1 in age, clinical features, and outcome among
leading causes.
2 ative agent of hepatitis E in humans and the
leading cause for acute viral hepatitis worldwide.
3 Peri-implantitis is the
leading cause for IR.
4 l pathogenic Escherichia coli (ExPEC) is the
leading cause in humans of urinary tract infection and b
5 The
leading causes include vaccine-preventable diseases.
6 Kawasaki disease is the
leading cause of acquired heart disease among children i
7 Noroviruses are a
leading cause of acute gastroenteritis.
8 Respiratory syncytial virus (RSV) is the
leading cause of acute respiratory infections (ARI) in h
9 Stroke remains a
leading cause of adult disability and the demand for str
10 jection (ABMR) has been long recognized as a
leading cause of allograft failure after kidney transpla
11 sisted introductions of exotic species are a
leading cause of anthropogenic change in biodiversity; h
12 Pneumonia is the
leading cause of antibiotic use and hospitalization in V
13 Neisseria meningitidis is a
leading cause of bacterial meningitis and sepsis worldwi
14 Staphylococcus aureus is a
leading cause of bacterial pneumonia, and we have shown
15 Chlamydia trachomatis is the
leading cause of bacterial sexually transmitted infectio
16 Haemorrhage is the
leading cause of battlefield and civilian trauma deaths.
17 under immunosuppressed conditions and is the
leading cause of birth defects related to infectious dis
18 ) is a common complication of diabetes and a
leading cause of blindness among the working-age populat
19 pid progression of diabetic retinopathy, the
leading cause of blindness and vision loss in working ag
20 is a chronic, multifactorial disorder and a
leading cause of blindness in the elderly.
21 Inherited retinal disorder (IRD) is a
leading cause of blindness, and CRX is one of a number o
22 ocular hypertension and risk for glaucoma, a
leading cause of blindness.
23 The etiology of intussusception, the
leading cause of bowel obstruction in infants, is unknow
24 ve breast cancer (TNBC) after operation is a
leading cause of breast cancer related death.
25 Lung cancer is the world's
leading cause of cancer death and shows strong ancestry
26 Prostate cancer (PCa) is the second
leading cause of cancer death in men in America, and the
27 Prostate cancer (PCa) is the second
leading cause of cancer death in men.
28 alignancy, which is set to become the second
leading cause of cancer death in our society.
29 year survival rate and may become the second
leading cause of cancer death in the United States.
30 the development of gastric cancer, the third
leading cause of cancer death worldwide.
31 s a world health problem and it is the third
leading cause of cancer deaths worldwide.
32 Although prostate cancer is the
leading cause of cancer mortality for African men, the v
33 Lung cancer, the
leading cause of cancer mortality, exhibits heterogeneit
34 contemporary therapy, relapsed ALL remains a
leading cause of cancer-related death in children.
35 Advanced ovarian cancers are a
leading cause of cancer-related death in women and are c
36 Breast cancer is the second
leading cause of cancer-related death in women and is a
37 Cervical cancer was the
leading cause of cancer-related death in women in easter
38 Pancreatic ductal adenocarcinoma (PDAC) is a
leading cause of cancer-related death with a median surv
39 e fifth most common cancer and is the second
leading cause of cancer-related death worldwide, and NAF
40 Hepatocellular carcinoma (HCC) is the fourth
leading cause of cancer-related death worldwide, but its
41 ost commonly diagnosed cancer and the fourth
leading cause of cancer-related death worldwide.
42 every nine men in the USA and is the second
leading cause of cancer-related death.
43 Metastasis is the
leading cause of cancer-related death.
44 ant therapeutic advances, remains the second
leading cause of cancer-related death.
45 Pancreatic cancer is the fourth
leading cause of cancer-related deaths in Japan.
46 tor for the development of gastric cancer, a
leading cause of cancer-related deaths worldwide.
47 Gastric cancer (GC) is the third
leading cause of cancer-related mortality worldwide and
48 ng cancer; however, this disease remains the
leading cause of cancer-related mortality worldwide.
49 ldren and while highly curable, it remains a
leading cause of cancer-related mortality.
