ライフサイエンスコーパス: leader

1 A sequence conservation at the 3' end of the leader.

2 preferentially at the repeat proximal to the leader.

3 rdinate and inspection and punishment by the leader.

4 ans, patients, caregivers, and health system leaders.

5 dge leaders', rather than mostly key opinion leaders.

6 sustained long-term attention from political leaders.

7 on the guidance and mentorship of scientific leaders.

8 or why they behave differently from negative leaders.

9 ng have risen as a top priority for hospital leaders.

10 reening of wealthy individuals and corporate leaders.

11 t source of radio emission from the positive leaders.

12 ized that women can be inspiring and capable leaders.

13 atory elements located in 5' mRNA transcript leaders.

14 current density well below that of lightning leaders.

15 plemented by hospital and health care system leaders.

16 of resources deemed high-yield by well-being leaders.

17 ntific, ethics, clinical, and administrative leaders.

18 as well as the experience of our WiSE group leaders.

19 ly charged ends-called positive and negative leaders(1).

20 both reconnect positive leaders to negative leaders(11,16,17,20-22) and cause multiple cloud-to-grou

21 tern that is different from that of negative leaders(11-13,16,17).

22 he disconnections form primarily on positive leaders(22), or why the current in cloud-to-ground light

23 ecome transiently disconnected from negative leaders(9,12,16,18-20), which may lead to current pulses

24 e data from the GLOBAL LEADERS trial (GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-Pl

25 The GLOBAL LEADERS (GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-pl

26 l collaborative partnerships that help local leaders adapt effective treatments to local resources an

27 (GLOBAL LEADERS Adjudication Sub-Study [GLASSY]; NCT03231059).

28 enges these practices faced, the cost levers leaders adjusted, and the government subsidies sought.

29 tched donor is leader-matched and shares a T leader allotype.

30 Using chimeras, we analyzed the role of leader and follower cells in the collectively migrating

31 We find that leader and follower cells need to sense the attractant C

32 Co-targeting of both leader and follower cells with PDH and GLUT1 inhibitors,

33 ls is regulated by the energetic statuses of leader and follower cells.

34 ound that cancer cells dynamically rearrange leader and follower positions during collective invasion

35 Scientists assigned to the leader and specialized archetypes tended to have longer

36 supporting), as did late-career researchers (leader and supporting).

37 School leaders and authorities should be realistic about expect

38 and brightest students to nuclear medicine, leaders and mentors in the field must educate themselves

39 with education of staff/patients by opinion leaders and prenatal counseling for women and partners,

40 nd academic advancement of Black/AA women as leaders and surgeon-scientists is needed.

41 t upstream short ORFs located in the 5' mRNA leaders, and amongst canonical ORFs during the activatio

42 Entrepreneurs, nonfounder CEOs/leaders, and inventor employees all show more innovative

43 tions between entrepreneurs, nonfounder CEOs/leaders, and inventor employees have received limited at

44 orts, as anthropologists, physicians, tribal leaders, and local officials, to develop and implement a

45 der branches, are as bright as the lightning leaders, and report several other optical characteristic

46 adership; (ii) the appeal of dominance-style leaders; and (iii) sex biases in leadership emergence in

47 majority of male scientists belonged to the leader archetype, while the larger proportion of women b

48 (COVID-19) social distancing policies, local leaders are concerned about future pandemic waves and la

49 On the European side, the project leaders are Despina Sanoudou (Biomedical Research Founda

50 so reformed the methods by which future IDSA leaders are identified and given roles.

51 er, followers confer a net safety benefit to leaders, as prey leading others were less likely to be a

52 dum of understanding and clearly designating leaders at both institutions are important criteria for

53 ors reflect on lessons learned that may help leaders at other institutions mitigate the inevitable di

54 Semistructured interviews with 30 surgical leaders at teaching hospitals affiliated with health sys

55 ca (IDSA), women played a minor role as IDSA leaders, awards recipients, and presenters at the nation

56 tter able to use this information to predict leaders' behavior and thus improve interpersonal synchro

57 Here, we demonstrate that leader binding by a biosynthetic enzyme in the lasso pep

58 and structural data illustrate how a single leader-binding domain can engage sequence-divergent lead

59 function by stabilizing the structure of the leader binds directly to the [UUUU]:[GGAG] helix.

