ライフサイエンスコーパス: latent

1 adation by the ubiquitin-proteasome pathway, latent 26S proteasomes in the cytosol must assume an act

2 d the hypothesis that the dynamics of neural latent activity, which captures the dominant co-variatio

3 In this chemical strategy, we developed a latent agonist that upon photochemical activation releas

4 vIRF-2 and vIRF-2-USP7 interaction in HHV-8 latent and lytic biology.IMPORTANCE Human herpesvirus 8-

5 ites and regulate viral transcription during latent and lytic cycles of replication.

6 or of key cellular pathways, modulates HHV-8 latent and lytic infection, and is targeted by vIRFs 1,

7 n United States, where radiation components, latent and sensible heat fluxes, and meteorological cond

8 These results demonstrate that EBV latent antigens can function as master regulators of thi

9 h EBV latent antigens, and we found that EBV latent antigens cooperatively facilitate KLF14 expressio

10 of the E2F-Rb-HDAC complex together with EBV latent antigens, and we found that EBV latent antigens c

11 ming calibration experiments to manipulate a latent attribute and assessing the correlation between i

12 eek and that removing fruitless reveals this latent behavior in males.

13 tions, here we propose PALMER, a constrained latent block model that allows to identify indirect rela

14 Latent block models can be alternatives in this case but

15 mine if the asymptomatic plants harbored the latent blueberry red ringspot virus (BRRV) in their root

16 l measurements could contribute to inferring latent categories (e.g., geographic location), which inc

17 ncy strongly decreased clearance even at low latent cell frequencies.

18 such models assumes that a single successful latent cell reactivation event leads to observable virem

19 heterogeneity of cell types by transferring latent cell representations across multiple datasets.

20 The ability to isolate unstimulated latent cells from infected individuals enables previousl

21 Using a bivariate latent change score model, we provide evidence that the

22 from 2004-2014 Nationwide Inpatient Samples, latent class analysis (LCA) was applied to 10 procedure

23 a cohort of NERD patients with the means of latent class analysis (LCA).

24 several categorized and continuous indices, latent class analysis based on any use of each substance

25 iabetes and in diabetes groups, defined by a latent class analysis of diabetes duration, complexity,

26 We used cross-sectional latent class analysis to characterise patterns of bevera

27 We performed nonsupervised clustering using latent class analysis to identify subgroups of patients

28 Latent class analysis was performed with prenatal and ea

29 Using Bayesian Latent Class Analysis, we estimated the sensitivity and

30 Model performance was evaluated against the latent class analysis-derived phenotype.Measurements and

31 Among the latent class groups, children in families with diverse o

32 ified CAV trajectories by using unsupervised latent class mixed models.

33 To characterize latent classes of diagnostic and/or treatment procedures

34 10 procedure groups and differences between latent classes on injury, patient, hospital and healthca

35 hopedic procedures were equally likely among latent classes, skin-related, physical medicine and reha

36 group-based trajectory modeling to identify latent clusters of patients who follow distinct trajecto

37 ell population significantly associated with latent CMV infection, confirming the findings in previou

38 The detection of latent Colletotrichum spp infection in olive drupes is c

39 NE system is associated with attention on a latent construct level, measured by several indicator ta

40 We posit that stable latent cortical dynamics within the manifold are the fun

41 vide evidence that peptides derived from EBV latent cycle proteins can impair the recognition of NKG2

42 he HSV-1 lytic cycle and reactivation in the latent cycle.

43 al network model can accurately diagnose the latent cytomegalovirus (CMV) in healthy individuals, eve

44 Since these T cells can influence lytic/latent decisions in reactivating neurons, we argue that

45 ell RNA-sequencing make it possible to infer latent developmental processes from the transcriptomic p

46 ts commissioned in metastatic disease hijack latent developmental programs, accessing sites that are

47 When trained with different latent dimensionalities, models learn strongly associate

48 best identified in models trained with more latent dimensionalities.

49 dels trained using an intermediate number of latent dimensionalities.

50 most researchers fit a single algorithm and latent dimensionality.