50 venous thromboembolism (VTE), are the third
leading cause of cardiovascular death in the United Stat
51 h protozoa of the genus Cryptosporidium is a
leading cause of child morbidity and mortality associate
52 Kawasaki disease (KD) is the
leading cause of childhood acquired heart disease in dev
53 Retinopathy of prematurity is a
leading cause of childhood blindness worldwide, but clin
54 ney and urinary tract (CAKUTs) represent the
leading cause of chronic kidney disease and end-stage ki
55 n-alcoholic fatty liver disease (NAFLD) is a
leading cause of chronic liver disease worldwide.
56 onalcoholic fatty liver disease (NAFLD) is a
leading cause of chronic liver disease, with global publ
57 ronic hepatitis C virus (HCV) infection is a
leading cause of cirrhosis worldwide and kills more Amer
58 chronic blood-borne pathogen in the US and a
leading cause of complications from chronic liver diseas
59 fects over half the world's population, is a
leading cause of congenital birth defects, and poses ser
60 ses, such as human cytomegalovirus (HCMV), a
leading cause of congenital infection and a major pathog
61 e.IMPORTANCE HSV-1 ocular infections are the
leading cause of corneal blindness.
62 hs endothelial corneal dystrophy (FECD) is a
leading cause of corneal endothelial (CE) degeneration r
63 d their loss, due to disease or trauma, is a
leading cause of deafness.
64 Heart failure was the
leading cause of death (10 of 17; 59%), and LV systolic
65 awareness that cardiovascular disease is the
leading cause of death (LCOD) among women is critical to
66 Cardiovascular disease (CVD) is the
leading cause of death among American Indians and Alaska
67 Cardiovascular disease (CVD) is the
leading cause of death among women in the United States.
68 ysregulated host response to infection, is a
leading cause of death and disability among children wor
69 Traumatic brain injury (TBI) is the
leading cause of death and disability due to trauma.
70 hypoxic-ischaemic encephalopathy (HIE) is a
leading cause of death and disability in children.
71 Stroke is a
leading cause of death and disability.
72 remain a major threat to humanity and are a
leading cause of death and disability.
73 As a
leading cause of death and morbidity, heart failure (HF)
74 Stroke is a
leading cause of death and the leading cause of long-ter
75 Cardiac arrest (CA) is a
leading cause of death and there is a necessity for anim
76 Tuberculosis (TB) is the
leading cause of death due to a single infectious diseas
77 Mycobacterium tuberculosis, the
leading cause of death due to infection, has a dynamic a
78 e following acute myocardial infarction is a
leading cause of death due to the inability of cardiomyo
79 Tuberculosis (TB) is the
leading cause of death from a single infectious agent, r
80 Mycobacterium tuberculosis is the
leading cause of death from bacterial infection.
81 Breast cancer is the second
leading cause of death from cancer in women in sub-Sahar
82 Mycobacterium tuberculosis (Mtb) is the
leading cause of death from infection worldwide(1).
83 Infections were the
leading cause of death in both early (47.2%) and late (3
84 Pediatric cancer is a
leading cause of death in children and adolescents.
85 se serious nosocomial infections and are the
leading cause of death in cystic fibrosis patients.
86 Heart failure (HF), the
leading cause of death in developed countries, occurs in
87 ction (respectively, HFrEF and HFpEF) is the
leading cause of death in developed countries.
88 Although cardiomyopathy has emerged as a
leading cause of death in Duchenne muscular dystrophy (D
89 people worldwide every year and remains the
leading cause of death in hospitals(1,2).
90 Suicide is the 10th
leading cause of death in North America and the foremost
91 Arterial cardiovascular events are the
leading cause of death in patients with JAK2V617F myelop
92 SC) may exceed 20%, and BTC is currently the
leading cause of death in patients with PSC.
93 Cancer is the
leading cause of death in Puerto Rico (PR).
94 oved survival, tuberculosis (TB) remains the
leading cause of death in the HIV-infected population.
95 Suicide is the 10th
leading cause of death in the United States.
96 Alzheimer's Disease (AD) is the sixth
leading cause of death in the United States.
97 ion and cardiovascular disease, which is the
leading cause of death in the United States.
98 Cardiovascular disease is the
leading cause of death in the US, and poor diet and lack
99 Cardiovascular disease (CVD) is a
leading cause of death in the US.
100 tegies for cardiovascular disease (CVD), the
leading cause of death in the world.
