ライフサイエンスコーパス: leptin receptor

1 s related to lipid metabolism, including the leptin receptor.

2 ent and blocked by targeted knockdown of the leptin receptor.

3 sis is associated with a polymorphism in the leptin receptor.

4 of tyrosine residues on the long form of the leptin receptor.

5 ndent db/db mice harboring a mutation in the leptin receptor.

6 e that express Cre in neurons expressing the leptin receptor.

7 mitochondrial function in the absence of the leptin receptor.

8 tional characteristics of neurons expressing leptin receptor.

9 e has prominent astrocytic expression of the leptin receptor.

10 ue to a recessive, autosomal mutation in the leptin receptor.

11 that express both short and long isoforms of leptin receptor.

12 an 80-fold increased serum level of soluble leptin receptor.

13 ng (Ob-Rb), and soluble (Ob-Re) forms of the leptin receptor.

14 reted but neither binds to nor activates the leptin receptor.

15 ing and gene transcription downstream of the leptin receptor.

16 t adrenocortical cells coexpress CYP11B2 and leptin receptors.

17 ptional regulation for long-term satiety via leptin receptors.

18 (TB/TB) mice, which lack functional neuronal leptin receptors.

19 was compromised despite normal activation of leptin receptors.

20 t all astrocytes in the hypothalamus express leptin receptors.

21 in inhibiting signaling from the insulin and leptin receptors.

22 red weights in db/db mice with no functional leptin receptors.

23 re seen in aged ENTPD1-null mice with normal leptin receptors.

24 a key negative regulator of the insulin and leptin receptors.

25 hich express both short and long isoforms of leptin receptors.

26 itopes, was supported by RT-PCR detection of leptin receptor-a and -b mRNAs in primary hypothalamic a

27 We conclude that leptin receptor activation and JAK2/PI3K signaling may b

28 We hypothesized that leptin receptor activation in other neuronal subtypes wo

29 xcitability in some hypothalamic neurons via leptin receptor activation of the JAK2 and PI3K intracel

30 tivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to pot

31 , whereas no such association was found with leptin receptor, adiponectin, or C-reactive protein.

32 hypothalamus, we crossed mice with a floxed leptin receptor allele (Leprfl) to mice transgenic for N

33 nstrated that humans with the ancestral Q223 leptin receptor allele were nearly four times less likel

34 g of the complex relationships among leptin, leptin receptor and diabetes-related traits.

35 s in control (db/-) mice with one functional leptin receptor and dramatically lowered weights in db/d

36 Leptin receptor and free fatty acid (FFA) receptor, GPR1

37 Using histological mapping of leptin receptor and ghrelin receptor expression, we foun

38 r the skeletal stem cell markers Nestin-GFP, Leptin receptor and Gremlin1.

39 ression, we found that cells containing both leptin receptors and ghrelin receptors are mainly locate

40 ers were used to examine connections between leptin receptors and respiratory motoneurons.

41 ons that innervated the CA3 region expressed leptin receptors and these cells were not activated by s

42 in along with the long and short isoforms of leptin receptor, and in response to leptin treatment sho

43 shown higher affinity upon binding with the leptin receptor, and similarly to native hormone activat

44 Leptin receptor antagonism would be a promising approach

45 We tested whether treatment with a pegylated leptin receptor antagonist (PLA) attenuates cachexia in

46 However, treatment with a leptin receptor antagonist failed to alter DMH NPY expre

47 Leptin receptor antagonist, PESLAN-1, increased G-CSF- o

48 h the peptide Leu-Asp-Phe-Ile (LDFI), a full leptin-receptor antagonist, completely reversed the lept

49 Although leptin and the leptin receptor are found in fish, the hormone is not ex

50 Leptin receptors are also found in other brain regions,

51 e in mice, but, unlike what is observed when leptin receptors are deleted from hypothalamic neurons,

52 ts of leptin to regulate energy balance, but leptin receptors are distributed throughout the brain, a

53 ogether, our data suggest that 5-HT(2C)R and leptin receptors are expressed by distinct subpopulation

54 We hypothesized that since leptin receptors are found on the liver and the liver pl

55 However, leptin receptors are more widely expressed in the brain

56 To ascertain how central leptin receptors are regulated, the effects of leptin ch

57 ecade of research has not only revealed that leptin receptors are widely expressed in the CNS, but ha

58 to leptin and recent evidence has shown that leptin receptors are widespread throughout the developin

59 t testicular seminoma behavior, highlighting leptin receptor as a potential target for novel potentia

60 showed similar changes, but the increase of leptin receptor (+) astrocytes was barely seen in ob/ob

61 h-fat diet, there was a striking increase of leptin receptor (+) astrocytes, most prominent in the do

62 mammary tumor model, the lack of peripheral leptin receptors attenuated tumor progression and metast

63 mice resistant to obesity by overexpressing leptin receptor-b on the aP2-Lepr-b promoter.

