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2 d for potential confounders and incident AF, left atrial abnormality was associated with incident isc
4 l venous approach was used to gain right and left atrial access under general anesthesia in healthy s
6 ngs add to the hypothesis that the posterior left atrial adipose tissue mass contributes to structura
9 ry disease), each gram increase of posterior left atrial adipose tissue was associated with 1.32 odds
10 atrial fibrillation, ultrasound M-mode-based left atrial anatomies were successfully created, and abl
12 ESI >3.7 g/day was associated with larger left atrial and left ventricular dimensions (p < 0.05).
15 nificant improvement in AF symptoms, o2peak, left atrial and ventricular function, lipid levels, and
16 associated with reductions in inflammation, left atrial and ventricular remodeling, sleep apnea, blo
17 x, left ventricular volume index and maximal left atrial anterior-posterior diameter while RGS3 can i
19 er the empirical electrical isolation of the left atrial appendage (LAA) could improve success at fol
21 of this study was to evaluate the impact of left atrial appendage (LAA) exclusion on short-term outc
22 the characterization of left atrial (LA) and left atrial appendage (LAA) flow dynamics in patients wi
23 formed in sinus rhythm at 6 months to assess left atrial appendage (LAA) function were included in th
29 Long-term data on the safety and efficacy of left atrial appendage closure (LAAC) for stroke preventi
31 erapy on coagulation system activation after left atrial appendage closure (LAAC) remains unknown.
34 Atrial Fibrillation) trial demonstrated that left atrial appendage closure (LAAC) with the Watchman d
36 an updated overview of current transcatheter left atrial appendage closure devices and review the res
38 fibrillation patients receiving the WATCHMAN left atrial appendage closure technology was designed to
39 Fibrillation Patients Receiving the WATCHMAN Left Atrial Appendage Closure Technology, patients with
42 [PST] or patient's self-management [PSM] and left atrial appendage closure) are based on the concept
43 rocedure (mitral and tricuspid valve repair, left atrial appendage closure, and paravalvular leak clo
44 vices and review the results associated with left atrial appendage closure, focusing on procedural an
47 ty leading to stasis of blood flow following left atrial appendage electrical isolation (LAAEI) could
50 AF the intramyocardial blood vessels of the left atrial appendage have an increased CML presence and
51 tion in alcohol intake, and occlusion of the left atrial appendage in patients with atrial fibrillati
52 mly assigned to undergo empirical electrical left atrial appendage isolation along with extensive abl
53 ng the effectiveness of empirical electrical left atrial appendage isolation for the treatment of LSP
55 ring repeat procedures, empirical electrical left atrial appendage isolation was performed in all pat
56 ventricular tachycardia ablation and Lariat left atrial appendage ligation that involve the epicardi
60 reviewed 301 consecutive patients undergoing left atrial appendage occlusion at Aarhus University Hos
61 Closure Technology, patients with a WATCHMAN left atrial appendage occlusion device had consistently
62 of stroke, site-specific therapy directed at left atrial appendage occlusion has been now studied for
63 oing trials are addressing the usefulness of left atrial appendage occlusion in both primary and seco
65 Device-related thrombosis (DRT) following left atrial appendage occlusion is a rare but feared com
67 cological, percutaneous therapies, including left atrial appendage occlusion, for stroke prevention h
68 w of stroke prevention strategies, including left atrial appendage occlusion, in patients with atrial
71 omized clinical trials, PROTECT-AF (Watchman Left Atrial Appendage System for Embolic PROTECTion in P
74 ar) follow-up of Percutaneous Closure of the Left Atrial Appendage Versus Warfarin Therapy for Preven
75 tral annulus along the posterior base of the left atrial appendage visualized by selective angiograph
76 ctural parameters of the left atrium and the left atrial appendage which have been shown to be associ
82 itus had a greater left ventricular mass and left atrial area than patients without diabetes mellitus
83 adjustments for left ventricular mass index, left atrial area, and interim heart failure events parti
84 fice area, vena contracta, color Doppler jet/left atrial area, left atrial volume index, left ventric
85 cellular components, and ultrastructure) in left atrial biopsies from 121 patients with persistent/l
86 ial LGE signal intensity divided by the mean left atrial blood pool intensity was calculated for each
88 s were analyzed using left ventricle cavity, left atrial cavity, or inferior vena cava as the IDIF.
