ライフサイエンスコーパス: learning and memory

1 conditioning to facilitate associative fear learning and memory.

2 he center of molecular mechanisms underlying learning and memory.

3 esses long-term potentiation, a surrogate of learning and memory.

4 support a role for DGCs in enhancing spatial learning and memory.

5 s in the hippocampus, a region important for learning and memory.

6 ownregulation of AMPARs, thereby attenuating learning and memory.

7 omplex 1 (mTORC1) is crucial for hippocampal learning and memory.

8 lasticity in brain functions including mood, learning and memory.

9 glutamatergic neurons results in deficits in learning and memory.

10 underlies higher cognitive processes such as learning and memory.

11 e hippocampus is an essential brain area for learning and memory.

12 her hexapods, contain networks essential for learning and memory.

13 ccompanied by significantly enhanced spatial learning and memory.

14 ts from the mushroom body, site of olfactory learning and memory.

15 ncluding disruption of hippocampus-dependent learning and memory.

16 targeting of AMPARs, is required for LTP and learning and memory.

17 consistent with its role in various kinds of learning and memory.

18 Stress can either promote or impair learning and memory.

19 tivity, comprising the biophysical basis for learning and memory.

20 s modulators of complex behaviors, including learning and memory.

21 f these centers to their functional roles in learning and memory.

22 ed vagus nerve stimulation (VNS) in enhanced learning and memory.

23 g of GABAergic interneurons, impairs spatial learning and memory.

24 to adaptive responses of the brain including learning and memory.

25 lated by neural activity and correlated with learning and memory.

26 ocampal growth and life-long disturbances in learning and memory.

27 portant role in dendritic translation and in learning and memory.

28 ypical PKC, PKMzeta, a protein implicated in learning and memory.

29 morphological modifications, and ultimately, learning and memory.

30 strategy to improve learning in disorders of learning and memory.

31 mporal coding of IEGs underlying associative learning and memory.

32 tagging, two major mechanisms of associative learning and memory.

33 ka virus (ZIKV) impact hippocampal-dependent learning and memory.

34 cue-reward pairing, and supported behavioral learning and memory.

35 e hippocampal circuit, and it is crucial for learning and memory.

36 ritical for neurological function, including learning and memory.

37 neuronal morphology resulting in deficits in learning and memory.

38 plasticity, a molecular mechanism underlying learning and memory.

39 M) is widely used to evaluate rodent spatial learning and memory.

40 tabolic status to neural functions including learning and memory.

41 differentially related to distinct forms of learning and memory.

42 rain, potentially playing important roles in learning and memory.

43 ss of synaptic markers and for impairment of learning and memory.

44 t mechanisms are known to play a key role in learning and memory.

45 fications in PV+ cells that are required for learning and memory.

46 s) are glycoproteins in the brain central to learning and memory.

47 ion thought to provide the cellular basis of learning and memory.

48 s, altered DG cell composition, and impaired learning and memory.

49 most extensively studied cellular model for learning and memory.

50 ved in many forms of synaptic plasticity and learning and memory.

51 strength of synaptic changes associated with learning and memory.

52 development and they have been implicated in learning and memory.

53 fferential effects on spatial and contextual learning and memory.

54 nceptualized at a basic level as maladaptive learning and memory.

55 cade within the brain is crucial for optimal learning and memory.

56 R trafficking during synaptic plasticity and learning and memory.

57 processes ranging from muscle contraction to learning and memory.

58 ich provides a compelling cellular model for learning and memory.

59 has been appreciated since early studies on learning and memory.

60 ong been considered a cellular correlate for learning and memory.

61 icity, is accepted as the cellular basis for learning and memory.

62 portant roles in neurogenesis, as well as in learning and memory.

63 e signal to the nucleus that is critical for learning and memory.

64 erations and, thus, developmental changes in learning and memory.

65 behavioral deficits, particularly in spatial learning and memory.

66 creased Abeta pathology and improved spatial learning and memory.

67 field potential have long been implicated in learning and memory.

68 ions in rsk2 and associated with deficits in learning and memory.

69 Physical exercise is a powerful modulator of learning and memory.

70 urther resolve loss of hippocampal-dependent learning and memory.

71 Aminergic signaling modulates associative learning and memory.

72 involved in higher brain functions including learning and memory.

73 l insight into the role of this structure in learning and memory.

74 ired hippocampal LTP, as well as deficits in learning and memory.

75 lobal roles in cognitive activities, such as learning and memory.

76 echanism for higher brain functions, such as learning and memory.

