ライフサイエンスコーパス: lethal disease

1 ecently been reported to cause severe, often lethal disease.

2 le-strand breaks in DNA, and cause invasive, lethal disease.

3 sponse, resistant mice became susceptible to lethal disease.

4 entially be repurposed for treatment of this lethal disease.

5 ptions and the poor prognosis of this common lethal disease.

6 omising new biologic approach to combat this lethal disease.

7 ed follow-up and an emphasis on advanced and lethal disease.

8 d in the clinical care of patients with this lethal disease.

9 lls is needed to effectively protect against lethal disease.

10 Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease.

11 successfully treating this almost invariably lethal disease.

12 uest the liver cancer, a currently incurable lethal disease.

13 of H1 and H5 subtypes and protect mice from lethal disease.

14 tment of pancreatic adenocarcinoma, a highly lethal disease.

15 ave failed to protect nonhuman primates from lethal disease.

16 block tumor progression is critical for this lethal disease.

17 mmune responses that protect animals against lethal disease.

18 Pancreatic ductal adenocarcinoma (PDA) is a lethal disease.

19 ered patient with COVID-19 protected against lethal disease.

20 ent in OX40 signals still eventually develop lethal disease.

21 represent therapeutic targets in this highly lethal disease.

22 , effective, and targeted therapies for this lethal disease.

23 -induced inflammation and protecting against lethal disease.

24 f these inflammatory cytokines prevented the lethal disease.

25 al and appealing therapeutic target for this lethal disease.

26 and that CD4+ T cells were unable to induce lethal disease.

27 more likely (95% CI, 2.3 to 128) to develop lethal disease.

28 gral to the hallmark invasive nature of this lethal disease.

29 olved in T-cell exhaustion and prevention of lethal disease.

30 ally heterogeneous, ranging from indolent to lethal disease.

31 hts into the development of this potentially lethal disease.

32 was able to completely protect rabbits from lethal disease.

33 ariability, ranging from silent infection to lethal disease.

34 e and its ramifications for the cure of this lethal disease.

35 cerns about the potential pandemic spread of lethal disease.

36 to either a mild, self-limiting infection or lethal disease.

37 ants which lead to either viral clearance or lethal disease.

38 of patients with this highly infectious and lethal disease.

39 velopment of therapeutic approaches for this lethal disease.

40 alignant melanoma is a common and frequently lethal disease.

41 y and economically costly, and a potentially lethal disease.

42 SmCC of the GI tract is a rare and lethal disease.

43 key sera protected 100% of the hamsters from lethal disease.

44 linically silent encephalitis into uniformly lethal disease.

45 ating that antibodies alone can protect from lethal disease.

46 mbinant allele was associated with perinatal lethal disease.

47 ly protected from the development of acutely lethal disease.

48 with FK-506 were not protected from acutely lethal disease.

49 iagnose, and treat this rare but potentially lethal disease.

50 induce lymphocyte proliferation and acutely lethal disease.

51 drocortisone results in an acute, fulminant, lethal disease.

52 ective therapies are needed for this rapidly lethal disease.

53 mpt to improve the cure rate for this highly lethal disease.

54 rgp120-immunized animals were protected from lethal disease.

55 rapy for patients suffering from this highly lethal disease.

56 resistant to cytotoxic chemotherapy and is a lethal disease.

57 therapeutic target for the treatment of this lethal disease.

58 btype that is associated with progression to lethal disease.

59 ecades, metastatic prostate cancer remains a lethal disease.

60 mmune checkpoint inhibitors in this globally lethal disease.

61 e metastatic setting, ccRCC remains a highly lethal disease.

62 inst late-stage prostate cancer, a currently lethal disease.

63 as targetable vulnerabilities in this highly lethal disease.

64 was strongly associated with higher risk of lethal disease.

65 sociated with a lower risk of progression to lethal disease.

66 ial therapy with potential efficacy for this lethal disease.

67 n receptor (AR) antagonist enzalutamide is a lethal disease.