101 Cancer is the second
leading cause of death in the world.
102 Cardiovascular disease (CVD) is the
leading cause of death in women, who have a notable incr
103 of gestation) and its complications are the
leading cause of death of babies in the world, and those
104 ine strategies to mitigate what is still the
leading cause of death of men and women worldwide.
105 Stroke is the second
leading cause of death worldwide and a leading cause of
106 Suicide is a
leading cause of death worldwide and perhaps the most pu
107 However, stroke remains the second
leading cause of death worldwide and the number one caus
108 Pancreatic cancer is the fourth
leading cause of death worldwide due to its poorest prog
109 Preterm birth is the
leading cause of death worldwide in children under five
110 Cardiovascular disease (CVD) is the
leading cause of death worldwide, causing over 17 millio
111 reat advances in treatment, cancer remains a
leading cause of death worldwide.
112 e leading cause of disability and the second
leading cause of death worldwide.
113 uctive Pulmonary Disease (COPD) is the third
leading cause of death worldwide.
114 Heart failure is a
leading cause of death worldwide.
115 obstruction, and emphysema that represents a
leading cause of death worldwide.
116 sease (COPD) each year, and it is the fourth
leading cause of death.
117 rtality from cancer will probably become the
leading cause of death.
118 Suicide is a
leading cause of death.
119 y acute respiratory distress syndrome is the
leading cause of death.
120 lly involved in heart failure development, a
leading cause of deaths worldwide.
121 Alzheimer's disease, the
leading cause of dementia in the elderly, is a neurodege
122 Clostridioides difficile is the
leading cause of diarrhea in hospitalized U.S. patients
123 Astroviruses (AstV) are a
leading cause of diarrhea, especially in the very young,
124 Acute ischemic stroke is the
leading cause of disability and among the leading causes
125 Major depressive disorder is a
leading cause of disability and significant mortality, y
126 Neurological disorders are the
leading cause of disability and the second leading cause
127 illions of people worldwide and ranking as a
leading cause of disability for almost three decades.
128 Chronic neurological diseases are the
leading cause of disability globally.
129 Efforts to prevent depression, the
leading cause of disability worldwide, have focused on a
130 Major depressive disorder (MDD) is a
leading cause of disability worldwide, yet current treat
131 econd leading cause of death worldwide and a
leading cause of disability.
132 Depression is a
leading cause of disability.
133 Cardiovascular diseases remain the
leading cause of disease burden in the world.
134 s that by 2030, major depression will be the
leading cause of disease burden worldwide.
135 particulate matter pollution (PM2.5) is one
leading cause of disease burden, but no study has quanti
136 r in ~80% of DM1 patients and are the second
leading cause of DM1-related deaths.
137 hetic with a high bioavailability and is the
leading cause of drug overdose death in the U.S.
138 evere primary graft dysfunction (PGD) is the
leading cause of early death following cardiac transplan
139 nale: Primary graft dysfunction (PGD) is the
leading cause of early morbidity and mortality after lun
140 is a major complication of diabetes and the
leading cause of end-stage renal failure.
141 Campylobacter jejuni is a
leading cause of enteric bacterial illness in the United
142 Norovirus is a
leading cause of epidemic acute gastroenteritis (AGE) in
143 en unexpected death in epilepsy (SUDEP) is a
leading cause of epilepsy-related mortality in young adu
144 Although diabetic kidney disease is the
leading cause of ESKD in the United States, identifying
145 Clostridium perfringens is a
leading cause of food-poisoning and causes avian necroti
146 ponse to NoV.IMPORTANCE NoV infections are a
leading cause of gastroenteritis in the United States.
147 m for studying human norovirus, which is the
leading cause of gastroenteritis worldwide and thus a si
148 Human norovirus is the
leading cause of gastroenteritis worldwide, yet basic qu
149 Norovirus (NoV) infections are a
leading cause of gastroenteritis.
150 Human noroviruses (HuNoV) are the
leading cause of gastroenteritis.
151 Alcohol use disorder (AUD) is a
leading cause of global disease burden.
