ライフサイエンスコーパス: leap

1 l-free local extracellular action potential (LEAP).

2 e, but no quantum algorithm has yet made the leap.

3 as the eel attains greater height during the leap.

4 and only shifted to new equilibria in sudden leaps.

5 ral evolution and can result in evolutionary leaps.

6 ded to larger than 100 without any technical leaps.

7 tal convergence and an ankle specialized for leaping.

8 of siblings during grooming, and repetitive leaping.

9 s with more arboreal quadrupedalism and less leaping.

10 ssed, and this is frequently accomplished by leaping.

11 Is evolution always gradual or can it make leaps?

12 al, randomised, double-blind, phase 3 study (LEAP-002), patients aged 18 years or older with unresect

13 Here, we report results from LEAP-003 which evaluated first-line lenvatinib plus pemb

14 ath protein or ligand 1 [PD-(L)1] therapy in LEAP-004.

15 re, randomised, double-blind, phase 3 study (LEAP-012), patients were recruited from 137 global sites

16 In the LEAP-017 study, we evaluate whether lenvatinib in combin

17 t evidence from 2 phase III clinical trials (LEAP 1 and LEAP 2), and discusses its potential role in

18 The Lefamulin Evaluation Against Pneumonia (LEAP 1) study was a global noninferiority trial to evalu

19 MRC-2, Antithrombin III, SAA, CRP, NPS-PLA2, LEAP-1, and LBP.

20 from 2 phase III clinical trials (LEAP 1 and LEAP 2), and discusses its potential role in the treatme

21 e, even if they have the potential to make a leap, a hostile environment may preclude their doing so.

22 A whale leaping above the surface expends an enormous amount of

23 Many species that run or leap across sparsely vegetated habitats, including horse

24 t free-ranging fox squirrels (Sciurus niger) leaping across unfamiliar, simulated branches decided wh

25 The use of machine learning to make leaps across informational and social contexts to infer

26 occasionally occurs as a sudden and dramatic leap ahead but more often proceeds at a subtler and stea

27 challenges, functional MRI has been used to leap ahead of these quandaries to identify relationships

28 Details about the binomial tau-leap algorithm, software and a manual are available at t

29 me, the grouping method of the shuffled frog leaping algorithm (SFLA) is incorporated with the basic

30 shown to be as accurate but much faster than leaping algorithms and algorithms for integration of dif

31 iting of cagemates during grooming, repeated leaping and episodes of perseverance of any and all norm

32 d compulsion-like behaviors such as repeated leaping and perseverance of any and all normal behaviors

33 harness the strength of data sets growing by leaps and bounds every day, cultural norms in biomedical

34 zed sizes of extra dimensions, have grown by leaps and bounds over the past few years.

35 lular degradation machinery are advancing in leaps and bounds, and diverse modalities are emerging.

36 esearch on corroles will continue to grow by leaps and bounds, most especially in areas of human heal

37 h evolutionary information has progressed in leaps and bounds.

38 C class I molecules took several interesting leaps and twists in the past year.

39 ts who have difficulty 'thinking before they leap' and are at high risk of falling.

40 with influenza-J-LEAPS peptides (influenza-J-LEAPS) and injected intravenously into infected mice.

41 olerance (EAT), Learning Early About Peanut (LEAP), and Peanut Allergy Sensitization (PAS) cohorts.

42 uch as ordinary differential equations and t-Leaping approximations.

43 Results suggest that the main purpose of the leaping attack is to strongly deter potential eel predat

44 But their most astonishing behavior is the leaping attack, during which eels emerge from the water

45 on of dansylated derivative into the CTC-PAL Leap autosampler coupled to a Sciex API 4000 mass spectr

46 uit resistances that develop during an eel's leaping behavior were determined.

47 e that the JBC not only made this remarkable leap, but made it first and farthest, and paved a path f

48 c odor potentiated their abnormal repetitive leaping, but novel or familiar nonthreatening odors did

49 orsomobility of the spine during running and leaping, but our results are independent of running spee

50 However, such functional leaps by combination of unrelated domains have not been

51 LEAP can accelerate our understanding of stem cell model

52 of autistic females (ABIDE: Cohen's d=1.25; LEAP: Cohen's d=1.29).