89 We sought to examine the association between left atrial conduction velocity and LGE in patients with
91 entricular damage), Stage 2 (mitral valve or left atrial damage), Stage 3 (tricuspid valve or pulmona
92 -up of 976.5 days between patients with LAE (left atrial diameter > 45 mm; LAE group) and those witho
93 ajor exclusions were ejection fraction <35%, left atrial diameter >60 mm, ventricular pacing dependen
94 (-0.24 mm [95% CI, -0.39 to -0.10]), smaller left atrial diameter (-0.75 mm [95% CI, -0.95 to -0.56])
95 root diameter (0.40 mm [95% CI, 0.08-0.73]), left atrial diameter (0.34 mm [95% CI, -0.09 to 0.78]),
97 ds ratio, 0.35 [95% CI, 0.16-0.79], P=0.01), left atrial diameter (odds ratio, 0.52 per 1 cm increase
99 mprising 1643 patients (31.3% paroxysmal AF, left atrial diameter 41+/-3.1 mm) were included in the f
100 ears; mean CHA2DS2-VASc score was 4.1+/-1.4; left atrial diameter averaged 4.7+/-0.8 cm; and 48% had
101 ventricular posterior wall diameter z score, left atrial diameter z score, peak left ventricular outf
102 confidence interval, 2.070-7.143; P<0.001), left atrial diameter>/=50 mm (hazard ratio 2.083; 95% co
103 egnancy have a greater aortic root diameter, left atrial diameter, and left ventricular mass and high
104 es, cardiac structure (aortic root diameter, left atrial diameter, left ventricular mass, and fractio
107 and E/e' ratio (11 vs. 7; P < 0.001), and a left atrial dilatation (40 vs. 29 mL/m(2) ; P = 0.011).
111 o [HR] per decade, 1.55; 95% CI, 1.11-2.15), left atrial dimension (HR per centimeter diameter, 1.43;
112 wall thickness, LV diastolic dimension, and left atrial dimension (P<0.01 for all; n=2392; mean age,
113 had associated cardiovascular disease, mean left atrial dimension was 46+/-6 mm, and median CHA2DS2-
115 s also exhibited a signi fi cant increase in left atrial ejection fraction at 2 months after gene del
116 Left ventricular adaptation was similar; left atrial ejection fraction improved by +3.17% (P < 0.
118 ng fraction: -6.2% [-10.2 to -2.1], P=0.003; left atrial emptying fraction:-3.5% [-6.9 to -0.1], P=0.
120 s, including LV ejection fraction (LVEF) and left atrial end-diastolic volume indexed to body surface
125 ive physiology, characterized by progressive left atrial enlargement and diastolic dysfunction with p
126 d age, female sex, greater right atrial than left atrial enlargement and lower systolic pulmonary art
130 nce of LV hypertrophy was 21%, prevalence of left atrial enlargement was 83%, prevalence of elevated
131 traditionally have been used as markers for left atrial enlargement, and both have been associated w
133 ic Csk knockout in mice led to increased AF, left atrial enlargement, fibrosis, and inflammation, phe
134 rutinib for 4 weeks results in inducible AF, left atrial enlargement, myocardial fibrosis, and inflam
135 r hypercontractility, diastolic dysfunction, left-atrial enlargement and left ventricular fibrosis, a
136 to 0.039+/-0.005 cm(-2) s(-)(1) (P<0.001) in left atrial epicardium (LA(epi)), and prolonged AF cycle
137 patients with heart failure, we showed that left atrial ETV1 expression is downregulated at the RNA
139 ent, were predominantly found in the lateral left atrial free wall, and likely acted as drivers.
141 al contraction (MV A Peak) indicating poorer left atrial function was associated with lower retinal v
142 in patients with heart failure (HF) reduces left atrial hypertension by shunting oxygenated blood to
143 sure was </=15 mm Hg in 54%, indicating that left atrial hypertension was absent in a majority of pat
144 eficial in this cohort but could also worsen left atrial hypertension, exacerbating lung congestion.