60 Because amoeboid leader bleb-based migration (LBBM) occurs in confined sp

61 We show that they are formed at unsuccessful leader branches, are as bright as the lightning leaders,

62 t is, psychological fusion) with a political leader can fuel partisans' willingness to actively parti

63 thermore, it has been inferred that positive leaders can become transiently disconnected from negativ

64 of self-governance institutions because such leaders can directly affect local users' perceived costs

65 zational behavior, we propose that voluntary leaders can facilitate a cooperative process of local ru

66 but not intercellular communication, induces leader cell activity and collective migration through th

67 inhibition of ADORA1 or AKT signaling caused leader cell collapse and halted collective invasion.

68 Cx43 hemichannels, as a critical pathway in leader cell function and collective invasion.

69 Forward invasion of the leader cell gradually depletes its available energy, eve

70 successfully recapitulated the dependence of leader cell lifetime on collagen density.

71 energy level by glucose starvation decreases leader cell lifetime whereas increasing the cellular ene

72 ng leader-follower switching thus decreasing leader cell lifetime.

73 Leader cells exhibit higher glucose uptake than follower

74 riched specifically at the invasive front of leader cells in invasive cell strands.

75 Recent studies suggest that leader cells in the front sense the guidance cue, relay

76 n proposed that a subgroup of cells known as leader cells localize at the front edge of a collectivel

77 terogeneity within invasive chains, in which leader cells preferentially utilize mitochondrial respir

78 In this manner, leader cells steer the collective and set the collective

79 a pyruvate dehydrogenase (PDH) dependency in leader cells that can be therapeutically exploited with

80 This work demonstrates that K14(+) leader cells utilize both chemical and mechanical cues f

81 he system revealed the formation of invasive leader cells with upregulated Delta-like ligand 4 (DLL4)

82 rate that pre-existing, randomly distributed leader cells within primary tumor organoids use CXCR4 an

83 NHE1 localized to the leading edges of leader cells, as well as to cryptic lamellipodia in subm

84 1 localized not only to the leading edges of leader cells, but also in cryptic lamellipodia in submar

85 ns generated by sprouts revealed that mainly leader cells, not stalk cells, exert contractile forces

86 postulates that specially equipped "hub" or "leader" cells within the beta-cell network drive islet o

87 dentification of highly connected "hub" (or "leader") cells and of follower populations subservient t

88 In both experiments, infants in the leader condition looked significantly longer if shown th

89 itions, the protagonist was either a leader (leader condition) or a nonleader equal in rank to the ot

90 using strains expressing different glutamine leader constructs fused to GFP.

91 ed in real-world conflicts because competing leaders construe their position as one of defense, and p

92 Here, we show that the dimeric 5'-leader contains more than two dozen NC binding sites wit

93 n the wider elephant society through loss of leaders crucial to younger male navigation in unknown, r

94 e conserved upstream ORF present in the mRNA leader derepress PRL protein synthesis and attenuate the

95 of the study was to evaluate the role of the leader dimorphism in GVHD after HLA-B-mismatched unrelat

96 quantitative survey was done among Rohingya leaders displaced to refugee camps in Bangladesh.

97 pri-let-7 is trans-spliced to the SL1 splice leader downstream of the let-7 precursor stem-loop, whic

98 eed, it is still not understood how positive leaders emit radio-frequency radiation or why they behav

99 ach to a new 2 x 2 game, where one player, a leader, ensures via inspection and punishment that the o

100 al effects of movement momentum on irregular leader exit in African countries between 1990 and 2014,

101 remature termination codon at position +5 in leader exon of Igh (Ter5H) allele.

102 nd identify a role for exosomes in promoting leader-follower behavior in 2D and 3D migration.

103 ng time-dependent cross correlation to infer leader-follower interactions between each pair of group

104 T) states in subpopulations that establish a leader-follower relationship to collectively invade.

105 in denser collagen matrices by accelerating leader-follower switching thus decreasing leader cell li

106 its available energy, eventually leading to leader-follower transition.

