ライフサイエンスコーパス: leading edge

1 ta1 regulated the positioning of Abi1 at the leading edge.

2 ntegrin-beta first accumulated at the cell's leading edge.

3 positioning of new rows of adhesions at the leading edge.

4 ics and actin cytoskeleton remodeling at the leading edge.

5 ngth results in waving protrusion of a short leading edge.

6 alizes both to adhesion complexes and to the leading edge.

7 osomes (but not other organelles) toward the leading edge.

8 f Rac2 and then Cdc42 immediately behind the leading edge.

9 ctions, and lead migrating clusters near the leading edge.

10 ssembly predominates over disassembly at the leading edge.

11 5% and with >80% of the regulon genes in the leading edge.

12 igher pPLCgamma1, which was localized at the leading edge.

13 induced calcium mobilization in cells at the leading edge.

14 se string indents the dorsal surface at each leading edge.

15 en protrusion to adhesion and advance of the leading edge.

16 HSP90alpha-AHA1-survivin complex toward the leading edge.

17 omotes reorientation of the Golgi toward the leading edge.

18 ation and Arp2/3 complex localization at the leading edge.

19 triphosphate (PIP3) from distributing to the leading edge.

20 regulates Arp2/3 complex localization at the leading edge.

21 gulate the Arp2/3 complex and Cofilin at the leading edge.

22 l morphology, including the loss of a single leading edge.

23 red for the dynamic remodeling of the cell's leading edge.

24 those that do, reorient to maintain the same leading edge.

25 n sheath enables membrane trafficking to the leading edge.

26 force transmission from the cell body to the leading edge.

27 hr-7 regulates Rab5a trafficking to the cell leading edge.

28 lipodial protrusions at each follicle cell's leading edge.

29 ymerization against the membrane at the cell leading edge.

30 and Rab6IP2 in microtubule tethering at the leading edge.

31 plex assemble branched actin networks at the leading edge.

32 important for the recruitment of Abi1 to the leading edge.

33 cell migration, with larger forces near the leading edge.

34 s rotatin localizes at the centrosome in the leading edge.

35 ces generated by the actomyosin cable at the leading edge.

36 the plasma membrane and the diglycine to the leading edge.

37 ns localize in nascent adhesions at the cell leading edge.

38 ntegrin at sites of cell adhesion and at the leading edge.

39 edge progression, and (ii) destabilises the leading edge.

40 where normal stresses almost vanish at their leading edge.

41 osphorylated cortactin is enriched along the leading edge.

42 localized pressure gradient at the bacterial leading edge.

43 essary and sufficient for p190A targeting to leading edges.

44 s and no measurable shifts in their northern leading edges.

45 usions associated with invadopodia and other leading edges.

46 entrosome and Golgi reorientation toward the leading edge, a hallmark of cell polarization to ensure

47 ere is a significant decrease in the rate of leading edge actin extension in WAVE2 KO cells, and an i

48 that a surprising intercellular coupling of leading edge actin networks forms the basis of mutual re

49 spensable for transient NA stabilization and leading edge advance.

50 hesions (NAs) within the protrusion to drive leading edge advance.

51 The dependence of myosin II in leading-edge advancement helps explain the previously re

52 ssociation times (between each binding event leading edge), allow for sensitive and quantitative meas

53 lopodia-based probing mechanism ahead of the leading edge allows cells to migrate efficiently, by sen

54 Gene set enrichment and leading edge analyses identified Sphingosine kinase 1 (S

55 s a net inflow of water and ions at the cell leading edge and a net outflow of water and ions at the

56 elicit mechanosensitive signaling within the leading edge and align the ECM, creating microtracks con

57 typic differences between individuals at the leading edge and core of the range.

58 anoids use CXCR4 and DDR2 to polarize to the leading edge and direct migration.

59 By driving reorientation of the Golgi to the leading edge and driving forward trafficking, particular

60 the cell rear in response to turning of the leading edge and facilitates efficient turning by rapidl

61 GflB localizes to the leading edge and functions as a Galpha-stimulated, Rap1-

62 is balance, including population size at the leading edge and mating system.