51 aximally correlated, maximally interpretable latent dimensions of brain connectivity and clinical sym

52 LDA(Latent Dirichlet allocation)-link connects microbes to g

53 stics are widely used for estimation of such latent dynamics and have been successfully utilized in t

54 in the recorded neurons, the low-dimensional latent dynamics remained stable.

55 Both modules harbor a reservoir of latent dynamics, and their interaction forms a control s

56 gical data with underlying heterogeneous and latent dynamics.

57 logy and that strategies that keep the virus latent (e.g., block and lock) or those that reactivate t

58 -target reactivity can be minimized by using latent electrophiles that only become activated towards

59 and were retained long term, suggesting that latent epitope expression is sufficient to retain gB-CD8

60 Latent factors impact the gene expression values for eac

61 tion modeling to assess the effects of these latent factors on recovery and relapse.

62 We found that the latent factors strongly encoded the direction of the sti

63 ecision-making, we extracted low-dimensional latent factors that captured the population-wide fluctua

64 ric), we explored the derived weights of the latent factors, finding they highlight the importance of

65 tional reactivity in early development, with latent fear-associated memories emerging later in adoles

66 ug-target interaction prediction that learns latent features from drug-target interaction network.

67 We introduce a new latent fingermark (LFM) development method, where compou

68 iably establish the time since deposition of latent fingerprints.

69 e propagation; however, the virus can remain latent for years with some plants of 'Emerald' never dev

70 gma; on one hand, it infects and persists in latent form in the vast majority of the global populatio

71 In contrast, IRF-7 expression restricted latent gammaherpesvirus infection in the peritoneal cavi

72 Incorporating these BMP15 residues into latent GDF9 generated a highly potent growth factor, cal

73 arrier to a HIV-1 cure is the persistence of latent genomes despite treatment with antiretrovirals.

74 del of population growth that identifies the latent growth behavior and response to perturbation, whi

75 A latent growth curve model was applied across the whole s

76 e compared between groups using multivariate latent growth curve modeling.

77 al PTSD symptom trajectories identified with latent growth mixture modeling (random forest: AUC = 0.8

78 Latent growth mixture modeling was used to identify clas

79 s of depressive symptoms were obtained using latent growth mixture modelling, cognitive decline was a

80 We used Latent Growth Mixture Models (LGMM) to detect subgroups

81 Under TAE-induced ischemia, latent HCC cells demonstrated reduced metabolism and dev

82 leads with large sensible heat flux but low latent heat flux tend to dissipate low clouds.

83 quare error) CABLE's previous predictions of latent heat fluxes during periods of water stress at two

84 This enhancement was attributed to the high latent heat of fusion of the LFTFs which increased the e

85 mouse Pg emphasizes the importance of the Pg latent heavy chain (residues 1-561) in PAM binding and s

86 VDZ may have promoted the reactivation of a latent HHV-8 infection endowed with oncogenic potentiali

87 women on ART would have a lower frequency of latent HIV compared to men.

88 These genes may contribute to latent HIV infection in the gut and may serve as new tar

89 Latent HIV infection is the main barrier to cure, and mo

90 tion is associated with reduced frequency of latent HIV infection, we hypothesized that women on ART

91 to suppress residual HIV replication and/or latent HIV reactivation in CNS reservoirs, thereby reduc

92 Persistent viral replication and latent HIV reactivation in the CNS, even under ART, are

93 with ZL0580 renders them more refractory to latent HIV reactivation, indicating an epigenetic reprog

94 tifying residual plasma viremia to study the latent HIV reservoir and cure interventions.

95 eted as a strategy to reduce the size of the latent HIV reservoir is an avenue that should be explore

96 current approaches aimed at eliminating the latent HIV reservoir.

97 s are being sought to reduce the size of the latent HIV reservoir.

98 We measured the frequency of latent HIV using the quantitative viral outgrowth assay,

99 are generally regarded as the main source of latent HIV/simian immunodeficiency virus (SIV) infection

100 as a potentially curative approach to treat latent HSV infection.

