ライフサイエンスコーパス: lectin receptor

1 l antibody or delivered via DC-SIGN, another lectin receptor.

2 esting stimulation via a dendritic cell (DC) lectin receptor.

3 inding is mediated by a porcine Kupffer cell lectin receptor.

4 endocytic Mrc1 (MMR, CD206) mannose-binding lectin receptor.

5 t spores and depends upon Dectin-1, a C-type lectin receptor.

6 n and, thus, likely to be mediated by C-type lectin receptors.

7 ens to dendritic cells (DCs) through various lectin receptors.

8 tein-specific N-glycan ligand for pancreatic lectin receptors.

9 2p13.1 to p13.2) which contains genes for NK lectin receptors.

10 r integrin and minor roles for scavenger and lectin receptors.

11 us expression of sucrase-isomaltase and most lectin receptors.

12 nd blocks their ability to engage inhibitory lectin receptors.

13 ough innate immune receptors, such as C-type lectin receptors.

14 ducible gene 1-like receptors and the C-type lectin receptors.

15 reflect the functions of multiple endocytic lectin receptors.

16 bearing cryptic ligands of various endocytic lectin receptors.

17 hment mechanisms such as heparan sulfates or lectin receptors.

18 molecules but prominent expression of C-type lectin receptors.

19 c expression pattern was observed for C-type lectin receptors.

20 The interaction of C-type lectin receptor 2 (CLEC-2) on platelets with Podoplanin

21 receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immu

22 occur in mice lacking alpha-granules, C type lectin receptor-2 (CLEC-2), or protease activated recept

23 In a targeted screen of C-type lectin receptors, a Clec2d reporter responded to lysates

24 TLRA/C-type lectin receptor agonist combinations were screened for e

25 onsisting of a Toll-like receptor and C-type lectin receptor agonist pairing that significantly incre

26 at distinct combinations of TLRAs and C-type lectin receptor agonists may enhance Th1 responses of ne

27 s the simplest, single domain, type I C-type lectin receptor and showed it was expressed mainly on th

28 y unrecognized link between a myeloid C-type lectin receptor and Th2 immunity.

29 n the signaling cascade downstream of C-type lectin receptors and as critical mediators of the anti-f

30 strated that although mannose-binding C-type lectin receptors and CD4 are the principal receptors for

31 ptors, including Toll-like receptors, C-type lectin receptors and NOD-like receptors.

32 ng and activating dendritic cells via C-type lectin receptors and reduce side effects.

33 exhibited a restricted repertoire of C-type lectin receptors and relied on CD4 for uptake of Env.

34 uman and murine immune cells employed C-type lectin receptors and Siglecs to help capture the Spike p

35 patterns impact their recognition by C-type lectin receptors and the immunomodulatory effect of the

36 The relationships between distinct lectin receptors and their endogenous ligand repertoires

37 d member of the "Dectin-2 cluster" of C-type lectin receptors and was originally thought to be expres

38 [IL]-10, IL-1RA, CD163, scavenger and C-type lectin receptors) and collagen genes, whereas they were

39 nized by Mincle (macrophage inducible C-type lectin receptor), and its adjuvanticity depends on the i

40 receptors, RIG-I-like RNA helicases, C-type lectin receptors, and many more.

41 ti-fungal innate immune signaling via C-type lectin receptors, and several immune-related disorders a

42 of FcgammaRII, type II Fc receptors, C-type lectin receptors, and sialic acid-binding immunoglobulin

43 Although C-type lectin receptor- and Toll-like receptor-induced signalin

44 In this context, endocytic C-type lectin receptors are attractive targeting molecules.

45 tionalized with antibody, ss-DNA, aptamer or lectin receptors, are particularly useful for direct det

46 n (STAT)1, which suppresses CD209a, a C-type lectin receptor associated with severe disease.

