1 on high-fat diet treated with metformin was
largely ablated by AMPK deficiency under the conditions
2 mutant CNS, the first genetic background to
largely abrogate this distinct APA signature.
3 Effective treatment
largely abrogated cough aerosol culture positivity; howe
4 lations within and between pathways that are
largely absent from RNA.
5 procal crosses, whereas maternal biases were
largely absent in low-fitness individuals.
6 We find that grid cell firing patterns are
largely absent in rTg4510 mice, while head-direction tun
7 ynamic dark chromophore in green mEos4b thus
largely accounts for the observed lower switching contra
8 RNA sequencing, we show that these cells are
largely activated DCs acquiring features compatible with
9 hat the miRNA cargo of plasma CD31(+) EVs is
largely affected by T2DM and related complications, enco
10 ata set, coherence and our new MIF estimator
largely agree.
11 een transposase and CRISPR-Cas integrase are
largely architectural, and it appears that evolutionary
12 and infectious disease transmission studies
largely assume a dominant, within-individual haplotype.
13 rol was reversed, and that for triglycerides
largely attenuated.
14 Drug overdose deaths (
largely attributable to opioid misuse) in the United Sta
15 This evolutionary success is
largely attributed to neck elongation and its impact on
16 e locomotor transition from water to land is
largely based on a few exemplar fossils such as Tiktaali
17 syndromes are scarce and recommendations are
largely based on expert opinion.
18 Largely based on one randomized controlled trial, standa
19 opment, interventions for anxious youths are
largely based on principles of extinction learning studi
20 Current cancer treatments are
largely based on the genetic characterization of primary
21 These behaviors can
largely be differentiated by the average dryness of the
22 This is
largely because circadian genes operate in virtually eve
23 us decisions on anticoagulation duration has
largely been disappointing.
24 , their performance improvements have so far
largely been driven by trial and error efforts due to a
25 However, these data have
largely been ignored because corroborating evidence in h
26 r night-time temperatures; a nuance that has
largely been ignored in the literature.
27 nnervation of subregions in the VTA and were
largely biased toward synaptic contact with local GABA n
28 subtractive-suppression mechanism, mediated
largely by LP-to-A1 axons preferentially innervating spe
29 that SNP-heritability enrichments are driven
largely by many low-effect common SNPs.
30 as of damage and stimulate revascularization
largely by paracrine activation of angiogenic functions
31 nhibitory effect of RGFP966 on expansions is
largely bypassed, consistent with the direct deacetylati
32 method to two empirical datasets containing
largely categorical variables: an anthropological survey
33 However, the evidence for this has been
largely circumstantial.
34 ublic health decision making, but demand has
largely come from individual consumers.
35 omy and an esophagectomy for GEJ cancer show
largely comparable results with regard to long-term surv
36 ting literature identified in this review is
largely comprised of preclinical animal studies.
37 talytic methods for their formation has been
largely confined to the use of a select few lyases over
38 macrophage-like THP-1 cells (THP1-MPhi) have
largely conserved gene expression patterns.
39 The treatment effects were
largely consistent across different subgroups except for
40 d established B. napus, which has adapted to
largely control homoeologous recombination.
41 drug in which inter-patient variability was
largely decreased compared to that in the total populati
42 ctionally organized thalamic nucleus that is
largely dedicated to visual processing.
43 Inpp5e(rdg) function
largely depended on the presence of cilia and on smoothe
44 reveals that intracellular fragmentation is
largely dependent on autoactivation.
45 n early periprosthetic joint infection (PJI)
largely depends on the presence of a mature biofilm.
46 ngth and number of loops - are sufficient to
largely determine network exploration times for a variet
47 Societal awareness and values will
largely determine whether conservation initiatives recei
48 Treatment efficacy for diabetes mellitus is
largely determined by assessment of HbA1c (glycated hemo
49 The reinforcing efficacy of cocaine is
largely determined by its capacity to inhibit the dopami
50 is shows that the ease of crystallization is
largely determined by the number of competing polymorphs
51 n the mouse occurs during perinatal ages and
largely determines the ovarian reserve that will be avai
52 We show that GluA3
largely determines the ultrafast kinetics of endbulb syn
53 re bacteria varied from host to host and was
largely different between two time points.
54 to those present in literature for Ferrovia (
largely diffused in Italy).
55 well studied but the two perspectives remain
largely disconnected.
56 hroism spectroscopy revealed the presence of
largely disordered species and suggested the presence of
57 for transposon silencing, whereas piRNAs are
largely dispensable.
