ライフサイエンスコーパス: leakiness

1 ed transient increase in bundle-sheath CO(2) leakiness ( ).

2 to the lamina along their lengths, that is 'leakiness'.

3 pled synthase activity accompanied by proton leakiness.

4 ity but exhibited growth deficits and proton leakiness.

5 J, preventing persistent endothelial barrier leakiness.

6 , presumably because of angiogenic capillary leakiness.

7 ndothelial junctions and prevent microvessel leakiness.

8 any significant influence on the nanovalves' leakiness.

9 ngpt1, thereby preventing diapedesis-induced leakiness.

10 ably integrated TRE-reporter from exhibiting leakiness.

11 also characterized by an increase in mucosal leakiness.

12 nsporter and, perhaps, for minimizing cation leakiness.

13 hat possess both high dynamic ranges and low leakiness.

14 fusion, and fibrinogen levels, to assess BBB leakiness.

15 tabin2 depletion, and subsequent RyR2 Ca(2+) leakiness.

16 thetic induction and decreased bundle sheath leakiness.

17 Occludin and Claudin-5 and increased barrier leakiness.

18 ased photosynthetic rates, and bundle sheath leakiness.

19 y and pro-oxidative stressors to endothelial leakiness.

20 cells by decreasing intratumoral microvessel leakiness.

21 Capture is thus determined by leakiness.

22 ng EC proliferation associated with vascular leakiness.

23 ation, increased ANG2 expression, and vessel leakiness.

24 after irradiation while increasing vascular leakiness.

25 intrinsic property of VEGF to promote vessel leakiness.

26 d the opposite effect of increased Delta and leakiness.

27 rage of tumor vessels and decreased vascular leakiness.

28 lux does not correlate with increased vessel leakiness.

29 ed P(BAD)-riboswitch exhibited no detectable leakiness.

30 enhanced lumen formation, and reduced vessel leakiness.

31 ical-mechanical coupling, but increased RyR2 leakiness, a paradoxical response further exacerbated by

32 tially inhibited and a reduced level of cell leakiness, a prominent feature of F+ cells abortively in

33 MR imaging-assayed acute change in vascular leakiness after a single dose of bevacizumab was an earl

34 gonists were effective at preventing barrier leakiness after LPS administration.

35 laser endomicroscopy and found that mucosal leakiness also declined with age.

36 Strikingly, this does not coincide with BBB leakiness, altered expression of genes crucial for BBB b

37 liar to mutT bacteria due to transcriptional leakiness, although there is no evidence that this is a

38 of NF-kB to inhibitor of NF-kB predetermines leakiness and activation probability of cells.

39 on and three levels of regulation to prevent leakiness and allow tight control over neoantigen expres

40 mposes little metabolic burden, exhibits low leakiness and an 80-fold green light response, and funct

41 existing systems have shortcomings including leakiness and attenuated activity.

42 of immune cells, increased lymphatic vessel leakiness and changes in the gene expression patterns of

43 RyR2 leakiness and cognitive dysfunction could be ameliorated

44 s well known, lipid vehicles exhibit maximum leakiness and contents release in the vicinity of phase

45 th Sunitinib demonstrated decreased membrane leakiness and damage owing to myofiber regeneration and

46 of immune cells, increased lymphatic vessel leakiness and decreased expression of lymphatic specific

47 terminant of the persistent vascular barrier leakiness and edema formation associated with inflammato

48 growth factor A (VEGFA) promote blood vessel leakiness and edema in ocular diseases.

49 We observed that lung endothelial barrier leakiness and edema induced by raising pulmonary microve

50 rombocytopenia would increase tumor vascular leakiness and facilitate the effective delivery of chemo

51 t-derived xenografts (PDX), such as vascular leakiness and increased hypoxia.

52 tween these cells contribute to tumor vessel leakiness and may permit access of macromolecular therap

53 A Glu(54) to Asp(54) change increased proton leakiness and reduced malate growth 79-90%.

54 ultivar differences in cold-induced membrane leakiness and seedling vigor.

55 nsitive reporter system to quantify promoter leakiness and show that leakiness for P(tac) > P(tac)-ri

56 has been developed that demonstrates minimal leakiness and significant induction with doxycycline.

57 a, which in turn induced pleural vasculature leakiness and triggered NF-kappaB activation in pleural

58 inase C activation leads to tight junctional leakiness and, consequently, to increased transepithelia

59 n the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels.