77 s AD pathologies in 5xFAD mice, rescuing the learning and memory.

78 n various physiological processes, including learning and memory.

79 on factor regulating circuit development and learning and memory.

80 they produce - that plays a crucial role in learning and memory.

81 ng been considered an important component of learning and memory.

82 levels, restored synapse number and improved learning and memory.

83 ting, self-reflection, empathy, and episodic learning and memory.

84 iations instead arise from natural errors in learning and memory.

85 aviors in invertebrates and mammals, such as learning and memory.

86 the development of brain circuit functions, learning and memory.

87 ion in a context that is relevant for normal learning and memory.

88 d stereotypic behavior, and impaired spatial learning and memory.

89 cal and functional plasticity that underlies learning and memory.

90 In the hippocampus, CaMKII is required for learning and memory.

91 plexes are critical for synaptic plasticity, learning, and memory.

92 clustering facilitates circuit integration, learning, and memory.

93 s important for reward, motivation, emotion, learning, and memory.

94 rength necessary for long-term potentiation, learning, and memory.

95 n mental chronometry, perception, awareness, learning, and memory.

96 al mechanism underlying synaptic plasticity, learning, and memory.

97 esicle pools for optimal synaptic responses, learning, and memory.

98 ggregation propensity, resistance to stress, learning, and memory.

99 Mushroom bodies are essential for visual learning and memory [14-16], and therefore we investigat

100 assessed for changes in locomotor activity, learning, and memory 6 weeks later.

101 The mechanisms underlying the maturation of learning and memory abilities are poorly understood.

102 Morris water maze test revealed an impaired learning and memory ability of 9-mo-old APP/PS1 mice (P

103 lates energy homeostasis, and is involved in learning and memory acquisition.

104 These models capture patterns of learning and memory across a broad range of tasks, yet d

105 There is mounting evidence, however, that learning and memory also guide movement.

106 mance on two spatial cognitive tasks-spatial learning and memory and a consecutive reversal learning

107 process, whereby cognitive processes such as learning and memory and decision-making are modified by

108 ve biases (where cognitive processes such as learning and memory and decision-making are modified by

109 ehavior, hyperhedonia, hyperphagia, impaired learning and memory and exaggerated startle responses.

110 ation, and local translation of key mRNAs in learning and memory and expand on the notion of dynamic

111 t brain function in the essential process of learning and memory and may be compromised in degenerati

112 evelopment of the brain and support enhanced learning and memory and resistance to mood disorders suc

113 dle-aged mice enhances hippocampal-dependent learning and memory and restores it to normal performanc

114 t a novel role for Akt2 in neurodevelopment, learning and memory and show that Akt2 is a critical and

115 n had no impact on age-associated decline in learning and memory and that by 20 months post infection

116 in regulating both cognitive (e.g., spatial learning and memory) and mood behaviors.

117 e results suggest a potential role of Amh in learning and memory, and a possible cause of the sex dif

118 s complex results in hyperactivity, impaired learning and memory, and abnormal maturation and mainten

119 euronal plasticity is the cellular basis for learning and memory, and it is crucial for the refinemen

120 represent the cellular mechanisms underlying learning and memory, and many forms of plasticity are in

121 glutamate and impacts synaptic transmission, learning and memory, and neurotoxicity.

122 jecting subicular neurons in object-location learning and memory, and show that this projection modul

123 behavioral studies in female mice to analyze learning and memory, and then targeted PDE4D activation

124 receptor (mAChR) plays an important role in learning and memory, and therefore is a target for devel

125 ticipate in hippocampal functions, including learning and memory, anxiety and stress regulation, and

126 behavioural phenotype showing impairments in learning and memory, anxiety-like behaviour and sensorim

127 when neuronal circuits that are required for learning and memory are formed.

128 Emotional learning and memory are functionally and dysfunctionally

129 i regulating integration of sensory stimuli, learning and memory are likely to play a key role in obe

130 However, hippocampal synaptic plasticity, learning, and memory are impaired in these mutant mice.

131 d in part age-related impairments in spatial learning and memory as well as associative fear memory.

132 the hippocampal formation and is involved in learning and memory as well as in spatial navigation.