53 ve of autistic males (ABIDE: Cohen's d=0.48; LEAP: Cohen's d=1.34).

54 ("peanut BBEA") was developed utilizing the LEAP cohort and then validated using two independent coh

55 Immunological studies from the LEAP cohort demonstrated that regular peanut consumption

56 Sera from 341 children (LEAP cohort) were assayed at baseline, 1, 2.5, and 5 yea

57 t tree nuts, with levels being higher in the LEAP consumption group.

58 ded Release Antiretroviral Resource Program (LEAP) convened a workshop with the aim of shaping the re

59 ow that, taking sign epistasis into account, leaps could become an important factor of evolution in c

60 nd discovery, with the EU-AIMS/AIMS-2-TRIALS LEAP data set (681 individuals, 6-30 years of age); and

61 In this secondary analysis of LEAP data, we aimed to determine risk subgroups within t

62 is was conducted on the publically available LEAP dataset, exploring relationships between peanut tol

63 iew evidence that such nongradual, saltatory leaps, driven through chromosomal rearrangements or geno

64 A major technological leap emerges from the development of genetically encoded

65 Here we introduce LEAP (LEAP estimates animal pose), a deep-learning-based metho

66 Here we present Social LEAP Estimates Animal Poses (SLEAP), a machine learning

67 Across both ABIDE and LEAP, features positively predictive of neurotypical mal

68 In this viewpoint, we describe the LEAP fellowship, its outcomes, and how it could be adapt

69 The progress reported represents a major leap for all-inorganic PSCs and paves the way for their

70 processes hinders achieving the qualitative leap for net-zero emissions.

71 t genomes within the past year was a quantum leap for socio- and ant genomics.

72 The presented methodology is a paradigmatic leap for the determination of the relative stereochemist

73 ditions such as FXS and autism are a quantum leap for the neuroscience field, which has traditionally

74 molar levels, thereby representing a quantum leap for the use of gel-based proteomics in biomarker di

75 nts, advocates, and facilitators of this big leap for their patients.

76 Cancer organoids are a leap forward as a culture model that faithfully represen

77 novel biologic therapies represents a giant leap forward for asthma treatment, but efficacy is rarel

78 methods in molecular rulers is an important leap forward for biophysics.

79 sed SIP technologies represent a significant leap forward for culture-independent 'functional phyloge

80 anisotropy direction, which is a significant leap forward for large-scale nanomanufacturing of anisot

81 onic channels, something that should prove a leap forward for strategies aimed at developing new sele

82 tructures and at interfaces is a significant leap forward for the determination of macromolecular dyn

83 transmission and growth chains, providing a leap forward for the field.

84 thuringiensis (Bt) lines, China made a great leap forward from IRGM rice basic research to potential

85 in stability toward water, which marks a big leap forward in metal alkylidyne chemistry in general.

86 In this manuscript, we make a significant leap forward in mid-infrared technology by developing a

87 ed quantum technology, marking a significant leap forward in optoelectronic technologies, with potent

88 These findings provide a quantum leap forward in our understanding of the cellular determ

89 s and monitoring, representing a substantial leap forward in personalized medicine and oncology.

90 The only giant leap forward in survival occurred during the 1970s, with

91 f Cell, Hughes and coworkers provide a great leap forward in the analysis of essential yeast genes by

92 OFs in photocatalysis, marking a significant leap forward in the design of advanced photocatalytic ma

93 The proposed method is expected to provide a leap forward in the design of catalysts for asymmetric t

94 In all, these results provide a leap forward in the design of selective fluorination of

95 streamline research represents a significant leap forward in the field.

96 s, the adult neurogenesis field is poised to leap forward in the next decade.