152 emic heart disease (IHD) and stroke, are the
leading cause of global mortality and a major contributo
153 Staphylococcus aureus is a
leading cause of health care-associated infections in th
154 Staphylococcus aureus is a
leading cause of healthcare- and community-associated in
155 enital cytomegalovirus (cCMV) infection is a
leading cause of hearing loss and neurological disabilit
156 Given that adverse remodeling is the
leading cause of heart failure and death in the USA, the
157 Ischemic heart disease is a
leading cause of heart failure and despite advanced ther
158 Hepatitis B virus (HBV) is the
leading cause of hepatocellular carcinoma (HCC) worldwid
159 Bronchiolitis is the
leading cause of hospital admission for respiratory dise
160 n-resistant enterococci (VRE) are the second
leading cause of hospital-acquired infections (HAIs) att
161 pathogens are a group of bacteria that are a
leading cause of hospital-acquired infections and a majo
162 Heart failure (HF) is a
leading cause of hospitalizations and readmissions in th
163 disease due to hepatitis C virus (HCV) is a
leading cause of human immunodeficiency virus (HIV)-rela
164 Staphylococcus aureus remains a
leading cause of human infection.
165 za viruses are highly infectious and are the
leading cause of human respiratory diseases and may trig
166 MYH7 (beta myosin heavy chain 7) represent a
leading cause of hypertrophic cardiomyopathy (HCM).
167 ng adolescents is rising globally and is the
leading cause of illness and disability among adolescent
168 nical relevance because preterm birth is the
leading cause of infant and under 5 year old child morta
169 Abusive head trauma (AHT) is the
leading cause of infant death and long-term morbidity fr
170 evastate people living with HIV and remain a
leading cause of infection-related deaths in this popula
171 Streptococcus pneumoniae (pneumococcus) is a
leading cause of infections worldwide.
172 loidy rate observed during female meiosis, a
leading cause of infertility and congenital disorders.
173 ansmitted bacterial disease globally and the
leading cause of infertility and preventable infectious
174 Scale (GCS) score was 13 (IQR 9-15), and the
leading cause of injury was road-traffic incident (6548
175 age-related macular degeneration (AMD), the
leading cause of irreversible blindness in the elderly.
176 a global public health problem and it is the
leading cause of irreversible blindness worldwide.
177 sease of retinal ganglion cells (RGCs), is a
leading cause of irreversible blindness worldwide.
178 d neurodegeneration in glaucoma, the world's
leading cause of irreversible blindness, and measured ho
179 degeneration is a hallmark of glaucoma, the
leading cause of irreversible blindness.
180 Glaucoma is a
leading cause of irreversible sight-loss and has been sh
181 Age-related macular degeneration (AMD), a
leading cause of irreversible vision impairment in the U
182 Glaucoma is a
leading cause of irreversible vision loss predicted to a
183 ge-related macular degeneration (AMD) is the
leading cause of legal blindness in adults 65 years of a
184 Hepatitis B virus (HBV) is a
leading cause of liver disease.
185 Hepatitis B virus (HBV) is a
leading cause of liver failure and hepatocellular carcin
186 ic steatohepatitis (NASH) represents another
leading cause of liver-related morbidity and mortality.
187 Stroke is a leading cause of death and the
leading cause of long-term disability, but its electroph
188 Respiratory syncytial virus (RSV) is the
leading cause of lower respiratory tract infection among
189 Respiratory syncytial virus is the
leading cause of lower respiratory tract infection among
190 Parainfluenza virus (PIV) is a
leading cause of lower respiratory tract infections.
191 Prostate cancer is the second
leading cause of male cancer death in the United States.
192 Pulmonary embolism (PE) is a
leading cause of maternal mortality, and deep vein throm
193 Liver disease is a
leading cause of morbidity and mortality among Human Imm
194 Cardiovascular disease (CVD) remains the
leading cause of morbidity and mortality for women in th
195 In particular, pulmonary disease is a
leading cause of morbidity and mortality in individuals
196 Cancer remains a
leading cause of morbidity and mortality worldwide, requ
197 unistic pathogen Pseudomonas aeruginosa is a
leading cause of morbidity and mortality worldwide.
198 Cardiac disease remains the
leading cause of morbidity and mortality worldwide.
199 Heart failure (HF) is a
leading cause of morbidity and mortality worldwide.
200 for a third of all cases of sepsis, and is a
leading cause of morbidity and mortality.