47 activity and parasite growth involved C-type lectin receptors, because mannose injection decreased ar

48 The C-type lectin receptor blood dendritic cell Ag 2 (BDCA2) is exp

49 ractions with CD4 and mannose-binding C-type lectin receptors, but not with the chemokine receptors C

50 Our results demonstrate that lectin receptors can potentially function as eNAD(+)-bin

51 f the chemokine receptor CCR5 and the C-type lectin receptor CD161, both implicated in regulating tis

52 The immunoglobulin-like lectin receptor CD169 (Siglec-1) mediates the capture of

53 y an 18-fold higher expression of the C-type lectin receptor CD209a, a murine homolog of human DC-spe

54 Here, we show that the C-type lectin receptor CD69 controls tTreg cell development and

55 CLEC-2 is a member of new family of C-type lectin receptors characterized by a cytosolic YXXL downs

56 We recently showed that the C-type lectin receptor CLEC-1 is able to recognize necrotic cel

57 The C-type lectin receptor CLEC-2 activates platelets through Src a

58 The C-type lectin receptor CLEC-2 signals through a pathway that is

59 during development by activating the C-type lectin receptor, CLEC-2, on platelets.

60 Here, we identified functions of one C-type lectin receptor, CLEC12A, in facilitating DC binding and

61 emonstrate that the expression of the C-type lectin receptor CLEC4A2 is a distinguishing feature of v

62 he genes most upregulated in pDC were C-type lectin receptor CLEC4E, IL-1Rs (IL-1R1 and -2), proinfla

63 We investigated the role of the C-type lectin receptor, CLEC5A, in macrophage activation and pu

64 Here, we have identified the C-type lectin receptor CLECSF8 (CLEC4D, MCL) as a key molecule

65 w that a toll-like receptor (TLR) and C-type lectin receptor (CLR) agonist pairing of monophosphoryl

66 ycans that support recognition by the C-type lectin receptor (CLR) DC-specific intercellular adhesion

67 loglycoprotein receptor (DC-ASGPR), a C-type lectin receptor (CLR) expressed on human DCs, resulted i

68 Dectin-1 is a C-type lectin receptor (CLR) expressed on the surface of variou

69 Whether the PRRs of the C-type lectin receptor (CLR) family including Dectin-2 may be i

70 Members of the C-type lectin receptor (CLR) family stand out among the special

71 replication significantly upregulated C-type lectin receptor (CLR) macrophage-inducible Ca2+-dependen

72 The myeloid C-type lectin receptor (CLR) MINCLE senses the mycobacterial ce

73 , trehalose dimycolate, activates the C-type lectin receptor (CLR) Mincle.

74 al infection stimulates the canonical C-type lectin receptor (CLR) signaling pathway via activation o

75 Dectin-1, a C-type lectin receptor (CLR), is largely known to induce inflam

76 hat are associated with activation of C-type lectin receptors (CLR) Dectin-1- and Dectin-2-mediated C

77 significant mRNA upregulation of both C-type lectin receptors (CLR) Mincle and MCL in Msg protein pre

78 The C-type lectin receptors (CLR) MINCLE, MCL, and DECTIN-2 are exp

79 C-type lectin receptors (CLRs) are essential in shaping the imm

80 C-type lectin receptors (CLRs) are pattern recognition receptor

81 C-type lectin receptors (CLRs) comprise a heterogeneous group o

82 C-type lectin receptors (CLRs) expressed by myeloid cells const

83 everal spleen tyrosine kinase-coupled C-type lectin receptors (CLRs) have emerged as important patter

84 owever, the role of TRAF6 and TAK1 in C-type lectin receptors (CLRs) in response to fungal infection

85 Herein we demonstrate that 2 C-type lectin receptors (CLRs) Mcl and Mincle play an important

86 C-type lectin receptors (CLRs) play key roles in antifungal def

87 C-type lectin receptors (CLRs) represent a family of pattern re

88 C-type lectin receptors (CLRs) such as Dectin-2 function as pat

89 Dendritic-cell (DC)-associated C-type lectin receptors (CLRs) take up antigens to present to T

90 The innate pattern recognition C-type-lectin receptors (CLRs), including mannose receptor (MRC

91 attern recognition receptors, such as C-type lectin receptors (CLRs), on dendritic cells (DCs).

