

22 ck protein synthesis by interacting with the large ribosomal subunit.

23 mature 5.8S and 28S rRNAs, components of the large ribosomal subunit.

24 led in the crystallographic structure of the large ribosomal subunit.

25 al protein synthesis by interacting with the large ribosomal subunit.

26 7/L12 dimers and thereby anchors them to the large ribosomal subunit.

27 bosomal protein genes of either the small or large ribosomal subunit.

28 nding of tRNA in the functional sites of the large ribosomal subunit.

29 ypeptide component of the mitochondrial 54 S large ribosomal subunit.

30 in that penetrates deep into the core of the large ribosomal subunit.

31 ng to the peptidyl transferase center of the large ribosomal subunit.

32 inhibition from antibiotics that target the large ribosomal subunit.

33 ssembly steps to drive the biogenesis of the large ribosomal subunit.

34 lease of the ribosomal protein L13a from the large ribosomal subunit.

35 the peptidyl transferase center (PTC) of the large ribosomal subunit.

36 at a previously unknown binding site on the large ribosomal subunit.

37 phorylation and the release of L13a from the large ribosomal subunit.

38 somal protein uL23 at the tunnel exit on the large ribosomal subunit.

39 ) within the 23S ribosomal RNA (rRNA) of the large ribosomal subunit.

40 enters the peptidyltransferase center of the large ribosomal subunit.

41 lease of the nuclear export adapter from the large ribosomal subunit.

42 te to the peptidyl transferase center of the large ribosomal subunit.

43 ss through an exit tunnel that traverses the large ribosomal subunit.

44 ubunit in a quality control complex with the large ribosomal subunit.

45 of the P-site tRNA toward the A site of the large ribosomal subunit.

46 ion on leaderless mRNAs does not require the large ribosomal subunit.

47 BSE) that participates in recruitment of the large ribosomal subunit.

48 subunits and also affected the stability of large ribosomal subunits.

49 icles are converted to translation-competent large ribosomal subunits.

50 lar consequences of deficiency for small and large ribosomal subunits.

51 iated with ribosomes, predominantly with 60S large ribosomal subunits.

52 eaving incomplete nascent chains attached to large ribosomal subunits.

53 ng the assembly of yeast and human small and large ribosomal subunits.

54 factors to release nascent polypeptides from large ribosomal subunits.

55 l proteins to the RNAs forming the small and large ribosomal subunits.

56 ncy causes the aggregation of both small and large ribosomal subunits.

57 inhibiting the association of the small and large ribosomal subunits.

58 undant tertiary structure interaction in the large ribosomal subunit; 186 adenines in 23S and 5S rRNA

59 mall ribosomal subunit (30S) relative to the large ribosomal subunit (50S) during translation is wide

60 tilis, the final maturation steps of the two large ribosomal subunit (50S) rRNAs, 23S and 5S pre-rRNA

61 riant in the essential, conserved, nucleolar large ribosomal subunit (60S) assembly factor RBM28.

62 During the early stages of human large ribosomal subunit (60S) biogenesis, an ensemble of

63 wn the presence of expansion segments in the large ribosomal subunit (60S) of Trypanosoma brucei.

64 o a conformation compatible with binding the large ribosomal subunit (60S).

65 mes, along with genes encoding the small and large ribosomal subunits, a ribosomal protein S3, and 25

66 Ribosomes or 60S large ribosomal subunits activate the GTPase cycle of SR

67 f the nascent peptide with components of the large ribosomal subunit along the path it follows betwee

68 it may change the folding or dynamics of the large ribosomal subunit, altering the rate of GTP hydrol

69 FRET between the Cy3-labeled L1 stalk of the large ribosomal subunit and a Cy5-labeled tRNA(Lys) in t

70 (RPL9 or L9), an essential component of the large ribosomal subunit and a putative tumor suppressor,

71 e orchestration of the early assembly of the large ribosomal subunit and in faithful protein producti

72 igosaccharide antibiotic, interacts with the large ribosomal subunit and inhibits bacterial protein s

73 260c as LTO1; required for biogenesis of the large ribosomal subunit and initiation of translation in

74 rgest and most variable ES of the eukaryotic large ribosomal subunit and is located at the surface of