107 d that ROCK2 inhibition triggers the initial leader/follower polarization of the CRC cell cohorts and

108 ols and benchmarking to be shared with local leaders for targeted antibiotic stewardship program inte

109 The Vascular Leaders Forum brought together 100 stakeholders, includi

110 501c(3) organization, convened the Vascular Leaders Forum on March 1 and 2, 2019, in Washington, DC,

111 The Vascular Leaders Forum reviewed the natural history of peripheral

112 The LF study (LEADERS FREE) reported superior outcomes of HBR patients

113 Leader frequencies were defined in 2 004 742 BeTheMatch

114 RNase P catalyzes removal of the 5' leader from precursor tRNAs (pre-tRNAs) in all three dom

115 Forty-one surgical opinion leaders from 19 countries and 5 continents were involved

116 Community leaders from 590 Rohingya hamlets and eight urban wards

117 Men with prostate cancer and thought leaders from a variety of disciplines provided a range o

118 eutics for Pain workshop convened scientific leaders from academia, industry, government and patient

119 uring flash activity that can trigger upward leaders from tall objects in the USA and in Brazil.

120 In this article, leaders from the American College of Physicians (ACP) di

121 Our findings suggest that the decoupling of leaders from the costs that they incite amplifies the de

122 ese facets of cancer immunotherapy, academic leaders from these various disciplines discussed current

123 ype responsible for the initiation of upward leaders from towers.

124 justing for variables, female physician code leader gender was independently associated with a higher

125 We analyzed whether physician code leader gender was independently associated with sustaine

126 The GLOBAL LEADERS (GLOBAL LEADERS: A Clinical Study Comparing Two

127 our genes, however, the different transcript leaders greatly affected translation.

128 Radio emission from positive leaders has nevertheless been mapped(13-15), and exhibit

129 known about whether they are also viewed as leaders (i.e., authorities) in the field.

130 ied the inclusion of an ID-trained physician leader in ASP, and this has led to the development of cu

131 f Investigative Dermatology (JID) has been a leader in our understanding of many aspects of the major

132 m and copper, within the scope of Germany, a leader in recycling.

133 ommitted to serving as a global champion and leader in RHD care and prevention.

134 Historically, California has been a world leader in the development and application of environment

135 Brazil has become a global leader in the production of commodity row crops such as

136 FT ICR mass spectrometry continues to be the leader in the resolving power among all mass spectrometr

137 orge Floyd killing and our responsibility as leaders in academic surgery to condemn and eliminate rac

138 To develop as leaders in AI-ML, radiology residents may seek a formati

139 Transcript leaders in Cryptococcus and other fungi are substantiall

140 quires a new approach to training tomorrow's leaders in epidemic prevention and response.

141 As a result, leaders in health care cannot properly assess the financ

142 le is known about the role of older males as leaders in long-lived social species.

143 rms for improved health outcomes, calling on leaders in national governments, global health instituti

144 is study was to compare female and male code leaders in regard to cardiopulmonary resuscitation outco

145 The HLA-B leader informs GVHD risk after HLA-B-mismatched unrelate

146 de concrete suggestions for the practitioner-leaders interested in creating, improving, and sustainin

147 Formal succession planning for ICU leaders is crucial to the success of critical care organ

148 (S) genome sequences showed mutations in the leader (L) and L* proteins of DA-C(L) variant, which may

149 oss conditions, the protagonist was either a leader (leader condition) or a nonleader equal in rank t

150 as pulsing radio sources along the positive leader length and were named "needles".

151 de on cardiovascular events and mortality in LEADER (Liraglutide Effect and Action in Diabetes: Evalu

152 ipants, were included: ELIXA (lixisenatide), LEADER (liraglutide), SUSTAIN-6 (semaglutide), EXSCEL (e

153 The preferred HLA-B-mismatched donor is leader-matched and shares a T leader allotype.

154 Prospective identification of leader-matched donors is feasible for most patients in n

155 was higher with leader mismatching than with leader matching (OR 1.73, 1.02-2.94; p=0.042 for grade 2

156 s its RNA-binding motif for regulation of 5' leader-mediated ATF4 translation.