64 These high levels of circulating leptin receptor bind leptin and likely alter its clearan

65 aldosterone, whereas deficiency in leptin or leptin receptors blunted obesity-induced increases in CY

66 neurons coexpress neurotensin as well as the leptin receptor but do not coexpress other peptide neuro

67 mobilize Ca(2+) even in cells overexpressing leptin receptors (C6-ObRb).

68 diet-induced obese mice, desensitization of leptin receptors caused by hyperleptinemia is believed t

69 Leptin receptor clusters in the vicinity of the cilium o

70 beta(FS) for leptin receptor concentrations and free leptin index als

71 Therefore, leptin and leptin receptor concentrations from 3068 siblings in 113

72 calculated as the ratio of leptin to soluble leptin receptor concentrations.

73 Exogenous expression of the leptin receptor conferred resistance in susceptible cell

74 quent validation of data for adiponectin and leptin receptors confirmed that receptors for both are e

75 ryonic and adult hippocampal neurons express leptin receptors coupled to activation of STAT3 and phos

76 Mice lacking a functional leptin receptor (db/db) had decreased clearance of C. di

77 t increases, whereas deficiency of leptin or leptin receptors decreases, total Bdnf mRNA levels, with

78 of metabolic syndrome attributable to double-leptin receptor defect (obese ZSF1) with the combined tr

79 tudied high-fat-diet-induced obese (DIO) and leptin receptor-defective (LepR(-/-)) rodents with and w

80 In addition, leptin receptor deficiency in T cells inhibits Th17 diff

81 ease in Wnt2b expression under conditions of leptin receptor deficiency, which also induced a delay i

82 was elevated in mice with astrocyte-specific leptin receptor deficiency.

83 Congenital leptin-receptor deficiency should be considered in the d

84 serum leptin cannot be used as a marker for leptin-receptor deficiency.

85 gical antagonists and mouse models including leptin receptor deficient (db/db) and diet-induced obese

86 gnalling on taste responses in lean control, leptin receptor deficient db/db, and diet-induced obese

87 stinct models to test our hypothesis: 1) the leptin receptor deficient mouse (dbdb) model of diabetic

88 Leptin-receptor deficient (Lepr(db/db) ) and C57BL/6 mic

89 Leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) female mice compared w

90 Here, we show that leptin receptor-deficient (db/db) mice lacking MKP-1 are

91 thalamic cells into hypothalami of postnatal leptin receptor-deficient (db/db) mice that develop morb

92 lso occurred in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice, and was parallel

93 In male leptin receptor-deficient (db/db) mice, treatment with R

94 ineffective in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mouse models.

95 cular or multiple subcutaneous injections to leptin receptor-deficient (db/db), diet-induced obese, a

96 Materials and Methods In this study, 20 leptin receptor-deficient and three MPO knockout mice we

97 blished animal model of type 2 diabetes, the leptin receptor-deficient db(-)/db(-) mouse, and also th

98 e effects in leptin-deficient ob/ob mice and leptin receptor-deficient db/db mice.

99 to inhibit synaptic responses in slices from leptin receptor-deficient db/db mice.

100 matically investigated skeletal pathology in leptin receptor-deficient diabetic mice on a C57BLKS bac

101 However, leptin receptor-deficient larvae have increased numbers

102 Leptin receptor-deficient mice (db/db mice) are more vul

103 Skin wounds were made on the backs of leptin receptor-deficient mice and treated with AMD3100

104 dipose tissue from SFRP5-deficient mice into leptin receptor-deficient mice indicated that the effect

105 Conversely, longform leptin receptor-deficient mice were protected from sepsi

106 Saline-injected and control diet-fed leptin receptor-deficient mice were used as respective c

107 tion of exogenous IL-22 in genetically obese leptin-receptor-deficient (db/db) mice and mice fed with

108 ow that adult zebrafish lacking a functional leptin receptor do not exhibit hyperphagia or increased

109 h inducible endothelium-specific deletion of leptin receptors (End.LepR-KO) or littermate controls (E

110 k place in bone marrow (BM) chimeras lacking leptin receptor exclusively in BM-derived cells, indicat

111 inst amebiasis and that polymorphisms in the leptin receptor explain differences in susceptibility of

112 iprocal to ARC(AgRP) neurons, ARC-projecting leptin receptor-expressing GABAergic vDMH neurons exhibi

113 Thus, leptin receptor-expressing GABAergic vDMH neurons form p

114 We report that leptin receptor-expressing neurons (LepRb neurons) in th

115 d to chemically characterize a population of leptin receptor-expressing neurons in the midbrain.

