ライフサイエンスコーパス: lepromatous

1 ulate in the lesions of individuals with the lepromatous (also known as disseminated) form of human l

2 indicate that macrophages from patients with lepromatous and tuberculoid leprosy and from normal dono

3 ymorphism are associated, respectively, with lepromatous and tuberculoid leprosy.

4 h robust production of Th1-type cytokines to lepromatous disease, characterized by elevated levels of

5 rm (T-lep) as compared with the disseminated lepromatous form (L-lep) of the disease.

6 of patients with the clinically progressive lepromatous form of leprosy; in contrast, galectin-3 was

7 In contrast, lesions from patients with the lepromatous form of the disease who lack effective cell-

8 uberculoid as compared with the disseminated lepromatous form of the disease.

9 The lepromatous form of this disease is characterized by hyp

10 increased in the lesions of the progressive, lepromatous form vs the self-limited, tuberculoid form o

11 Peripheral blood T cell responses in the lepromatous form were strongly regulated by CD28 during

12 onocytes in individuals with the progressive lepromatous form, except during reversal reactions in wh

13 Analogous to the tuberculoid and lepromatous forms of leprosy, CD may have two clinical m

14 nse occurring in the microenvironment of the lepromatous granuloma.

15 atients compared with the highly susceptible lepromatous group.

16 in the lesions of subjects with progressive lepromatous (L-lep) versus the self-limited tuberculoid

17 d in a rare form of leprosy known as diffuse lepromatous leprosy (DLL).

18 d in a rare form of leprosy known as diffuse lepromatous leprosy (DLL).

19 cess whereby some patients with disseminated lepromatous leprosy (L-lep) transition toward self-limit

20 in Winchester, UK, showing skeletal signs of lepromatous leprosy (LL) have been studied using a multi

21 alterations were most frequently observed in lepromatous leprosy (LL) patients.

22 In histological sections (n = 10), 1 lepromatous leprosy (LL), 1 DLL, and 3 Lucio reactions c

23 In histological sections (n=10), one lepromatous leprosy (LL), one DLL, and three Lucio react

24 tured human pathogen associated with diffuse lepromatous leprosy and a reactional state known as Luci

25 eprosum (ENL), which occurs in patients with lepromatous leprosy and is characterized by neutrophil i

26 oor cellular immune response associated with lepromatous leprosy and may have important implications

27 Patients with lepromatous leprosy are unresponsive to lepromin skin-te

28 Lesions in lepromatous leprosy contained macrophages with a regulat

29 The lepromatous leprosy granuloma is a dynamic entity requir

30 ymorphonuclear leukocytes from patients with lepromatous leprosy iodinate ingested bacteria normally.

31 The chronic course of lepromatous leprosy may be interrupted by acute inflamma

32 ular exhaustion to the hyporesponsiveness of lepromatous leprosy patients by evaluating the classical

33 ytes from the blood of either tuberculoid or lepromatous leprosy patients.

34 immune defect leading to the development of lepromatous leprosy resides in the lymphocyte or in the

35 In Brazil, most patients develop lepromatous leprosy, a clinical form characterized by po

36 in skin lesions of patients with progressive lepromatous leprosy, correlating and colocalizing with I

37 0-CD40L interaction, which is not evident in lepromatous leprosy, probably participates in the cell-m

38 The striking finding was that in lepromatous leprosy, T cells did not efficiently recogni

39 Multibacillary disease is similar to human lepromatous leprosy, with variable/high levels of antibo

40 tana Roo, Mexico, was diagnosed with diffuse lepromatous leprosy.

41 reported almost exclusively in patients with lepromatous leprosy.

42 d human polymorphism that is associated with lepromatous leprosy.

43 ability of M. leprae residing in Mphi in the lepromatous lesion.

44 suggested that the absence of expression in lepromatous lesions was most likely due to local factors

45 4+CD28+ or CD4+CD28-, and T cell clones from lepromatous lesions were predominantly CD8+CD28-.

46 urthermore, IL-10, a cytokine predominant in lepromatous lesions, blocked the IFN-gamma up-regulation

47 In tuberculoid lepromatous lesions, DC-SIGN+ cells were positive for ma

48 ly expressed in disseminated and progressive lepromatous lesions.

49 pressed in tuberculoid lesions compared with lepromatous lesions.

50 pression was similar in both tuberculoid and lepromatous lesions.

51 have recently been recognized as a model of lepromatous neuritis; the major site of early accumulati

52 Interestingly, IL-12Rbeta2 in lepromatous patients could be up-regulated by stimulatio

53 ere significantly up-regulated in lesions of lepromatous patients suffering from the disseminated for

54 leprae-induced IL-12 production by PBMC from lepromatous patients was not dependent on CD40L-CD40 lig

55 contribute to the hyporesponsive profile of lepromatous patients, and that PD-1 blockade could contr

56 ant tuberculoid as compared with susceptible lepromatous patients, and, in vitro, monocytes produced

57 AG-3 is increased in the skin lymphocytes of lepromatous patients, as well as membrane-bound and solu

58 sion in ENL when compared with nonreactional lepromatous patients, both locally in the skin lesions a

59 e responsive to IL-12; however, T cells from lepromatous patients, the susceptible form of leprosy, d

60 nsiveness against mycobacterial lipid Ags in lepromatous patients, we used T cell clones to probe the

61 d IFN-gamma in tuberculoid patients, but not lepromatous patients, while IL-4 production was not indu

62 , who are able to restrict the pathogen, and lepromatous patients, who have disseminated infection.

63 was more strongly expressed in lesions from lepromatous patients, who manifest specific T cell anerg

64 cobacterium leprae in tuberculoid but not in lepromatous patients.

65 ivated T cells from tuberculoid but not from lepromatous patients.

66 ts than in with unresponsive and susceptible lepromatous patients.

67 loid compared with expression in progressive lepromatous patients.

68 les (Suriname) and in 5% from the habitat of lepromatous red squirrels (British Isles).

69 (Lophocebus aterrimus) were inoculated with lepromatous tissue that had been serially passaged in fo

70 Using test samples isolated from lepromatous tissue, we also evaluated amplification fide

71 SIVsm) by day 30 postinoculation (p.i.) with lepromatous tissue.