146 ntricular (LV) dysfunction, ischemic MR, and left atrial infarction (LAI); and 2) to analyze how LA r
147 n FEV1/FVC ratio was associated with smaller left atrial internal dimension (beta = -0.038 cm per SD
148 luded pulmonary vein isolation in 50 (100%), left atrial isthmus line in 47 (94%), anterior line in 4
149 imaging was used for the characterization of left atrial (LA) and left atrial appendage (LAA) flow dy
151 ence of dual muscular coronary sinus (CS) to left atrial (LA) connections, coupled with rate-dependen
157 oncentric left ventricular (LV) hypertrophy, left atrial (LA) enlargement and dysfunction, and LV dia
164 ata have been reported on the association of left atrial (LA) late gadolinium enhancement (LGE) with
165 /- 10; 14 men) obtained using a reference 3D left atrial (LA) LGE sequence with 1.3 mm x 1.3 mm x 2.5
166 onths of high intensity exercise training on left atrial (LA) mechanical and electric remodeling in s
167 tudy sought to determine the implications of left atrial (LA) myopathy and dysrhythmia across the spe
168 d, we investigated left ventricular (LV) and left atrial (LA) pathophysiological changes and their pr
170 ious studies showed that the quantity of the left atrial (LA) periatrial fat tissue predicts recurren
179 sought to (1) identify reference values for left atrial (LA) volumes and phasic function indices by
180 ional area, vs. 3.0 +/- 0.6% in control) and left atrial (LA: 11.8 +/- 0.5% vs. 5.4 +/- 0.8% control)
182 Prior studies have demonstrated regional left atrial late gadolinium enhancement (LGE) heterogene
185 ) with measures of left ventricular (LV) and left atrial mechanical function on cardiac magnetic reso
186 ickness and image intensity ratio defined as left atrial myocardial LGE signal intensity divided by t
188 clinical in vivo study, we demonstrate that left atrial myocardium with increased gadolinium uptake
190 In vitro I-1c gene transfer in isolated left atrial myocytes from both pigs and rats increased c
191 Stage 0), left ventricular damage (Stage 1), left atrial or mitral valve damage (Stage 2), pulmonary
193 l voltage amplitude (right atrial, P=0.0005; left atrial, P=0.0001), slower conduction velocities (ri
194 conduction velocities (right atrial, P=0.02; left atrial, P=0.0002), and higher prevalence of electro
195 on Feature tracking of cardiac MRI to derive left atrial peak reservoir strain provided incremental p
197 key nonclinical factors (arrhythmia burden, left atrial physiology and anatomy, chemical and electro
199 e relationship between the esophagus and the left atrial posterior wall is variable, and the esophagu
200 The close proximity of esophagus to the left atrial posterior wall predisposes esophagus to ther
201 +/- 44 mm Hg to 12 +/- 6 mm Hg; p = 0.007), left atrial pressure (29 +/- 11 mm Hg to 20 +/- 8 mm Hg;
202 hypertension (PH), with or without elevated left atrial pressure (eLAP), and mortality in candidates
203 iations between PH, with or without elevated left atrial pressure (eLAP), and mortality in candidates
204 he 26 patients (77%) with a normal predicted left atrial pressure (grade I diastolic dysfunction) had
205 f the 24 patients with an elevated predicted left atrial pressure (grade II/III diastolic dysfunction
206 systemic hypotension occurred with a fall in left atrial pressure and little change in left ventricul
208 evice is feasible, seems to be safe, reduces left atrial pressure during exercise, and could be a new
209 rt failure, interventions to reduce elevated left atrial pressure improve symptoms and reduce the ris
210 nd we describe the design of REDUCE Elevated Left Atrial Pressure in Heart Failure (REDUCE LAP-HF I),
217 nt device that allows shunting to reduce the left atrial pressure provides clinical and hemodynamic b
219 EF is complex but characterised by increased left atrial pressure, especially during exertion, which
221 pressure is directly related to an enhanced left atrial pressure, which is common to both heart fail
222 a heterogeneous clinical syndrome, elevated left atrial pressure-either at rest or with exertion-is
224 reath-hold to the atrioventricular junction, left atrial pulmonary vein junction, and freewall left v
225 reflect RFC catheter instability in certain left atrial regions, and thus required fewer lesions for
228 the most common adjunctive lesions included left atrial roof or posterior/inferior lines, and cavotr
229 e performed gene expression profiling in 265 left atrial samples from patients who underwent cardiac
232 Tm-E180G mice had a significant reduction in left atrial size (1.99+/-0.19 [n=7] versus 2.70+/-0.44 [