63 e of PFN1, Arp2/3 no longer localizes to the leading edge and Mena/VASP is non-functional.

64 brain-expressed protein (KIBRA) at the cell leading edge and overexpression of KIBRA was able to rev

65 icrometers from the cell body, extending the leading edge and promoting highly persistent directional

66 trate rigidity at a distance in front of the leading edge and regulated their responses based on the

67 ochannel bifurcation, they often split their leading edge and start moving into both channels, before

68 ences protrusive activity from the epidermal leading edge and the protrusion area changes in accord w

69 n intermediate filaments and to membranes at leading edges and macropinosomes.

70 ulation of F-actin and myosin L chain at the leading edge, and accumulation of phosphorylated myosin

71 restricts the rate of actin extension at the leading edge, and appears to couple actin networks to th

72 the signalling networks present at the glial-leading edge, and novel proteins, including members of t

73 istribution of integrin tensions at the cell leading edge, and showed that force distribution in foca

74 The EMPOWER trial incorporates leading-edge approaches in human motivation, derived fro

75 Stress fibers newly formed near the leading edge are enriched in NMIIA, but over time, they

76 uent inhibition of Myosin II activity at the leading edge are required for mesenchymal chemotaxis.

77 ns that "zipper" up proximally, but at their leading edges are free to make junctions containing the

78 mble a contractile actomyosin cable at their leading edge, as well as dynamic filopodia that finally

79 maging showed that, whereas most MIIA at the leading edge assembled into dorsal contractile arcs, a s

80 It is marked by a sharp leading edge at the potential minimum and a curved rear.

81 ordinating cytoskeletal rearrangement at the leading edge, both of which processes are early signalin

82 (i) forward and reverse movement of the RNAP leading edge, but not trailing edge, relative to DNA, an

83 es in which local depletion of VASP from the leading edge by adhesions-along with lateral propagation

84 tion of the lens epithelium, directed at the leading edge by an innate mesenchymal subpopulation of v

85 cable contributes to the fluidization of the leading edge by driving sequential eviction and intercal

86 p2/3-dependent actin network assembly at the leading edge by promoting barbed-end capping there.

87 by promoting F-actin assembly at the myotube leading edge, by restoring the expression of additional

88 ted zipping dynamics and found that apposing leading edge cells come together at their apical ends an

89 ols the specification and differentiation of leading edge cells during Drosophila melanogaster dorsal

90 t traction stresses are limited primarily to leading edge cells in mesendoderm explants, and that the

91 This leading-edge circuit includes a putative amplification m

92 with actomyosin-rich purse strings near each leading edge) close an eye-shaped opening that is filled

93 tip complex in migrating B16F1 cells: small leading-edge clusters of the adaptor protein lamellipodi

94 centrioles align between the nucleus and the leading edge creating an axis of migration with apically

95 d targets with actin-rich projections at the leading edge, creating an initially actin-enriched conta

96 r a set-reset latch, two-bit shift register, leading-edge detector, digital-to-analog converter (DAC)

97 that invokes net membrane deposition at the leading edge due to an imbalance between the endocytic a

98 lar extensions that drive advancement of the leading edge during cell migration.

99 formation of branched actin networks at the leading edge during cell motility and endo/exocytosis, w

100 4P-containing vesicles move to the migratory leading edge during migration and that some of these ves

101 is required for the construction of a motile leading edge during wound healing.

102 The leading edge dynamically switches between the formation

103 4) whether Arp2/3, previously implicated in leading edge dynamics and migration, contributes to canc

104 Thus, CIN coordinates the leading edge dynamics by controlling active cofilin leve

105 s in contractility, adhesion, migration, and leading edge dynamics.

106 he Canada Excellence Research Chairs (CERC), Leading Edge Endowment Fund (LEEF), Don Rix BC Leadershi

107 on at the leading edge oscillates, with VASP leading-edge enrichment greatest just prior to protrusio

108 involve a cycle of behaviours beginning with leading edge extension.

109 ctivation of Rac2 in regions distal from the leading edge, followed by the activation of Rac1, a seco

110 es, rocket nozzle inserts, and nose cones or leading edges for hypersonic aerospace vehicles.