58 umption and average systolic blood pressure,
largely disregarding the impact of a healthy lifestyle i
59 However, they are
largely dormant functionally, due to IFN-I-induced negat
60 Our analyses suggest diversification was
largely driven by colonization of novel geographic areas
61 Winter survival was
largely driven by conditions during the preceding summer
62 Instead, our memory for a scene may be
largely driven by its visual composition, with a tendenc
63 Resistance to pyrazinamide is
largely driven by mutations in pyrazinamidase (pncA), re
64 Circadian regulation of metabolism is
largely driven by rhythmic transcriptional activation of
65 results suggest that ecosystem responses are
largely driven by surface peat, but that the vast C bank
66 nce is increasing at a nearly epidemic rate,
largely driven by the human papillomavirus (HPV).
67 These failures were
largely due to a lack of MMP-selective agents; according
68 This is
largely due to an increasing physiological knowledge of
69 es in malaria control this century have been
largely due to distribution of long-lasting insecticidal
70 mammals have yet to be adequately explored,
largely due to its low abundance in most mammalian genom
71 Its pathogenicity in humans is
largely due to its propensity to form biofilms, surface-
72 Khulan water use is poorly understood,
largely due to the difficulty of mapping waterpoints use
73 ncreased light harvesting capacity of PSI is
largely due to the more efficient recruitment of LHCII a
74 chanisms in humans are still not understood,
largely due to the reliance on non-human animal models.
75 n population averages or disparities and was
largely due to the strength of the dynamic mechanisms am
76 ms underlying specific dream contents remain
largely elusive.
77 The rapid progress of MAS DNP has been
largely enabled through the understanding of rational de
78 In addition, FRO2 and AHA2 are not
largely endocytosed in response to non-iron metal excess
79 ar structure and exercise function have been
largely established in men.
80 an S209D phosphomimetic Foxo1 (SD-Foxo1) was
largely excluded from the nucleus of CD8 T cells and fai
81 targeting catabolic pathways have, however,
largely failed to preserve muscle mass in cachexia, sugg
82 ary in response to the number of raters were
largely feature-dependent.
83 and summarize recent advances in the field,
largely focused on recent studies in zebrafish, with com
84 Thus far, proteomics in nephrology has
largely focused on the discovery and validation of bioma
85 Studies thus far, however, have
largely focussed on refolding full-length proteins from
86 Antibiotic resistance was
largely found in Ecc lineage 1, which had a higher rate
87 Notably, this increase in impact arises
largely from diagnosis of TB amongst those with HIV who
88 stressors influence BEF relationships comes
largely from small, experimental studies.
89 ng a founder population that was established
largely from the Neolithic peoples of southern Europe an
90 es reveal that AT1aR neurons in the area are
largely glutamatergic and send projections to the parave
91 as the oral administration of these drugs is
largely hampered by their low and highly variable bioava
92 ctional performance of such systems is still
largely hampered by their poor electrical conductivities
93 The accumulation of PunA in eggs was
largely higher than that of alpha-ESA.
94 The data instead support a
largely host-neutral explanation for the distribution of
95 und, selectivity is a challenge owing to the
largely identical binding pockets.
96 treatments, suggesting that the effects were
largely if not entirely due to consumption of NA-chelate
97 ongly affect the impact of stressors, yet is
largely ignored for the frequently occurring combination
98 important aspect of qPCR data that has been
largely ignored is the presence of non-detects: reaction
99 crystallize in chiral space groups has been
largely ignored until recently, partly due to difficulti
100 tivated beta(2)-AR (Nb60) molecules are also
largely immobile but relatively less sensitive to endocy
101 ieved using calibration standards in plasma,
largely improving efficiency and consistency.
102 tionally, genome maintenance has been viewed
largely in terms of DNA-protein interactions.
103 that the errors in Fourier coefficients are
largely in the phases in crystallography but in both pha
104 for cardiovascular prophylaxis appears to be
largely inadequate in reducing platelet activation in th
105 iability and determined current policies are
largely inadequate to ensure surgeon proficiency and may
106 both subspaces, but the information is kept
largely independent from each other.
107 We found that m(6)A QTLs are
largely independent of expression and splicing QTLs and
108 This effect is
largely independent of ISG15 conjugation and relies on I
109 le of CI is turned over at a higher rate and
largely independently of the rest of the complex by mito
110 ss all environments tested, ADH activity was
largely influenced by a single QTL encompassing the Adh-
111 Zona incerta (ZI) is a
largely inhibitory subthalamic region connecting with ma
112 by native mass spectrometry, makes the gates
largely insensitive to stoichiometric imbalances in the
113 pentylmethyl ether); and (5) the reaction is
largely insensitive with respect to common hydrosilane r
114 10 mice, while head-direction tuning remains
largely intact.