97 ts, caregivers, and researchers are facing a leap forward in the quantity of data that are available

98 er drug resistance, signifying a substantial leap forward in the realm of metal polymer-based cancer

99 d sewage sludge, and represent a significant leap forward in understanding the pathogen content of cl

100 owever, mass spectrometry has made a quantum leap forward offering new capabilities in soft electrosp

101 ow for low-cost rapid assessment and a great leap forward to be more ecological and inclusive of all

102 ith the remarkable performances, represent a leap forward toward effective point-of-care devices for

103 tion by Stockwell and colleagues documents a leap forward toward the continued development of small m

104 A great leap forward toward the general synthesis of P-stereogen

105 Therefore, our method represents a large leap forward towards automating biological ontology alig

106 The next technological leap forward will be enabled by new materials and invent

107 RNA therapies have recently taken a giant leap forward with the approval of Onpattro(TM), a siRNA

108 olic engineering strategies, should enable a leap forward within the coming decade.

109 ding of this defense system has made a major leap forward.

110 It is crucial for leaping forward renewable energy technology to develop h

111 Both topics have seen significant leaps forward by deep learning within the past five year

112 sequencing (RNA-seq) have enabled tremendous leaps forward in our understanding of bacterial transcri

113 Fundamental leaps forward in our understanding of the biology drivin

114 Despite great leaps forward in preventing and treating malaria, severa

115 des physico-chemical insight into the recent leaps forward in the performance of NC field-effect tran

116 channels that play a vital role in the FF's leap-forward improvement and hence the DJ PSC's performa

117 dies which have set the stage for each major leap forwards, such as the emergence of the cholinergic

118 The abrupt surgical leap found the medical community and society unprepared

119 s as a coherent unit or do individual cells "leap frog" each other at the wound margin?

120 marily by inactivation of the light chain by leap-frogging events.

121 n the end-stage effector phase of arthritis, leap-frogging the initiating events.

122 Limber pine is successfully "leap-frogging" over bristlecone pine, probably because o

123 Mended bulk crystals show modulus leap from 4 to 12 GPa and hardness from 400 to 1000 MPa.

124 dicted that renewable energy production must leap from [Formula: see text] of the global energy mix i

125 have been a key element in this evolutionary leap from an enteric to a flea-transmitted systemic path

126 chnologies, demonstrating these technologies leap from laboratory to industry.

127 The ENCODE project represents a major leap from merely describing and comparing genomic sequen

128 e are accepted, albeit imperfect models, the leap from promising preclinical drug results to positive

129 e microfluidics a much-needed opportunity to leap from research papers to true productivity, and gain

130 uccessful clinical trials comes in the giant leap from rodent models to humans.

131 IST reference library spectra, a significant leap from the 35%-45% coverage of only b and y ions.

132 However, the leap from the micro level of molecular function to the m

133 Omics technologies made a huge leap from trendy and very expensive to routinely execute

134 e no differences in allergic disease between LEAP groups.

135 These leaps have normally been associated with the introductio

136 se a hydrogen-deuterium exchange MS (HDX-MS) LEAP HDX system for automated specific amino acid footpr

137 3% among 42 animals tested, which is a major leap in antiadhesion performance.

138 aring a structural feature that results in a leap in anticancer potency.

139 spond to stimuli holds the key to a progress leap in autonomous systems.

140 REM sleep-like stages could mark a leap in cognitive evolution, by regulating the visuomoto

141 over three decades, represents an important leap in combatting weed resistance and feeding a growing

142 neural network would allow a transformative leap in compactness and function of these artificial neu

143 A new study asserts that a late evolutionary leap in cyanobacterial nitrogen fixation terminated a lo

144 Under optimized conditions, a leap in emission quantum yield to a record high 21% was

145 This vast leap in genomic capacity was strictly dependent on mitoc

146 hree-dimensional (3D) printing enables a big leap in geometrical flexibility.

147 healthy subjects, represents a technological leap in human gastrointestinal system modeling and provi

148 , fluorescence microscopy has made a quantum leap in its resolving power due, in large part, to advan

149 lculations, and finally reveal a significant leap in light-perception quantum efficiency from 35% to

150 st crack propagation is key for the observed leap in mechanical response.