92 degradation, as virus engagement with C-type lectin receptors (CLRs), such as DC-SIGN (DC-specific IC

93 C-type lectin receptors (CLRs), the carbohydrate-recognizing mo

94 recognition receptors (PRRs) known as C-type lectin receptors (CLRs).

95 pattern recognition receptors such as C-type lectin receptors (CLRs).

96 We chose C-type lectin receptors (CTLs) expressed on immune cells as a m

97 kDa Mfa1 (minor) fimbria, targets the C-type lectin receptor DC-SIGN for invasion and persistence wit

98 The C-type lectin receptor DC-SIGN is a pattern recognition recepto

99 (DCs), including cells expressing the C-type lectin receptor DC-SIGN, persisted at sites of HSV-2 rea

100 nt antibodies 2G12 and PGT123, or the C-type lectin receptor DC-SIGN.

101 g transfected cell lines, the type II C-type lectin receptor DC-specific ICAM-3-grabbing nonintegrin

102 ndritic cells (DCs) via targeting the C-type lectin receptor DC-specific intercellular adhesion molec

103 The endocytic C-type lectin receptors DC-SIGN and Langerin display expression

104 Here we show that C-type lectin receptors, DC-SIGN, L-SIGN and the sialic acid-bi

105 e, we found that the FcRgamma-coupled C-type lectin receptor DCAR (dendritic cell immunoactivating re

106 port intradermally injected mAbs against the lectin receptor DEC-205/CD205 in vivo.

107 d pulmonary dendritic cells express a C-type lectin receptor, DEC-205 (CD205), which mediates antigen

108 The C-type lectin receptor dectin-1 functions as a pattern recognit

109 tic cells (DCs) and macrophages via a C-type lectin receptor dectin-1 pathway.

110 The Syk-coupled C-type lectin receptor Dectin-1 was the first non-Toll like rec

111 The myeloid C-type lectin receptor Dectin-2 directs the generation of Th2 a

112 n (Mn), an Mn (sugar) polymer, by the C-type lectin receptor Dectin-2 on host macrophages leads to a

113 sonization but appears to require the C-type lectin receptor Dectin-3, a receptor not previously eval

114 Measuring the expression of C-type lectin receptors dectin-1, dectin-2, dectin-3, and manno

115 us TLRs (TLR2, TLR3, TLR4, and TLR7), C-type lectin receptors (Dectin-1, Dectin-2, and Mincle), and t

116 we demonstrated that activation of a C-type lectin receptor, dectin-1, in MDSC differentially modula

117 Previously we identified the novel type II lectin receptor, dectin-1, that is expressed preferentia

118 ucan that activates the CARD9-coupled C-type lectin receptor, Dectin-1.

119 e marrow-derived dendritic cells from C-type lectin receptor-deficient mice revealed that the immunos

120 sed glycomimetics targeting the human C-type lectin receptor dendritic cell-specific intercellular ad

121 Fcgamma receptor I (FcgammaRI; CD64) and the lectin receptor dendritic cell-specific intercellular ad

122 Conversely, signaling via other C-type lectin receptors did not alter disease course.

123 ype lectin-like (MICL), an inhibitory C-type lectin receptor, directly recognizes DNA in NETs; this i

124 mannose-dependent ligands for innate immune lectin receptors, disrupting the phylogenic basis of thi

125 toll-like receptors (TLRs) and fungal C-type lectin receptors (e.g., dectin-1).

126 molecule-3-grabbing nonintegrin) is a C-type lectin receptor expressed on macrophages and dendritic c

127 Previously, we identified dectin-2, a C-type lectin receptor expressed selectively by LC-like XS cell

128 ectin receptor with high homology to type II lectin receptors expressed by natural killer (NK) cells.