101 ted proteins is attributable to acute and/or latent HSV-1 infection in mature hippocampal neurons, a

102 l ganglionic CD8(+) T cells during acute and latent HSV-1 infection.

103 the data indicate that viral promoters shape latent HSV-1-specific CD8(+) T cell populations and shou

104 The majority of cells with latent human immunodeficiency virus 1 infection are loca

105 The virus remains latent in neurons, and it can reactivate later in life,

106 ng between ATB and asymptomatic Mtb-infected latent individuals.

107 tb bacteremia with progressive phenotypes of latent infection and active pulmonary tuberculosis.

108 The establishment of latent infection and subsequent reactivations, during wh

109 KSHV latent infection decreases mitochondrial numbers, but th

110 t Mtb infection, as shown by reactivation of latent infection following simian immunodeficiency virus

111 harmacological HIV-1 reactivation to reverse latent infection has been extensively studied.

112 EBV establishes latent infection in B cells, which is the typical progra

113 e virus was highly deficient in establishing latent infection in germinal center B cells.

114 mplex virus 1 (HSV-1) establishes a lifelong latent infection in peripheral nerve ganglia.

115 nt oncogenic potential that is linked to its latent infection of B lymphocytes, during which virus re

116 nd reactivation (LUHMES) to characterize the latent infection of two HSV-1 wild-type strains.

117 sly underwent Ag-driven proliferation during latent infection with MCMV.

118 The establishment of latent infection, which is lifelong and can precede tumo

119 g from bacterial clearance to progressive or latent infection.

120 h the possibility to discriminate active and latent infection.

121 ty of HIV to establish a reversibly silent, "latent" infection is widely regarded as the main barrier

122 can infect many types of cells and establish latent infections in neurons.

123 us 1 (HSV-1) establish and maintain lifelong latent infections in neurons.

124 buted to their ability to establish lifelong latent infections in the dorsal root ganglia (DRG).

125 roinvasive pathogens that establish lifelong latent infections in the host peripheral nervous system

126 Nonprimary infections due to recurrence of latent infections or reinfection with new virus strains

127 ntegrated into the host genome, resulting in latent infections that are difficult to clear.

128 counts, which takes advantage of the common, latent information in the entire sample of curves, inste

129 Our results demonstrate that latent information is represented through reliable firin

130 le of DG-CA3 circuitry in the maintenance of latent information within the hippocampus.

131 versibly abolishes the CA1 representation of latent information.

132 lts provide a candidate neural mechanism for latent inhibition and illustrate a new role of dopamine

133 -rank matrices to simultaneously explore the latent key isoforms, and achieve function prediction by

134 lls are enriched for HIV-infected cells in a latent-like state.

135 We found that multiple gene products of the latent locus localize to the mitochondria.

136 ction with M tuberculosis or reactivation of latent M tuberculosis infection during such treatment.

137 esicles from 74 individuals presumed to have latent M. tuberculosis infection (LTBI) based on close c

138 minal kinase (JNK) signaling, induced by the latent membrane protein 1 (LMP1) of Epstein-Barr virus (

139 One key viral factor in this process is latent membrane protein 2A (LMP2A), which has been descr

140 y immunogenic EBV nuclear antigen (EBNA) and latent membrane proteins (LMPs), is expressed in newly i

141 s an elevated hepatic NADH/NAD(+) ratio as a latent metabolic parameter that is shaped by human genet

142 ow such dissociations.SIGNIFICANCE STATEMENT Latent motor memories formed during sensorimotor adaptat

143 tion, could discriminate active disease from latent Mtb infection (LTBI).

144 CD4+ T cells derived from individuals with latent Mtb infection supported more efficient HIV-1 tran

145 s, Streptomyces exospores, and metabolically latent Mycobacterium cells.

146 osis (TB) is variable among individuals with latent Mycobacterium tuberculosis infection (LTBI), but

147 se of isoniazid-rifapentine for treatment of latent Mycobacterium tuberculosis infection.

148 arm regions of the prodomain in the pro- and latent myostatin homodimers, suggesting a 1:1 (antibody:

149 g induces conformational changes in pro- and latent myostatin that span the arm region, the loops con

150 We conclude that parenchymal astrocytes are latent neural stem cells and that targeted interventions

151 overed during latency establishment and that latent neurons exhibited even higher VGSC activity.