151 Here, a recent leap in MEG technology-featuring a factor 10 reduction i

152 Metagenomics caused a quantum leap in microbial ecology.

153 This leap in our ability to record structural changes on the

154 A quantum leap in our knowledge of mutagenesis in human cancers ha

155 r the "resistosome," have afforded a quantum leap in our understanding of how plant NLRs function.

156 kshop on Carcinoma in situ was an impressive leap in our understanding of the interaction between pre

157 The past decade has witnessed a quantum leap in our understanding of the origins, diffusion, and

158 ors, recent structural data have catalysed a leap in our understanding of the three steps of chemical

159 biomarkers have made the use of NGS a major leap in personalized medicine.

160 lizable approach for achieving a performance leap in polymeric materials and provides a complementary

161 laser frequency lines, have enabled a great leap in precision spectroscopy and metrology since semin

162 This leap in predictive power offers better opportunities for

163 he potential gain we can expect of a further leap in pressure by moving from the current 1500 bar to

164 ning of single subjects, has spurred another leap in progress, allowing fMRI researchers to reliably

165 This work is a leap in silicon anode development and provides insights

166 Such a leap in source power would transform neutron scattering

167 By attaining a quantum leap in spatial and temporal resolution within the frame

168 There has been an evolutionary leap in SPECT imaging with the advent of camera systems

169 , which are likely to provide the next major leap in the efficiency of high-throughput DNA analysis.

170 Lithium metal anodes offer a huge leap in the energy density of batteries, yet their imple

171 lticellular heterotrophs, there is a quantum leap in the energy required to build a replacement soma,

172 pected in the future, and this might bring a leap in the field of genetic technology.

173 signal the potential for yet another quantum leap in the field.

174 uantum information science, there has been a leap in the formulation of novel game strategies that le

175 owever, the root cause of such a fluctuating leap in the ionic valency remains elusive.

176 ance contrast agents represent a substantial leap in the type of information that can be derived from

177 The past 20 years witnessed an enormous leap in understanding of the central regulation of whole

178 additionally, with the potential for quantum leaps in both identity and pathogenicity, such as the co

179 encing technologies have enabled significant leaps in capacity to generate large volumes of DNA seque

180 xchanges of protein sequence modules support leaps in function unavailable through point mutations du

181 nd coherent X-ray radiation, and fundamental leaps in high energy density science and laboratory astr

182 that saw few new therapies approved, despite leaps in knowledge.

183 mbines modern bioimaging informatics, recent leaps in labeling and microscopy, and the widely recogni

184 cal changes can arise from single mutational leaps in natural populations, producing new adaptive all

185 ediates, there have been no major conceptual leaps in our understanding of protein folding reactions

186 high-resolution imaging have enabled recent leaps in our understanding of RG-II structure, synthesis

187 pandemic, which showcases the extraordinary leaps in our understanding of the immune response to SAR

188 ative structural analyses suggest that major leaps in protein function occur through gene recombinati

189 mputational approaches have made significant leaps in recent years, we propose that machine-learning

190 been a prerequisite for discovery, and great leaps in scientific understanding are accompanied by an

191 the nervous system but requires significant leaps in sensitivity in high-resolution mass spectrometr

192 Building on recombinant DNA technology, leaps in synthesis, assembly, and analysis of DNA have r

193 Molecular genetics has led to monumental leaps in the understanding of long QT syndrome, and a ne

194 Quantum leaps in therapy-including the use of early, aggressive

195 Significant leaps in tissue engineered airway transplantation have c

196 me duplication as the force driving the 'big leap' in vertebrate morphological innovation.

197 t abnormal behavior (repetitive climbing and leaping) in the D1CT-7 mice at doses insufficient to ind

198 gal systematics has undergone an exponential leap, incorporating genomics, web-based systems, and DNA

199 Subjects screened for the LEAP interventional trial comprise the LEAP screening st

200 ort was instrumental in my ability to make a leap into independent research.

201 Centers for Disease Control and Prevention, LEAP is a single-year in-place, structured training for

202 utations, the probability of a multimutation leap is low, and accordingly the contribution of such le

203 LEAP is the first high throughput, non-invasive, label-f

204 ow, and accordingly the contribution of such leaps is minor at best.

