1 Kawasaki disease is the
leading cause of acquired heart disease among children i
2 Noroviruses are a
leading cause of acute gastroenteritis.
3 Respiratory syncytial virus (RSV) is the
leading cause of acute respiratory infections (ARI) in h
4 Stroke remains a
leading cause of adult disability and the demand for str
5 jection (ABMR) has been long recognized as a
leading cause of allograft failure after kidney transpla
6 sisted introductions of exotic species are a
leading cause of anthropogenic change in biodiversity; h
7 Pneumonia is the
leading cause of antibiotic use and hospitalization in V
8 Neisseria meningitidis is a
leading cause of bacterial meningitis and sepsis worldwi
9 Staphylococcus aureus is a
leading cause of bacterial pneumonia, and we have shown
10 Chlamydia trachomatis is the
leading cause of bacterial sexually transmitted infectio
11 Campylobacter jejuni is one of the
leading causes of bacterial gastroenteritis worldwide.
12 Staphylococcus aureus is among the
leading causes of bacterial infections worldwide.
13 Haemorrhage is the
leading cause of battlefield and civilian trauma deaths.
14 under immunosuppressed conditions and is the
leading cause of birth defects related to infectious dis
15 ) is a common complication of diabetes and a
leading cause of blindness among the working-age populat
16 pid progression of diabetic retinopathy, the
leading cause of blindness and vision loss in working ag
17 is a chronic, multifactorial disorder and a
leading cause of blindness in the elderly.
18 Inherited retinal disorder (IRD) is a
leading cause of blindness, and CRX is one of a number o
19 ocular hypertension and risk for glaucoma, a
leading cause of blindness.
20 tions, for example, retinitis pigmentosa are
leading causes of blindness worldwide.
21 The etiology of intussusception, the
leading cause of bowel obstruction in infants, is unknow
22 ve breast cancer (TNBC) after operation is a
leading cause of breast cancer related death.
23 Lung cancer is the world's
leading cause of cancer death and shows strong ancestry
24 Prostate cancer (PCa) is the second
leading cause of cancer death in men in America, and the
25 Prostate cancer (PCa) is the second
leading cause of cancer death in men.
26 alignancy, which is set to become the second
leading cause of cancer death in our society.
27 year survival rate and may become the second
leading cause of cancer death in the United States.
28 the development of gastric cancer, the third
leading cause of cancer death worldwide.
29 s a world health problem and it is the third
leading cause of cancer deaths worldwide.
30 Although prostate cancer is the
leading cause of cancer mortality for African men, the v
31 Lung cancer, the
leading cause of cancer mortality, exhibits heterogeneit
32 contemporary therapy, relapsed ALL remains a
leading cause of cancer-related death in children.
33 Advanced ovarian cancers are a
leading cause of cancer-related death in women and are c
34 Breast cancer is the second
leading cause of cancer-related death in women and is a
35 Cervical cancer was the
leading cause of cancer-related death in women in easter
36 Pancreatic ductal adenocarcinoma (PDAC) is a
leading cause of cancer-related death with a median surv
37 e fifth most common cancer and is the second
leading cause of cancer-related death worldwide, and NAF
38 Hepatocellular carcinoma (HCC) is the fourth
leading cause of cancer-related death worldwide, but its
39 ost commonly diagnosed cancer and the fourth
leading cause of cancer-related death worldwide.
40 every nine men in the USA and is the second
leading cause of cancer-related death.
41 Metastasis is the
leading cause of cancer-related death.
42 ant therapeutic advances, remains the second
leading cause of cancer-related death.
43 Pancreatic cancer is the fourth
leading cause of cancer-related deaths in Japan.
44 tor for the development of gastric cancer, a
leading cause of cancer-related deaths worldwide.
45 Gastric cancer (GC) is the third
leading cause of cancer-related mortality worldwide and
46 ng cancer; however, this disease remains the
leading cause of cancer-related mortality worldwide.
47 ldren and while highly curable, it remains a
leading cause of cancer-related mortality.
48 on primary bone cancer and ranks amongst the
leading causes of cancer mortality in young adults.
49 Gastric cancer is one of the
leading causes of cancer-related death due to late diagn
50 Pancreatic cancer is one of the world's
leading causes of cancer-related death.