152 tioselective N-allylation of N-silyl pyrrole latent nucleophiles with allylic fluorides followed by h

153 Further analysis demonstrated that KSHV latent open reading frame K12 (ORFK12) gene (kaposin A)-

154 thms applied to gene expression data extract latent or hidden signals representing technical and biol

155 In endemic areas, screening for latent or subclinical histoplasmosis should be implement

156 temperatures, and it had a relatively short latent period (nearly 30 minutes) in which it produced p

157 thological alterations during the clinically latent period and at 180 days post-exposure to irradiati

158 n of infection and a distinct infection-free latent period.

159 ean, being able to detect the infection in a latent phase, for the first time, in olive drupes, 16 ha

160 regulation, genome packaging, and during the latent phase, site-specific integration.

161 Such a latent phenotyping approach provides insights into commo

162 Now that this latent phenotyping model has been validated in a general

163 Latent phenotyping offers a promising approach to elucid

164 cess in high dimensions from low-dimensional latent positions.

165 lecular redox probes, Formaldehyde oxidative latent probe (FOLP) and dihydroxy-formaldehyde oxidative

166 (FOLP) and dihydroxy-formaldehyde oxidative latent probe (HFOLP), for the selective profiling of end

167 dditional information that characterizes the latent process can often be extracted from simulators an

168 ysis based on any use of each substance, and latent profile analysis based on use frequency.

169 Latent profile analysis identified groups of adolescents

170 Latent projections uncover complex features of data in v

171 9 subjects showed sequence variations in the latent protein, LMP1, which alters NK responses to EBV.

172 does not originate directly from individual latent proviruses but rather from recombination events i

173 CD4+ T cells containing defective or intact latent proviruses were found in seven of eight individua

174 perimentally manipulate, measure and analyse latent psychological attributes, such as memory, confide

175 e, we define the notion of a low-dimensional latent representation of stimulus identity, which is gen

176 ctions to emerge from fitting a hierarchical latent representation of the mind to multivariate, multi

177 er (VAE) to learn a continuous numerical, or latent, representation of molecular structure to expand

178 mits the biological features captured in the latent representations and, consequently, limits what ca

179 k prediction, they focus on mapping genes to latent representations in isolation, without aggregating

180 predictions regarding maintenance of robust latent representations in the presence of confounding ba

181 dividuals is critical for characterizing the latent reservoir and evaluating the impact of cure inter

182 identify combinations effective at targeting latent reservoir HIV-1 viruses from 10 individuals.

183 However, HIV-1 persists in a latent reservoir in resting CD4(+) T cells, and rebound

184 neal cavity under conditions where the viral latent reservoir is predominantly hosted by peritoneal B

185 be used to estimate the size of the residual latent reservoir on ART.

186 longitudinal measurements available, the HIV latent reservoir was not detected post-alloBMT in four p

187 regs) may be key contributors to the HIV/SIV latent reservoir, since they harbor high levels of HIV/S

188 l center response and expansion of the viral latent reservoir.

189 ith a 2.06-2.54 log(10) reduction in the HIV latent reservoir.

190 erminal center response and expansion of the latent reservoir.

191 for efficient methods to accurately quantify latent reservoirs, particularly in pediatric studies whe

192 Probabilistic latent semantic analysis (pLSA) is commonly applied to d

193 task errors and sensory prediction errors to latent sensorimotor memories, we perturbed target locati

194 We propose that guanidinium reactivates a latent septin assembly pathway that was suppressed durin

195 Some plant proteases contain a latent sequence known as the plant-specific insert (PSI)

196 We discuss evidence both that there are latent sex differences revealed by ELS and that ELS itse

197 Our matrix decomposition algorithm learns latent signatures of drugs and side effects that are bot

198 distinction to LNs, in the CNS, the size of latent SIV reservoirs was higher in the CD11b+ microglia

199 ndependently of their embryonic origin, have latent skin competence explaining why aberrant hair foll

200 Latent social group structure-based allyship estimates,

201 nt a Bayesian statistical approach that uses latent space models to better model accessible regions,

202 mpressed and integrated in a low-dimensional latent space that encodes the given data in a more effic

203 and a cofactor (heme) in both the acute and latent stages of infection.