111 ally organize actin nucleation for efficient leading edge formation and cell movement.

112 simultaneously increasing uropod elongation, leading edge formation, and random migration.

113 and cytoskeleton remodeling, which promoted leading-edge formation.

114 of this pathway, neutrophils exhibit larger leading edges, higher membrane tension, and profoundly d

115 We show that CIN translocates to the leading edge in a PI3-kinase-, Rac1-, and cofilin-depend

116 I is concentrated in arc-like regions of the leading edge in between FLPs, and its activity is requir

117 but are insufficient to produce a continuous leading edge in fibroblasts lacking Arp2/3 complex.

118 ow directly from microtubule tips toward the leading edge in growth cones of hippocampal neurons.

119 tility and mitochondrial movement toward the leading edge in invasive breast cancer cells.

120 mor organoid and migrated (polarized) to the leading edge in response to biochemical and biomechanica

121 GLK and IQGAP1 colocalized at the leading edge including filopodia and lamellipodia of mig

122 promotes cytoskeletal rearrangements at the leading edge, increased focal adhesion and cellular stif

123 ized by the persistent protrusion of a broad leading edge, increasing cell-substrate adhesion strengt

124 RAC1 potentiated ORAI1 translocation to the leading edge, increasing the availability of surface ORA

125 to show that actin-based protrusions at the leading edge initiate macrophage fusion.

126 that an actin-based protrusion formed at the leading edge initiates macrophage fusion.

127 ion of active control of bow shock waves via leading edge injection, including subsonic coolant eject

128 menon is documented for a supersonic airfoil leading edge injection.

129 eral PG (pPG) synthesis (outer ring) and the leading-edge (inner ring) of septal PG (sPG) synthesis.

130 ntrast, flow of the actin network behind the leading edge is highly persistent.

131 egion expands with a sharp transition at the leading edge; it is this sharp gradient in hydrophilicit

132 filopodia, associated tip complexes, and the leading edge just behind the anti-capping protein mammal

133 e show that mitochondria actively infiltrate leading edge lamellipodia, thereby increasing local mito

134 he cell polarizes, forms lamellipodia at the leading edge (LE), and triggers the concurrent retractio

135 driving Drosophila dorsal closure--migratory leading-edge (LE) and nonmigratory amnioserosal (AS) cel

136 The leading edge localization of phosphorylated cortactin is

137 s for the rapid production and adaptation of leading-edge machinery in migrating cells, the invasion

138 However, recent evidence suggests that the leading edge may be dispensable for migration, raising t

139 in (F-actin) retrograde flow (RF) to promote leading edge membrane protrusion.

140 t assembly at multiple locations, including: leading edge membranes, focal adhesions, and the surface

141 pharmacological activation of AMPK increases leading edge mitochondrial flux, ATP content, and cytosk

142 A have aberrant lateral protrusions, altered leading-edge morphology, and decreased directional persi

143 associated kinesin (MCAK), thereby promoting leading-edge MT growth and cell polarization.

144 species ranges shifted northward at both the leading edge (northern boundary) and trailing edge (sout

145 Individuals at the leading edge of a biological invasion experience novel e

146 acilitate f-actin polymerization to push the leading edge of a cell forward during self-propelled mot

147 One cell class responds to the leading edge of a figure and is suppressed by ground mot

148 ion of cytosolic PLAC8, CDH3, and VIM at the leading edge of a human colorectal tumor, supporting a r

149 Erk1/2 activity are concentrated toward the leading edge of a sheet.

150 d for the first time, which emerged from the leading edge of a slowly drifting complex convective clo

151 sent observations of temporal changes at the leading edge of an interface between sub-thermocline lay

152 in most new species introductions, or at the leading edge of an ongoing invasion, is likely to be sma

153 More specifically, the leading edge of binding events follows a Poisson point p

154 tly binds and phosphorylates stathmin at the leading edge of cancer cells.