157 plantations, acute GVHD risk was higher with leader mismatching than with leader matching (OR 1.73, 1

158 Incorporation of the roc leader mRNA in front of a heterologous gene was sufficie

159 Administrators and practice leaders must be proactive with practice modifications an

160 th practice staff (n = 25) and health system leaders (n = 11), provider (n = 25), and patient (n = 47

161 valuation of Cardiovascular Outcome Results [LEADER]; NCT01179048).

162 field surveys in large US companies, student leader nominations and elections, and experiments), East

163 o a postdoc and married mother of two to the leader of an ever-changing group of fantastic coworkers-

164 an inspiring researcher, mentor, and eminent leader of cell biology.

165 A CUG triplet located in the 5' leader of POLG messenger RNA (mRNA) initiates almost as

166 The leader of the matched allotype could be considered to be

167 ould be considered to be as important as the leader of the mismatched allotype for GVHD.

168 the various sections was aggregated, and the leader of the task force (J.D.S.) merged the material in

169 iated by interactions between the dimeric 5'-leader of the unspliced viral RNA and the nucleocapsid (

170 -function studies identify a stem-loop in 5' leader of tRNAvalV that inhibits RNase P cleavage and fu

171 survey questionnaire was distributed to the leaders of 27 qualifying organizations.

172 tion study suggested that women are inferior leaders of cardiopulmonary resuscitation efforts.

173 Leaders of each program performing and/or evaluating VCA

174 We urge leaders of infectious disease societies, divisions, and

175 e, including discussions with colleagues and leaders of private-practice radiology groups from across

176 y punishment suggests that adults expect the leaders of social groups to intervene in within-group tr

177 f leadership emergence in a human group when leader or follower roles are not designated a priori.

178 hical climate antecedents at the individual, leader, organizational, and environmental levels and exa

179 nurse when compared with male physician code leaders paired with a female code nurse.

180 water-soluble proteins, the H-segment of the leader peptidase helix used in the von Heijne and White

181 Finally, we explored the roles of the leader peptide and of the RiPP precursor peptide recogni

182 r cargo proteins following processing of the leader peptide and prior to ATP-dependent alternating ac

183 ence of thioether bridges and removal of the leader peptide are required for RumC's antimicrobial act

184 ) of a PCAT subsequent to the removal of the leader peptide by the PEP domain.

185 se domain in complex with a covalently bound leader peptide demonstrates the basis for substrate reco

186 osition -21 in the gene segment encoding the leader peptide dictates whether NK cell regulation prima

187 strict sequence specificity is necessary for leader peptide engagement.

188 rovide a model for understanding the role of leader peptide recognition in the translocation cycle, a

189 le as intercellular mediators, most lack the leader peptide typically required for protein secretion.

190 of binding regardless of the presence of the leader peptide, suggesting that although the PEP domain

191 tion of OlvS(A) activity showed that it is a leader peptide-independent and S-adenosyl methionine-dep

192 motif, and HMGL51 contained a mitochondrial leader peptide.

193 dimorphism in exon 1 of HLA-B gives rise to leader peptides containing methionine (Met; M) or threon

194 The cargo proteins have N-terminal leader peptides that are cleaved off by the cysteine pro

195 binding domain can engage sequence-divergent leader peptides using a conserved motif that facilitates

196 that two CtAs are bound via their N-terminal leader peptides, but only one is positioned for cleavage

197 survey of individuals appointed as new group leaders, PIs or university lecturers in the UK between 2

198 We argue that voluntary local leaders play an important role in the initiation of self

199 including 1) strong social cohesion, whereby leaders played a critical role in knowledge exchange; 2)

200 largely insensitive to perturbations of the leader portion of the precursor peptide.

201 Local leaders possess significant and growing authority over r

202 Furthermore, these key opinion leaders predict that machine learning technology and dat

203 anded CGG repeats (CGG RAN) from the FMR1 5'-leader produces toxic proteins that contribute to neurod

204 Negative leaders propagate in discrete steps, emitting copious ra

205 Positive leaders propagate more continuously and thus emit very l

206 ndogenous stress response antagonist by FMDV leader protease (L(pro)) or 3C(pro), we demonstrate an e

207 that FMDV can suppress SG formation via its leader protease (L(pro)).