68 eras to treat a specific, identifiable, and lethal disease.

69 viable alternative in the treatment of this lethal disease.

70 asive bladder cancer (MIBC) is a potentially lethal disease.

71 he host, from asymptomatic to severe or even lethal disease.

72 mostly harmless endemic virus gives rise to lethal disease.

73 igher in the ~50% of tumors that progress to lethal disease.

74 ed 100% of guinea pigs against JUNV and GTOV lethal disease.

75 pport productive EBOV replication or develop lethal disease.

76 its therapeutic potential in combatting this lethal disease.

77 ential for clinical translation against this lethal disease.

78 prostate cancer with biochemical relapse and lethal disease.

79 dvanced breast cancers that have resulted in lethal disease.

80 he great need for better treatments for this lethal disease.

81 ation for more effective treatments for this lethal disease.

82 not protect Mavs(-/-) mice from WNV-induced lethal disease.

83 radicating smallpox, one of the world's most lethal diseases.

84 ncreasing numbers of patients with otherwise lethal diseases.

85 ment of hepatocellular carcinoma (HCC), both lethal diseases.

86 echanism of pathogenesis in these common and lethal diseases.

87 in life is associated with severe, sometimes lethal, disease.

88 ts exhibited moderate to severe, potentially lethal, disease.

89 Peripartum cardiomyopathy is a rare lethal disease about which little is known.

90 virus 3 (TeHV-3) is the causative agent of a lethal disease affecting several tortoise species.

91 le-negative breast cancer are among the most lethal diseases affecting women, with few targeted thera

92 tected 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and

93 of prognosis, we could improve prediction of lethal disease among men with moderate Gleason 7 tumors,

94 Oral squamous cell carcinoma (OSCC) is a lethal disease and early death usually occurs as a resul

95 completely protected mice of three ages from lethal disease and effected more-rapid virus clearance.

96 CCA remains a highly lethal disease and further scientific and clinical insig

97 ip to identify patients at increased risk of lethal disease and inform therapeutic approaches.

98 dd further detrimental effects to an already lethal disease and jeopardise clinical outcomes.

99 Three Ebolavirus genus viruses cause lethal disease and lack targeted therapeutics: Ebola vir

100 virus pose the threat of pandemic spread of lethal disease and make it a priority to develop safe an

101 0% of patients with high-risk HRNMIBC have a lethal disease and may be better treated by primary radi

102 he mouse Ace2 locus in a manner that confers lethal disease and permits cell-specific, Cre-mediated l

103 treatment, which protected all animals from lethal disease and reduced serum and tissue viral loads

104 H7N9 viruses, including association between lethal disease and spread to the alveolar spaces and kid

105 ecreate and explore underpinning pathways of lethal disease and treatment resistance.

106 ffect is not sufficient to protect mice from lethal disease, and this therapeutic approach requires f

107 s is thus central to the development of this lethal disease, and, more generally, could play an impor

108 Thus, rather than being solely a lethal disease, anthrax often occurs as a sublethal infe

109 d new insights into the pathogenesis of this lethal disease are urgently needed.

110 that transforms into a highly aggressive and lethal disease at a rate of 2% per year.

111 of the inability to distinguish potentially lethal disease at diagnosis.

112 ure significantly improved the prediction of lethal disease beyond knowing whether the Gleason score

113 BOV GP) are implicated in protection against lethal disease, but the characteristics of the human ant

114 within T-cell activation pathways to prevent lethal disease by inappropriate responses against dissem

115 It causes a lethal disease called myxomatosis in European rabbits bu

116 bacterial pathogen that causes a potentially lethal disease called tularemia.

117 evere combined immunodeficiency (XSCID) is a lethal disease caused by a defect in the gene encoding t

118 intranasal administration protects mice from lethal disease caused by a number of different influenza

119 rus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus (EBOV).