75 The loop is located in the large ribosomal subunit and is part of a conserved 58-nt

76 al stalk structure in the active site of the large ribosomal subunit and is thought to assist in the

77 he known assembly hierarchy of the bacterial large ribosomal subunit and offers a coherent view of ho

78 ng mode of Staphylococcus aureus RsfS to the large ribosomal subunit and present a 3.2 angstrom resol

79 r (RsfS) that binds to uL14 protein onto the large ribosomal subunit and prevents its association wit

80 ure establishes how Ltn1 associates with the large ribosomal subunit and properly positions its E3-ca

81 S enhances tRNA binding to the P site of the large ribosomal subunit and slows down spontaneous inter

82 strates that the initial contact between the large ribosomal subunit and the Sec61 complex is importa

83 is for its involvement in recruitment of the large ribosomal subunit and the switch between viral tra

84 teracts with the central protuberance of the large ribosomal subunit and with the P site-bound tRNA t

85 ells blocks rRNA maturation and synthesis of large ribosomal subunits and induces a reversible, p53-d

86 the last decade, structures of the small and large ribosomal subunits and of the intact ribosome have

87 ase mode leads to the accumulation of NCs on large ribosomal subunits and proteotoxic aggregation of

88 view of the interface between the small and large ribosomal subunits and the conformation of the pep

89 ern of rRNA degradation, particularly in the large ribosomal subunit, and accumulate rRNA fragments a

90 n all forms of life, rRNAs for the small and large ribosomal subunit are co-transcribed as a single t

91 Nearly all the bridges between the small and large ribosomal subunits are indicated by CG interaction

92 etely synthesized nascent chains obstructing large ribosomal subunits are targeted for degradation by

93 This points to the 21S rRNA or the large ribosomal subunit as the most likely target of Mtg

94 to show that this protein interacts with the large ribosomal subunit as well as with a series of non-

95 served between the factor's G domain and the large ribosomal subunit, as well as between domain IV an

96 RPL5-mutated iPSCs exhibited defective 60S (large) ribosomal subunit assembly, accumulation of 12S p

97 In eukaryotes, the large ribosomal subunit-associated quality control compl

98 he efficiency of late steps in biogenesis of large ribosomal subunits at low temperatures, presumably

99 The drug binds to both small and large ribosomal subunits at nine independent sites.

100 ntial GTPases YphC and YsxC are required for large ribosomal subunit biogenesis in Bacillus subtilis.

101 ifested at the biological level by affecting large ribosomal subunit biogenesis, ribosomal subunit jo

102 ichia coli GTPase, CgtA(E), in late steps of large ribosomal subunit biogenesis.

103 a trans-acting factor in rRNA processing and large ribosomal subunit biogenesis.

104 op15 is an RRM protein that is essential for large ribosomal subunit biogenesis.

105 perates with the N-terminal extension of the large ribosomal subunit bL27m to provide stability to th

106 d that the Sec61 oligomer is attached to the large ribosomal subunit by a single connection.

107 We characterized rRNA of the H. sapiens large ribosomal subunit by computation, circular dichroi

108 is the dimethylation of a nucleotide in the large ribosomal subunit by erythromycin resistance methy

109 to be fundamentally an RNA machine, and the large ribosomal subunit can carry out peptidyl transfer

110 The large ribosomal subunit catalyses the reaction between t

111 of this site's physical separation from the large ribosomal subunit catalytic centers.

112 The large ribosomal subunit catalyzes peptide bond formation

113 The large ribosomal subunit catalyzes peptide bond formation

114 nserved, independently folding domain in the large ribosomal subunit consists of 58 nt of rRNA and a

115 Domain V of the 23S/25S/28S rRNA of the large ribosomal subunit constitutes the active center fo

116 L4 and L22, proteins of the large ribosomal subunit, contain globular surface domain

117 The structures of large ribosomal subunits containing resistance mutations

118 Crystal structures of H. marismortui large ribosomal subunits containing the mutation G2099A

119 s the smallest nucleic acid component of the large ribosomal subunit, contributing to ribosomal assem

120 center in the Haloarcula marismortui (H.ma) large ribosomal subunit crystals and consequently allows

