ライフサイエンスコーパス: leak current

1 ial or as a constitutively active epithelial leak current.

2 excitability via an increased GLT1b-mediated leak current.

3 generated by a calcium-inactivated potassium leak current.

4 consistent with myotonia, but also conduct a leak current.

5 desensitization to calcium of the potassium leak current.

6 ion is produced by blockade of an outward K+ leak current.

7 and are thus dependent on persistent sodium leak currents.

8 tentiation of glutamate-activated as well as leak currents.

9 all but significant changes in potassium and leak currents.

10 ive 5HT-induced currents and 5HT-independent leak currents.

11 c nucleotide-gated (HCN) channels, or sodium leak currents.

12 ranges the receptor architecture and induces leak currents.

13 rons in acute SCN slices revealed that Na(+) leak current amplitudes/densities are similar during the

14 urrent) that effectively acted as a negative leak current and counterbalanced the temperature-induced

15 y described hDAT conductances, including the leak current and the current associated with electrogeni

16 a G4-specific helicase DHX36, increasing K+ leak currents and membrane hyperpolarisation in HEK293 c

17 We also find that CA2 neurons have larger leak currents and more negative resting membrane potenti

18 TASK-1 carries a background or "leak" current and is a member of the two-pore domain pot

19 hondrial depolarization, ischaemia-sensitive leak current, and time to K(ir) 6.2 opening.

20 +), DAT displayed a cocaine-sensitive cation leak current approximately 10-fold larger than the subst

21 ion substrate, NIS exhibited a Na+-dependent leak current (approximately 35% of maximum substrate-ind

22 Second, Na(+)-mediated leak currents are eliminated.

23 temperatures, and subtraction of additional leak currents at elevated temperatures was sufficient to

24 These larger "leak currents" at V(rest) also lowered R(in) and produce

25 application, which provides support for the leak current being mediated by GLT1b itself.

26 ange intracortical afferents or scaling K(+) leak current, but not several other Na(+) and K(+) intri

27 Depolarizing sodium (Na(+)) leak currents carried by the NALCN channel regulate the

28 The Na(+) leak-current channel (NALCN) regulates locomotion, respi

29 -sulfonamide (NBQX)-sensitive portion of the leak current corresponded to a current generated by glut

30 Leak currents, defined as voltage and time independent f

31 Analysis of GluR1Lc leak current demonstrated that the 2,3-dioxo-6-nitro-1,2

32 alanine transport but still catalyzed anion leak current, demonstrating that substrate transport is

33 ed here demonstrate that NALCN-encoded Na(+) leak currents differentially modulate daily rhythms in t

34 Persistently depolarizing sodium (Na(+)) leak currents enhance electrical excitability(1,2).

35 ntified a set of three maximal conductances (leak current, [Formula: see text]Leak; a persistent K cu

36 sistance for high power efficiency, (ii) low leak current from the probe into the in vitro experiment

37 iring rates of SCN neurons, a role for Na(+) leak currents has also been suggested.

38 e) activates a NALCN channel-dependent Na(+)-leak current (I(L-Na)).

39 The native cerebellar granule neurone (CGN) leak current, IK(SO), is sensitive to block by zinc, wit

40 TC neurone, which contained only IT, Ih, K+ leak current (ILeak) and those currents responsible for

41 K+ outward currents: a voltage-independent 'leak' current (Ileak) operating at all negative potentia

42 es similarly augment the sustained K+ M- and leak-currents (IM and IK(L)).

43 and resulted in a 5-fold enhancement of the leak current in GLT1b-expressing oocytes with only a min

44 The leak current in Li(+) was also potently inhibited by low

45 ates, was modeled by the reduction in the K+ leak current in PY and TC cells and by a decrease in int

46 erefore, was effectively contributing to the leak current in the HN cells.

47 nts reported here explored the role of Na(+) leak currents in regulating daytime and nighttime repeti

48 in isolated neural circuits due to increased leak currents in rhythm-generating neurons.

49 rens, TadNaC6, that conducts Na(+)-selective leak currents in vitro sensitive to blockade by both ext

50 (A), I(K dr), I(Na), I(Ca L), I(Ca N), and I(leak) currents in postnatal cat RGCs.

51 The leak current increased slowly over 4 d of treatment with

52 The leak currents indicated that the mutated residues are ac

53 led the ability of IMI to reduce detrimental leak-current influences on neuronal networks over a broa

54 We propose that a nonspecific leak current introduced by the intracellular microelectr

55 he TTX- and Cs(+)-resistant background Na(+) leak current is absent in the mutant hippocampal neurons

56 Ca(2+) channel activation, CDI, and outward leak currents is sufficient to sustain the oscillating b

57 n-activated current (H), a non-voltage-gated leak current (leak), and a neuromodulatory current (MI).

58 tent sodium current (NaP) and K(+)-dominated leak current (Leak), primarily contribute to preMN/MN su

59 This leak current occurred in the absence of extracellular ca

60 Leak currents of different magnitudes appeared in the DI

61 By estimating the leak current parameters in regions in which there was li

62 hat persistent sodium (NaP) and K+-dominated leak currents primarily contribute to subthreshold I-V r

63 The epsilon subunit caused the appearance of leak currents recorded in the absence of GABA.

64 This result, and the small size of the leak current relative to the currents evoked by saturati

65 A depolarizing 'leak' current supports this firing pattern, but its mole

66 tudy demonstrated that ENaC mediates a Na(+) leak current that affects the steady state membrane pote

67 tor neurons, including a nonselective cation leak current that contributed to the resting potential,

68 ain (K(2P)) potassium channel that carries a leak current that is time- and voltage-independent.

69 batrin; 0.05-100 microm) resulted in a large leak current that was blocked by bicuculline (50 microm)

70 lase with semicarbazide (2 mm) decreased the leak current that was induced by vigabatrin by 47%.

71 Mutant Q185A receptors also had an increased leak current that was sensitive to picrotoxin, indicatin

72 n ion channel family that produces potassium leak currents that oppose excitation and stabilize the r

73 2P) channels of the TREK subfamily generate 'leak' currents that regulate neuronal excitability, resp

74 d current, hDAT also mediates a constitutive leak current, the voltage and ionic dependencies of whic

75 3 alone reveals a constitutive, depolarizing leak current through hCHT.

76 ix (S4) of the Na(V)1.4 VSDs can result in a leak current through the VSD and hypokalemic periodic pa

77 and the upregulation of voltage-independent leak currents through a two-pore-domain potassium channe

78 of gating pores that were detected as proton leak currents through the VSDs.

79 sporter, we recorded the Na(+)-induced anion leak current to determine the K(m) of EAAC1 for Na(+).

80 The ATP1A1 mutations all caused inward leak currents under physiological conditions, and the CA

81 Dynamic clamp-mediated addition of leak currents was sufficient to stop neuronal oscillatio

82 Hyperpolarization-activated (IH) and leak currents were not altered during the application of

83 Proton-leak currents were not increased in E818K.

84 The leak currents were partially blocked by pentamidine but

85 K2P) channels are responsible for background leak currents which regulate the membrane potential and

86 sis to asparagine, Na(+) activated the anion leak current with a K(m) of about 2 m, indicating dramat