155 nization of the cortical cytoskeleton at the leading edge of cells and extracellular Ca(2+) entry is

156 nd that NCS1 preferentially localizes to the leading edge of cells and overexpression increases the m

157 Filopodia protrude from the leading edge of cells and play important roles in cell m

158 vealed a link between platelet forces at the leading edge of cells and the dynamic actin-rich ring nu

159 ation of Rac and inactivation of RhoA at the leading edge of cells moving in 3D matrix.

160 showing that phospho-STIM1 localizes at the leading edge of cells, and that both phospho-STIM1 and O

161 that SOCE regulates membrane ruffling at the leading edge of cells.

162 ading to the positioning of adhesions at the leading edge of cells.

163 actin formation and single pseudopods at the leading edge of cells.

164 as signaling, C2GAP1, which localizes at the leading edge of chemotaxing cells and is activated by an

165 from the microenvironment to polarize to the leading edge of collectively migrating tumors.

166 strate that P2X7 expression increases at the leading edge of corneal epithelium after injury in an or

167 nism for controlling signaling events at the leading edge of directionally migrating cells.

168 lial surface such that it is enriched at the leading edge of each cell.

169 Receptors on the growth cone at the leading edge of elongating axons play critical guidance

170 PKCs, is focally enriched at the up-gradient leading edge of fibroblasts responding to a shallow grad

171 ofluorescence analysis localized PHIP to the leading edge of glioblastoma cells, together with severa

172 Brain disorders are at the leading edge of global disease burden worldwide.

173 report that increased GLI1 expression in the leading edge of HNSCC tumors is further increased by irr

174 acrine manner to direct cell motility at the leading edge of infection.

175 hat LASP1 is selectively concentrated at the leading edge of lamellipodia in migrating cells and axon

176 n and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patterns of

177 of the formation of 'sticky fingers' at the leading edge of migrating cells and show that an MIT com

178 The leading edge of migrating cells contains rapidly translo

179 mulated in lamellipodia and filopodia at the leading edge of migrating cells in association with acti

180 ocal adhesions are dynamic constructs at the leading edge of migrating cells, linking them to the ext

181 At the leading edge of migrating cells, protrusion of the lamel

182 One example is the leading edge of migrating cells, which contains filament

183 reveal activation of Rab13 by DENND2B at the leading edge of migrating cells.

184 ndled actin filaments that protrude from the leading edge of migrating cells.

185 dopods are alternative ways of extending the leading edge of migrating cells.

186 Scrib, Lgl1, and myosin II colocalize at the leading edge of migrating cells.

187 ix adhesion, and cellular protrusions at the leading edge of migrating cells.

188 A, and promotes polarized trafficking to the leading edge of migrating fibroblasts.

189 n of sparsely labeled F-actin network at the leading edge of migrating human keratinocytes, revealing

190 Precise optoPlexin activation at the leading edge of migrating osteoblasts readily induces lo

191 s contractile force and Rac1 activity at the leading edge of migratory cells and the spine head of ne

192 e that associates with actin at the cellular leading edge of motile cells and suppresses FAK.

193 apability of producing pushing forces at the leading edge of motile cells without the implication of

194 II in the cortex of vegetative amoebae, the leading edge of motile cells, and the cleavage furrow of

195 s, including actin network dynamics near the leading edge of motile cells.

196 ly endosome-associated PxdA localizes to the leading edge of moving peroxisomes.

197 To drive growth at the leading edge of myelin at the interface with the axon, m

198 HL investigation and treatment remain at the leading edge of oncological research.

199 binding decrease microtubule density at the leading edge of polarized cells, suggesting that tubulin

200 calizes to the cell edge, importantly to the leading edge of polarized cells, where it regulates the

201 philin-1 was detected at the plasma membrane leading edge of primary podocytes, where it elicited rem

202 the p-EMT program spatially localized to the leading edge of primary tumors.

203 es that track with elongating RNAPII and the leading edge of RNA synthesis.

204 Speculative fiction examines the leading edge of science and can be used to introduce ide

205 c solutions for both subshear cracks and the leading edge of slip pulses.

206 F4G-eIF3-40S interactions place eIF4E at the leading edge of the 40S subunit, and mRNA is threaded in

207 is non-migratory, solid-like and jammed, the leading edge of the advancing cell layer is shown to bec

208 ional measures and more novel methods at the leading edge of the biological sciences.