120 Long QT syndrome type 3 (LQT3) is a lethal disease caused by gain-of-function mutations in t

121 ein-losing enteropathy (CHAPLE disease) is a lethal disease caused by genetic loss of the complement

122 , enteropathy, X-linked (IPEX) syndrome is a lethal disease caused by mutations in a transcription fa

123 Rabies is a lethal disease caused by neurotropic viruses that are en

124 This is the first report of lethal disease caused by SNV in an adult small-animal mo

125 Classic galactosemia is a potentially lethal disease caused by the dysfunction of galactose 1-

126 Lethal disease caused by the fungus Cryptococcus neoform

127 gainst Argentine hemorrhagic fever, an often-lethal disease caused by the Junin arenavirus.

128 7BL/6 (B6) mice are resistant to mousepox, a lethal disease caused by the orthopoxvirus ectromelia vi

129 oach, Amorim et al. studied the abundance of lethal disease-causing mutations in humans and found tha

130 f pancreatic ductal adenocarcinoma, a highly lethal disease characterized by a robust fibroinflammato

131 Systemic light chain amyloidosis is a lethal disease characterized by excess immunoglobulin li

132 ulmonary fibrosis (IPF) is a progressive and lethal disease characterized by excessive extracellular

133 Pulmonary arterial hypertension (PAH) is a lethal disease characterized by excessive proliferation

134 human respiratory coronaviruses cause acute lethal disease characterized by exuberant inflammatory r

135 y death) syndrome is a recessively inherited lethal disease characterized by fetal growth retardation

136 Gastric adenocarcinoma (GAC) is a lethal disease characterized by genomic and clinical het

137 Advanced urothelial cancer is a frequently lethal disease characterized by marked genetic heterogen

138 TKOS is a potentially lethal disease characterized by T-wave inversions in the

139 ight chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid

140 nfection of FK506-treated mice resulted in a lethal disease characterized by viremia, lack of serocon

141 Pancreatic cancer is an almost uniformly lethal disease, characterized by late diagnosis, early m

142 ight loss, whereas 11SB23 produces acute and lethal disease closely resembling that observed with Cri

143 we show that mice expressing hTfR1 develop a lethal disease course marked by an increase in serum IFN

144 8 to 10; RR, 1.22; 95% CI, 1.03 to 1.45) and lethal disease (death or distant metastasis; RR, 1.19; 9

145 plasma cells and remains an incurable, often lethal disease despite therapeutic advances.

146 In humanized mice, lethal disease develops, characterized by histopathologi

147 th low doses of virus results in a uniformly lethal disease even though little infection is detected

148 amide, prolongs survival, but resistance and lethal disease eventually prevail.

149 a Gram-negative bacterium that causes acute, lethal disease following inhalation.

150 , intracellular bacterium that causes acute, lethal disease following inhalation.

151 bacterial dose required to produce an acute lethal disease following intraperitoneal infection of mi

152 frican swine fever is a contagious and often lethal disease for domestic pigs with a significant econ

153 th neuroendocrine differentiation (NED) is a lethal disease for which effective therapies are urgentl

154 -grade serous ovarian carcinoma (HGSOC) is a lethal disease for which improved screening and treatmen

155 Pancreatic cancer is a highly lethal disease, for which mortality closely parallels in

156 We found that Muc2-deficient mice succumb to lethal disease from ETBF colonization in a B. fragilis t

157 teristics and high efficacy in both of these lethal disease guinea pig models.

158 CeMV outbreaks of lethal disease have repeatedly been observed in Europe,

159 which henipaviruses cause severe and usually lethal disease, HeV and NiVs caused only mild or asympto

160 y microRNAs (miRs) modulating AR activity in lethal disease, hormone-responsive and -resistant PC cel

161 VV caused lethal disease in all mouse strains.

162 is a strong correlate of protection against lethal disease in animals.

