ライフサイエンスコーパス: late

1 -term ICCs ranged from 0.29 (night) to 0.51 (late).

2 herapy early and 267 (49%) commenced therapy late.

3 year period since 800 CE, exceeded only by a late-1500s megadrought.

4 making it the most inactive period since the late 1970s.

5 IVIM MRI as a method was introduced in the late 1980s, but recently it started attracting more inte

6 Accumulated evidence since the mid to late 1990s, however, indicates that low-dose CT screenin

7 continuation of research that started in the late 19th century and that continued throughout the 20th

8 showed utilization growth through the mid to late 2000s (images per 1000 enrollees per year for Medic

9 wed by significant declining trends from the late 2000s through early 2010s (images per 1000 enrollee

10 drome coronavirus 2 (SARS-CoV-2), emerged in late 2019 and has since become a global pandemic.

11 ease 2019 (COVID-19) was first identified in late 2019 in Wuhan, Hubei Province, China and spread glo

12 he global pandemic of COVID-19 that began in late 2019.

13 f faster-moving landfalling Texas TCs in the late 21(st) century.

14 ing cause of death in both early (47.2%) and late (36.4%) periods.

15 ed melting criterion seems to be general for late 3d metals bearing systems.

16 Late absolute scaffold recoil was less among patients wi

17 we report a detailed characterization of two late-acting Fe-S cluster-carrier proteins from Arabidops

18 Two or more early rejections (<1 y) or any late acute rejection (>1 y) have been associated with co

19 arly adaptation trials compared to baseline, late adaptation, or aftereffect trials.

20 ter is therefore generally attributed to the late addition of a small fraction of hydrated materials,

21 ated with greater iron concentration through late adolescence and young-adulthood.

22 in incidence of psychotic experiences during late adolescence as well as an unmet need for care in yo

23 nce to suggest that these features emerge in late adolescence or early adulthood.

24 ociated with poorer cognitive ability during late adolescence.SIGNIFICANCE STATEMENT Brain tissue iro

25 iatric affliction manifested behaviorally at late adolescence/early adulthood.

26 associated with increased periprocedural or late adverse outcomes compared with those without signif

27 nce behavior; values >=2.5 are predictive of late allograft rejection.

28 e association between PRO scores and time to late AMD in either eye.

29 Four predictive models for progression to late AMD or atrophic AMD were only developed (each inclu

30 quency of rare variants was compared between late AMD patients and control individuals with logistic

31 OR = 6.56; P = 0.0003) genes was observed in late AMD patients compared with control individuals.

32 AMD, 25.1% in intermediate AMD, and 51.1% in late AMD.

33 liver injury occurred in 2, 7, and 3 early, late, and sequential treatment arm patients, respectivel

34 rotein 1 [SERBP1] in mammals), and recently, late-annotated short open reading frame 2 (Lso2; coiled-

35 n, but not short-chain, Vi conjugate induced late apoptosis of Vi-specific B cells in spleen and earl

36 icals and minimize the risk of unanticipated late-appearing polymorphs.

37 sholds over the forecast period (from mid-to-late April).

38 act between individuals that continues until late April.

39 sedimentary rocks to examine changes in the Late Archean atmosphere immediately prior to the Great O

40 ral doses, even when treatment is started as late as 48 h post infection.

41 aracterize DNA consensus motifs of early and late ASFV core promoters, as well as a polythymidylate s

42 ng the latest Tommotian/early Atbadanian and late Atdabanian/early Botoman, and notably small body si

43 cores relative to vaccine recipients with no late boost (all adjusted p<0.05, except for the polyfunc

44 Groups with late boosts had increased functionality and polyfunction

45 -born [embryonic day 9.5 (E9.5) to E10.5] or late-born (E11.5-E12.5) neurogenic waves, where late-bor

46 -born [embryonic day 9.5 (E9.5) to E10.5] or late-born (E11.5-E12.5) neurogenic waves.