234 io [HR], 1.39 [95% CI, 1.22-1.58]; P<0.001), left atrial size (per cm: HR, 1.32 [95% CI, 1.19-1.46];
235 g clinical predictors with the evaluation of left atrial size by echocardiography serving as the sole
236 and 10 cm/s, respectively), whereas E/e' and left atrial size demonstrated good agreement with guidel
237 ptide levels, C-reactive protein levels, and left atrial size were associated with arrhythmia recurre
240 (tissue Doppler imaging [TDI] e', E/e', and left atrial size) with concomitant N-terminal pro-brain
241 rsistent AF, hypertension, coronary disease, left atrial size, left ventricular ejection fraction, an
245 strain, global circumferential strain, peak left atrial strain, and peak longitudinal strain of righ
246 s (namely segmental left ventricular strain, left atrial strain, and right ventricular strain) are al
249 Basket electrodes were within 1 cm of 54% of left atrial surface area, and a mean of 31 electrodes pe
250 res of LV geometry, including LV mass index, left atrial systolic diameter, interventricular septum,
251 ths (IQR: 11.8 to 14.2 months), no device or left atrial thrombosis, device dislodgement, or a new de
252 rs of stroke, CHADS2 score and CHA2DS2-Vasc, left atrial thrombus (LAT), the five-grades of LASEC and
254 .20 [95% CI, 0.08-0.31], P=0.001), and lower left atrial total emptying fraction (beta coefficient pe
255 s a disease of variable interactions between left atrial triggers and substrate most commonly of left
256 [apnea-hypopnea index <5]), right atrial and left atrial voltage distribution, conduction velocities,
258 1), Sokolow-Lyon Index ( r=-0.54; P<0.0001), left atrial volume ( r=-0.49; P<0.0002), and Mainz Sever
260 astolic dysfunction (P = .003) and increased left atrial volume (57 +/- 11 vs 46 +/- 12 mL/m(2), P =
261 olume (beta=0.350; adjusted P=0.048), higher left atrial volume (beta=0.214; adjusted P=0.009), and h
262 than with enalapril in all others, including left atrial volume (from 30.4 mL/m2 to 28.2 mL/m2 vs fro
265 s (odds ratio, 2.61; CI, 1.04-6.57; P=0.04), left atrial volume (odds ratio, 1.24; CI, 1.02-1.51; P=0
266 g transmitral flow, tissue velocity, maximum left atrial volume [LAV], and estimated pulmonary artery
267 tion rate was higher (51.9%/y) in those with left atrial volume above the median value of 73.5 mL.
270 ricular global longitudinal strain (GLS) and left atrial volume index (LAVI) have been recently propo
271 purpose of this study was to assess whether left atrial volume index (LAVI) measured in routine clin
272 DVI), LV end-systolic volume index (LVESVI), left atrial volume index (LAVI), and ratio of early tran
273 interval, 1.04-1.43; P=0.015) and increased left atrial volume index (LAVi; adjusted hazard ratio/un
275 d diastolic function (based on e', E/e', and left atrial volume index) were each independently and ad
276 rate, older age, elevated creatinine, larger left atrial volume index, and larger left ventricular en
277 iastolic volume indexes (LVESVI and LVEDVI), left atrial volume index, and ventricular-vascular coupl
278 ntracta, color Doppler jet/left atrial area, left atrial volume index, left ventricular end-diastolic
279 e, including carotid intima-media thickness, left atrial volume index, monocyte count and serum YKL-4
281 with greater left ventricular (LV) mass and left atrial volume indexed to height(2.7) in both men an
282 nal pro B-type natriuretic peptide; however, left atrial volume reduction varied by baseline level of
284 V end-systolic volume, LV ejection fraction, left atrial volume, and LV dyssynchrony at 1-year in CRT
286 of cardiac structure (left ventricular mass, left atrial volume, and mitral annulus e-prime) and dise
287 s, mass, maximal wall thickness, morphology, left atrial volume, and mitral valve leaflet lengths (al
288 ection fraction, relative wall thickness and left atrial volume, and worse New York Heart Association
289 dverse) LV mass, LV end diastolic volume and left atrial volume, but not with other cardiac measures,
290 AEDVI), representing the minimum or residual left atrial volume, has not been fully evaluated as a pr
291 s and heart failure hospitalizations; higher left atrial volume, NT-proBNP (N-terminal pro-B-type nat
297 1 +/- 36 ml to 122 +/- 30 ml; p < 0.001) and left atrial volumes (106 +/- 36 ml to 69 +/- 24 ml; p <
298 systolic circumferential strain (PSCS), and left atrial volumes and function, whereas phosphorus-31
299 sis, clustered by patient, and adjusting for left atrial wall thickness, conduction velocity was asso