163 hemorrhagic fever virus (SHFV) causes highly lethal disease in Asian macaques resembling human illnes

164 Cystic fibrosis is the most common inherited lethal disease in Caucasians.

165 lphaherpesvirus, is the causative agent of a lethal disease in chickens characterized by generalized

166 uctal adenocarcinoma (PDAC) remains a highly lethal disease in critical need of new therapeutic strat

167 t ASFV strains cause a highly infectious and lethal disease in domestic pigs for which there is no va

168 Ebola virus (EBOV) causes lethal disease in ferrets, whereas Marburg virus (MARV)

169 s compared with Chile-9717869, did not cause lethal disease in hamsters, and showed reduced ability t

170 ypanosomes are ancient eukaryotes that cause lethal disease in humans and cattle.

171 Ebola virus (EBOV) causes lethal disease in humans but not in mice.

172 d from animal reservoirs to cause severe and lethal disease in humans, but there are currently no FDA

173 atory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized by exac

174 a wide range of animals and causes a severe, lethal disease in humans.

175 ses are dermatotropic DNA viruses that cause lethal disease in humans.

176 adenocarcinoma (PDAC) is an almost uniformly lethal disease in humans.

177 pecies and are capable of causing severe and lethal disease in humans.

178 mice but was completely defective in causing lethal disease in IL-1R(-/-) mice, indicating that the p

179 However, they do not cause lethal disease in immunocompetent mice unless they are a

180 y the massively increased bacterial load and lethal disease in interferon-gamma knockout mice.

181 le to replicate at high temperature or cause lethal disease in mice.

182 nt viruses replicate slowly and do not cause lethal disease in mice.

183 from RQ to YE (YE-Nef) both induce an acute lethal disease in monkeys.

184 f either component was sufficient to prevent lethal disease in Muc2-deficient mice.

185 ogen Vibrio coralliilyticus causes a rapidly lethal disease in N. vectensis and that heat-inactivated

186 humans despite the fact that REBOV can cause lethal disease in nonhuman primates.

187 an swine fever virus (ASFV) can cause highly lethal disease in pigs and is becoming a global threat.

188 us (ASFV) is contagious and can cause highly lethal disease in pigs.

189 These hamsters demonstrated a systemic and lethal disease in response to infection.

190 del organism Ceratonova shasta, which causes lethal disease in salmonids.

191 , unlike Malawi-Lil-20/1-Delta9GL, induced a lethal disease in swine like parental ASFV-G.

192 imilarity with Chile-9717869, does not cause lethal disease in Syrian hamsters.

193 l inoculation, but only MX/7218 virus caused lethal disease in this species.

194 utations, one of which resulted in perinatal lethal disease in three families, were associated with c

195 While B. bronchiseptica causes lethal disease in TLR4-deficient mice, B. pertussis and

196 virus (CMV) satRNA that induces an epidemic lethal disease in tomato.

197 Testudinid herpesvirus 3 (TeHV-3) causes a lethal disease in tortoises, several species of which ar

198 Ebola virus (EBOV) causes lethal disease in up to 90% of EBOV-infected humans.

199 er virus (CDV) and rabies virus (RABV) cause lethal disease in wild and domestic carnivores.

200 It is a highly lethal disease in women and men, and new treatments are

201 nted DIV vaccine provides protection against lethal disease in young animals following homologous and

202 uding slow bee paralysis virus (SBPV), cause lethal diseases in honeybees and bumblebees, resulting i

203 Kinetoplastid parasites cause lethal diseases in humans and animals.

204 African trypanosomes-parasites that cause lethal diseases in humans and livestock-employ an antige

205 ted in the near eradication of many formerly lethal diseases in many countries, including the complet

206 e highly infectious pathogens that can cause lethal diseases in various species of fish.

207 o metastases and death from prostate cancer (lethal disease) in 403 patients and found the strongest

208 tibody, transformed transient myocarditis to lethal disease, in association with widespread polymorph

209 Pancreatic ductal adenocarcinoma (PDA) is a lethal disease, in part, because of the lack of effectiv

210 all types of blood cell--can treat numerous lethal diseases, including leukaemias and lymphomas.