121 nt of the hypervariable domains D1/D2 of the large ribosomal subunit (D1/D2 LSU) as a barcoding marke

122 we evaluated the ability of CGB agar and D2 large ribosomal subunit DNA sequencing (D2 LSU) to diffe

123 ward/outward movement of the L1 stalk of the large ribosomal subunit during the subunit-joining step

124 rs all interact with the L7/L12 stalk of the large ribosomal subunit during their respective GTP-depe

125 The L1 stalk is a mobile domain of the large ribosomal subunit E site that interacts with the e

126 nt protein (EGFP) reporter fused to the L10a large ribosomal subunit (EGFPL10a).

127 preinitiation complex (i.e., small, but not large, ribosomal subunits, eIF3, eIF4E, eIF4G) are coord

128 uring this process, the protein Rqc2 and the large ribosomal subunit elongate stalled polypeptides wi

129 mortui to anisomycin and the affinity of its large ribosomal subunits for the drug indicates that its

130 Distinct rRNA elements and proteins of the large ribosomal subunit form four connections with the P

131 the mechanism of inhibition of a key step in large ribosomal subunit formation.

132 We have shown that Rpl3, a protein of the large ribosomal subunit from baker's yeast (Saccharomyce

133 ve developed an affinity purification of the large ribosomal subunit from Deinococcus radiodurans tha

134 atomic resolution crystal structures for the large ribosomal subunit from Haloarcula marismortui and

135 Using the atomic structures of the large ribosomal subunit from Haloarcula marismortui and

136 have determined the crystal structure of the large ribosomal subunit from Haloarcula marismortui at 2

137 rystallographic electron density maps of the large ribosomal subunit from Haloarcula marismortui at v

138 he 2.4-A resolution crystal structure of the large ribosomal subunit from Haloarcula marismortui reve

139 etermined using the crystal structure of the large ribosomal subunit from Haloarcula marismortui.

140 We focus on the conformation of the large ribosomal subunit from Haloarcula marismortui.

141 etermination of the crystal structure of the large ribosomal subunit from Haloarcula marismortui.

142 Here we present the crystal structure of the large ribosomal subunit from Staphylococcus aureus, a ve

143 ost-termination release and recycling of the large ribosomal subunit from the ER membrane.

144 nylated tRNA substrates to randomly modified large ribosomal subunits from Escherichia coli and captu

145 Analysis of the Haloarcula marismortui large ribosomal subunit has revealed a common RNA struct

146 tui) and bacterial (Deinococcus radiodurans) large ribosomal subunits have been reported, it remains

147 ment of the L1 stalk, a mobile domain of the large ribosomal subunit, have been shown to accompany th

148 methylcytosine RNA methyltransferase, to the large ribosomal subunit in a process crucial for mitocho

149 l inner membrane and associates with the 54S large ribosomal subunit in a salt-dependent manner.

150 tein RbgA is involved in the assembly of the large ribosomal subunit in Bacillus subtilis, and homolo

151 Ribosomal protein L14e is a component of the large ribosomal subunit in both archaea and eukaryotes.

152 lution crystal structures of the eubacterial large ribosomal subunit in complex with them.

153 or cell growth and plays a crucial role in a large ribosomal subunit in Escherichia coli.

154 SBDS migrates together with the 60S large ribosomal subunit in sucrose gradients and copreci

155 herichia coli 70S ribosome, RRF binds to the large ribosomal subunit in the cleft that contains the p

156 or G (EF-G) and the L7/L12-stalk base of the large ribosomal subunit in the GDP state.

157 inhibit protein synthesis by binding to the large ribosomal subunit in the tRNA accommodation corrid

158 etermine localization and orientation of the large ribosomal subunit in these sections.

159 to an snoRNP essential for processing of the large ribosomal subunit in vertebrates.

160 embranes, the Sec61beta(c) sequence binds to large ribosomal subunits in preference over small subuni

161 n apparent block in the nucleolar release of large ribosomal subunits in terminally differentiated la

162 m, and it is known to also be a component of large ribosomal subunits in the cytoplasm.