51 ns a highly lethal malignancy and one of the
leading causes of cancer-related deaths worldwide.
52 pancreatic cancer, and esophageal cancer are
leading causes of cancer-related deaths worldwide.
53 venous thromboembolism (VTE), are the third
leading cause of cardiovascular death in the United Stat
54 h protozoa of the genus Cryptosporidium is a
leading cause of child morbidity and mortality associate
55 Kawasaki disease (KD) is the
leading cause of childhood acquired heart disease in dev
56 Retinopathy of prematurity is a
leading cause of childhood blindness worldwide, but clin
57 ney and urinary tract (CAKUTs) represent the
leading cause of chronic kidney disease and end-stage ki
58 n-alcoholic fatty liver disease (NAFLD) is a
leading cause of chronic liver disease worldwide.
59 onalcoholic fatty liver disease (NAFLD) is a
leading cause of chronic liver disease, with global publ
60 ronic hepatitis C virus (HCV) infection is a
leading cause of cirrhosis worldwide and kills more Amer
61 chronic blood-borne pathogen in the US and a
leading cause of complications from chronic liver diseas
62 fects over half the world's population, is a
leading cause of congenital birth defects, and poses ser
63 ses, such as human cytomegalovirus (HCMV), a
leading cause of congenital infection and a major pathog
64 e.IMPORTANCE HSV-1 ocular infections are the
leading cause of corneal blindness.
65 hs endothelial corneal dystrophy (FECD) is a
leading cause of corneal endothelial (CE) degeneration r
66 d their loss, due to disease or trauma, is a
leading cause of deafness.
67 Heart failure was the
leading cause of death (10 of 17; 59%), and LV systolic
68 awareness that cardiovascular disease is the
leading cause of death (LCOD) among women is critical to
69 Cardiovascular disease (CVD) is the
leading cause of death among American Indians and Alaska
70 Cardiovascular disease (CVD) is the
leading cause of death among women in the United States.
71 ysregulated host response to infection, is a
leading cause of death and disability among children wor
72 Traumatic brain injury (TBI) is the
leading cause of death and disability due to trauma.
73 hypoxic-ischaemic encephalopathy (HIE) is a
leading cause of death and disability in children.
74 Stroke is a
leading cause of death and disability.
75 remain a major threat to humanity and are a
leading cause of death and disability.
76 As a
leading cause of death and morbidity, heart failure (HF)
77 Stroke is a
leading cause of death and the leading cause of long-ter
78 Cardiac arrest (CA) is a
leading cause of death and there is a necessity for anim
79 Tuberculosis (TB) is the
leading cause of death due to a single infectious diseas
80 Mycobacterium tuberculosis, the
leading cause of death due to infection, has a dynamic a
81 e following acute myocardial infarction is a
leading cause of death due to the inability of cardiomyo
82 Tuberculosis (TB) is the
leading cause of death from a single infectious agent, r
83 Mycobacterium tuberculosis is the
leading cause of death from bacterial infection.
84 Breast cancer is the second
leading cause of death from cancer in women in sub-Sahar
85 Mycobacterium tuberculosis (Mtb) is the
leading cause of death from infection worldwide(1).
86 Infections were the
leading cause of death in both early (47.2%) and late (3
87 Pediatric cancer is a
leading cause of death in children and adolescents.
88 se serious nosocomial infections and are the
leading cause of death in cystic fibrosis patients.
89 Heart failure (HF), the
leading cause of death in developed countries, occurs in
90 ction (respectively, HFrEF and HFpEF) is the
leading cause of death in developed countries.
91 Although cardiomyopathy has emerged as a
leading cause of death in Duchenne muscular dystrophy (D
92 people worldwide every year and remains the
leading cause of death in hospitals(1,2).
93 Suicide is the 10th
leading cause of death in North America and the foremost
94 Arterial cardiovascular events are the
leading cause of death in patients with JAK2V617F myelop
95 SC) may exceed 20%, and BTC is currently the
leading cause of death in patients with PSC.
96 Cancer is the
leading cause of death in Puerto Rico (PR).
97 oved survival, tuberculosis (TB) remains the
leading cause of death in the HIV-infected population.
98 Suicide is the 10th
leading cause of death in the United States.
99 Alzheimer's Disease (AD) is the sixth
leading cause of death in the United States.