205 Learning Early About Peanut Allergy (LEAP) is an interventional study aiming to assess whethe

206 aracterized the reliability and stability of LEAP, its relationship to the field potential, and its e

207 Here we introduce LEAP (LEAP estimates animal pose), a deep-learning-based

208 In the LEAP (Learning Early About Peanut Allergy) trial, early

209 Leaping lizards show that inertial control of body attit

210 nted insectivore-frugivores with a scurrying-leaping locomotion.

211 icipants ages 6 to 30 years from the EU-AIMS LEAP (Longitudinal European Autism Project).

212 ct, we should not forget that her conceptual leap met with considerable resistance from the scientifi

213 Furthermore, the binomial tau-leap method avoids negative populations and accurately c

214 Results indicate that the binomial tau-leap method is computationally 100-1000 times more effic

215 utilized the recently developed binomial tau-leap method to carry out stochastic simulations of the e

216 t utilizes the cutting-edge Oculus Rift, and Leap Motion hand detection, resulting in intuitive navig

217 with desired functionalities is an important leap necessary in leveraging the fascinating molecular s

218 ures with desired properties is an important leap necessary in leveraging the fascinating molecular s

219 of 0.864 across all pathologies-a noteworthy leap of approximately 0.352 compared to YOLOv5 + ResNet

220 Since then, a quantum leap of complexity has been achieved by a scaffolded 'or

221 n the likely prokaryotic line that made this leap of eukaryogenesis.

222 Starting a new research campus is a leap of faith.

223 on the general expectation that WGDs lead to leaps of bodyplan complexity.

224 ater' rather than making sudden cooperative 'leaps of faith' powerfully reinforces the stability and

225 that unrestrained, resting Ae. aegypti males leap off their perches and take flight when they hear fe

226 LEAP offers fast prediction on new data, and training wi

227 phasize the importance of macro-evolutionary leaps, often involving large-scale chromosomal alteratio

228 in the 12-month extension of the LEAP study (LEAP-On).

229 ed limbs synchronously while descending from leaps or heights, with such "flutter-gliding" presented

230 The behavior consists of an approach and leap out of the water during which the eel presses its c

231 onsiderable power needed for large whales to leap out of the water may represent the single most expe

232 CONCH represents a substantial leap over concurrent visual-language pretrained systems

233 ake mouse cortex, representing a substantial leap over existing integrated microscopes.

234 ed organogenesis approach represents a major leap over existing methods, offering a robust platform f

235 alian cells represents a major technological leap over RNA interference, the prior state of the art.

236 nd sensitization to egg and milk occurred in LEAP participants and was not affected by peanut consump

237 e was noted across study time points; 76% of LEAP participants had at least 1 allergic disease at 60

238 etween peanut allergy and the MALT1 locus in LEAP participants in the peanut avoidance group with 58.

239 end point (36 months for EAT, 60 months for LEAP/PAS).

240 DCs were stimulated with influenza-J-LEAPS peptides (influenza-J-LEAPS) and injected intraven

241 Influenza-J-LEAPS peptides were synthesized by conjugating the bindi

242 utilizes an augmented reality headset (Magic Leap, Plantation, FL) to display a real-time 3-dimension

243 ght to this group is part of a framework-the LEAP Process-that includes a landscape analysis of what

244 hnique that has recently undergone a quantum leap progression in its achievable resolution and its ap

245 Our data demonstrate that influenza-J-LEAPS-pulsed DCs reduce virus replication in the lungs,

246 The LEAP randomized controlled trial provides the first dire

247 LEAP raw data were retrieved from ITNTrialShare.org.

248 Here we report a method termed LEAP-RBP (Liquid-Emulsion-Assisted-Purification of RNA-B

249 By virtue of its high specificity and yield, LEAP-RBP distinguishes RNA-bound and RNA-free protein le

250 combination process can perform a series of "leaping" rearrangements and inadvertently shift their re

251 This developmental leap requires coordinated activation of megakaryocyte-sp

252 ngs on insect gait dynamics and demonstrated LEAP's applicability for unsupervised behavioral classif

253 from murid I-a precursors by an evolutionary leap ("saltation"), perhaps involving intense selective

254 r the LEAP interventional trial comprise the LEAP screening study cohort.