133 long been known to play an important role in learning and memory as well as long term potentiation (L

134 significantly impaired hippocampal-dependent learning and memory, as assayed by social recognition me

135 (5000 m for 12 weeks) exhibited deficits in learning and memory associated with hippocampal function

136 we found a significant reduction in spatial learning and memory at 24 days post-rmTBI compared to re

137 ion at 4 months (23.3% v 40.4%; P = .01) and learning and memory at 6 months (11.5% v 24.7% [P = .049

138 or short-term DAGL-alpha disruption impairs learning and memory at electrophysiological and selectiv

139 any central nervous system processes such as learning and memory, attention, motor control, and senso

140 reduces synaptic strength and is relevant to learning and memory, autism, and sensitization to cocain

141 ated neurogenic remodeling adversely affects learning and memory behavior in response to repeated ins

142 ons with neurons, coupled with diminution of learning and memory behaviors.

143 throughout their life and tested for spatial learning and memory, brain amyloidosis, tau pathology, a

144 ond messenger in neurons that contributes to learning and memory, but how the coordination of action

145 (LTP), an electrophysiological surrogate of learning and memory, but normal Abeta levels.

146 Curiosity plays a fundamental role for learning and memory, but the neural mechanisms that stim

147 Neuronal ApoE receptors are linked to learning and memory, but the pathways governing their ab

148 model posits that the dentate gyrus improves learning and memory by enhancing discrimination between

149 healthy longevity and dissociable systems of learning and memory by nearly disjoint sets of genetic a

150 naptic plasticity and cellular mechanisms of learning and memory can be elicited or disrupted in the

151 and temporal lobes together regulate complex learning and memory capabilities.

152 reduced synaptic functionality and impaired learning and memory capabilities.

153 ), salience detection (anterior insula), and learning and memory (caudate and parahippocampal gyrus).

154 HAT levels specifically in the mushroom body learning and memory center in the Drosophila brain prote

155 Mushroom bodies are the iconic learning and memory centers of insects.

156 ould guide future functional studies of this learning and memory centre.

157 chamber to further investigate the nature of learning and memory changes.

158 multifaceted functions in brain development, learning and memory consolidation by selectively elimina

159 ocampus, a brain region that is critical for learning and memory, contains a large number of neurons

160 sible for persistent synaptic plasticity and learning and memory defects in adult mice.

161 ant-specific Drosophila models, which showed learning and memory defects upon CNOT1 knockdown.

162 ippocampus and cortex neurodegeneration, and learning and memory defects.

163 intracerebroventricular injection exhibit a learning and memory deficit in object recognition, fear

164 rus overexpressing Cav-1 (AAV-Cav-1) rescues learning and memory deficits and reduces pathology (i.e.

165 but elicits varying magnitudes of behavioral learning and memory deficits in mice.

166 e adult brain prevents hippocampus-dependent learning and memory deficits, restores motor function af

167 vels induce AD-associated neuropathology and learning and memory deficits.

168 l effectively rescued adult neurogenesis and learning and memory deficits.

169 ts in neuronal polyribosome aggregations and learning and memory deficits.

170 mutant mice displayed hippocampal-dependent learning and memory deficits.

171 abeled cell changes and prevented associated learning and memory deficits.

172 sible for synapse damage, neurodegeneration, learning, and memory deficits in AD.

173 , without affecting performance in a spatial learning- and memory-dependent task.

174 Here we investigate learning and memory differences in zebrafish (Danio reri

175 naptic plasticity, and hippocampal-dependent learning and memory due to a failure in learning-induced

176 ST population caused stereotypies as well as learning and memory dysfunction.

177 cience reveal multiple, interacting forms of learning and memory (e.g., semantic associative memory,

178 Hippocampus-dependent learning and memory emerge late in altricial mammals [14

179 rocessing speed (eta(p) (2) 0.057-0.067) and learning and memory (eta(p) (2) 0.048-0.052).

180 urotransmitter dopamine has been linked with learning and memory for a long time, dopaminergic effect

181 ENT It is established that exercise promotes learning and memory formation and alleviates the symptom

182 uces the Mus musculus Bdnf gene and promotes learning and memory formation.

183 Exercise promotes learning and memory formation.

184 of markers involved in synaptic plasticity, learning, and memory formation such as Egr-1, Arc1, and

185 ing the initiation of synaptic transmission, learning, and memory formation.

186 Here, we investigated the learning and memory function of CaMK2N1 by knocking-down

187 mpal neurogenesis plays an important role in learning and memory function throughout life.

188 ever, how replay supports both goal-directed learning and memory-guided decision making is unclear.