115 The computation of elapsed time is therefore
largely invisible to standard methods of monitoring neur
116 d potential consequences for productivity is
largely lacking.
117 he use of Bcl-xl inhibitors as senolytics is
largely limited by their on-target and dose-limiting pla
118 assumption that the signaling pathways were
largely linear.
119 MSST over 1950-2010 is externally forced and
largely linked to the representation of volcanic aerosol
120 It
largely localizes in the cell nucleus and regulates CD39
121 bination rate within and between populations
largely manifested as differences in genome-wide recombi
122 These interactions are
largely mediated by three conserved, surface-exposed lys
123 However, in this
largely MHC-class-I-negative tumor, the mechanism of act
124 However, precise tuning of these aspects is
largely missing in the design of artificial catalysts.
125 Targeted prevention programs are
largely missing.
126 tance, and second- and third-generation TKIs
largely mitigate this problem.
127 s) have attracted much interest due to their
largely modifiable electronic properties.
128 chestrates this integration process has been
largely neglected by historical approaches independently
129 n attributed to the movement of the halides,
largely neglecting the contribution of protons, on the b
130 ens, we found infections to be controlled by
largely non-overlapping subsets of miRNAs, seemingly ref
131 Parkinson disease (PD) is a devastating,
largely nonfamilial, age-related disorder caused by the
132 that activity related to these processes was
largely nonoverlapping, shedding light on two complement
133 to lure discrimination and source memory was
largely nonoverlapping.
134 rate of age-related decline, consistent with
largely nonprogressive peripheral retinal dysfunction.
135 prove fatal for device performance, and are
largely not responsible for device shunting.
136 and caregivers, US acute care facilities are
largely not using lifts to safely mobilize patients.
137 e findings described in this Perspective are
largely novel and yet to be extensively validated.
138 Yet, the mechanisms of self-assembly remain
largely obscure due to a lack of experimental tools for
139 nda that takes the biology of masting from a
largely observational field of ecology to one rooted in
140 These recommendations have focused
largely on health care delivery practices and occasional
141 Ideas about how this circuit works are based
largely on models those consider only firing rate as the
142 e genetic control of puberty timing is based
largely on studies in women.
143 Early drug generations focused
largely on symptom control and pain management, effectiv
144 ed to increased tumor growth and metastasis,
largely on the basis of overexpression studies and the a
145 recommendations for surveillance were based
largely on the likelihood that patients with adenomas wo
146 ion and charge recombination dynamics depend
largely on the presence or absence of C(60).
147 iO(3) with high strain sensitivity (>2,650),
largely outperforming state-of-the-art Si-nanowire strai
148 rmation relating to different behavior occur
largely outside of the BG.
149 These timing maps
largely overlap with numerosity and visual field map net
150 configurational entropy is an important yet
largely overlooked parameter, providing an intriguing pe
151 et the quantitative biases it introduces are
largely overlooked.
152 We caution that the evidence is
largely preliminary and suggest directions for future re
153 ced irreversible structural damage should be
largely prevented.
154 The identified fusions were
largely private and 4 specific recurring events were fou
155 that research in eukaryotes and bacteria has
largely progressed in isolation.
156 ior staging manual updates, the changes made
largely provided simplification of more complex staging
157 eins sustain the action of beta-catenin in a
largely PYGO-independent manner.
158 Discrete phylogeographic analysis
largely recapitulates the documented spread of the HIV t
159 nd chemical evolution is likely to have been
largely regulated by plate tectonics for most of its his
160 HSEs of the HSP70 gene family have
largely remained conserved in canonical sequence motifs
161 eld of metabolomics research, this issue has
largely remained unaddressed; MS signal intensities are
162 owever, how Bcl-6 controls T(FH) biology has
largely remained unclear, at least in part due to the in
163 range of isoforms whose biological relevance
largely remains to be determined.
164 The g-iELISA might
largely replace trypanolysis for monitoring gHAT elimina
165 , and with large wavelength ranges have been
largely reserved to pulsed neutron sources.
166 ransporter GBIHBP1 that is highly active and
largely resistant to physiological inhibitors of LPL.