47 In particular, late-born CUX1-positive neurons are widely dispersed thr

48 In contrast, late-born V3 INs became fate-restricted to ventral lamin

49 e-born (E11.5-E12.5) neurogenic waves, where late-born V3 INs display increasingly restricted subpopu

50 of kidney allograft failure, both early and late, both nonimmune and alloimmune, to gain better insi

51 Therapeutic control of late Ca(2+) spark activity may provide an additional app

52 first duplication, which occurred in the mid/late Cambrian by autotetraploidization (that is, direct

53 es such as IL-1beta and IL-18 and concurrent late CAR T cell expansion characterized the HLH-like syn

54 ed around 318 million years ago in the early Late Carboniferous and their early fossil record is cent

55 olumetric regression, at least from early to late childhood.

56 pt for normalization of Bb, MBL, and CD59 in late chronic mtTBI (n = 15).

57 etween the early cohorts (1979-1997) and the late cohorts (1998-2013).

58 of pancreatic-enteric anastomoses is a major late complication of a pancreaticoduodenectomy for the t

59 atakely forsterae gen. et sp. nov., from the Late Cretaceous epoch of Madagascar that possesses a lon

60 ribed based on two fossil specimens from the Late Cretaceous Kachin amber of northern Myanmar.

61 cess during the last 20 million years of the Late Cretaceous.

62 SOCS3, Bcl3, and Id2, which render pDCs and late DC progenitors refractory to physiological stimuli

63 prognosis, with a very high in-hospital and late death rate.

64 enting generation of architecture resembling late developmental stages.

65 ymptom of diabetes but not the sole cause of late diabetic complications; instead, other diabetes-rel

66 Due to its late diagnosis and dismal prognosis, pancreatic ductal a

67 The late diagnosis of cancer has a negative impact on the he

68 Due to late diagnosis of this disease, the mortality of this co

69 t 10 or more letters compared with eyes with late DME (47.4% vs. 33.9% [P = 0.001] and 8.2% vs. 13.5%

70 l analysis on muscle biopsies, while our two late DUX4 target gene expression biomarkers associate wi

71 in PMD included inflammatory response, early/late E2-response, and cholesterol homeostasis.

72 the characteristics and behaviors related to late eating may be useful in the development of future i

73 The identified (60)Fe influx may signal a late echo of some million-year-old supernovae with the (

74 new evidence is available, the International Late Effects of Childhood Cancer Guideline Harmonization

75 The International Late Effects of Childhood Cancer Guideline Harmonization

76 (c) We further show late-emerging shh-GFP positive radial glia cells in the

77 ence for peri-procedural, delayed-early, and late endocarditis after TAVR was 2.59, 0.71, and 0.40 ev

78 k Rab7 activation and show severe defects in late endosome morphology and endosomal LDL trafficking,

79 e two lipid receptors, which interact in the late endosome(9), are necessary for the membrane fusion

80 8/LAMTOR1-mediated peripheral positioning of late endosomes allows delivery of SRC proto-oncogene, no

81 olesterol accessible to a D4H probe, between late endosomes and the PM.

82 In NMDAR-LTD, however, they are diverted to late endosomes for degradation.

83 tether with endocytic organelles (lysosomes/late endosomes) by forming membrane contact sites.

84 een the ER and several organelles, including late endosomes.

85 cholesterol at membrane contacts between the late endosomes/lysosomes (LEL) and the endoplasmic retic

86 ppm), warm climates similar to those of the late Eocene continued with only brief interruptions, whi

87 fy and profile differentiation stage-matched late erythroblast F cells and non-F cells (A cells) from

88 itionally equivalent meal was presented as a late-evening snack.

89 RAG2, a late evolutionary addition in V(D)J recombination, appea

90 It is a late-evolving epidermal appendage that has the primary f

91 f inspiration (I), post-inspiration (PI) and late-expiration (E2).

92 pe, characterized by insulin resistance with late failure of insulin production, severe hyperglycemia

93 itamin D intervention trial conducted during late fall and winter in 2 areas of Sweden (latitude 63 d

94 A late first IPTp-SP dose fail to provide optimal protecti

95 ferential perianth expansion during mid- and late flower developmental stages by promoting cell divis

96 significantly worsened renal function in the late follow-up and should be avoided in elective AAA cas

97 f patients lost to follow-up (LTFU, >90 days late for last appointment).