100 ion and cardiovascular disease, which is the
leading cause of death in the United States.
101 Cardiovascular disease is the
leading cause of death in the US, and poor diet and lack
102 Cardiovascular disease (CVD) is a
leading cause of death in the US.
103 tegies for cardiovascular disease (CVD), the
leading cause of death in the world.
104 Cancer is the second
leading cause of death in the world.
105 Cardiovascular disease (CVD) is the
leading cause of death in women, who have a notable incr
106 of gestation) and its complications are the
leading cause of death of babies in the world, and those
107 ine strategies to mitigate what is still the
leading cause of death of men and women worldwide.
108 Stroke is the second
leading cause of death worldwide and a leading cause of
109 Suicide is a
leading cause of death worldwide and perhaps the most pu
110 However, stroke remains the second
leading cause of death worldwide and the number one caus
111 Pancreatic cancer is the fourth
leading cause of death worldwide due to its poorest prog
112 Preterm birth is the
leading cause of death worldwide in children under five
113 Cardiovascular disease (CVD) is the
leading cause of death worldwide, causing over 17 millio
114 reat advances in treatment, cancer remains a
leading cause of death worldwide.
115 e leading cause of disability and the second
leading cause of death worldwide.
116 uctive Pulmonary Disease (COPD) is the third
leading cause of death worldwide.
117 Heart failure is a
leading cause of death worldwide.
118 obstruction, and emphysema that represents a
leading cause of death worldwide.
119 sease (COPD) each year, and it is the fourth
leading cause of death.
120 rtality from cancer will probably become the
leading cause of death.
121 Suicide is a
leading cause of death.
122 y acute respiratory distress syndrome is the
leading cause of death.
123 and is a significant contributor to 3 of the
leading causes of death among young persons (aged 10-24
124 are associated with barrier dysfunction, are
leading causes of death and disability.
125 FICANCE STATEMENT Brain stroke is one of the
leading causes of death and major disabilities in the el
126 Highly hazardous pesticides are among the
leading causes of death by suicide in low-income and mid
127 These five causes were found among the six
leading causes of death in most francophone countries.
128 Trauma is one of the
leading causes of death in people under the age of 49 an
129 Myocardial infarction (MI) is one of the
leading causes of death worldwide, and inflammation is c
130 rdiovascular and cerebrovascular events, the
leading causes of death worldwide.
131 monia resulting from infection is one of the
leading causes of death worldwide.
132 psy data are mainstays for the estimation of
leading causes of death, but both are non-specific and f
133 Cardiovascular diseases are
leading causes of death, globally, and health systems th
134 lly involved in heart failure development, a
leading cause of deaths worldwide.
135 Alzheimer's disease, the
leading cause of dementia in the elderly, is a neurodege
136 Clostridioides difficile is the
leading cause of diarrhea in hospitalized U.S. patients
137 Astroviruses (AstV) are a
leading cause of diarrhea, especially in the very young,
138 These pathogens are
leading causes of diarrhoea in young children and have b
139 Acute ischemic stroke is the
leading cause of disability and among the leading causes
140 Major depressive disorder is a
leading cause of disability and significant mortality, y
141 Neurological disorders are the
leading cause of disability and the second leading cause
142 illions of people worldwide and ranking as a
leading cause of disability for almost three decades.
143 Chronic neurological diseases are the
leading cause of disability globally.
144 Efforts to prevent depression, the
leading cause of disability worldwide, have focused on a
145 Major depressive disorder (MDD) is a
leading cause of disability worldwide, yet current treat
146 deficits after traumatic brain injury are a
leading cause of disability worldwide, yet no effective
147 econd leading cause of death worldwide and a
leading cause of disability.
148 Depression is a
leading cause of disability.
149 Cardiovascular diseases remain the
leading cause of disease burden in the world.
150 s that by 2030, major depression will be the
leading cause of disease burden worldwide.
151 particulate matter pollution (PM2.5) is one
leading cause of disease burden, but no study has quanti
152 r in ~80% of DM1 patients and are the second
leading cause of DM1-related deaths.
153 hetic with a high bioavailability and is the
leading cause of drug overdose death in the U.S.