208 sidue in foot-and-mouth disease virus (FMDV) leader proteinase (Lpro) (W105) that is involved in the

209 Foot-and-mouth disease virus (FMDV) leader proteinase (Lpro) affects several pathways of the

210 activity of Cas1-Cas2 integrase outside the leader-proximal region of a CRISPR array suggests that t

211 the involvement of 'innovation and knowledge leaders', rather than mostly key opinion leaders.

212 ation of small plasma structures on positive leaders re-ignited the search.

213 guage style of Donald Trump and other recent leaders reflect long-evolving political trends.

214 Herein, IDSA leaders reflect on their paths to IDSA leadership, hopin

215 cing by fructose and glucose requires the 5' leader region of the mRNA specifying the protein, design

216 ural Gag protein with an extra 88-amino-acid leader region that determines its activity.

217 , such as '5'-UGA(C/G)GG-3', are found in 5' leader regions of regulated genes and shown to be respon

218 t it can also terminate transcription within leader regions, performing regulatory functions and avoi

219 h upstream ORFs (uORFs) situated in their 5'-leader regions.

220 G1 first recognized a 12-bp sequence at the leader-repeat junction and performed leader-side inserti

221 on is primarily directed by sequences at the leader-repeat junction as well as an adenine-rich sequen

222 as2 proteins insert prespacers always at the leader-repeat junction of the CRISPR array.

223 from the genomic promoter to synthesize the leader RNA and virus replication in host cells, but not

224 te, we probed the structures of capped HIV-1 leader RNAs by deuterium-edited nuclear magnetic resonan

225 The leader sequence adjacent to the repeat further stabilize

226 pre-tRNAs) as it catalyzes removal of the 5'-leader sequence from pre-tRNAs with its NYN metallonucle

227 We show that 10 bp of the CRISPR leader sequence is critical for stimulating polarized in

228 ersed repeat (MIR) transposition into the 5' leader sequence of the mammalian POLG gene, which became

229 Their substrates contain a leader sequence that is excised by an N-terminal peptida

230 slation of ATF4 mRNA through a regulatory 5' leader sequence with multiple upstream Open Reading Fram

231 The conservation of the leader sequence within a given RiPP class, in otherwise

232 ted into the secretory pathway with a signal/leader sequence, they will be exposed to the host's glyc

233 through sequence-specific recognition of the leader sequence, which is removed after the installation

234 clustered mutations in the U5, PBS, and gag leader sequences (GLS), generating potential strain-spec

235 ISPR arrays with 1-2 spacers and preceded by leader sequences but devoid of cas genes.

236 E Uncapped viral RNAs often rely on their 5' leader sequences to initiate translation, and the Tritic

237 n M leader shared allotype compared with a T leader shared allotype (OR 1.98, 1.39-2.81; p=0.0001 for

238 2-2.94; p=0.042 for grade 2-4) and with an M leader shared allotype compared with a T leader shared a

239 congruent with American norms concerning how leaders should communicate.

240 Leaders should continue to study the 24/7 work environme

241 scientists, policymakers and organisational leaders should devote more attention and resources towar

242 at the leader-repeat junction and performed leader-side insertion before proceeding to spacer-side i

243 side or spacer-side insertions, although the leader-side insertion was faster than spacer-side.

244 r stabilizes EfaCas1-Cas2 contacts, enabling leader-side integration and subsequent spacer-side integ

245 epeat sequence and could perform independent leader-side or spacer-side insertions, although the lead

246 oice from a biased random source, electing a leader, simulating cellular automata, generating determi

247 In T. brucei, spliced leader (SL)-mediated trans-splicing of pre-mRNAs is an o

248 The role of spliced leaders (SL) within the cell is unclear and an accurate

249 All three of the archetypes we found - leader, specialized, and supporting - were encountered f

250 ion of multiple actions by engaged community leaders (steering committees) is of critical importance

251 In the GLOBAL LEADERS study, time-to-first-event analysis did not show

252 utaneous coronary intervention in the GLOBAL LEADERS study.