116 ocs3 in either proopiomelanocortin (POMC) or leptin receptor-expressing neurons, at levels similar to

117 ction for the hormone leptin have focused on leptin receptor-expressing neuropeptidergic neurons.

118 s a physiologic signal that acts directly on Leptin-Receptor-expressing mesenchymal stromal cells in

119 olic changes in obese mice can rapidly alter leptin receptor expression and astrocytic activity, and

120 e taste cells show a significant decrease in leptin receptor expression and elevated expression of gl

121 at diet-induced obesity increases astrocytic leptin receptor expression and function in the hypothala

122 Interestingly, both leptin receptor expression and ghrelin receptor expressi

123 liver plays an important role in control of leptin receptor expression and shedding.

124 Direct control of leptin receptor expression by insulin could also be demo

125 ptin and IGF1 levels in serum, and IGF1R and leptin receptor expression in tissues.

126 t feeding is unrelated to down-regulation of leptin receptor expression or number and does not involv

127 of LRP6 allele is associated with increased leptin receptor expression, which is a likely cause of h

128 Ob-R (all forms of leptin receptor) expression in the choroid plexus (CP) w

129 His group also defined roles for leptin receptor feedback inhibition and hypothalamic mTo

130 Leptin receptor-free tumor cells display reduced STAT3 t

131 Removal of leptin receptors from AGRP neurons diminishes fasting-in

132 dress this, we and others have been removing leptin receptors from candidate first-order neurons.

133 By deleting leptin receptors from distinct brain regions and neurona

134 Mice carrying a defective leptin receptor gene (db/db mice) are metabolically chal

135 interval: 1.14, 3.55, 9 studies, I(2) = 0%), leptin receptor gene (LEPR) polymorphism rs1137100 (odds

136 levels (P < 5 x 10(-8)); all mapping to the leptin receptor gene (LEPR).

137 which obesity results from a mutation in the leptin-receptor gene (LEPR), but the prevalence of such

138 Leptin-mediated leptin/leptin-receptor gene expression likely amplifies leptin

139 b/db mice, bearing a natural mutation in the leptin receptor, have a markedly increased bacterial loa

140 he female mouse by selective ablation of the leptin receptor in each neuronal population: Vgat-Cre;Le

141 Deletion of the gene encoding the leptin receptor in either population leads to reduced in

142 Given the established role of the leptin receptor in leukemia cells, the data suggest an i

143 R reveals the liver as the source of soluble leptin receptor in LIRKO mice, with an increase in expre

144 mouse genetic studies that a deletion of the leptin receptor in neurons results in an increase in bon

145 Induced deletion of the leptin receptor in Prrx1-creER(T2); Lepr(fl/fl) mice rev

146 ion and diabetes, we studied the role of the leptin receptor in regulating distinct immune cells duri

147 ed by leptin deficiency, inactivation of the leptin receptor in serotonergic neurons recapitulates th

148 n treatment induced expression of the leptin/leptin receptor in the lung epithelial cells via activat

149 Despite the markedly increased levels of leptin receptor in their circulation, LIRKO mice exhibit

150 e JCI, Scott et al. demonstrate that loss of leptin receptors in a subset of hindbrain neurons increa

151 with enhanced signaling through insulin and leptin receptors in animal models of diet-induced obesit

152 he native leptin and LepNPEG5K and activated leptin receptors in hypothalamus at lower dose than nati

153 ctions were normalized by targeted rescue of leptin receptors in LepRb(TB/TB) mice, which lack functi

154 gnitive processes that involve activation of leptin receptors in limbic structures, such as the hippo

155 Leptin receptors in the hypothalamus are known to signal

156 preproglucagon (PPG) neurons, which express leptin receptors in the mouse and send direct projection

157 ouse, in which obesity arises as a result of leptin receptor insensitivity.