154 evere primary graft dysfunction (PGD) is the
leading cause of early death following cardiac transplan
155 nale: Primary graft dysfunction (PGD) is the
leading cause of early morbidity and mortality after lun
156 Obesity is among the
leading causes of elevated cardiovascular disease mortal
157 l bowel obstruction (SBO) remains one of the
leading causes of emergency room visits and is still ass
158 is a major complication of diabetes and the
leading cause of end-stage renal failure.
159 Campylobacter jejuni is a
leading cause of enteric bacterial illness in the United
160 Norovirus is a
leading cause of epidemic acute gastroenteritis (AGE) in
161 en unexpected death in epilepsy (SUDEP) is a
leading cause of epilepsy-related mortality in young adu
162 Although diabetic kidney disease is the
leading cause of ESKD in the United States, identifying
163 Clostridium perfringens is a
leading cause of food-poisoning and causes avian necroti
164 ponse to NoV.IMPORTANCE NoV infections are a
leading cause of gastroenteritis in the United States.
165 m for studying human norovirus, which is the
leading cause of gastroenteritis worldwide and thus a si
166 Human norovirus is the
leading cause of gastroenteritis worldwide, yet basic qu
167 Norovirus (NoV) infections are a
leading cause of gastroenteritis.
168 Human noroviruses (HuNoV) are the
leading cause of gastroenteritis.
169 Alcohol use disorder (AUD) is a
leading cause of global disease burden.
170 emic heart disease (IHD) and stroke, are the
leading cause of global mortality and a major contributo
171 Staphylococcus aureus is a
leading cause of health care-associated infections in th
172 Staphylococcus aureus is a
leading cause of healthcare- and community-associated in
173 ioides (formerly Clostridium) difficile is a
leading cause of healthcare-associated infections.
174 enital cytomegalovirus (cCMV) infection is a
leading cause of hearing loss and neurological disabilit
175 Given that adverse remodeling is the
leading cause of heart failure and death in the USA, the
176 Ischemic heart disease is a
leading cause of heart failure and despite advanced ther
177 Hepatitis B virus (HBV) is the
leading cause of hepatocellular carcinoma (HCC) worldwid
178 Bronchiolitis is the
leading cause of hospital admission for respiratory dise
179 n-resistant enterococci (VRE) are the second
leading cause of hospital-acquired infections (HAIs) att
180 pathogens are a group of bacteria that are a
leading cause of hospital-acquired infections and a majo
181 Heart failure (HF) is a
leading cause of hospitalizations and readmissions in th
182 disease due to hepatitis C virus (HCV) is a
leading cause of human immunodeficiency virus (HIV)-rela
183 Staphylococcus aureus remains a
leading cause of human infection.
184 za viruses are highly infectious and are the
leading cause of human respiratory diseases and may trig
185 uni is a zoonotic pathogen and is one of the
leading causes of human gastroenteritis worldwide.
186 MYH7 (beta myosin heavy chain 7) represent a
leading cause of hypertrophic cardiomyopathy (HCM).
187 ng adolescents is rising globally and is the
leading cause of illness and disability among adolescent
188 ed macular degeneration (AMD), are among the
leading causes of incurable blindness in the Western wor
189 nical relevance because preterm birth is the
leading cause of infant and under 5 year old child morta
190 Abusive head trauma (AHT) is the
leading cause of infant death and long-term morbidity fr
191 evastate people living with HIV and remain a
leading cause of infection-related deaths in this popula
192 Streptococcus pneumoniae (pneumococcus) is a
leading cause of infections worldwide.
193 Pneumonia is the
leading cause of infectious related death costing 12 bil
194 loidy rate observed during female meiosis, a
leading cause of infertility and congenital disorders.
195 ansmitted bacterial disease globally and the
leading cause of infertility and preventable infectious
196 Scale (GCS) score was 13 (IQR 9-15), and the
leading cause of injury was road-traffic incident (6548
197 age-related macular degeneration (AMD), the
leading cause of irreversible blindness in the elderly.
198 a global public health problem and it is the
leading cause of irreversible blindness worldwide.
199 sease of retinal ganglion cells (RGCs), is a
leading cause of irreversible blindness worldwide.
200 d neurodegeneration in glaucoma, the world's
leading cause of irreversible blindness, and measured ho
201 degeneration is a hallmark of glaucoma, the
leading cause of irreversible blindness.