201 us increasing susceptibility to infection, a
leading cause of morbidity in those living with SCI.
202 Consequently, infection is a
leading cause of mortality after SCI.
203 socioeconomic burden worldwide and remains a
leading cause of mortality and disability despite signif
204 Tuberculosis (TB) is the
leading cause of mortality and morbidity in people livin
205 Tuberculosis (TB) is a
leading cause of mortality due to infectious disease, bu
206 Cardiovascular events are among the
leading cause of mortality in kidney and liver transplan
207 Background Cardiac involvement is the
leading cause of mortality in patients with Fabry diseas
208 Excessive alcohol use is the third
leading cause of mortality in the United States, where a
209 Chronic ethanol consumption is a
leading cause of mortality worldwide, with higher risks
210 Pneumonia is a
leading cause of mortality worldwide.
211 mulation of extracellular matrix (ECM), is a
leading cause of mortality worldwide.
212 mmation manifested as atherosclerosis is the
leading cause of mortality worldwide.
213 Cancer is a major health concern and a
leading cause of mortality.
214 a major carrier of the West Nile Virus, the
leading cause of mosquito-borne disease in the continent
215 The
leading cause of mutation due to oxidative damage is 8-o
216 s the most common nosocomial infection and a
leading cause of mycoses-related deaths.
217 Group B streptococcus (GBS) is the
leading cause of neonatal invasive disease worldwide.
218 causing imbalance, dizziness and falls, is a
leading cause of neurological disability.
219 cytomegalovirus (CMV) infections comprise a
leading cause of newborn impairments worldwide and are p
220 llular pathogen Chlamydia trachomatis is the
leading cause of noncongenital blindness and causative a
221 Clostridioides difficile is the
leading cause of nosocomial infections and a worldwide u
222 n, animal, and environmental commensal and a
leading cause of nosocomial infections, which are often
223 ) is a complex musculoskeletal disease and a
leading cause of pain and disability worldwide.
224 The pathophysiology of the
leading cause of pediatric acute nephritis, acute postin
225 Preterm birth (PTB) is the
leading cause of perinatal mortality and newborn complic
226 Stroke is a
leading cause of permanent disability.
227 Staphylococcus aureus is a
leading cause of pneumonia.
228 njury (TBI) causes early seizures and is the
leading cause of post-traumatic epilepsy.
229 Although S. aureus is a
leading cause of postsurgical infections, national estim
230 Noncompressible truncal hemorrhage is the
leading cause of potentially preventable death in trauma
231 nt and drug-induced liver injury (DILI) is a
leading cause of preclinical and clinical drug terminati
232 Misuse of prescription opioids is a
leading cause of premature death in the United States.
233 Tobacco use is the
leading cause of preventable death in the US.
234 Cigarette smoking is the
leading cause of preventable morbidity and mortality.
235 wild turkey (Meleagris gallopavo) nests is a
leading cause of reduced recruitment for the recovering
236 Respiratory syncytial virus (RSV) is a
leading cause of respiratory tract illness in young chil
237 Respiratory syncytial virus (RSV) is a
leading cause of respiratory tract infection (RTI) in yo
238 Vibrio parahaemolyticus is the
leading cause of seafood-borne diarrheal diseases.
239 of all live births worldwide, making it the
leading cause of sensorineural hearing loss (SNHL) in ch
240 ory syncytial virus (RSV) is recognised as a
leading cause of severe acute respiratory disease and de
241 Human noroviruses are the
leading cause of severe childhood diarrhea worldwide, ye
242 ertensive disorders of pregnancy (HDP) are a
leading cause of severe maternal morbidity (SMM), yet me
243 a significant threat to human health as the
leading cause of severe respiratory disease.
244 Chlamydia trachomatis is the
leading cause of sexually transmitted infections that ma
245 ted summer temperature is reported to be the
leading cause of stress in dairy and beef cows, which ne
246 Hypertrophic cardiomyopathy is the
leading cause of sudden cardiac death (SCD) in children
247 Long QT syndrome (LQTS) is a
leading cause of sudden cardiac death in early life and
248 Drug-induced liver injury (DILI) is a
leading cause of termination in drug development program
249 impact on patients and relatives, and is the
leading cause of the global burden from skin disease.
250 Late antibody-mediated rejection (ABMR) is a
leading cause of transplant failure.