211 In rabbits, protection from lethal disease is induced by intradermal injection of va

212 rd improving detection and treatment of this lethal disease is to understand its origin.

213 ns (such as studies of late-onset or rapidly lethal diseases), it may be more practical to identify f

214 In lethal diseases like cancer, where new therapies are oft

215 macaques unexpectedly survived this usually lethal disease, making it possible to compare physiologi

216 absence of perforin, vaccination resulted in lethal disease mediated by dysregulated CD8(+) T cell ex

217 sults in an asymptomatic infection; the only lethal disease model for a pathogenic hantavirus is Ande

218 l muscular dystrophy, a much more severe and lethal disease model, does not improve all aspects of mu

219 e prophylaxis strategies in the ANDV/hamster lethal disease model.

220 allenge dosages (1.0 x 10(4) PFU) in the rat lethal disease model.

221 ia-specific CD8 T cells eradicated otherwise lethal disease more efficiently than wild-type cells and

222 Anthrax, a potentially lethal disease of animals and humans, is caused by the G

223 virus 3 (CyHV-3) is the causative agent of a lethal disease of carp and encodes for an Il10 homolog (

224 etiological agent of a contagious and often lethal disease of domestic pigs that has significant eco

225 African swine fever is a lethal disease of domestic pigs, geographically expandin

226 (ASFV) is the etiological agent of an often lethal disease of domestic pigs.

227 Feline infectious peritonitis is a lethal disease of felids caused by systemic infection wi

228 r virus (ASFV) causes a contagious and often lethal disease of feral and domestic swine.

229 African swine fever virus (ASFV) causes a lethal disease of pigs with high economic impact in affe

230 ), the etiological agent of a severe, highly lethal disease of swine.

231 s marinus is the causative agent of Dermo, a lethal disease of the eastern oyster Crassostrea virgini

232 Here, we investigate a lethal disease of unknown etiology that affects sanctuar

233 Juvenile myelomonocytic leukemia (JMML) is a lethal disease of young children characterized by hypers

234 high degree of infectivity but did not cause lethal disease or exhibit extrapulmonary virus spread.

235 Pancreatic cancer is a lethal disease owing to its intrinsic and acquired resis

236 < 0.001) compared with not recurrent and not lethal disease (P-heterogeneity < 0.001).

237 nt peritoneal mesothelioma (DMPM), a rapidly lethal disease, poorly responsive to conventional therap

238 have been partially or fully characterized, lethal disease predominantly involves a variety of strai

239 g ML-IAP expression by immunohistochemistry, lethal disease progression was associated with the loss

240 While RB loss was associated with lethal disease, RB-deficient tumors had no proliferative

241 Yersinia pestis causes a rapid, lethal disease referred to as plague.

242 ry, facilitating long-term remission of this lethal disease.Significance: Coordinated neoadjuvant and

243 e 7B2 null, but not the PC2 null, exhibits a lethal disease state.

244 osphorylation of proteins is associated with lethal diseases such as cancer.

245 f critical importance in diagnosis of common lethal diseases such as malaria, tuberculosis, HIV, and

246 rome coronavirus 2 has resulted in a new and lethal disease termed coronavirus disease-2019 (COVID-19

247 LMA MAD exposure resulted in uniformly lethal disease that accurately reflected the human condi

248 ic ductal adenocarcinoma (PDA) constitutes a lethal disease that affects >30,000 people annually in t

249 gue (BT) is a debilitating and in many cases lethal disease that affects ruminants of economic import

250 ted with ANDV, but not SNV, develop a highly lethal disease that closely resembles HPS in humans.