167 s of the complement-like system through RNAi
largely restores ookinete-to-oocyst transition but oocys
168 Zygotic transcription of these genes
largely retained features of their regulation in space a
169 and tumor time-activity curves indicative of
largely reversible uptake of (18)F-Gln in tumors.
170 Effects were
largely similar at low and high competition centers.
171 network connectivity (vessel grouping) with
largely solitary vessels.
172 in the most severe form, while children are
largely spared from respiratory illness but can develop
173 Cis-eQTLs are
largely specific to cell type or stimulation, and 31% an
174 mplitude coupling revealed a highly similar,
largely state-invariant (i.e., intrinsic) spatial compon
175 odifications, and differential compaction is
largely sufficient to reveal the locations of genes and
176 ary to "on target toxicities." Management is
largely supportive and may include discontinuation of th
177 sence of Lon, but advantageous mutations are
largely suppressed when Lon is reintroduced.
178 laminins have been shown to cause a range of
largely syndromic conditions affecting the competency of
179 adenocarcinoma and found that it is mediated
largely through secondary mutations in EGFR-either C797S
180 ds and how host and parasite interact remain
largely to be discovered.
181 stly unstudied at the single-cell level, due
largely to engineering challenges related to sample stab
182 ovian threat conditioning has been relegated
largely to the extinction or reversal of previously acqu
183 The early-generated,
largely transient neurons of the subplate play a key rol
184 Microsatellite markers provide evidence for
largely transient within-breeding season temporal proces
185 h associated mucociliary dysfunction remains
largely unaddressed.
186 anscriptional output of most other genes was
largely unaffected by acute Mediator ablation.
187 that receptor distribution and mobility are
largely unaffected by contact to the coverslip but the m
188 con components, SecA and insertase YidC were
largely unaffected.
189 Resting-state functional connectivity was
largely unaltered in children with in utero exposure.
190 d (COSMOS) for tracking neural activity in a
largely uncharacterized spatiotemporal regime.
191 at take place in dystrophin's absence remain
largely uncharacterized, as they are potentially obscure
192 It remains
largely unclear, however, what defines the range and spe
193 cuit mechanisms causing such symptoms remain
largely unclear.
194 al models, but the underlying mechanisms are
largely unclear.
195 ession of tau misfolding and aggregation are
largely unclear.
196 cted for improving grain productivity remain
largely unclear.
197 , connective tissue proteome dynamics remain
largely undefined, as do differences in turnover rates o
198 teristics, and postoperative outcomes remain
largely undefined.
199 timeline to reduce greenhouse gas emissions,
largely undermining the Paris goals.
200 iple times, but most of these systems remain
largely understudied with respect to viral origin, trans
201 hts, leaving the observed heritability of HF
largely unexplained.
202 er crust gabbros in particular, has remained
largely unexplored by microbiologists.
203 ing which such development occurs, have been
largely unexplored due to the lack of real-space imaging
204 rrosion structures forming during this still
largely unexplored electrochemical phenomenon.
205 into the regulation of rice uniformity via a
largely unexplored plant nuclear signalling pathway.
206 sub-serving auditory working memory, remains
largely unexplored.
207 of these extracellular RNA fragments remains
largely unexplored.
208 ction of lncRNAs in HPV16-related CC remains
largely unexplored.
209 in this spectral range (800-2500 nm) remains
largely unexplored.
210 w this in turn impacts cell function remains
largely unexplored.
211 s vital to their practical applications, are
largely unexplored.
212 citons into discrete Landau levels, which is
largely unexplored.
213 ions, the structures of solvated 2D COFs are
largely unexplored.
214 evolutionary histories of most variants are
largely unexplored.
215 f these different interventions has remained
largely unexplored.
216 es, the mechanisms leading to cell death are
largely unexplored.
217 lf-assembly and compartmentalization remains
largely unexplored.
218 isms giving rise to these predictions remain
largely unexplored.
219 glass structure at the division site [13] is
largely unexplored.
220 l role of alpha-klotho in metabolism remains
largely unexplored.
221 water discharges from coastal sources remain
largely unexplored.
222 fic differences in codon usage biases remain
largely unexplored.
223 t around the decision to pursue LVAD remains
largely unexplored.
224 y in the absence of ligand the riboswitch is
largely unfolded, lacking the PK helix so that translati
225 neurofibromatosis type 1 (NF1) is a rare and
largely unknown complication of NF1.Objectives: To descr
226 egies are shaped by winter habitat choice is
largely unknown due to the general inability to track bi
227 The causative disease mechanism is
largely unknown, and no treatment is currently available
228 ese and other functionally related genes are
largely unknown, particularly in cancers not classically
229 , but the causatives genes at these loci are
largely unknown, so that functional investigation and cl
230 vity regulates synaptic vesicle recycling is
largely unknown.