98 Radiographically, no late frame fractures or erosions were identified.

99 cal techniques, we found an increase in I(Na,late) from -0.34 to -0.59 A F(-1) and a decrease in Na(+

100 CDKs phosphorylate and render RB inactive in late G1/S, promoting entry into S phase.

101 ith DSP and were strongly associated with LV late gadolinium enhancement (90%), even in cases of acut

102 he prognostic value of inducible ischemia or late gadolinium enhancement by CMR.

103 Preoperative CMR showed late gadolinium enhancement in 70% of the patients, wher

104 ages and fibro-fatty replacement in areas of late gadolinium enhancement presence.

105 h normal ventricular function (4/5, 80% with late gadolinium enhancement).

106 Multivariable analysis adjusted for late gadolinium enhancement.

107 ersisted after adjusting for the presence of late gadolinium enhancement.

108 SP-2509 does inhibit viral DNA replication, late gene expression, and virus production.

109 Late gene transcription in the beta- and gammaherpesviru

110 ate transcripts does not require the primary late-gene-specific viral transactivation factor, suggest

111 hat primary fibroblasts from DC patients and late generation telomerase knockout mice display lower n

112 virus and confirmed that it fails to produce late genes and infectious virions.

113 cy on viral DNA and to promote elongation on late genes later in infection.

114 the production of capsid proteins and other late genes, whose production is transcriptionally contro

115 f control (CON, n = 11-12) and IUGR (n = 12) late gestation fetal sheep.

116 Consequently, 9 sheep in late gestation were anesthetized with isofluorane and ma

117 on remain long-term complications leading to late graft failure in penetrating keratoplasty (PK).

118 We further demonstrate that late graft rejection in recipients treated with this reg

119 We matched patients in the early and late groups using propensity scores calculated on the ba

120 coding of alpha power patterns revealed that late (>500 ms latency) in the cue-to-target foreperiod,

121 TDP-43 and tau are associated with early or late hippocampal atrophy in Alzheimer's disease and prim

122 Poleward SWW intensification during the Late Holocene could then have reinforced deep mixing alo

123 monsoon rainfall in MSEA during the mid- to late Holocene, coincident with African monsoon failure d

124 ed tomography (CT) scan improvement, whereas late IFN-alpha2b was associated with delayed recovery.

125 and that repression of alpha gene expression late in infection is mediated by prolonged promoter-prox

126 leading to a near depletion of KIF1A protein late in infection.

127 ith the evolution of new regions but appears late in synapsid evolution.

128 laminin-111 protein therapy either early or late in the disease process could serve as an effective

129 Our results describe a requirement for MAFB late in the human pancreatic developmental program and i

130 nd the principal lineages of the Ulvophyceae late in the Neoproterozoic Era.

131 ted whether this integration occurs early or late in the process of perception.

132 roinflammatory M1-like macrophages developed late in this process of chronic UA crystal nephropathy a

133 Late initiation of HIV antiretroviral therapy (ART) in p

134 is time derive from a single introduction in late January or early February 2020, which subsequently

135 and caecilians have been traced back to the Late Jurassic Eocaecilia, both of which exemplify the st

136 Late juvenile males had a CY spigot on each PMS, whereas

137 LYPXnL, two highly conserved sequences named late (L) domains, which bind TSG101 and Alix, respective

138 nsistent selection against early (small) and late (large) migrants counters prevailing ecological the

139 However, only in late larvae and adults, UNC-3 is required to maintain ex

140 ivates the Dorsal (NF-kappaB) pathway during late larval stages.

141 ecline in cognitive performance from mid- to late life (1996-2013) among 2,169 Black and 8,707 White

142 level of behavioral CVH in both midlife and late life (versus poor level in both midlife and late li

143 ognitive decline, respectively, from mid- to late life among Black and White adults.

144 life (versus poor level in both midlife and late life) was significantly associated with a lower dem

145 that hemispheres epigenetically converge in late life.

146 network structure of depressive symptoms in late-life because of their distinct etiologic factors, c

147 he importance of the noradrenergic system in late-life cognition.

148 Late-life declines in avian song, and possibly other sex

149 ide critical insights into the precursors of late-life dementias.