209 FL2 normally localizes to the leading edge of the cell cortex where it shears MTs, thu

210 ic cells and underwent redistribution to the leading edge of the cell in hypoxia with a corresponding

211 on other +TIPs, EB1 and CLIP-170, but in the leading edge of the cell, CLASPs display lattice-binding

212 pression of GOLPH3 drives trafficking to the leading edge of the cell, which is functionally importan

213 The optically activated region becomes the leading edge of the cell, with Cdc42 activating Rac and

214 opulation of migratory myofibroblasts at the leading edge of the closing VBW that express the actin-b

215 ion is driven by cell wall remodeling at the leading edge of the engulfing membrane, with peptidoglyc

216 int membrane poration can be produced at the leading edge of the HeLa cell in standoff distance Sd </

217 equently, the initiation of FA growth at the leading edge of the lamella.

218 ted as a polarisation wave starting from the leading edge of the monolayer and progressively propagat

219 ward-directed beam is mainly produced at the leading edge of the plasma column.

220 n experiments were conducted at the southern leading edge of the range of S. viridula (33 degrees S)

221 asive species in nature, cancer cells at the leading edge of the tumor possess a different phenotype

222 olonization of suitable area at the northern leading edge of their breeding distributions and adaptio

223 The leading edge of this design space is the Pareto frontier

224 The leading edge of this reflector, which is characterised b

225 ch uncovered localized NCEH1 activity at the leading edge of triple-negative breast cancer tumors, su

226 During spreading and migration, the leading edges of cells undergo periodic protrusion-retra

227 This pathway is prominent at the leading edges of cells where phosphatidylinositol-3,4-bi

228 e migration and invasion when upregulated in leading edges of certain classes of cancer cells.

229 sa cells and actomyosin purse strings in the leading edges of epidermal cells promote closure, wherea

230 tion of distinctive phenotypic traits at the leading edges of expansions.

231 hot spots are clustered in the lamellipodial leading edges of HT29 human colon cancer cells and are c

232 rse strings are localized at each of the two leading edges of lateral epidermis ("lids" of the eye).

233 NHE1 localized to the leading edges of leader cells, as well as to cryptic lam

234 Accordingly, NHE1 localized not only to the leading edges of leader cells, but also in cryptic lamel

235 Par3 is recruited at the leading edges of migrating cells and in focal adhesion,

236 that Ang-1 triggers Cdc42 activation at the leading edges of migrating ECs, which is dependent on PA

237 quires proper regulation of the F-actin-rich leading edges of migrating neurons and neurite growth co

238 se junctions is accompanied by fusion of the leading edges of successive evaginations to form discret

239 grin-dependent lamellipodial crawling at the leading edges of the epidermal tongue.

240 s remodels the tissue interfaces between the leading edges of the lateral epidermis and the amniosero

241 temperature changes at both the trailing and leading edges of their breeding distributions.

242 tricted in their habitat associations at the leading edges of their range margins, but some species h

243 onsistent with the left dorsal stripe, black leading edges on the dorsal surfaces of the wings, and a

244 tions, we show that VASP localization at the leading edge oscillates, with VASP leading-edge enrichme

245 ing forward trafficking, particularly to the leading edge, overexpression of GOLPH3 drives traffickin

246 of the 5th (the trailing edge) and 95th (the leading edge) percentiles of the spatial distribution of

247 tion, and that, as the TSS changes, the RNAP leading-edge position changes, but the RNAP trailing-edg

248 4(10) promoter sequences, the TSS, the RNAP leading-edge position, and the RNAP trailing-edge positi

249 Changes in the RNAP leading-edge position, but not the RNAP trailing-edge po

250 Inhibiting actomyosin dynamics back from the leading edge prevents junction shrinkage and inhibits th

251 which (i) decelerates the wave speed and the leading edge progression, and (ii) destabilises the lead

252 P1, GTP-bound (active) ARF6, and EFA6 at the leading edge promoted the ARF6 GTPase cycling and cell m

253 of Src-phosphorylated RhoGDI1 to the cell's leading edge promotes local activation of Rac1 and Cdc42

254 Septin mutants mislocalize the leading-edge protein (LEP) complex required for normal P

255 wrapping by regulating repetitive cycles of leading edge protrusion and spreading.