251 Escherichia coli is the
leading cause of urinary tract infection, one of the mos
252 Uropathogenic Escherichia coli (UPEC), a
leading cause of urinary tract infections, is associated
253 s such as cerebral small vessel disease, the
leading cause of vascular dementia.
254 Human noroviruses (HuNoVs) are the
leading cause of viral gastroenteritis worldwide; yet cu
255 Respiratory syncytial virus (RSV) is a
leading cause of viral pneumonia and bronchiolitis durin
256 Diabetic macular edema (DME) is a
leading cause of vision loss in diabetics.
257 Age-related macular degeneration is a
leading cause of vision loss worldwide, and VEGF inhibit
258 h of retinal neurons and photoreceptors is a
leading cause of vision loss.
259 Depression is a
leading cause of worldwide disability but there remains
260 wheat growing regions of the world and is a
leading cause of yield loss in wheat.
261 Campylobacter jejuni is one of the
leading causes of bacterial gastroenteritis worldwide.
262 Staphylococcus aureus is among the
leading causes of bacterial infections worldwide.
263 tions, for example, retinitis pigmentosa are
leading causes of blindness worldwide.
264 on primary bone cancer and ranks amongst the
leading causes of cancer mortality in young adults.
265 Gastric cancer is one of the
leading causes of cancer-related death due to late diagn
266 Pancreatic cancer is one of the world's
leading causes of cancer-related death.
267 ns a highly lethal malignancy and one of the
leading causes of cancer-related deaths worldwide.
268 pancreatic cancer, and esophageal cancer are
leading causes of cancer-related deaths worldwide.
269 and is a significant contributor to 3 of the
leading causes of death among young persons (aged 10-24
270 are associated with barrier dysfunction, are
leading causes of death and disability.
271 FICANCE STATEMENT Brain stroke is one of the
leading causes of death and major disabilities in the el
272 Highly hazardous pesticides are among the
leading causes of death by suicide in low-income and mid
273 These five causes were found among the six
leading causes of death in most francophone countries.
274 Trauma is one of the
leading causes of death in people under the age of 49 an
275 Myocardial infarction (MI) is one of the
leading causes of death worldwide, and inflammation is c
276 rdiovascular and cerebrovascular events, the
leading causes of death worldwide.
277 monia resulting from infection is one of the
leading causes of death worldwide.
278 psy data are mainstays for the estimation of
leading causes of death, but both are non-specific and f
279 Cardiovascular diseases are
leading causes of death, globally, and health systems th
280 These pathogens are
leading causes of diarrhoea in young children and have b
281 Obesity is among the
leading causes of elevated cardiovascular disease mortal
282 l bowel obstruction (SBO) remains one of the
leading causes of emergency room visits and is still ass
283 uni is a zoonotic pathogen and is one of the
leading causes of human gastroenteritis worldwide.
284 ed macular degeneration (AMD), are among the
leading causes of incurable blindness in the Western wor
285 -associated pulmonary embolism is one of the
leading causes of maternal mortality.
286 Bipolar disorders (BDs) are among the
leading causes of morbidity and disability.
287 Cancer is one of the
leading causes of morbidity and mortality in the globe.
288 Stroke is one of the
leading causes of morbidity and mortality in the United
289 As one of the
leading causes of morbidity and mortality worldwide, dia
290 Cardiovascular disease (CVD) and cancer are
leading causes of morbidity and mortality worldwide.
291 d cerebrovascular diseases are currently the
leading causes of mortality and disability worldwide.
292 Cardiovascular diseases (CVDs) are among the
leading causes of mortality and morbidity worldwide.
293 Prostate cancer is one of the
leading causes of mortality in men.
294 he leading cause of disability and among the
leading causes of mortality worldwide.
295 te myocardial infarction (MI), is one of the
leading causes of mortality worldwide.
296 Since liver disease is one of the
leading causes of non-AIDS-related mortality in HIV-posi
297 ommon degenerative joint pathologies and are
leading causes of pain and disability in adults.
298 Stroke remains one of the
leading causes of permanent disability and death worldwi
299 Obesity is one of the
leading causes of preventable deaths.
300 Bordetella pertussis is among the
leading causes of vaccine-preventable deaths and morbidi