150 Late-life depression (LLD) is a prevalent and disabling

151 ogy to identify core behavioral pathology of late-life depression and targets it with simple interven

152 ion of insulin signaling results in improved late-life ejaculate performance, indicating simultaneous

153 whereas people with midlife intermediate and late-life ideal biological CVH metrics had a significant

154 f the current study was to determine whether late-life insomnia is associated with reduced motivation

155 In secondary exploratory analyses, late-life insomnia was associated with reduced motivatio

156 used with sterile males also showed enhanced late-life offspring production when allowed to reproduce

157 uence of educational quantity and quality on late-life physical and mental health.

158 ng health behaviors may be crucial to reduce late-life risk of dementia.

159 by siRNA transfection, inhibits SM-dependent late lytic gene transcription but not transcription of o

160 plex that binds to TATT motifs unique to EBV late lytic promoters.

161 During late M-phase of the cell-cycle, Cdc6 binds to ORC and th

162 ne in preclinical Alzheimer's disease during late middle-age.

163 In the case of carnivorous taxa, Late Miocene pre-GABI endemic sparassodonts consumed pre

164 ons were estimated to begin diverging in the late Miocene, along with a possible ancestral distributi

165 Health-related late mortality and SMN risks among 5-year survivors of c

166 Overall, 20-year all-cause late mortality was 6.6% (95% CI, 6.0 to 7.1).

167 A repair-associated signature as a prominent late mutational process, whereas APOBEC signature target

168 ury "R3(injury) " (N = 61), and fibrosis "R4(late) " (N = 8).

169 rly all donors had dementia; three (two pure LATE-NC and one pure ADNC) donors had mild cognitive imp

170 s, whereas community-based cohorts have more LATE-NC cases.

171 itive impairment and another two donors with LATE-NC did not have dementia.

172 ty and specificity of differentiating severe LATE-NC from FTLD-TDP cases with blind evaluation was ~9

173 n of a new diprotodontian marsupial from the late Oligocene (~26-25 Ma) Namba Formation of South Aust

174 rmes, several having already occurred by the late Oligocene.

175 Late onset Alzheimer disease (LOAD) is traditionally con

176 tress results in at least some of the hira-1 late-onset abnormalities.

177 mechanisms and novel therapeutic targets of late-onset Alzheimer's Disease (LOAD), we performed an i

178 common genome-wide significant risk loci for late-onset Alzheimer's disease (LOAD).

179 windows of opportunity to reduce the risk of late-onset Alzheimer's disease.

180 No late-onset cCMVI-related HL was detected during a median

181 tochondrial stress likely contributes to the late-onset defects, given that hira-1 mutants display mi

182 Late-onset FECD is a uniquely advantageous model for stu

183 ts might explain the missing heritability of late-onset human diseases, such as Alzheimer's disease,

184 Late-onset inflammatory toxicities resembling hemophagoc

185 Whereas late-onset RTD may mimic different acquired or genetic c

186 factor 3 in colostrum with a reduced risk of late-onset sepsis (HR: 0.63; 95% CI: 0.41, 0.97).

187 tween human milk oligosaccharides (HMOs) and late-onset sepsis in very-low-birth-weight infants, and

188 ring at birth, but are at risk of developing late-onset SNHL.

189 inase 2 (LRRK2) are the most common cause of late-onset, autosomal-dominant familial Parkinson's dise

190 The second pulse of the Late Ordovician mass extinction occurred around the Hirn

191 ith ADAD2 expressed predominantly in mid- to late-pachytene spermatocytes suggesting a role for both

192 ion of continents by vascular land plants in late Paleozoic, would certainly affect terrestrial P inp

193 both endocrine and non-endocrine tissues in late pancreas development.

194 Subcloning these late passage cells to clonal density, to mimic lung inju

195 a closed-tube Linear-After-The-Exponential (LATE)-PCR assay for pyrazinamide susceptibility in Mycob

196 ening had better diagnostic performance than late percentage T1 shortening (AUC, 0.97 vs 0.90, respec

197 PFC inactivation deteriorated the quality of late-phase (>150 ms from image onset) IT population code

198 g for superselective catheterisation whereas late phases are better for visualisation of tumour enhan

199 with the best fossil records, three from the Late Pleistocene (~25 to 10 ka [1,000 y ago]) and one fr

200 tly large effective population size over the Late Pleistocene to Holocene.