60 d pumping altogether, possibly due to UNC-68 leakiness and/or malfunctional SR Ca(2+) homeostasis.

61 ransient due to increased ryanodine receptor leakiness and/or sarco/endoplasmic reticulum Ca ATPase a

62 een minimal uninduced background expression (leakiness) and maximal induced expression.

63 mediators of cerebral hypoperfusion and BBB leakiness, and Abeta and hyperphosphorylated tau, in mul

64 Detergent sensitivity, leakiness, and growth characteristics of the novel vesic

65 Furthermore, the orthogonality, low leakiness, and high dynamic range of our inducible Cas13

66 he strength of any CCM or degree of pyrenoid leakiness, and limitations to inorganic carbon in the aq

67 ng rate, lymphatic vessel density, lymphatic leakiness, and lymphatic macromolecule clearance (all P

68 ed tissue oxygenation, limited microvascular leakiness, and prevented airway ischemia, even in the ab

69 ed tissue oxygenation, limited microvascular leakiness, and prevented airway ischemia.

70 cal processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells

71 Sunitinib rapidly decreased vessel leakiness, and this effect was more pronounced in patien

72 ol ratio (L:M), which primarily assesses gut leakiness, and which also measures absorption.

73 we show amyloid protein-induced endothelial leakiness (APEL) in human microvascular endothelial mono

74 hypoperfusion and blood-brain barrier (BBB) leakiness are pathological features of Alzheimer's disea

75 ctural features of blood-brain barrier (BBB) leakiness around microthrombi in a mouse model of trauma

76 ter membrane stability, implicating membrane leakiness as a potential mechanism of physiological decl

77 2/20), but not PLD(57), induces POPC vesicle leakiness as measured by entrapped CF leakage.

78 rebral hypoperfusion and blood-brain barrier leakiness associated with Alzheimer's disease and vascul

79 anoma-derived exosomes also induced vascular leakiness at pre-metastatic sites and reprogrammed bone

80 and Verapamil increases tumor angiogenesis, leakiness, blood flow, and Gemcitabine delivery.

81 c, unclosed phagolysosomal compartment whose leakiness blunts the toxicity of lysosomal enzymes, ther

82 ation by secreting Angpt1, reducing vascular leakiness but slowing niche recovery.

83 tor (PAF) induces severe endothelial barrier leakiness, but the signaling mechanisms remain unclear.

84 -2495 recapitulates this arrhythmogenic RyR2 leakiness by unzipping N-terminal and central domains.

85 Leakiness can be problematic in the context of Cas9 nucl

86 Only through progressively increasing the leakiness can the model qualitatively reproduce the expe

87 This partitioning of benefits, also called 'leakiness', can produce negative frequency dependence of

88 r vessel leakiness, mediators of endothelial leakiness, consequences of tumor vessel leakiness, genom

89 anic NPs to intentionally induce endothelial leakiness, creating a window of opportunity to control d

90 ing progressive vascular disorganization and leakiness culminating in massive ascites.

91 Obesity induces lymphatic leakiness, decreases initial lymphatic vessel density, i

92 We experimentally determined leakiness, defined as the proportion of air going throug

93 mplex, impeding BBB recovery and causing BBB leakiness during poststroke recovery.

94 or may fail to yield a null phenotype due to leakiness (e.g. use of cryptic splice sites or downstrea

95 d defective junctions, resulting in vascular leakiness, edema, and impaired heart function.

96 discussed the cellular basis of tumor vessel leakiness, endothelial barrier function of blood vessels

97 BBB leakiness, evidenced by elevated fibrinogen in brain tis

98 The ubiquity of leakiness favors a 'race to the bottom' as members of a

99 to quantify promoter leakiness and show that leakiness for P(tac) > P(tac)-riboswitch > P(BAD); while

100 accine-derived protection, and (IV) vaccine "leakiness." For scenarios I-IV, successful booster strat

101 CO(2) fixation rate, probably to avoid CO(2) leakiness from bundle sheath cells.

102 ement observed was associated with a reduced leakiness from tumor vessels, consistent with induction

103 lial leakiness, consequences of tumor vessel leakiness, genomic analysis of vascular targets, targeti

104 Although heightened vessel leakiness has been linked to glial and neuronal-derived

105 ng pathways that mediate endothelial barrier leakiness (hyperpermeability) that are important in the

106 geted inflammation, cellular injury, and gut leakiness in a randomized clinical trial comparing combi

107 Our data demonstrate that barrier leakiness in asthmatic patients is induced by TH2 cells,

108 fully appreciate the consequences of vessel leakiness in cancer.