255 not constant, UTC contains discontinuities (leap seconds), which complicates its use in computer net

256 ng local mechanical stress, whereby crystals leap several centimeters in air.

257 study, Learning Early About Peanut Allergy (LEAP), showed that early introduction of peanut products

258 Antigen-specific LEAPS-stimulated DCs were effective in reducing influenz

259 D and Levodopa in Early Parkinson's Disease (LEAP) studies.

260 ing peanuts in the 12-month extension of the LEAP study (LEAP-On).

261 The LEAP study also showed the potential for early improveme

262 of high-risk infants were excluded from the LEAP study because of an SPT wheal size of more than 4 m

263 All but one of the 9 LEAP study consumers with peanut allergy (9/312) were co

264 is the case in ground-breaking research, the LEAP study raises almost as many questions as it resolve

265 his paper, the authors analyze data from the LEAP Study to illustrate the methods and benefits of inv

266 y associated with eczema severity across the LEAP study, whereas at 12 and 60 months of age, it was r

267 al Examination of Attitudes and Preferences (LEAP) Study (1999-2002), a Connecticut study of seriousl

268 In Learning Early About Peanut Allergy (LEAP) study participants eczema severity was assessed, a

269 in the Learning Early about Peanut Allergy (LEAP) study participants.

270 In the Learning Early About Peanut Allergy (LEAP) study, early peanut introduction in high-risk 4- t

271 in the Learning Early About Peanut Allergy (LEAP) study.

272 erance [Learning Early About Peanut Allergy (LEAP) study].

273 al (the Learning Early About Peanut Allergy [LEAP] study) provided evidence that earlier dietary pean

274 The temperature-leap tactic was critical for maintaining protein solubil

275 g to 37 degrees C, following the temperature-leap technique described by Xie and Wetlaufer, who used

276 A LEAP Technologies autosampler was customized to perform

277 ligand epitope antigen presentation system (LEAPS) technology as a new immune-based treatment for in

278 uncover a LC3C-Endocytic-Associated-Pathway (LEAP) that selectively recruits plasma-membrane (PM) car

279 lutions for the probability of multimutation leaps, that is, several mutations occurring simultaneous

280 porary domains of life, or viruses have been leaping the phylogenetic chasms that separate the domain

281 Arboreal animals often leap through complex canopies to travel and avoid predat

282 tal-parietal systems that enable inferential leaps through structural abstraction might contribute to

283 in life and relies on action potential (AP) leaps through the nodes of Ranvier (NRs) along myelinate

284 ion systems would be characterized by large "leaps" through sequence space rather than isolated point

285 The long-awaited leap to an in vivo biochemistry is at last underway.

286 how some Photorhabdus species have made the leap to becoming human pathogens.

287 hat is critical for activity, and is a major leap toward identifying the nature and consequences of m

288 The release of version 5.0 has marked a leap towards a modern software for evolutionary analyses

289 ed Pluripotent Stem Cells (iPSCs) is a major leap towards personalised approaches to disease modellin

290 orded Red-Headed Agama lizards (Agama agama) leaping towards a vertical surface by first vaulting ont

291 roups were determined among infants from the LEAP trial based on the probability of developing peanut

292 ibility and implications of implementing the LEAP trial intervention.

293 children enrolled or screened as part of the LEAP trial were assayed at 4-11 months (baseline) and 60

294 sudden jumps to release the internal strain, leaping up to several centimeters.

295 We validated LEAP using videos of freely behaving fruit flies and tra

296 f five early stages comprising developmental leaps were explored.

297 ody SPECT/CT systems has taken another major leap with the introduction of a ring-shaped gantry equip

298 ochastic simulation algorithm (SSA), and tau-leaping with automatic step size selection.

299 n chain of the human MHC class I molecule (J-LEAPS) with 15 to 30 amino acid-long peptides derived fr

300 of agile landing maneuvers enabled targeted leaping without falling.