ライフサイエンスコーパス: latrophilin

1 as interactors for the lectin-like domain of latrophilins.

2 teins as endogenous postsynaptic ligands for latrophilins.

3 r nanomolar-affinity binding to postsynaptic latrophilins.

4 rs: a G-protein-coupled receptor called CIRL/latrophilin 1 (CL1) and a cell-surface protein called ne

5 e probably by binding to two receptors, CIRL/latrophilin 1 (CL1) and neurexin Ialpha.

6 r alpha-latrotoxin have been described: CIRL/latrophilin 1 (CL1) and neurexin-1alpha.

7 ADGRL1 (latrophilin 1), a well-characterized adhesion G protein-

8 The G-protein-coupled receptor CIRL1/latrophilin-1 (CL1) and the type-1 membrane proteins neu

9 Latrophilin-1 (Lphn1, aka CIRL1 and CL1; gene symbol Adg

10 ons of soluble teneurin-binding fragments of latrophilin-1 decreased synapse density, suggesting that

11 urin binding but has no effect on binding of latrophilin-1 to another ligand, FLRT3.

12 Latrophilin-1, -2, and -3 are adhesion-type G protein-co

13 ternative splicing at an N-terminal site; in latrophilin-1, this alternative splicing modulates teneu

14 vation between the adhesion-GPCRs Celsr1 and Latrophilin-1.

15 ch includes olfactomedin, TIGR, Noelin-2 and latrophilin-1.

16 e adhesion G protein-coupled receptor (ADGR) Latrophilin 2 (LPHN2) as a novel determinant of endothel

17 ential requirement for adhesion GPCR ADGRL2 (latrophilin 2) in epidermal differentiation.

18 deaminase, lipocalin 2, synaptotagmin 4, and latrophilin 2, whose time-dependent induction following

19 Latrophilin-2 (Lphn2) and latrophilin-3 (Lphn3) are adhe

20 cell surface molecules teneurin-3 (Ten3) and latrophilin-2 (Lphn2) in the medial and lateral hippocam

21 s of the adhesion G protein-coupled receptor latrophilin-2 (Lphn2) with its partner teneurin-3 instru

22 nd knockout mice, we show in this study that latrophilin-2 (Lphn2), a cell-adhesion G protein-coupled

23 In mouse CA1-region neurons, Latrophilin-2 and Latrophilin-3 are essential for format

24 Here, we show that Latrophilin-2 and Latrophilin-3 exhibit constitutive GPC

25 in-3 to rescue the synapse-loss phenotype in Latrophilin-2 and Latrophilin-3 knockout neurons in vivo

26 Our results suggest that Latrophilin-2 and Latrophilin-3 require GPCR signaling i

27 hat the adhesion G protein-coupled receptors latrophilin-2 and latrophilin-3 selectively direct forma

28 The same mutation impaired the ability of Latrophilin-2 and Latrophilin-3 to rescue the synapse-lo

29 EMT markers including slug, runx2, RhoA, and latrophilin-2.

30 Adhesion G protein-coupled receptor latrophilin 3 (ADGRL3), a cell adhesion molecule highly

31 PCR family, GPR56 (also known as ADGRG1) and latrophilin 3 (LPHN3 (also known as ADGRL3)).

32 rotein-coupled receptor L3 (ADGRL3; formerly latrophilin 3, LPHN3) is associated with Attention-Defic

33 Here, we use adhesion GPCR latrophilin-3 (ADGRL3) as a model receptor to investigat

34 Latrophilin-3 (encoded by Adgrl3, also known as Lphn3)-a

35 Latrophilin-2 (Lphn2) and latrophilin-3 (Lphn3) are adhesion GPCRs that serve as p

36 mouse CA1-region neurons, Latrophilin-2 and Latrophilin-3 are essential for formation of entorhinal-

37 Latrophilin-3 binds to two transcellular ligands: fibron

38 Here, we show that Latrophilin-2 and Latrophilin-3 exhibit constitutive GPCR activity that in

39 synapse-loss phenotype in Latrophilin-2 and Latrophilin-3 knockout neurons in vivo.