109 The different leakiness in cell cycle regulation between two stage-spe

110 tant component of capillary walls, affecting leakiness in healthy or tumor vasculature.

111 from conventionally established endothelial leakiness in homeostatic and pathologic conditions, as w

112 The enhanced vascular leakiness in K2(Delta/Delta) mice was due to aberrant va

113 We tested for subtle generalized BBB leakiness in patients with lacunar stroke and control pa

114 Also, leakiness in repairing DNA lesions and uncapped telomere

115 terface contributing to outcross failure and leakiness in self-recognition.

116 ts increases with age, partly as a result of leakiness in the aged thymus, allowing reentry of naive

117 P4-IgG revealed increased blood flow and BBB leakiness in the entorhinal cortex.

118 linked region, and along with observation of leakiness in the phenotypic expression of sex, suggest a

119 due to a lack of microsatellite markers and leakiness in the Rfv3 phenotype, which prevented definit

120 Despite the leakiness in the system, B cell-specific MHCII deletion

121 pression studies suggest that tight junction leakiness in these two strains of MDCK cells is conferre

122 focused on the significance of blood vessel leakiness in tumors.

123 intestine in nutrient malabsorption and gut leakiness in vitro.

124 elium in vivo and correlates with epithelial leakiness in vitro.

125 y on a treadmill and reduced muscle membrane leakiness in vivo that is characteristic of mdx and Sgcd

126 ine-type structures, indicating significant "leakiness" in the pathway which converts oligomannose to

127 d IgA in lung secretions because of "mucosal leakiness" in these mice.

128 measurements of tumor blood flow and vessel leakiness, in vivo phage display, magnetic resonance ima

129 knockdown tumors have significantly reduced leakiness, increased oxygenation, and greater apoptosis.

130 awater oligotrophy by reducing its selective leakiness, increasing the acquisition of essential nutri

131 owth factor-A (VEGF)-and blood-brain barrier leakiness, indicated by raised levels of fibrinogen, wer

132 itric oxide production trigger marrow vessel leakiness, instigating pro-leukemic function.

133 Blood vessel leakiness is an early, transient event in acute inflamma

134 This leakiness is concerning because it increases vaccination

135 This leakiness is largely attributable to a tumor-secreted cy

136 This leakiness is shown here to result in as much as a 20-fol

137 cer therapy, but the structural basis of the leakiness is unclear.

138 Our finding that nuclear "leakiness" is dramatically accelerated during aging and

139 receptor-2 activation, promoting less vessel leakiness, less tissue inflammation, and better perfusio

140 gies (which enhance blood vessel numbers and leakiness) may be optimized for combination therapies as

141 on of blood vessels, monitoring tumor vessel leakiness, mediators of endothelial leakiness, consequen

142 ically inert mode of nonfunctional "promoter leakiness," merely a byproduct of transcriptional regula

143 dow chamber, indicating that although vessel leakiness might be acting as a source of acid, it is not

144 alogous to nanomaterials-induced endothelial leakiness (NanoEL), a major phenomenon in nanomedicine d

145 e coined as nanomaterial-induced endothelial leakiness (NanoEL).

146 n between pipeline material and age with the leakiness of all material types increasing with age.

147 Leakiness of blood vessels in tumors may contribute to d

148 the complex virus-cell interactions and the leakiness of cellular promoters in the viral genome.

149 ed a lower Delta and thus a lower calculated leakiness of CO(2) (the ratio of CO(2) leak rate from th

150 Abnormal leakiness of connexin hemichannels is likely a mechanism

151 cells within the central corneal epithelium, leakiness of corneal neovessels, loss of axons in cornea

152 arly, concentration-dependent, and transient leakiness of EC.

153 a (0.5 ng/mL) induced an early, irreversible leakiness of EC.

154 ions-a change that correlates with increased leakiness of endothelial barriers.

155 nea and function as a pump to counteract the leakiness of its basement membrane.

156 The intrinsic leakiness of LTR often makes the measurement of low-leve

157 ate inflammatory conditions by promoting gut leakiness of microbial products, by sensitizing immune c

158 difficult to detect directly because of the leakiness of proteoliposomes, vesicle aggregation and ru

159 g4-deficient embryos correlate with relative leakiness of residual end joining in these mutant backgr

160 ing can reduce the vascularity of tumors and leakiness of surviving vessels, but little is known abou

161 the bacterial plasma membrane, resulting in leakiness of the bacterial cells, loss of ATP, and loss

162 Nerve crush injury causes partial leakiness of the blood-nerve barrier, proliferation of e

163 We propose that the leakiness of the chaperonin system under physiological c

164 oxygen species (ROS), which are generated by leakiness of the electron transport chain (ETC).