158 this is lost, leading to markedly increased leptin receptors into the circulation.

159 al insulin resistance, and we show here that leptin receptor is required for this response.

160 expression and astrocytic activity, and that leptin receptor is responsible for leptin-induced calciu

161 P200 disrupts (whereas P110 promotes) leptin receptor isoform b clustering in the vicinity of

162 educed expression of Fto or Rpgrip1l affects leptin receptor isoform b trafficking and leptin signali

163 A concomitant increase was seen in leptin receptor isoform expression and activation of the

164 Y (NPY), pro-opiomelanocortin (POMC) and the leptin receptor isoform Ob-Rb, in the hypothalamus of ad

165 erate conditional knockouts (KOs) in mice of leptin receptor (L(2.1)KO), insulin receptor (I(2.1)KO),

166 is known about the structure of the liganded leptin receptor (LEP-R) complex.

167 appetite Cartpt) and to LAC responsiveness (leptin receptors Lepr, metabotropic glutamate receptors-

168 pid GE, we studied mice with mutation of the leptin receptor (Lepr(db/db)), which in our colony had a

169 Humans and mice lacking leptin or the leptin receptor (LepR) (ob/ob and db/db mice, respective

170 l residues under selection are away from the leptin receptor (LEPR) binding site.

171 e pathogens, such as Salmonella Typhimurium, leptin receptor (Lepr) expression increased in both mous

172 associations between 32 tagging SNPs in the leptin receptor (LEPR) gene and pancreatic cancer risk.

173 th week of age in mice formerly null for the leptin receptor (LepR) gene.

174 We found that Leptin Receptor (LepR) is a marker that highly enriches

175 Here, we uncover Sh2b1 in leptin receptor (LepR) neurons as a critical component o

176 o major neurotransmitters in the brain, from leptin receptor (LepR) neurons, we used mice with disrup

177 This study investigated the role of leptin receptor (Lepr) signaling in determining the bone

178 , we show that BBS proteins are required for leptin receptor (LepR) signaling in the hypothalamus.

179 vestigated the influence of Leptin (LEP) and leptin receptor (LEPR) SNPs on habitual physical activit

180 ing conformation between mutant LEP(I14) and LEPTIN receptor (LEPR) suggests that the conformation of

181 produced mice in which the long form of the leptin receptor (Lepr) was selectively ablated using Cre

182 pericytes, distinct from sinusoid-associated leptin receptor (LEPR)(+) cells.

183 However, GnRH neurons lack leptin receptor (LepR), indicating that leptin must indi

184 drocytes re-enter the cell cycle and express leptin receptor (lepr), suggesting conversion into proge

185 ying ablation of GH receptor (GHR) either in leptin receptor (LepR)- or steroidogenic factor-1 (SF1)-

186 en Scf was deleted from endothelial cells or leptin receptor (Lepr)-expressing perivascular stromal c

187 insulin receptor tyrosine kinase (IRTK) and leptin receptor (LEPR)-Janus kinase 2 (JAK2) in hypothal

188 odels of obesity-diet-induced obesity (DIO), leptin receptor (LepR)-null, and melanocortin 4 receptor

189 es have suggested that MSPCs are observed as leptin receptor (LepR)-positive cells, whereas osteoblas

190 arly growth response factor 3, vinculin, and leptin receptor (LepR).

191 for genetic variants in leptin (LEP) and the leptin receptor (LEPR).

192 sing neurons, some of which also express the leptin receptor (LepR).

193 and adipocytes in adult bone marrow express leptin receptor (LepR).

194 The importance of B-isoform of leptin receptor (LEPR-B) signaling in the hypothalamus,

195 ellular activity of PMV neurons that express leptin receptors (LepR PMV neurons).

196 c nerve activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse.

197 n the arcuate nucleus are GABAergic, express leptin receptors (LepR), and are known to influence repr

198 s not seen in animals deficient in leptin or leptin receptors (LepR).

199 Mechanistically, we found that attenuated leptin-receptor (LEPR) expression is essential for the d

200 matopoietic progenitors, megakaryocytes, and Leptin Receptor(+) (LepR(+)) stromal cells.

201 perivascular niche in bone marrow, in which leptin receptor(+) (LepR) stromal cells and endothelial

202 (CB) express the long functional isoform of leptin receptor, LepR(b) , but the role of leptin in CB

203 A long functional isoform of leptin receptor, LepR(b) , was detected in the carotid b

204 ng neurons are inhibitory and some coexpress leptin receptor (lepR1).