201 y patterns of nine herbivore families in the late Pliocene and early Pleistocene (3.6 to 1.05 Ma) fro

202 n = 60) or waitlist (n = 58) at baseline and late positive potential (LPP) data from 99 children (44

203 ced emotional reactivity, as measured by the late positive potential (LPP).

204 anced event-related potentials (ERPs) in the late-positive potential (LPP) window have been observed.

205 ts in recognition memory were evident at the late post-injury points.

206 es depressive behavior in sexually naive and late postpartum female mice respectively, with no effect

207 o 33 weeks), 2.30 (95% CI: 1.97 to 2.70) for late pre-term (34 to 36 weeks), and 1.47 (95% CI: 1.30 t

208 remained unchanged when adjusted for mid and late pregnancy exposures.

209 (95% CI: 10.4, 19.9 mg . kg-1 . d-1); during late pregnancy, it was determined to be 21 mg . kg-1 . d

210 rapy with either raltegravir or efavirenz in late pregnancy.

211 Uterine arteries from late pregnant wildtype and LOX-1 overexpressing mice wer

212 to examine the combined effect of early and late prenatal VD status in during pregnancies in women w

213 Consistent with late presentations, the mortality rate was high, whereas

214 hat was significantly different at early and late progressor time points (p < 0.0001), but not presen

215 arly lytic gene expression was terminated in late protein-expressing cells.

216 ed as refugia during glacial advances in the late Quaternary Period.

217 rotein concentration, and reaction time with late quenching were investigated.

218 t with a healthcare worker presenting with a late reactivation of Ebola virus disease (EVD) in the Un

219 duals exposed to a patient presenting with a late reactivation of EVD.

220 om early-recovered individuals compared with late-recovered HCT recipients.

221 ngest difference between early-recovered and late-recovered patients was observed in the titers of na

222 We identified 3 patients with late recovery from coma (17-37 days) following CA who re

223 ue to recurrent non-resolving VH in group I. late recurrent VH occurred in two eyes (11.8%) in group

224 Late relapses were associated with a significantly highe

225 e metabolic pathways linked to the early and late remodelling of the left and right ventricle over th

226 of SMC5/6 leads to DNA replication stress at late-replicating regions such as pericentromeric heteroc

227 ne Valley shows that the warm periods during late Roman, medieval and recent times were characterized

228 ence was observed in the 3-year incidence of late RT-related grade >= 3 GI (2.5% v 3.9%) or genitouri

229 Incidence of grade >= 3 late RT-related toxicities was compared by log-rank test

230 the occurrence of G4 structures peaks at the late S phase, thus correlating with the accumulation of

231 In addition to neointimal hyperplasia, late scaffold recoil contributed significantly to LLL of

232 n cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source

233 Populations in Mongolia from the late second millennium B.C.E. through the Mongol Empire

234 ng chromosomes, cellular mechanisms allowing late-segregating chromosomes to rejoin daughter nuclei r

235 Late severe infection occurred in 104 patients (33.6%).

236 s a wide range of hair-bundle regulators and late Six1 deletion disrupts hair-bundle polarity.

237 nature is the P3b event-related potential, a late slow wave that appears when observers are aware of

238 roduced commensurate behavioral deficits for late-solved images.

239 he most dramatic switch occurs from early to late spermatocyte, followed by the change from the mitot

240 Temperate forests are shaped by late spring freezes after budburst - false springs - whi

241 burst were also greater in early compared to late springs.

242 ic therapy, supporting the role of NETs in a late stage of TB pathogenesis.

243 Males exhibited only late stage reductions in acylcarnitines and elevations i

244 ng changes is similar in pre-symptomatic and late stage tissue.

245 nically into early-stage (without edema) and late-stage (with edema) disease.

246 ritical for, and the result of, A. fumigatus late-stage biofilm architecture.

247 e synthesis of unnatural amino acids and the late-stage derivatization of a tripeptide.