202 Glaucoma is a
leading cause of irreversible sight-loss and has been sh
203 Age-related macular degeneration (AMD), a
leading cause of irreversible vision impairment in the U
204 Glaucoma is a
leading cause of irreversible vision loss predicted to a
205 ge-related macular degeneration (AMD) is the
leading cause of legal blindness in adults 65 years of a
206 Hepatitis B virus (HBV) is a
leading cause of liver disease.
207 Hepatitis B virus (HBV) is a
leading cause of liver failure and hepatocellular carcin
208 ic steatohepatitis (NASH) represents another
leading cause of liver-related morbidity and mortality.
209 Stroke is a leading cause of death and the
leading cause of long-term disability, but its electroph
210 Respiratory syncytial virus (RSV) is the
leading cause of lower respiratory tract infection among
211 Respiratory syncytial virus is the
leading cause of lower respiratory tract infection among
212 Parainfluenza virus (PIV) is a
leading cause of lower respiratory tract infections.
213 Prostate cancer is the second
leading cause of male cancer death in the United States.
214 Pulmonary embolism (PE) is a
leading cause of maternal mortality, and deep vein throm
215 -associated pulmonary embolism is one of the
leading causes of maternal mortality.
216 Liver disease is a
leading cause of morbidity and mortality among Human Imm
217 Cardiovascular disease (CVD) remains the
leading cause of morbidity and mortality for women in th
218 In particular, pulmonary disease is a
leading cause of morbidity and mortality in individuals
219 Cancer remains a
leading cause of morbidity and mortality worldwide, requ
220 unistic pathogen Pseudomonas aeruginosa is a
leading cause of morbidity and mortality worldwide.
221 Cardiac disease remains the
leading cause of morbidity and mortality worldwide.
222 Heart failure (HF) is a
leading cause of morbidity and mortality worldwide.
223 Ischemic stroke is a
leading cause of morbidity and mortality worldwide.
224 for a third of all cases of sepsis, and is a
leading cause of morbidity and mortality.
225 us increasing susceptibility to infection, a
leading cause of morbidity in those living with SCI.
226 Bipolar disorders (BDs) are among the
leading causes of morbidity and disability.
227 Cancer is one of the
leading causes of morbidity and mortality in the globe.
228 Stroke is one of the
leading causes of morbidity and mortality in the United
229 As one of the
leading causes of morbidity and mortality worldwide, dia
230 Cardiovascular disease (CVD) and cancer are
leading causes of morbidity and mortality worldwide.
231 Consequently, infection is a
leading cause of mortality after SCI.
232 socioeconomic burden worldwide and remains a
leading cause of mortality and disability despite signif
233 Tuberculosis (TB) is the
leading cause of mortality and morbidity in people livin
234 Tuberculosis (TB) is a
leading cause of mortality due to infectious disease, bu
235 Cardiovascular events are among the
leading cause of mortality in kidney and liver transplan
236 Background Cardiac involvement is the
leading cause of mortality in patients with Fabry diseas
237 Excessive alcohol use is the third
leading cause of mortality in the United States, where a
238 Chronic ethanol consumption is a
leading cause of mortality worldwide, with higher risks
239 Pneumonia is a
leading cause of mortality worldwide.
240 mulation of extracellular matrix (ECM), is a
leading cause of mortality worldwide.
241 mmation manifested as atherosclerosis is the
leading cause of mortality worldwide.
242 Cancer is a major health concern and a
leading cause of mortality.
243 d cerebrovascular diseases are currently the
leading causes of mortality and disability worldwide.
244 Cardiovascular diseases (CVDs) are among the
leading causes of mortality and morbidity worldwide.
245 Prostate cancer is one of the
leading causes of mortality in men.
246 he leading cause of disability and among the
leading causes of mortality worldwide.
247 te myocardial infarction (MI), is one of the
leading causes of mortality worldwide.
248 a major carrier of the West Nile Virus, the
leading cause of mosquito-borne disease in the continent
249 The
leading cause of mutation due to oxidative damage is 8-o
250 s the most common nosocomial infection and a
leading cause of mycoses-related deaths.
251 Group B streptococcus (GBS) is the
leading cause of neonatal invasive disease worldwide.