256 Classical models of leading-edge protrusion rely on a treadmilling dendritic

257 Cells move via leading-edge protrusion, substrate adhesion, and retract

258 migrate with apical, centripetally polarised leading edge protrusions but remain attached to the basa

259 locks recruitment of GFP-NM-IIA filaments to leading edge protrusions in 2D, and this in turn blocks

260 als from each cell's trailing edge to induce leading edge protrusions in the cell behind, in part by

261 o1-mediated mitochondrial positioning at the leading edge provides localized energy production that p

262 morphology characterized by the formation of leading-edge pseudopods and a highly contractile cell re

263 In contrast to events at the cell leading edge, rear-polarized mechanisms that control dir

264 Signals at the leading edge recruit actin polymerization machinery to p

265 ign of novel flow control strategies for the leading edge shock topology and flow structures in super

266 In chemotaxing ameboid cells, a complex leading-edge signaling circuit forms on the cytoplasmic

267 nerate thrust on their anterior bodies using leading-edge suction mechanics, much like an airfoil.

268 e tension is approximately 30% higher at the leading edge than at the trailing edge.

269 f the actin cytoskeletal architecture at the leading edge that controls membrane protrusion and cell

270 , which integrates rapid fluctuations of the leading edge, that controls inherent cellular persistenc

271 r is correlated with an abnormal actin-based leading edge, the latter is consistent with blockage in

272 GTPases such as RhoA is required at the cell leading edge to achieve cell migration.

273 flow and it causes the flow topology at the leading edge to become non-symmetric despite the complet

274 of SCAR is compensated by WASP moving to the leading edge to generate morphologically normal pseudopo

275 Conversely, Lar signals from each cell's leading edge to stimulate trailing edge retraction in th

276 ells may tune the number of filaments at the leading edge to work in this force regime.

277 Cells employ protrusive leading edges to navigate and promote their migration in

278 actin and membrane remodeling to propel the leading edge up an attractant gradient.

279 When concentrated into discrete foci at the leading edge, VASP promotes filopodia assembly and forms

280 gests that its primary function is to induce leading-edge vortex (LEV) flow over bird's outer hand-wi

281 There are three key features: leading-edge vortices (a well-known mechanism that appea

282 No good predictor of expansions of the leading edge was found.

283 The role of ORAI1 at the leading edge was studied in genetically engineered U2OS

284 eed dispersal ability, whereas shifts at the leading edge were associated only with photosynthetic ca

285 tion more often and do not maintain the same leading edge when changing directions.

286 ipodia is supported by actin dynamics at the leading edge where a complex of proteins known as the WA

287 was severely disrupted, particularly at the leading edge, where both Arp2/3 and Mena/VASP-based fila

288 and exerts force upon actin filaments at the leading edge, where clutching forces occur.

289 EGF) triggered an enrichment of ORAI1 at the leading edge, where colocalized with cortactin (CTTN) an

290 biogenesis, F-actin is redistributed to the leading edge, where its polymerization-based forces push

291 tes at nascent focal adhesions at the cell's leading edge, where myosin X promotes actin convergence

292 rictional rollers congregates near the sharp leading edge whereas a denser rear comprises highly fric

293 579 and Y580 preferentially localizes to the leading edge, whereas Y881-phosphorylated Pyk2 is enrich

294 ive cancer cells were no longer able to form leading edges, which are required for adequate migration

295 caused filopodia to form exclusively at the leading edge, while higher concentrations inhibited filo

296 a gradient of activated Rac1 evident at the leading edge, while small protrusions, rapid turnover of

297 the Arp2/3 complex, fibroblast cells adopt a leading edge with filopodia-like protrusions (FLPs) and

298 re fluid-like ventral region surrounding the leading edge with smaller cells undergoing intercalation

299 larized morphology, extending forward with a leading edge with their trailing edge retracting back to

300 of SCAR/WAVE, WAVE1 and WAVE2, reside at the leading edge, yet it has remained unclear whether they p