189 Whereas DG's function in spatial learning and memory has been extensively investigated, i

190 different behaviors such as movement, sleep, learning, and memory has been well documented, the ident

191 tegral to the synaptic plasticity underlying learning and memory; however, this process cannot be exp

192 onal modification associated with cancer and learning and memory impairment, yet our understanding of

193 kg, i.p., 3 times per week, 4 weeks) rescued learning and memory impairments, as measured by three di

194 GSK3beta signaling, consistent with observed learning and memory impairments.

195 n barrier and promotes hippocampal dependent learning and memory in a BDNF-dependent manner.

196 neuron-specific expression of USP6 enhances learning and memory in a transgenic mouse model.

197 rations in various brain regions, as well as learning and memory in adults.

198 neuroplasticity, and significantly improves learning and memory in aged mice.

199 ce neither positively nor negatively impacts learning and memory in aging.

200 r genetics is associated with differences in learning and memory in animals and humans.

201 a crucial role for oestradiol in regulating learning and memory in females, a growing body of litera

202 d synaptic plasticity/maturation and spatial learning and memory in FXS mice, we investigated whether

203 itical role in many processes fundamental to learning and memory in health and are implicated in Alzh

204 gap, we examined behavioral tasks to assess learning and memory in homozygous Kv7.2 knock-in mice, K

205 ttenuate ketamine-induced deficits in verbal learning and memory in humans.

206 did not cause radiation-induced deficits in learning and memory in mice.

207 for fine-tuning Ras/ERK signaling as well as learning and memory in mice.

208 amyloids into the lateral ventricle impairs learning and memory in mice.

209 cipient dyads downplays the critical role of learning and memory in primate communication [1] - an ar

210 ting demonstrated a modest effect on spatial learning and memory in SAM-exposed rats.

211 nd perceptual training strategies to improve learning and memory in the adult auditory system.

212 such as psychomotor hyperactivity, impaired learning and memory in the recipient animals.

213 of forthcoming CCD are thought to depend on learning and memory in two ways: First, through direct e

214 s a powerful model for studying sensorimotor learning and memory in vertebrates.

215 ), a positive feedback process implicated in learning and memory in which postsynaptic depolarization

216 sed from neurons and known to play a role in learning and memory, in antidepressant-associated increa

217 t on CNS function, as demonstrated by normal learning and memory, in contrast with heterozygous NGF k

218 ticular hypoactivity and various deficits in learning and memory, including cerebellum-dependent dela

219 ety-like behaviors and enhanced the aversive learning and memory index in sham animals, although it h

220 An important tenet of learning and memory is the notion of a molecular switch

221 LTP, a fundamental mechanism of learning and memory, is a highly regulated process.

222 in synaptic strength underlie many forms of learning and memory, it remains challenging to connect c

223 enotypes primarily associated with AD [i.e., learning and memory (L&M)] and VaD (i.e., information pr

224 naptic plasticity and cellular mechanisms of learning and memory (LTP) are already functional in the

225 y fiber synapses, which play a major role in learning and memory, may remain dynamic throughout life.

226 is involved in physiological processes like learning and memory, motor control and reward, and patho

227 receptors (MRs) in the brain play a role in learning and memory, neuronal differentiation, and regul

228 promoter was paired with a quantification of learning and memory of contextual fear conditioning, exp

229 romising treatment modality for disorders of learning and memory, offering the possibility of precise

230 3) and monitored mouse weight, survival, and learning and memory over the ensuing 20 months.

231 ly, the cognitive domains represented verbal learning and memory (p = 0.0091, beta = -0.044) and verb

232 al and pathophysiological situations such as learning and memory, pain sensation, fear and anxiety, s

233 unit in neuronal circuits, are critical for learning and memory, perception, thinking, and reaction.

234 pal CA1 LTP, differentially disrupts spatial learning and memory performance in Morris water maze (MW

235 phorylation, whereas spatial and associative learning and memory performances were improved.

236 echanisms that normally serve reward-related learning and memory, primarily by evoking changes in glu

237 These cues are formed by normal learning and memory principles, and the understanding of

238 ide DNA methylation changes during olfactory learning and memory process in A. mellifera using whole

239 ent of DNA methylation in honeybee olfactory learning and memory process.

240 , and whether the hippocampus is involved in learning and memory processes early in life.

241 (sub)cortical networks and are implicated in learning and memory processes in monkeys and humans.

242 tes feeding-relevant biological signals with learning and memory processes to regulate feeding.

243 e to the medial diencephalon can impact upon learning and memory processes, highlighting an important

244 xcitability have been shown to underlie many learning and memory processes, little is known about the

245 Chronic stress leads to disruptions in learning and memory processes.

246 REB), a transcriptional factor involved with learning and memory processes.

247 ighly expressed in brain regions involved in learning and memory processes.