248 motryptophan was exploited as a platform for late-stage diversification by Suzuki-Miyaura cross-coupl

249 Late-stage diversification then provides ready access to

250 The strategy involves a late-stage fragment coupling between a tertiary carbon r

251 H methylation method that is compatible with late-stage functionalization of drug scaffolds and natur

252 Examples are demonstrated of the late-stage functionalization of natural products and dru

253 s method can be used for the preparation and late-stage functionalization of pharmaceuticals, as high

254 riety of substrates, including synthesis and late-stage functionalization of scaffolds relevant to me

255 rapid metallaphotoredox-catalysed method for late-stage installation of both tritium and carbon-11 in

256 The late-stage modification of pharmaceuticals by this metho

257 inate subunit joining through the release of late-stage mtLSU assembly factors.

258 ting our protocol, we have also demonstrated late-stage olefination and alkynylation of 2-pyridone, c

259 s an MHAT-induced radical bicyclization with late-stage oxidation to regenerate the aromatic terminat

260 nd derivatives and polyaromatics, and in the late-stage trifluoromethylthiolation of medicines and ag

261 Transfer of cDC2s isolated from late-stage wounds into healthy skin was sufficient to in

262 ommon intermediate 8 are detailed, enlisting late-stage, hydrogen atom transfer (HAT)-mediated free r

263 Best known for their role in fission at the late stages of CME, many studies have suggested that dyn

264 The presence of lutein esters at late stages of grain development may have a complementar

265 compared to those with gingivitis in mid and late stages of pregnancy.

266 by confocal microscopy during both early and late stages of S. epidermidis biofilm formation, and we

267 of nontreponemal tests, particularly in the late stages of syphilis, with clinically well-characteri

268 n of the matrix protein periostin during the late stages of tendon repair, suggesting that persistent

269 MAP20 is expressed during the late stages of vascular bundle development and localizes

270 assess the frequency and predictors of very-late stent-related events or MACE by stent type.

271 g to the capsid at low pH and facilitating a late step in entry involving uncoating and delivery of t

272 Late succession microbiomes conferred the strongest herb

273 Late summer Bd infection parameters are governed, at lea

274 Unadjusted late survival was similar regardless of degree of import

275 ntifungal susceptibility and either early or late survival, or fungal clearance.

276 pism for the placenta and is associated with late-term abortion, at which time the pathogen titer in

277 t not KLF4, occupied the bICP0 E promoter at late times during productive infection of bovine cells.

278 tidal deformability parameter Lambda, but at late times is also characterised by the frequency of the

279 g rapidly developed but will likely come too late to affect the first wave of a potential pandemic.

280 NL interactions coincides with a switch from late to early replication timing, but the latter can inv

281 6)A writer METTL3 specifically impacts viral late transcripts by reducing their splicing efficiency.

282 The upregulation of late transcripts does not require the primary late-gene-

283 t the proper time for their expression, KSHV late transcripts evade PPD through the activity of the h

284 c and early environmental exposures, whereas late transient rhinitis may relate to maternal factors a

285 Late transient rhinitis was associated with antenatal ex

286 y employed as ancillary ligands to stabilize late transition metal complexes and are conventionally c

287 We provide computational evidence that late transition metals adopt the axial position in heter

288 selection for novel mammalian behaviours in Late Triassic cynodonts, drove the functional divergence

289 trified Forest National Park, Arizona, where Late Triassic fossil trees are exposed, we found 13 exam

290 fferent from, and more homogeneous than, the Late UP sample.

291 aracteristics, occurrence rates of early and late vascular complications, patient outcomes, and use o

292 The presence of such pre-late-veneer Ru can only be established if its isotope co

293 ma, early viable NS relapse (< 2 years), and late viable NS relapse (> 2 years).

294 lts showed that mutant CHPK localization and late viral protein expression were severely affected in

295 Although both early and late viral transcripts contain m(6)A, depletion of m(6)A

296 ses within the rainy season (e.g., early vs. late) was lacking, limiting further analysis.

297 ak season" of elevated up-call detections in late winter and early spring corresponding to the season

298 pattern of accumulation of temperature from late winter to early spring is a critical factor in dete

299 emperatures started to increase earlier from late winter to early spring, cambial reactivation occurr

300 n early wounds (12 hours and day 1), whereas late wounds (day 7) show elevated neutrophil accumulatio