129 The two inhibitory C-type lectin receptors expressed by neutrophils, CLEC12A and D

130 C-type lectin receptors expressed mostly by myeloid cells play

131 tor (MR, CD206) is a transmembrane endocytic lectin receptor, expressed in selected immune and endoth

132 urthermore, common unique patterns of C-type lectin receptor expression were identified between these

133 ytes, macrophages, and DC; determined C-type lectin receptor expression; and tested the contribution

134 GR-1 is replaced by that of unrelated C-type lectin receptors fail to promote cross-presentation.

135 been the parallel discoveries in the C-type lectin receptor family and the Th effector arms of immun

136 known to interact with members of the C-type lectin receptor family of pattern recognition proteins,

137 Many members of the C-type lectin receptor family serve as pattern recognition rece

138 bbing nonintegrin (DC-SIGN), from the C-type lectin receptor family, plays one of the most important

139 primarily mediated by members of the C-type lectin receptor family.

140 Dectin-1 is a lectin receptor for beta-glucan that is important for in

141 n profile of all KIR family genes and C-type lectin receptor genes using RNA sequencing on NKTCL case

142 More recently, ATVs targeted to C-type lectin receptors have been exploited for induction of po

143 PAR)-2, Toll-like receptor (TLR), and C-type lectin receptors have been suggested to be important for

144 singly high affinities toward Concanavalin A lectin receptor in comparison to their homomultivalent a

145 Increasingly, roles are emerging for C-type lectin receptors in immune regulation.

146 ike receptor, the characterization of C-type lectin receptors in innate immunity requires the identif

147 eptors, receptor tyrosine kinase, and C-type lectin receptors in the context of recent progress in th

148 s blockade of CD4 and mannose-binding C-type lectin receptors including dendritic cell-specific inter

149 l immune response via FcRy-associated C-type lectin receptors, including Mincle, and caspase-recruitm

150 In particular, C-type lectin receptors, including the mannose receptor (MR), f

151 in and mRNA levels, thereby affecting C-type lectin receptor-induced modulation of IDO activity in DC

152 Thus, targeting glycosylation-dependent lectin-receptor interactions may increase the efficacy o

153 Additionally, Mincle, a C-type lectin receptor, interacts with Fu-Hp to amplify the inf

154 CLEC9A is a recently discovered C-type lectin receptor involved in sensing necrotic cells.

155 ate recognition domain of Langerin, a C-type lectin receptor involved in the host defense against vir

156 ation of both Toll-like receptors and C-type lectin receptors is required for IRF1-mediated IRGB10 re

157 ach is that structural information about the lectin/receptor is not required to obtain a multivalent

158 We discovered that layilin, a C-type lectin receptor, is predominantly expressed on Tregs in

159 Here, we identify a lectin receptor kinase (LecRK), LecRK-I.8, as a potentia

160 ogen infection and that both eNAD(P) and the lectin receptor kinase (LecRK), LecRK-VI.2, are required

161 We demonstrate that the lectin receptor kinase (LecRK), LecRK-VI.2, is a potenti

162 not Respond to Nucleotides 1), defective in lectin receptor kinase I.9 (Arabidopsis Information Reso

163 strate that HAAs are sensed by the bulb-type lectin receptor kinase LIPOOLIGOSACCHARIDE-SPECIFIC REDU

164 We demonstrate that the lectin receptor kinase RDA2 is essential for perceiving

165 bidopsis (Arabidopsis thaliana) P2K1 (L-type lectin receptor kinase-I.9), was shown to contribute to

166 demonstrate that the BABA-responsive L-type lectin receptor kinase-VI.2 (LecRK-VI.2) contributes to

167 mapped and is defective in a gene encoding a lectin receptor kinase.