163 n of RPL15, which encodes a component of the large ribosomal subunit, increased metastatic growth in

164 L15, a 15 kDa protein of the large ribosomal subunit, interacts with over ten other p

165 erved mechanism, which licenses entry of the large ribosomal subunit into translation.

166 ral subgroup and was most closely related to large ribosomal subunit introns that express single-moti

167 The binding interface on the large ribosomal subunit is buried by the small subunit d

168 ng ES27, and suggest a function for ES30.The large ribosomal subunit is linked to the channel by four

169 a physical association between Oxa1 and the large ribosomal subunit is presented.

170 ecent study shows that nuclear export of the large ribosomal subunit is regulated by a GTPase that bl

171 Sucrose density gradient centrifugation of large ribosomal subunits isolated from YphC-depleted cel

172 ng high-resolution structures for eukaryotic large ribosomal subunits, it remained unclear how these

173 curs within a highly conserved region of the large ribosomal subunit known as the peptidyl transferas

174 ite being abundant as a component of the 60S large ribosomal subunit, L11 does not induce p53 under n

175 he conventional exit tunnel of the bacterial large ribosomal subunit (L22, L23, L24, and L29).

176 has extensive identity and similarity to the large ribosomal subunit L7 proteins and shares an RNA-bi

177 sent in the high molecular mass RNA from the large ribosomal subunit (LSU) have been sequenced from r

178 Maturation of the large ribosomal subunit (LSU) in eukaryotes is a complex

179 the case of the N. crassa mitochondrial (mt) large ribosomal subunit (LSU) intron, it appears to act

180 ption of pre-ribosomal RNA (pre-rRNA) and to large ribosomal subunit (LSU) pre-rRNA processing indepe

181 the five cleavage sites of the kinetoplastid large ribosomal subunit (LSU) rRNA chain, which is known

182 domain complexed with L11 protein and of the large ribosomal subunit (LSU) suggest that this thermody

183 l DBP whose absence impairs formation of the large ribosomal subunit (LSU).

184 ofiles to other antibiotics specific for the large ribosomal subunit (macrolides and chloramphenicol)

185 studies indicate that SBDS functions in 60S large ribosomal subunit maturation and in mitotic spindl

186 We show here that large ribosomal subunits move out from the nucleolus and

187 proteins, associates with the mitochondrial large ribosomal subunit (mt-LSU).

188 linically relevant antibiotics targeting the large ribosomal subunit, namely macrolides, lincosamides

189 We present evidence that OT may bind to the large ribosomal subunit near the site where nascent poly

190 , yeast Rqc2 and bacterial RqcH, which sense large ribosomal subunits obstructed with nascent chains

191 Aborted translation produces large ribosomal subunits obstructed with tRNA-linked nas

192 termining the structures of complexes of the large ribosomal subunit of Deinococcus radiodurans (D50S

193 or this loop in the crystal structure of the large ribosomal subunit of Deinococcus radiodurans.

194 Crystal structures of the large ribosomal subunit of Haloarcula marismortui (Hma)

195 Here we describe three new structures of the large ribosomal subunit of Haloarcula marismortui (Hma)

196 oharringtonine, and bruceantin form with the large ribosomal subunit of Haloarcula marismortui at res

197 sticidin S, and virginiamycin M bound to the large ribosomal subunit of Haloarcula marismortui have b

198 Functionally active large ribosomal subunits of thermophilic bacterium Therm

199 Functional large ribosomal subunits of Thermus aquaticus can be rec

200 d polypeptide chains as they emerge from the large ribosomal subunit, or how these conformations comp

201 ed mutations in rpl-11.1 (L11 protein of the large ribosomal subunit), pab-1 [a poly(A)-binding prote

202 haploinsufficiency of Mrpl40 (mitochondrial large ribosomal subunit protein 40) as a contributor to

203 Large ribosomal subunit protein bL31, which forms inters

204 rin resistance is dependent on the essential large ribosomal subunit protein L10e in S. cerevisiae.

205 in the C-terminal domain of Escherichia coli large ribosomal subunit protein L9.

