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1 r the Release of Insects carrying a Dominant Lethal gene.
2  can be used to uncover neuronal defects for lethal genes.
3 tations reveals a group of 130 synthetically lethal genes.
4 ss likely to be disease genes than postnatal lethal genes.
5  are also discussed relative to other hybrid lethal genes.
6 years, identifying perhaps 250-350 embryonic lethal genes.
7 ied in a recent screen for A. aegypti larval lethal genes.
8 e of the few known paternal-effect embryonic lethal genes.
9 s, the white pupae and temperature-sensitive lethal genes.
10 cterium-phage combination, given a universal lethal gene and an inducible promoter which is triggered
11 orrelation in the expression of non-specific lethal genes and Parkinson's disease-associated genes wa
12 erference screen to search for Myc-synthetic lethal genes and uncovered a role for the SUMO-activatin
13 s of "conserved, essential" and "young, RNAi-lethal" genes and broadly confirmed the lethality of the
14  essential, perform functional analyses of a lethal gene, and analyze corresponding heterologous gene
15  to the two RBDs found in the Drosophila sex-lethal gene are each encoded in two exons, whereas the t
16  strains (TSS) that carry conditional female lethal genes are advantageous for genetic control progra
17 -acting factors encoded by the male-specific lethal genes are required for this process.
18 achine learning methods that predicted known lethal genes as well as an additional 1970 likely essent
19 ting engineered constructs that both carry a lethal gene, but suppress each other.
20 n of cells by the controlled expression of a lethal gene can be used to engineer plant traits such as
21 s designated as NTL T-DNA vectors (non-T-DNA lethal gene-containing T-DNA vectors).
22 ncers, where expression of BRCA1/2 synthetic lethal genes correlates with clinical outcome.
23 0 knockout mouse lines, here we identify 410 lethal genes during the production of the first 1,751 un
24     Programmable transcription factors drive lethal gene expression in hybrid offspring following und
25 ciency analysis places the locus between the lethal genes extra organs (eo) and lethal B20 (lB20).
26 pplications such as extracting synthetically lethal genes from the cancer literature.
27 instance the identification of synthetically lethal genes from the literature.
28 des aegypti mosquitoes containing a dominant lethal gene has been developed by a commercial company,
29 A detailed examination of the Drosophila Sex-lethal gene has led to two significant discoveries-the r
30                        One histone synthetic-lethal gene, HSL1, encodes a putative protein kinase tha
31 n of Wilms tumor 1 (Wt1) as a Kras synthetic-lethal gene in a mouse model of lung adenocarcinoma.
32 ic analysis of genomic edits in an embryonic lethal gene in F0 generation mice, or F0 mouse embryos,
33         We identify BUD31 as a MYC-synthetic lethal gene in human mammary epithelial cells, and demon
34 yme and potential use as a novel conditional lethal gene in plants are discussed.
35  the pehA gene as a heterologous conditional lethal gene in plants is discussed.
36  ability for our reference list of synthetic lethal gene interactions (R = 0.159).
37 cumulation of mutations can expose synthetic lethal gene interactions and oncogene-driven cellular re
38 e and over/under-expression in the synthetic lethal gene is evaluated using Kaplan-Meier analysis.
39 electively targeting the predicted synthetic lethal genes is tested in silico using shRNA and drug sc
40                                          The lethal gene of the suicide system consists of the three-
41 ows characterization of effects of recessive lethal genes on adult phenotypes and here enabled identi
42 e contains approximately 3479-4825 embryonic lethal genes, or about 13.7%-19% of all genes.
43 ons have disrupted one member of a synthetic lethal gene pair while leaving normal tissues untouched,
44 ed deletion of Ptpn1 and Ptpn2, an embryonic lethal gene pair, in adult mice.
45 ried out novel predictions of synthetic sick/lethal gene pairs at a genome-wide scale.
46 on networks are available and synthetic sick/lethal gene pairs have been extensively identified.
47  of well-established and validated synthetic lethal gene pairs is modest.
48 ening for genetic interactions and synthetic lethal gene pairs to identify combination therapies for
49 a-specific essential genes and 105 synthetic lethal gene pairs, we identified and validated the CDP-d
50  those that characterize the known synthetic lethal gene pairs.
51 dation, and 100 PPIs overlap human synthetic lethal gene pairs.
52                Among the strongest synthetic lethal genes, polarity defects are more apparent in par-
53 ypes after RNA interference of 147 embryonic lethal genes previously identified in a systematic scree
54 anscription factor to regulate a selectively lethal gene product.
55 n mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant leth
56 ty, and, in association with a conditionally lethal gene (SacB) permit efficient, high-fidelity trans
57  These results represent the first report of lethal gene silencing in Schistosoma.
58                The paternal-effect embryonic-lethal gene, spe-11, is required for normal development
59                              Transmission of lethal genes such as associated with Huntington's diseas
60 both; the release of Aedes carrying dominant lethal genes, such as the OX513A strain of A. aegypti; a
61 for a dominant, repressible, female-specific lethal gene system are used.
62  cohort of F0 CRISPants, where the embryonic lethal gene T/brachyury was targeted, we noted the prese
63                                    Synthetic lethal genes that exhibit transcriptomic buffering also
64  of transgenic mosquitoes harboring dominant lethal genes, the introduction of arbovirus-blocking mic
65                     Interestingly, embryonic lethal genes, the most essential genes in mouse, were le
66 ranzymes A and B also survived the otherwise lethal gene transfer.
67 t included use of sterile males, conditional lethal genes, translocations, compound chromosomes, and
68                                          The lethal gene used here is a CaMV 35S-barnase gene with an
69 ase was evaluated in plants as a conditional lethal gene useful for cell ablation and negative select
70                                            A lethal gene was incorporated into the non-T-DNA portion
71       Significant clustering of non-specific lethal genes was revealed alongside Parkinson's disease-
72 te that the B. subtilis skin element carries lethal genes, which are induced by the depletion of sknR
73 nase (FAK), represents a candidate synthetic lethal gene with GNAQ activation.
74    We identified APEX2 and FEN1 as synthetic lethal genes with both BRCA1 and BRCA2 loss of function.
75                  Identification of synthetic lethal genes with KRASG12C using genome-wide CRISPR/Cas9