251 Pancreatic cancer is a highly lethal disease that has seen little headway in diagnosis

252 Infective endocarditis is a potentially lethal disease that has undergone major changes in both

253 c fibrosis (CF), an inherited and eventually lethal disease that impairs the function of multiple org

254 Pulmonary hypertension (PH) is a lethal disease that is associated with characteristic hi

255 Argentine hemorrhagic fever is a potentially lethal disease that is caused by Junin virus (JUNV).

256 Amyotrophic lateral sclerosis (ALS) is a lethal disease that is characterized by the relentless d

257 ter understanding of the development of this lethal disease that is currently without efficient treat

258 atic ductal adenocarcinoma (PDA) is a highly lethal disease that is refractory to medical interventio

259 ed necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up

260 ed necrotising pancreatitis is a potentially lethal disease that nearly always requires intervention.

261 tor problems, in contrast to the wasting and lethal disease that occur during acute infection of immu

262 hospholipid syndrome (CAPS) is a potentially lethal disease that presents with rapidly progressive mu

263 s) are a group of genetically heterogeneous, lethal diseases that are characterized by neuronal, hepa

264 ian and uterine serous cancers are extremely lethal diseases that often present at an advanced stage.

265 ocally advanced lung cancer as a potentially lethal disease to one that is curable.

266 Phenotypes range from complete resistance to lethal disease to severe hemorrhagic fever characterized

267 heir hosts, which range from severe and even lethal disease to subclinical or nonpathogenic infection

268 ludes the definitive assignment of this male-lethal disease to the X chromosome and the mapping of a

269 DAC) contribute to the recalcitrance of this lethal disease to treatment.

270 from the Old World bringing novel and hence, lethal diseases to the New World, a foretaste, perhaps,

271 ctious bacterium that causes the potentially lethal disease tularemia.

272 ts in peroxisome biogenesis are the cause of lethal diseases typified by Zellweger syndrome.

273 explain why the risks from this potentially lethal disease vary according to location and age.

274 Whereas lethal disease was observed in immunodeficient mice, tum

275 Lethal disease was routinely observed in RNase L(-/-) PK

276 te promyelocytic leukemia, formerly a highly lethal disease, was recently shown to be highly responsi

277 ntify potential therapeutic targets for this lethal disease we investigated the contribution of B cel

278 Neither EIAV(17SU) nor EIAV(17TM) produced lethal disease when administered at infectious doses tha

279 tibility of Hartley guinea pigs to uniformly lethal disease when challenged with as few as 4 PFU of t

280 These antibodies protected guinea pigs from lethal disease when given post-virus challenge.

281 nits (NAU)/kg of FFP-protected hamsters from lethal disease when given up to 8 days after intranasal

282 Medulloblastoma is a highly lethal disease when it recurs.

283 VL in the hamster is a progressive, lethal disease which very closely mimics active human di

284 development of effective therapies for this lethal disease, which is refractory to standard treatmen

285 d in animals experiencing lung pathology and lethal disease, while the same animals experienced downr

286 pted Zaire ebolavirus (ZEBOV) caused rapidly lethal disease; wild-type ZEBOV and Sudan Ebolavirus and

287 Oral squamous cell carcinoma (OSCC) is a lethal disease with a 5-year mortality rate of around 50

288 eatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year survival rate of 4%.

289 e of Carvallo, termed Car(68), resulted in a lethal disease with a 63% mortality rate.

290 Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug resp

291 Ovarian cancer is a highly lethal disease with metastases present in the majority o

292 Breast cancer brain metastasis (BCBM) is a lethal disease with no effective treatments.

293 sceptible to infection with LASV and develop lethal disease with pathology similar to that reported i

294 Pancreatic cancer is a lethal disease with poor prognosis.

295 Metastatic breast cancer remains a lethal disease with poorly understood molecular mechanis

296 Acute pancreatitis is a potentially lethal disease, with a rising incidence in the Western w

297 95% CIs of total, advanced, high-grade, and lethal disease, with adjustment for a variety of possibl

298 Advanced hepatocellular carcinoma (HCC) is a lethal disease, with limited therapeutic options.

299 Pancreatic ductal adenocarcinoma (PDA) is a lethal disease, with surgery being the only curative mod

300 Colorectal cancer (CRC) is the fourth most lethal disease worldwide.