205 JNK3 deficiency in neurons that express the leptin receptor LEPRb was sufficient to cause HFD-depend

206 ere coexpressed with the long isoform of the leptin receptor LepRb.

207 he parabrachial nucleus (PBN) that coexpress leptin receptor (LepRb) and cholecystokinin (CCK) (PBN L

208 population co-expresses the long form of the leptin receptor (LepRb) and is activated by the anorecti

209 Here, we show that the leptin receptor (LepRb) colocalizes with brain-derived n

210 l signal of body energy stores, acts via the leptin receptor (LepRb) on neurons in multiple brain reg

211 Leptin acts via the long form of the leptin receptor (LepRb) on specialized sets of neurons i

212 mammals, NTS-producing neurons that express leptin receptor (LepRb) regulate the function of hypocre

213 Here we show that mNTS leptin receptor (LepRb) signaling also reduces appetitiv

214 hypothalamic circuits, we examined roles for leptin receptor (LepRb) signals in neonatal mice.

215 erous different cell types via the long-form leptin receptor (LepRb) to elicit its effects.

216 previous results suggest that GABAergic LHA leptin receptor (LepRb)-containing and neurotensin (Nts)

217 dy weight by activating the long form of the leptin receptor (LEPRb).

218 A subpopulation of POA neurons express leptin receptors (LepRb(POA) neurons) and modulate repro

219 The functional isoform of the leptin receptor, LepRb, and the glucocorticoid receptor

220 The expression of the long form leptin receptor, LepRb, was detected in hippocampal prog

221 Leptin receptors (LepRs) are expressed by vagal afferent

222 NTS inhibits food intake, while knockdown of leptin receptors (LepRs) in NTS neurons increases food i

223 bserved that AT1A receptors colocalized with leptin receptors (LEPRs) in the ARC.

224 ins energy balance by acting on hypothalamic leptin receptors (Leprs) that act on the signal transduc

225 is indirect, as GnRH neurons do not express leptin receptors (LEPRs).

226 hese leptin effects required the presence of leptin receptors (LEPRs).

227 nergy stores, acts through multiple types of leptin receptor long isoform (LepRb)-expressing neurons

228 Leptin, leptin receptor (long isoform), and PTH mRNA transcripts

229 /db mice devoid of the signaling form of the leptin receptor (LRb) and s/s mice that express LRb(S113

230 gal cholecystokinin-A receptors (CCKARs) and leptin receptors (LRbs) mediates short term satiety.

231 These results demonstrate that leptin receptor-mediated ERK activation plays an essenti

232 In this report, we assessed leptin receptor-mediated ERK activation, a pathway that

233 amplified by the action of leptin through a leptin receptor-mediated production of phosphoinositol-t

234 We recently reported that disruption of leptin receptor-mediated STAT3 activation augmented host

235 Leptin receptor mRNA and protein were expressed in fetal

236 Leptin receptor mRNA levels were reduced in the hypothal

237 thelial interactions were increased in obese leptin receptor mutant mice (Lepr(db/db),Psgl-1(+/+)) bu

238 prohibitin-2 knockout) mice and obese db/db (leptin receptor mutant) mice, two distinct mouse models

239 We crossed diabetic leptin receptor-mutant mice to mice lacking CaMKIIdelta

240 s model) or by crossing into mice carrying a leptin receptor mutation (db/db; type 2 diabetes mellitu

241 Unexpectedly, Socs3 upregulation in leptin receptor neurons results in increased expression

242 of obesity in mice with upregulated Socs3 in leptin receptor neurons suggests that Socs3's effect on

243 Twenty leptin receptor null (db/db) mice underwent treatment wi

244 Adult male leptin receptor null, homozygous db/db, or wild type mic

245 diet, fasting and refeeding were measured on leptin receptor number and gene expression.

246 Leptin receptor (Ob-R) was evaluated by quantitative PCR

247 -NS5A together stimulated TLR4-NANOG and the leptin receptor (OB-R)-pSTAT3 signaling pathways, result

248 signaling; IGF-I induced phosphorylation of leptin receptor (Ob-Rb) and leptin induced phosphorylati

249 vels of both leptin and the long form of the leptin receptor (Ob-Rb) were substantially increased wit

250 juxtapositional cytoplasmic sequence of the leptin receptor ObR is responsible for leptin transport.