206 odifying ribosome homeostasis by depleting a large ribosomal subunit protein or treating cells with s

207 somes and can stably interact with rpL23a, a large ribosomal subunit protein present at the tunnel ex

208 The large ribosomal subunit protein Rpl10p is required for s

209 In the yeast Saccharomyces cerevisiae, the large ribosomal subunit protein Rpl3p is methylated at h

210 ular stomatitis virus (VSV), we identify the large ribosomal subunit protein rpL40 as requisite for V

211 Ribosomal protein L5, a 34-kDa large ribosomal subunit protein, binds to 5 S rRNA and h

212 The study identified 42 of the 43 core large ribosomal subunit proteins and 58 (of 64 possible)

213 Analysis of the intact masses of the large ribosomal subunit proteins by electrospray mass sp

214 Large ribosomal subunit proteins L10 and L12 form a pent

215 and with published data from an analysis of large ribosomal subunit proteins, both from the yeast S.

216 These structures lack large ribosomal subunit proteins, suggesting that they a

217 diac VCP activity resulted in aggregation of large ribosomal subunit proteins.

218 between assembly of bacterial and eukaryotic large ribosomal subunits, providing insights into how th

219 The binding site in the large ribosomal subunit proximal to the 3'-end of tRNA i

220 uctures, the interface between the small and large ribosomal subunits rearranges in discrete steps al

221 To understand the structural basis for the large ribosomal subunit recruitment and the intricate in

222 the basis of these results, we propose that large ribosomal subunit release from the ER membrane is

223 Nuclear export of the large ribosomal subunit requires the adapter protein Nmd

224 Biogenesis of the large ribosomal subunit requires the coordinate assembly

225 Biogenesis of the small and large ribosomal subunits requires modification, processi

226 ther is predicted to modify a portion of the large ribosomal subunit RNA belonging to the peptidyltra

227 The group I intron from the large ribosomal subunit RNA of mouse-derived Pneumocysti

228 nteractions in the crystal structures of the large ribosomal subunit RNAs of Haloarcula marismortui a

229 only snoRNA essential for maturation of the large ribosomal subunit RNAs, 5.8S and 28S.

230 ical role in processing of precursors to the large ribosomal subunit RNAs.

231 For example, many of the genes for the large ribosomal subunit (RPLs) were CHI with act1Delta a

232 resin, we identified four nucleotides in the large ribosomal subunit rRNA (positions G2252, A2451, U2

233 RF interacts mainly with the segments of the large ribosomal subunit's (50S) rRNA helices that are in

234 panning the D1 and D2 regions (D1/D2) of the large ribosomal subunit-showed that sequence analysis pr

235 ribosomal protein L13a is released from the large ribosomal subunit soon after infection and inhibit

236 ned with the exit of a tunnel traversing the large ribosomal subunit, strongly suggesting that both s

237 in the direct vicinity of the A site of the large ribosomal subunit, suggesting a possible interacti

238 as a substrate, but not the fully assembled large ribosomal subunit, suggesting that the methylation

239 srupting a key contact between the small and large ribosomal subunits termed bridge B2a.

240 rotein L27 is a component of the eubacterial large ribosomal subunit that has been shown to play a cr

241 Defects in RbgA give rise to a large ribosomal subunit that is immature and migrates at

242 of the L1 stalk, a structural element of the large ribosomal subunit that is implicated in directing

243 ut the three-dimensional architecture of the large ribosomal subunit, the mechanism by which it facil

244 The model explains the evolution of the large ribosomal subunit, the small ribosomal subunit, tR

245 own antibiotics that affect functions of the large ribosomal subunit, these drugs act on only a few s

246 -affinity, saturable binding of ribosomes or large ribosomal subunits to the SR.

247 lation initiation, recruiting both small and large ribosomal subunits to viral RNA without the use of

248 quitin is ligated to L28, a component of the large ribosomal subunit, to form the most abundant ubiqu

249 The L1 stalk of the large ribosomal subunit undergoes large-scale movements

250 gests that a defect in the biogenesis of the large ribosomal subunit underlies the ribosome deficienc

251 icles obtained by extraction of T. aquaticus large ribosomal subunits were isolated and their RNA and

252 nd in the nascent peptide exit tunnel of the large ribosomal subunit with comparable affinities, the

253 Here we report that large ribosomal subunits with mutated A2451 showed signi