40 Our results suggest that Latrophilin-2 and Latrophilin-3 require GPCR signaling in synapse formatio

41 protein-coupled receptors latrophilin-2 and latrophilin-3 selectively direct formation of perforant-

42 on impaired the ability of Latrophilin-2 and Latrophilin-3 to rescue the synapse-loss phenotype in La

43 s examined (megalin, thrombospondin-4, KR18, latrophilin-3, and phosphatidylinositol-3-OH kinase P101

44 hich shows approximately 65% identity to rat latrophilin, a G-coupled, seven span transmembrane prote

45 Using latrophilin, a well-studied member of the LNB family, we

46 Latrophilin adhesion-GPCRs (Lphn1-3 or ADGRL1-3) and Unc

47 Given that postsynaptic latrophilin adhesion-GPCRs drive synapse formation and p

48 ion of the midline edges also required LAT-1/Latrophilin, an adhesion G protein-coupled receptor that

49 LTX(N4C) binds to both LTX receptors (latrophilin and neurexin) and greatly enhances the frequ

50 Like the latrophilins and other members of the secretin family of

51 ndependent receptors for latrotoxin (CIRL or latrophilin) and neurexin 1 alpha receptors were found t

52 erve terminals, neurexins and CLs (CIRLs and latrophilins), and then executes a critical, second step

53 However, Teneurins, Latrophilins, and FLRT proteins are also expressed durin

54 We show that latrophilins are abundantly and differentially expressed

55 Latrophilins are postsynaptic adhesion-GPCRs that engage

56 All latrophilins are subject to alternative splicing at an N

57 dhesion molecules, in addition to binding to latrophilins as heterophilic cell-adhesion molecules.

58 (2) a Ca(2+)-independent mechanism with CIRL/latrophilins as receptors, in which alpha-latrotoxin dir

59 l how the lectin and olfactomedin domains of Latrophilin bind across a spiraling beta-barrel domain o

60 1 decreased synapse density, suggesting that latrophilin binding to teneurin may directly or indirect

61 hesion, different from heterophilic teneurin-latrophilin binding.

62 e, and extracellular bacterial toxin-derived latrophilin-binding domains of Teneurin-3 are required f

63 ganization, suggesting that teneurin-induced latrophilin clustering mediates synaptogenesis.

64 ed proteins in which trans-synaptic teneurin-latrophilin complexes recruit phase-separated pre- and p

65 e, we present crystal structures of Teneurin-Latrophilin complexes that reveal how the lectin and olf

66 Here we show that the Drosophila aGPCR Latrophilin/dCIRL acts in mechanosensory neurons by modu

67 it is not known whether other teneurins and latrophilins display similar topographically restricted

68 ify a striking heterogeneity in teneurin and latrophilin expression along the spatiotemporal axis of

69 acellular C terminus binds the adhesion GPCR Latrophilin, forming a trans-cellular complex with synap

70 However, it is unknown whether latrophilins function as GPCRs in synapse formation.

71 ivo analyses demonstrate that the C. elegans latrophilin homolog LAT-1 directly interacts with the DS

72 apse organization by binding to postsynaptic latrophilins; however, the mechanism of action of teneur

73 yperactivity disorder, suggesting a role for latrophilins in human cognitive function.

74 onsistent with a role of teneurin binding to latrophilins in trans-synaptic interactions.

75 Here, we identify the Adhesion GPCR latrophilin (LPHN/ADGRL) as a positive modulator of Notc

76 he cartography of all teneurin (Tenm1-4) and latrophilin (Lphn1-3 [Adgrl1-3]) paralog expression in t

77 Latrophilins (LPHNs) are a small family of G protein-cou

78 Teneurins (Tenms) and latrophilins (Lphns) are well-known cell adhesion molecu

79 ell-adhesion molecules teneurins (TENs) with latrophilins (LPHNs/ADGRLs) promotes excitatory synapse

80 phan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishme

81 Thus, postsynaptic latrophilins promote excitatory synapse formation by sim

82 naling in synapse formation, indicating that latrophilins promote synapse formation in the hippocampu

83 Physiologically, this latrophilin role is crucial for balancing the number of

84 neuroligins, cerebellin/GluD complexes, and latrophilins, thereby shaping the input/output relations

85 We show that binding of Latrophilins to Teneurins and FLRTs directs the migratio

86 l-surface receptors, neurexins and CLs (Cirl/latrophilins), which probably have a physiological funct

87 a, together with binding studies, prove that latrophilin, which is linked to G proteins and inositol

88 We show that teneurin binds to latrophilins with nanomolar affinity and that this bindi