248 f Abeta in both cellular compartments affect learning and memory, reduce the number of synapses and t

249 pyramidal neurons, a critical cell type for learning and memory relevant to FXS phenotypes.

250 Learning and memory rely on dopamine and downstream cAMP

251 The hippocampus is critical for learning and memory, relying in part on pattern separati

252 s, yet the cellular substrates for olfactory learning and memory remain unknown.

253 vo to induce neural code transformations and learning and memory remains to be addressed.

254 ne; however, in mammals, the role of ERVs in learning and memory remains unclear.

255 A central goal in learning and memory research is to reveal the neural sub

256 he treatment ameliorated deficits in spatial learning and memory retention observed in irradiated mic

257 in BDNF are associated with improved spatial learning and memory retention.

258 h OSAS, which correlates with a lower verbal learning and memory score.

259 More broadly, models of learning and memory should consider intrinsic plasticity

260 t changes in neuronal gene expression during learning and memory.SIGNIFICANCE STATEMENT Precise neuro

261 well as activity, anxiety-related behavior, learning and memory, socialization, and depressive-like

262 ccuracy: P = 0.99, Cohen's d = 0.04), visual learning and memory (speed: P = 0.99, Cohen's d = 0.04;

263 ted expression of proximal genes involved in learning and memory, stem cell maintenance and different

264 works in the brain are simply a byproduct of learning and memory storage.

265 ught to depend on brain regions critical for learning and memory such as the prefrontal cortex (PFC)

266 e genes, some are critical genes involved in learning and memory, such as cdk5 and chrna7, indicating

267 re driven by molecular systems that underlie learning and memory, such as changes in cellular excitab

268 se DMGs, many are critical genes involved in learning and memory, such as Creb, GABA B R and Ip3k, in

269 asticity in regions of the brain involved in learning and memory, such as the hippocampus.

270 e expression in the brain and involvement in learning and memory suggest a central role in the nervou

271 mice, unlike EP2(-/-) mice, exhibited normal learning and memory, suggesting a confounding effect fro

272 lated immediate early gene, is essential for learning and memory, synaptic plasticity, and maturation

273 mise DG plasticity or spatial and contextual learning and memory tasks employed in our study, consist

274 as well as in hippocampal-dependent spatial learning and memory tasks, and on the production of endo

275 lacking PirB also perform better than WT in learning and memory tasks.

276 urther evaluation included other non-spatial learning and memory tasks.

277 performed a dual-task paradigm and a verbal learning and memory test during and out of symptomatic a

278 adversity is associated with impairments in learning and memory that may emerge later in life.

279 egrated expression of three major systems of learning and memory that regulate (1) associative condit

280 ain structures underlying procedural memory (learning and memory that rely on the basal ganglia and a

281 and how they relate to general processes of learning and memory, the review discusses how aging affe

282 ke and sleep SWRs both contribute to spatial learning and memory, thought to be mediated by the coord

283 integrative roles in cognition, ranging from learning and memory to flexible adaption.

284 ologic and pathologic processes ranging from learning and memory to stroke.

285 is thought to be the cellular equivalent of learning and memory, was impaired.

286 Given the interactions of sleep with learning and memory, we hypothesized that increasing sle

287 n data suggesting the importance of sleep in learning and memory, we tested a hypothesis that sleep p

288 n, deficits in hippocampal-dependent spatial learning and memory were exaggerated in E4 mice.

289 ed and information processing, attention and learning and memory were examined with the Trail Making

290 ing, we found that individual differences in learning and memory were positively associated with LC i

291 Hippo-DKO mice also display abnormal spatial learning and memory whereas CeA-DKO mice have impaired c

292 lin/IGF-1 signaling is important for spatial learning and memory whereas insulin/IGF-1 signaling in t

293 induced transcriptional programs related to learning and memory, which were sensitive to ACSS2 inhib

294 ith and affect developmental trajectories of learning and memory will inform treatment and prevention

295 ) is a leading cellular model for behavioral learning and memory with rich computational properties.

296 mushroom body (MB) is involved in olfactory learning and memory, with different compartments control

297 global cognition, attention, working memory, learning, and memory, with the exception of nonverbal me

298 ise (CE) is an effective approach to promote learning and memory, yet little is known about the under

299 stimulation (VNS) has been shown to enhance learning and memory, yet the mechanisms behind these enh

300 Exercise is a potent enhancer of learning and memory, yet we know little of the underlyin