204 Toxoplasma gondii, during both its acute and latent stages of infection.

205 Alternatively, induction of HIV from its latent state could accelerate the decrease in the reserv

206 om fast-growing lytic states to slow-growing latent states.

207 may play a part in the reactivation of this latent stem cell niche after injury.

208 The ependyma of the adult spinal cord is a latent stem cell niche that is reactivated by spinal cor

209 gnitive variables was performed to elucidate latent structure and canonical correlation analyses cond

210 y loss of functional OSN innervation reveals latent structure in the AL that develops independently o

211 f the vmPFC in schema-related processing and latent structure learning, the vmPFC may be required to

212 treebanks of sentences hand labeled for this latent structure.

213 ervised data-driven approaches for inferring latent structures that may give insight into biological

214 ss analogies and (orthogonal) projections to latent structures-discriminant analysis to characterise

215 However, latent T.gondii infection has been increasingly associat

216 rors in basal ganglia support exploration of latent task representations.

217 68 uninfected controls, 62 individuals with latent TB infection (LTBI) and 107 active pulmonary TB (

218 Contacts were evaluated for latent TB infection (LTBI) and TB, and the effectiveness

219 s in blood to discriminate PTB and EPTB from latent TB infection (LTBI) as well as EPTB from PTB in 2

220 ributed to reactivation of remotely acquired latent TB infection (LTBI) in non-U.S.-born persons who

221 infected individuals not developing disease (latent TB infection (LTBI)).

222 active tuberculosis (TB) in individuals with latent TB infection (LTBI), has been in use for over a d

223 redict reactivation disease progression from latent TB infection (LTBI).

224 des can also be detected in individuals with latent TB infection (LTBI).

225 l state and possible generation times during latent TB infection in humans.

226 f tuberculosis (TB) disease and treatment of latent TB infections.

227 nes in addition to collagens, such as Ltbp2 (latent TGF-beta-binding protein 2) and Sulf1 (sulfatase

228 ROS proteins with impaired ability to anchor latent TGF-beta1 on the cell surface.

229 our disease-associated mutants in presenting latent TGF-beta1 to the cell surface.

230 ain was specific for binding active, but not latent, TGFbeta-1.

231 lial cells, and we observed that decorin and latent TGFbeta1 complexed together.

232 Our latent thioester solid-phase linker was synthesized in 9

233 nd, strongly suggesting this behavior may be latent to other large Stokes-shift fluorophores.

234 peutic potential against KSHV.IMPORTANCE The latent-to-lytic switch in KSHV infection is one of the c

235 is activated only when expression of the EBV latent-to-lytic switch protein ZEBRA is turned on.

236 wnregulated ahead of expression of the viral latent-to-lytic switch protein.

237 Just before the new stimulus, this latent trace was reignited into activity that recapitula

238 revealed by ELS and that ELS itself produces latent transcriptomic changes revealed by adult stress.

239 havbeta8 binds with exquisite specificity to latent transforming growth factor-beta (L-TGF-beta).

240 ar protein previously shown to interact with latent transforming growth factor-beta binding protein 1

241 iomarkers, angiopoietin-2, thrombospondin-2, latent transforming growth factor-beta binding protein-4

242 These studies provide a paradigm for imaging latent, treatment-refractory cancer cells, suggesting th

243 critical risk factor for the reactivation of latent tuberculosis (TB) infection (LTBI).