168 evealed that a member of the A4 subfamily of lectin receptor kinases (LecRKs) of Arabidopsis (Arabido

169 tode trehalase enabled the identification of lectin receptor kinases LecRK-V.5 and LecRK-V.6 as key c

170 Additionally, 2 L-type lectin receptor kinases, GmLecRK02g and GmLecRK08g, asso

171 Selective ligands for the C-type lectin receptor L-SIGN offer promising avenues in antivi

172 human and murine forms of the myeloid C-type lectin receptor langerin for simple and complex ligands

173 ans cells (eLCs) uniquely express the C-type lectin receptor langerin in addition to the HIV entry re

174 Their exclusive expression of the C-type lectin receptor Langerin makes them prominent candidates

175 The C-type lectin receptor langerin plays a vital role in the mamma

176 al Langerhans cells (LCs) express the C-type lectin receptor langerin that functions as a pattern rec

177 This notably depends on the C-type lectin receptor, langerin or DC-SIGN, involved in gp120

178 utrophils elicited in the presence of C-type lectin receptor ligands have an increased ability to pro

179 Lectin receptor-like kinase (LecRK1) is involved in the

180 Here, we show that OsLIKE1 functions as a lectin receptor-like kinase (LecRLK) to play a critical

181 Lectin receptor-like kinases (LecRLKs) are class of memb

182 Lectin receptor-like kinases (LecRLKs) are members of RL

183 Lectin receptor-like kinases (Lectin RLKs) are a large f

184 lose-6,6-dibehenate (TDB) bind to the C-type lectin receptors macrophage-inducible C-type lectin (Min

185 ual activation of newborn DCs via the C-type lectin receptor, macrophage-inducible C-type lectin (tre

186 s mediated through the recognition of C-type lectin receptors, mainly elicited by structurally unique

187 damaged epithelium via expression of C-type lectin receptors, many of which signal through the Syk s

188 onintegrin (DC-SIGN), mannose binding C-type lectin receptors (MCLR), and heparan sulfate proteoglyca

189 f B cells binds gp120 through mannose C-type lectin receptors (MCLRs).

190 ts maintained the ability to bind the C-type lectin receptor MelLec, whose interaction with immunolog

191 ewis(X) (Le(X)) re-directs OVA to the C-type lectin receptor MGL1.

192 halose-6,6-dimycolate (TDM) binds the C-type lectin receptor MINCLE and induces inflammatory gene exp

193 The Syk-coupled C-type lectin receptor Mincle detected mucosal-resident commens

194 previously uninvestigated role of the C-type lectin receptor Mincle in pneumonic sepsis caused by K.

195 The C-type lectin receptor Mincle is known for its important role i

196 alose dimycolate (cord factor) by the C-type lectin receptor mincle partially explains this CARD9 req

197 ent of Toll-like Receptor 7/8 and the C-type lectin receptor Mincle.

198 ed the expression and function of the C-type lectin receptor Mincle.

199 In rodents, the C-type lectin receptors Mincle and Mcl bind TDB/TDM and activat

200 or (CLR) macrophage-inducible Ca2+-dependent lectin receptor (Mincle).

201 s on the expression levels of two key C-type lectin receptors, namely the mannose receptor and DC-spe

202 r immunoglobulinlike receptor (KIR) and CD94 lectin receptor negative.

203 vely recognized by Mincle (Clec4e), a C-type lectin receptor of the innate immune system that is stro

204 Mincle is a C-type lectin receptor of the innate immune system with the abi

205 accharide-coated beads, indicating selective lectin receptor/oligosaccharide interactions mediating c

206 responsible for this interaction involves a lectin receptor on the surface of the porcine Kupffer ce

207 have previously shown that different C-type lectin receptors on DCs play a major role in allergen re

208 tochastic activation of toll-like and c-type lectin receptors on macrophages causes neuroprotection o

209 Clec9a (C-type lectin receptor) or DNGR-1 (dendritic cell NK lectin gro

210 The C-type lectin receptor pathway activates both MAPK and NF-kappa

211 We sought to analyze C-type lectin receptor pathways as an alternative or a coactiva

212 C-type lectin receptors play important roles in immune cell int

213 functional engagement of an inhibitory host lectin receptor promotes bacterial innate immune evasion

214 ur data indicate pDCs express various C-type lectin receptors, recognize and respond to Aspergillus h

215 ined the mechanism by which Mincle, a C-type lectin receptor, regulates NET formation.