252 causing imbalance, dizziness and falls, is a
leading cause of neurological disability.
253 cytomegalovirus (CMV) infections comprise a
leading cause of newborn impairments worldwide and are p
254 Since liver disease is one of the
leading causes of non-AIDS-related mortality in HIV-posi
255 llular pathogen Chlamydia trachomatis is the
leading cause of noncongenital blindness and causative a
256 Clostridioides difficile is the
leading cause of nosocomial infections and a worldwide u
257 n, animal, and environmental commensal and a
leading cause of nosocomial infections, which are often
258 ) is a complex musculoskeletal disease and a
leading cause of pain and disability worldwide.
259 ommon degenerative joint pathologies and are
leading causes of pain and disability in adults.
260 The pathophysiology of the
leading cause of pediatric acute nephritis, acute postin
261 Preterm birth (PTB) is the
leading cause of perinatal mortality and newborn complic
262 Stroke is a
leading cause of permanent disability.
263 Stroke remains one of the
leading causes of permanent disability and death worldwi
264 Staphylococcus aureus is a
leading cause of pneumonia.
265 njury (TBI) causes early seizures and is the
leading cause of post-traumatic epilepsy.
266 Although S. aureus is a
leading cause of postsurgical infections, national estim
267 Noncompressible truncal hemorrhage is the
leading cause of potentially preventable death in trauma
268 nt and drug-induced liver injury (DILI) is a
leading cause of preclinical and clinical drug terminati
269 Misuse of prescription opioids is a
leading cause of premature death in the United States.
270 Tobacco use is the
leading cause of preventable death in the US.
271 Cigarette smoking is the
leading cause of preventable morbidity and mortality.
272 Obesity is one of the
leading causes of preventable deaths.
273 wild turkey (Meleagris gallopavo) nests is a
leading cause of reduced recruitment for the recovering
274 Respiratory syncytial virus (RSV) is a
leading cause of respiratory tract illness in young chil
275 Respiratory syncytial virus (RSV) is a
leading cause of respiratory tract infection (RTI) in yo
276 Vibrio parahaemolyticus is the
leading cause of seafood-borne diarrheal diseases.
277 of all live births worldwide, making it the
leading cause of sensorineural hearing loss (SNHL) in ch
278 ory syncytial virus (RSV) is recognised as a
leading cause of severe acute respiratory disease and de
279 Human noroviruses are the
leading cause of severe childhood diarrhea worldwide, ye
280 ertensive disorders of pregnancy (HDP) are a
leading cause of severe maternal morbidity (SMM), yet me
281 a significant threat to human health as the
leading cause of severe respiratory disease.
282 Chlamydia trachomatis is the
leading cause of sexually transmitted infections that ma
283 ted summer temperature is reported to be the
leading cause of stress in dairy and beef cows, which ne
284 Hypertrophic cardiomyopathy is the
leading cause of sudden cardiac death (SCD) in children
285 Long QT syndrome (LQTS) is a
leading cause of sudden cardiac death in early life and
286 Drug-induced liver injury (DILI) is a
leading cause of termination in drug development program
287 impact on patients and relatives, and is the
leading cause of the global burden from skin disease.
288 Late antibody-mediated rejection (ABMR) is a
leading cause of transplant failure.
289 Escherichia coli is the
leading cause of urinary tract infection, one of the mos
290 Uropathogenic Escherichia coli (UPEC), a
leading cause of urinary tract infections, is associated
291 Bordetella pertussis is among the
leading causes of vaccine-preventable deaths and morbidi
292 s such as cerebral small vessel disease, the
leading cause of vascular dementia.
293 Human noroviruses (HuNoVs) are the
leading cause of viral gastroenteritis worldwide; yet cu
294 Respiratory syncytial virus (RSV) is a
leading cause of viral pneumonia and bronchiolitis durin
295 Diabetic macular edema (DME) is a
leading cause of vision loss in diabetics.
296 Age-related macular degeneration is a
leading cause of vision loss worldwide, and VEGF inhibit
297 Diabetic macular edema (DME) remains a
leading cause of vision loss worldwide.
298 h of retinal neurons and photoreceptors is a
leading cause of vision loss.
299 Depression is a
leading cause of worldwide disability but there remains
300 wheat growing regions of the world and is a
leading cause of yield loss in wheat.