231 he major driving force for clearance remains
largely unknown.
232 s control synapse formation and function are
largely unknown.
233 nt of leukocytes in the peritoneal cavity is
largely unknown.
234 nitiate the biogenesis of this structure are
largely unknown.
235 rly major depressive disorder (MDD), remains
largely unknown.
236 diating lipid removal (i.e. deacylation) are
largely unknown.
237 ls evade the deleterious effects of CDCs are
largely unknown.
238 s severer dental caries than other sugars is
largely unknown.
239 to detectable frequencies by chance remains
largely unknown.
240 itochondrion of these parasites has remained
largely unknown.
241 echanisms underlying this observation remain
largely unknown.
242 landscape during maize domestication remain
largely unknown.
243 rise to specific patterns of MN activity are
largely unknown.
244 cells, but their biological functions remain
largely unknown.
245 atin organization in T. thermophila is still
largely unknown.
246 arming, but the reasons for such lags remain
largely unknown.
247 isms by which these changes happen are still
largely unknown.
248 ng PKA activity during cell migration remain
largely unknown.
249 regulation of NF-kappaB in tumor context is
largely unknown.
250 sitive versus tolerant to extreme drying are
largely unknown.
251 ractive effects and effect size (eta(2)) are
largely unknown.
252 and the underlying neural circuits are still
largely unknown.
253 ether this topography is informative remains
largely unknown.
254 hanisms underlying these associations remain
largely unknown.
255 and functioning of reef fish communities are
largely unknown.
256 act of this practice on grape aromas remains
largely unknown.
257 hogenesis of prenatally triggered asthma are
largely unknown.
258 s, maintains and reactivates from latency is
largely unknown.
259 ic correlations among these disorders remain
largely unknown.
260 However, the mechanism of modulation is
largely unknown.
261 in aqueous film-forming foam (AFFF) remains
largely unknown.
262 s of ribbon synapses change with age remains
largely unknown.
263 the incidence of acute incarceration remains
largely unknown.
264 of this key posttranscriptional regulator is
largely unknown.
265 but the underlying molecular mechanisms are
largely unknown.
266 ription factor IIH (TFIIH), is recruited are
largely unknown.
267 timately achieve this aberrant production is
largely unknown.
268 thropocene yet their interactive effects are
largely unknown.
269 context of host-pathogen interactions remain
largely unknown.
270 ism of Ag species on gamma-Al(2)O(3) remains
largely unknown.
271 and the interplay with ANP32 proteins remain
largely unknown.
272 factors driving long-term changes in GPP are
largely unknown.
273 different cell types in mammalian tissue are
largely unknown.
274 avior changes developmentally in ASD remains
largely unknown.
275 s respond to vertical loading forces remains
largely unknown.
276 ts specific role in pancreatic beta-cells is
largely unknown.
277 hysical properties of these materials remain
largely unknown.
278 ic connections and requirements involved are
largely unknown.
279 in critically ill patients remain, however,
largely unknown.
280 gnalling and its physiological relevance are
largely unknown.
281 l dynamics of ecosystem productivity remains
largely unknown.
282 from the primary site to the skeleton remain
largely unknown.
283 ies and differences among these proteins are
largely unknown.
284 ed to be functional from its origin is still
largely unknown.
285 ion of different cancer deposits to ctDNA is
largely unknown.
286 single cell-based molecular alterations are
largely unknown.
287 of these ancient primary DR sequences remain
largely unknown.
288 However, the mechanisms remain
largely unknown.
289 ymatic activities, the rates of which remain
largely unknown.
290 ncodes learning-related information is still
largely unknown.
291 cies; however, the underlying mechanisms are
largely unknown.
292 n on the terrestrial water balance are still
largely unquantified.
293 deregulation and genome organization remains
largely unstudied.
294 (TME) and its molecular underpinnings remain
largely unstudied.
295 Clinical trials to date have been
largely unsuccessful in identifying effective treatments
296 of a fixed saturation concentration remains
largely untested within living cells, in which the richl
297 ne biodiversity and inland fisheries remains
largely untested.
298 -term disease outcomes after passing TAS are
largely untested.
299 dulates plant species' distributions remains
largely untested.
300 SLIT was
largely used in clinical trials and clinical practice in