216 n (cis infection), whereas binding to C-type lectin receptors results both in cis replication, as wel

217 rt, we demonstrate that expression of C-type lectin receptor scavenger receptor-AI (SR-AI) is crucial

218 C-type lectin receptors sense a diversity of endogenous and exo

219 Therein, the endocytic C-type lectin receptors serve as pattern recognition receptors,

220 ene expression, particularly of TLRs, C-type lectin receptors, several complement components, as well

221 CD33-related sialic acid binding Ig-like lectin receptors (Siglecs) have been implicated in the c

222 alic acid-binding immunoglobulin superfamily lectin receptors (Siglecs) provide negative regulation.

223 s of glycan-binding proteins, such as C-type lectin receptors, Siglecs, and Galectins, in generating

224 s residing in the lymph node medulla use the lectin receptor SIGN-R1 to capture lymph-borne influenza

225 show that recruited IDCs express the C-type lectin receptor SIGN-R1, which mediates direct recogniti

226 IL-17 signaling, Chemokine signaling, C-type lectin receptor signaling and Toll-like receptor signali

227 illustrate the complexity of myeloid C-type lectin receptor signaling, and how an activating hemITAM

228 We propose that a C-type lectin receptor, SIGNR-1 (also called Cd209b), helps to

229 G2D reveals close homology with other C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69

230 The C-type lectin receptor-Syk (spleen tyrosine kinase) adaptor CAR

231 hway of ER quality control consists of a two-lectin receptor system consisting of Yos9p and Htm1/Mnl1

232 DNGR-1 is a C-type lectin receptor that binds F-actin exposed by dying cell

233 Dectin-1 (Clec7a) is a paradigmatic C-type lectin receptor that binds Syk through a hemITAM motif a

234 MGL is a C-type lectin receptor that binds Tn antigens and can route the

235 s a myeloid cell-expressed inhibitory C-type lectin receptor that can sense cell death under sterile

236 Mincle is a C-type lectin receptor that is critical in the immune response

237 Langerin is a C-type lectin receptor that recognizes glycosylated patterns on

238 occurs upon engagement of Dectin-1, a C-type lectin receptor that signals via spleen tyrosine kinase

239 ese findings place Dectin-2 among the C-type lectin receptors that activate arachidonic acid metaboli

240 ber of spleen tyrosine kinase-coupled C-type lectin receptors that have been implicated not just in f

241 rate that human NK cells also express C-type lectin receptors that influence recognition of polymorph

242 specific compartments is regulated by C-type lectin receptors that recognize glycan structures.

243 tly higher induction of CD23, a novel C-type lectin receptor, through NFATc1-mediated regulation of t

244 ed to DC surface receptors (including C-type lectin receptors, TLRs, and galectins).

245 us, CLEC9A functions as a SYK-coupled C-type lectin receptor to mediate sensing of necrosis by the pr

246 We show how the signaling capacity of lectin receptors using a similar signal transduction pat

247 Surprisingly, activity at the C-type lectin receptors was particularly powerful, with C5aR2 a

248 in DCs bound and internalized Env via C-type lectin receptors, whereas blood DC subsets, including CD

249 . albicans infection via signals from C-type lectin receptors, which signal through the adaptor CARD9

250 CLEC4M is a lectin receptor with a polymorphic extracellular neck re

251 DECTIN-1 is a type II lectin receptor with high homology to type II lectin rec

252 Siglec-6 is a lectin receptor with restricted expression in the placen