251 fined by elevated cell surface levels of the leptin receptor (OBR(hi)).

252 nd/or function, we created pancreas-specific leptin receptor (ObR) KOs using mice expressing Cre reco

253 While ARH-NPY neurons expressed leptin receptor (ObRb) and displayed the activation of S

254 is factor alpha (TNF-alpha), leptin, and the leptin receptor (OBRb).

255 halamo-pituitary-gonadal axis is mediated by leptin receptors on AgRP neurons.

256 pe 2 diabetes mouse model lacking functional leptin receptors, or from obese diabetic human donors fa

257 t fasting-associated increased expression of leptin receptor overlapping transcript (LEPROT) and LEPR

258 ) is a negative regulator of the insulin and leptin receptor pathways and thus an attractive therapeu

259 irst to illuminate the downstream effects of leptin receptor polymorphisms on intestinal infection by

260 Nearly all HSCs contacted leptin receptor positive (Lepr(+)) and Cxcl12(high) nich

261 ditional deletion of Vegfc in endothelial or leptin receptor-positive (LepR+) cells led to a disrupti

262 Leptin receptor-positive cells were synaptically connect

263 nce-promoting hematopoietic niche factors in leptin-receptor-positive stromal bone marrow cells.

264 lial cells, CXCL12-abundant reticular cells, leptin-receptor-positive stromal cells, and nestin-green

265 The marked leptin receptor protein expression in the astrocytes, sh

266 d the remaining four loci are in or near the leptin receptor protein gene, the apolipoprotein E gene,

267 A common polymorphism in the leptin receptor (Q223R) that increases susceptibility to

268 how individual phosphorylation sites on the leptin receptor recruit distinct signaling molecules.

269 uction of 61%) and by the biomarkers soluble leptin receptor (reduction of 43%) and glycated hemoglob

270 vation of STAT3 signaling by mutation of the leptin receptor (s/s mice) leads to reduced adipose mass

271 sed in response to leptin and decreased with leptin receptor signaling inhibition by AG490, a JAK2/ST

272 A series of leptin receptor signaling mutants showed that resistance

273 mpared to db/db mice (complete abrogation of leptin receptor signaling).

274 e formation as db/db mice, which lack normal leptin receptor signaling, have a reduced number of dend

275 The blockade of leptin/leptin receptor signaling, induced by genetic means or b

276 In the absence of leptin receptor signaling, the metabolic phenotype is le

277 is by activating JAK2, an initial trigger of leptin receptor signaling.

278 g alpha-AR signaling as well as by enhancing leptin receptor signaling.

279 educing adiposity under conditions of failed leptin receptor signaling.

280 egulatory effects of leptin depend on intact leptin receptor signaling.

281 t that RIIbeta-PKA modulates the duration of leptin receptor signalling and therefore the magnitude o

282 find that the negative feedback regulator of leptin receptor signalling, Socs3, is inhibited in the h

283 served elevated levels of leptin and soluble leptin receptor (sLR).

284 Plasma soluble leptin receptor (sOB-R) levels were inversely associated

285 Soluble leptin receptor (sOB-R) may regulate leptin's physiologi

286 examined plasma levels of leptin and soluble leptin receptor (sOB-R), as well as their interactions w

287 The soluble isoform of leptin receptor (sOb-R), secreted by the liver, regulate

288 n mice with a whole-pancreas knockout of the leptin receptor that exhibit improved glucose tolerance

289 he seven-span somatostatin receptor 3 or the leptin receptor that interacts with all subunits of the

290 t NAG neurons do indeed express a functional leptin receptor throughout the early postnatal period in

291 mutation of the tyrosine 985 residue in the leptin receptor, to determine its role in host defense a

292 sity in BBS mutant mice is due to defects in leptin receptor trafficking and leptin resistance.

293 ssess both TRH type 1 receptor and long-form leptin receptor [TRHR1; LepRb, respectively].

294 naling harboring a Y985L substitution in the leptin receptor, we show that leptin signaling inhibits

295 Leptin and soluble leptin receptor were two hubs of the network, with large

296 Leptin receptors were deleted from GABA and glutamate ne

297 We found that leptin receptors were expressed in hypothalamic astrocyt

298 cific migration because increased FFA induce leptin receptors, whereas higher leptin causes migration

299 hly correlated with the expression levels of leptin receptor, which is ubiquitously expressed in most

300 report that mice deficient in the peripheral leptin receptor, while harboring an intact central lepti