244 By contrast, screening for latent tuberculosis before immune checkpoint inhibitor t

245 erium tuberculosis (Mtb) during asymptomatic latent tuberculosis infection (LTBI) in humans is curren

246 Targeted testing and treatment (TTT) for latent tuberculosis infection (LTBI) is a recommended st

247 Treatment of latent tuberculosis infection (LTBI) is important for tu

248 ific inflammatory responses used to identify latent tuberculosis infection (LTBI) lose positivity dur

249 Among SIV adults, 14.4% were diagnosed with latent tuberculosis infection (LTBI), 63.5% were suscept

250 ce of a scar or vaccination history, against latent tuberculosis infection (LTBI), measured via IGRA,

251 known to influence T and B cell responses in latent tuberculosis infection (LTBI).

252 disease can be missed during evaluations for latent tuberculosis infection, and can manifest with sym

253 short-course rifapentine-based regimens for latent tuberculosis infection.Methods: Rifapentine pharm

254 plicated the choice of treatment regimen for latent tuberculosis infection.Objectives: To evaluate th

255 or in combination with rifapentine to treat latent tuberculosis infections.

256 ction, and can manifest with symptoms during latent tuberculosis treatment.

257 Among over 8000 patients treated for latent tuberculosis we found no evidence of acquired dru

258 oring the safety of rifampin monotherapy for latent tuberculosis.

259 lated (r = .443 to r = .782), and one shared latent underlying factor explained between 42.3% and 88.

260 We propose an integrative model to estimate latent unknown clusters (LUCID) aiming to both distingui

261 A latent variable analysis identified a profile of childre

262 Here, we introduce Phenotype Latent variable Extraction of disease misdiagnosis (PheL

263 This model is called the Gaussian process latent variable model (GPLVM).

264 PheLEx consists of a hierarchical Bayesian latent variable model, where inference of differential m

265 Latent variable modeling was used to examine network-lev

266 s of cognitive resilience quantified using a latent variable modelling approach and representing bett

267 sponse times, accuracy) through hierarchical latent variable models.

268 The encoded latent variable space is found to provide suitable metri

269 We show that this latent variable, by producing positive covariation among

270 for seasonal demographic covariation using a latent variable.

271 orms (second-order anti-smoking/vaping norms latent variable: standardized factor loading [beta] = 0.

272 iterative algorithm for obtaining the sparse latent variables and make different assumptions about th

273 ural organisation and examined whether these latent variables explained reports of the patterns of on

274 [Formula: see text] that is isometric to the latent variables of the manifold.

275 These models are based on latent variables probabilistically mapping the structure

276 artial least squares analysis, we identified latent variables relating amyloid or tau pathology with

277 Second-order CFA showed that latent variables representing experimental and survey no

278 Using computational modeling, we quantified latent variables that index mechanisms underlying persev

279 e brain represents and computes with dynamic latent variables.

280 , which is parametrized by a few normalized, latent variables.

281 as both discrete sequences and as continuous latent variables.

282 tte-Guerin vaccination and/or in controlled (latent) versus uncontrolled (TB) M. tuberculosis infecti

283 persistence, as it plays important roles in latent viral DNA replication and efficient segregation o

284 mmatory signals could induce upregulation of latent viral gene expression.

285 rategy attempts to reverse and eliminate the latent viral infection that prevents eradication of the

286 o assess the individual's ability to control latent viral infections.

287 before spaceflight had a 29% reduced risk of latent viral reactivation compared to crew with lower CR

288 physical fitness may protect astronauts from latent viral reactivation during long duration spaceflig

289 Latent viral reactivation is a commonly reported manifes

290 ring a mission would protect astronauts from latent viral reactivation.

291 T-cell quiescence and reduce the size of the latent viral reservoir.

292 e potential to enhance immune recognition of latent viral reservoirs as part of a strategy for HIV cl

293 block and lock) or those that reactivate the latent virus (e.g., shock and kill) would be detrimental

294 ious paradigms that included reactivation of latent virus as the source of infection in immune women

295 gene editing of HSV, eliminating over 90% of latent virus from superior cervical ganglia.

296 lt from primary infection or reactivation of latent virus is a longstanding question in the field.

297 due to primary infection or reactivation of latent virus remains unknown, and knowledge of the anti-

298 although HIV is not considered as a typical latent virus, it can establish a state of nonproductive

299 VGSC functional expression influenced by the latent virus.

300 rimary infection rather than reactivation of latent virus.