165 Leakiness of the endolysosomal compartment significantly

166 n and its consequence in contributing to the leakiness of the endothelial barrier.

167 hereby causing a general destabilization and leakiness of the lipid bilayer membrane.

168 edance plots, regardless of the tightness or leakiness of the paracellular shunt pathways.

169 addition of an exogenous inducer and (2) the leakiness of the promoter element in the absence of the

170 oportion of nonperfused vessels and reducing leakiness of the remaining vessels.

171 In two animals, the leakiness of the tumors before disruption was evaluated

172 response was a result of an increase in the leakiness of the vascular system to air seeding.

173 struct into LLC-PK1 renal epithelia produces leakiness of tight junctions to certain types of solutes

174 that low platelet count selectively induces leakiness of tumor vessels and favors the delivery of ch

175 The leakiness of tumor vessels is well documented in experim

176 y vessels in inflammation, could explain the leakiness of tumor vessels.

177 d tight junctions may contribute to enhanced leakiness of vasculature in Kindlin-2(+/-) mice.

178 ne energetic cost of the C(4) pathway is the leakiness () of bundle sheath tissues, whereby a variabl

179 Cross-presentation relies on the unusual "leakiness" of endocytic compartments in DCs, whereby int

180 e to drug absorption, and (iv) the relative "leakiness" of the human jejunum is not so different from

181 ricyte-endothelial crosstalk alters vascular leakiness or remodeling in the airways of mice under fou

182 urface of endothelial cells through vascular leakiness or whether the rapid accessibility results ins

183 on of the acute change in MR imaging-assayed leakiness, or Delta K(PS).

184 iency of the CO(2) -concentrating mechanism (leakiness, ) remains constant, can be used to screen for

185 rreversibility, hypersensitivity to promoter leakiness, restriction to proliferating cells, slow indu

186 reduced vessel patency and increased vessel leakiness, resulting in large increases in tumor hypoxia

187 formation that may underlie prolonged vessel leakiness.SIGNIFICANCE STATEMENT Although rarely express

188 associated with persistent vascular barrier leakiness such as acute lung injury.

189 maging-assayed change in tumor microvascular leakiness, tested as a potential biomarker, correlated s

190 cell fiber, leading to membrane ruptures and leakiness that induces myofiber necrosis, a subsequent i

191 the temperature response of g(m) , g(bs) and leakiness ( ), the amount of concentrated CO(2) that esc

192 For intact PLD(57) to cause CF leakiness, the soluble activator diC(4)PA must be presen

193 Angiopoietin/Tie2 signaling can reduce the leakiness through changes in endothelial cells.

194 TO-2 hamsters corrected muscle cell membrane leakiness throughout the body and normalized serum creat

195 he protective effect of Ang1 on blood vessel leakiness to plasma proteins raises the possibility of a

196 We attribute this leakiness to stable, relatively large, and heterogeneous

197 We demonstrate that this strategy reduces 'leakiness' to improve overall expression dynamic range,

198 Despite leakiness, vaccination may reduce pathogen load, affecti

199 efficacy, vascular enlargement, endothelial leakiness, venular marker expression, pericyte changes,

200 Chronic BBB leakiness was associated with cognitive impairment, as a

201 ole of HDAC activation on epithelial barrier leakiness was confirmed by HDAC inhibition, which improv

202 ts grown at elevated CO(2) and bundle sheath leakiness was estimated to be 24% and 33%, respectively,

203 eltapsi(m)) was decreased and inner membrane leakiness was increased moderately.

204 essel patency was reduced by 25%, and vessel leakiness was increased threefold, resulting in a 10-fol

205 Evidence of increased gut permeability or "leakiness" was also detected in SFB colonized mice.

206 Microthrombi and associated sites of BBB leakiness were identified by confocal imaging of injecte

207 several endothelial cell lines, but without leakiness when uninduced.

208 ll, alcohol-dependent subjects developed gut leakiness, which was associated with higher scores of de

209 g quantitative synthetic biology to mitigate leakiness while maintaining high expression, without mod

210 es of NPs to create controllable endothelial leakiness within short exposures, a phenomenon we coined