253 00 nM) reside within a ~150-nt region of the leader sufficient to promote RNA packaging (core encapsi

254 rmination, as well as the prevalence of mRNA leaders that use riboswitches and RNA-binding proteins.

255 ings with community members (including local leaders); the providers and community group, in which re

256 meeting, the number of supportive community leaders, the expectation of participants of receiving an

257 important gatherings of the world's economic leaders, the G20 Summit and ministerial meetings, takes

258 f populism and on the narratives of populist leaders, there is little empirical work on the relations

259 ailable and designed for hospital operations leaders, this modeling tool can inform preparations for

260 being played by the in vitro population from Leader to Deadlock.

261 ion event, suggesting that they expected the leader to intervene and rectify the wrongdoer's transgre

262 r 17-mo-old infants (n = 120) would expect a leader to intervene when observing a within-group fairne

263 The LNAA to VZVsncRNA12, encoded in the leader to ORF61, also significantly increased the levels

264 us validation in collaboration with industry leaders to accelerate high-quality clinical research int

265 ummit; and highlighted key questions for G20 leaders to address to put the future of DAH on course to

266 e discrimination, and I challenge scientific leaders to create equitable environments for Black women

267 d older adolescent mentors and in-class peer-leaders to encourage classes to conduct 2 new weekly act

268 Fusing LLT and SLT transcript leaders to green fluorescent protein indicated that for

269 may be targeted to highly connected opinion leaders to leverage their influence, or communication ma

270 2019 (COVID-19) pandemic challenges hospital leaders to make time-sensitive, critical decisions about

271 current pulses that both reconnect positive leaders to negative leaders(11,16,17,20-22) and cause mu

272 Acknowledging both the importance of diverse leaders to organizational success and shortfalls in dive

273 ystem goals enabled some surgical department leaders to take advantage of their health systems' reach

274 HSS impact evaluations, enabling healthcare leaders to track progress as well as identify and addres

275 gn, an initiative that encourages healthcare leaders to use metrics and data analysis to identify wor

276 Many leaders today do not rise through the ranks but are recr

277 internationally-recognized experts and local leaders together to evaluate issues around gastric cance

278 We show that Ddr promotes leader-trailer-polarized BMP-Smad signaling independentl

279 Spliced leader trans-splicing (SLTS) plays a part in the maturat

280 nd individual mRNAs are generated by spliced leader trans-splicing and polyadenylation, processes tha

281 Zap1-regulated genes, several produced long leader transcripts (LLTs) in one zinc status condition a

282 LLTs) in one zinc status condition and short leader transcripts (SLTs) in the other.

283 ing and elongating states of the ribosome on leadered transcripts, operons, and on leaderless transcr

284 the multinational, double-blind, randomized LEADER trial, 9,340 patients with T2D and high cardiovas

285 We used the data from the GLOBAL LEADERS trial (GLOBAL LEADERS: A Clinical Study Comparin

286 The GLOBAL LEADERS trial is a prospective, multicenter, open-label,

287 Nonfounder CEOs/leaders typically sit in between entrepreneurs and emplo

288 ical distancing recommendations of political leaders using data on mobility from a sample of mobile p

289 Gender of code leader was not associated with cardiopulmonary resuscita

290 rts, stakeholders, and national organization leaders was convened in response to current practice cha

291 risks of GVHD associated with HLA-B M and T leaders were established in 17 100 (50.3%) HLA-matched a

292 nd skillsets normally required of university leaders were ill-suited to mounting an emergency respons

293 r in group rounds where voluntary, unselfish leaders were present.

294 In doing so, university leaders were thrust into unchartered waters and forced t

295 Are voters as polarized as political leaders when it comes to their preferences about how to

296 cluding factors related to leadership (e.g., leaders who communicate a culture of quality improvement

297 t important enablers are motivated clinician leaders who persist to find a path forward despite obsta

298 with the Pacific island nation of Palau as a leader with the recently established National Marine San

299 27 (30.1%) were run by female physician code leaders with 251 (76.8%) obtaining return of spontaneous

300 aviour of practitioners through 'key opinion leaders', with the main purpose of enhancing and perpetu