ライフサイエンスコーパス: lethality

1 bbed "fully small-molecule-induced synthetic lethality").

2 can cause developmental defects or embryonic lethality.

3 naling, development, and subsequent neonatal lethality.

4 easures (MCMs) to combat irradiation-induced lethality.

5 ding flies high PCB 28 concentrations caused lethality.

6 tion of Thm1 and Thm2 causes mid-gestational lethality.

7 showed a phenotypic spectrum from 0 to 100% lethality.

8 he SAN and (cardiac) ganglia and in neonatal lethality.

9 Specc1lDeltaC510, that results in perinatal lethality.

10 th all 3 toxoids had 100% protection against lethality.

11 in mice, manifests with very early embryonic lethality.

12 otype with reduced weight gain and perinatal lethality.

13 syndromic phenotype with respect to LCA and lethality.

14 lomere integrity and stability increase cell lethality.

15 f influenza-induced PANoptosis and perinatal lethality.

16 esistance is the one of main reasons for the lethality.

17 RP inhibition can similarly induce synthetic lethality.

18 iven that Atad5 knock-out leads to embryonic lethality.

19 he major consequences of irradiation-induced lethality.

20 rn equines, supporting their embryonic/fetal lethality.

21 f S18-2 in zebrafish larvae led to embryonic lethality.

22 e and adult zebrafish that escape the larval lethality.

23 of the human reference; CAPZA2 rescues this lethality.

24 y developed OFT resulting in early embryonic lethality.

25 lesions relevant to APEX2-BRCA1/2 synthetic lethality.

26 ive tumour progression and those that confer lethality.

27 ene sets associated with metastasis-specific lethality.

28 urine Darc through DR1 in vivo to cause host lethality.

29 orsens the phenotypes and results in partial lethality.

30 s, and whole-body Slc25a37 deletion leads to lethality.

31 cient vascular development causing embryonic lethality.

32 ress resistance, mutagenesis, and antibiotic lethality.

33 ulted in hematopoietic failure and perinatal lethality.

34 regulated sarcoplasmic calcium and increased lethality.

35 yoblasts, developmental failure and prenatal lethality.

36 uced intestinal and hematopoietic injury and lethality.

37 ng in profound developmental delay and early lethality.

38 out of the MCU in adult heart does not cause lethality.

39 ntrauterine growth restriction and perinatal lethality.

40 or erythrocytes, is the critical target for lethality.

41 xamine the molecular role LC8 plays in viral lethality.

42 hich disrupts ovulation and causes embryonic lethality.

43 inal microflora resulting in sepsis-mediated lethality.

44 d in reduced cardiac contractility and early lethality.

45 c muscle defects, leading to early embryonic lethality.

46 2S/P322S mice exhibited substantial prenatal lethality.

47 muscular degenerative disease, and perinatal lethality.

48 developmental genes and subsequent embryonic lethality.

49 and MutY/M contribute to antibiotic-induced lethality.

50 elevated Dpp signaling results in embryonic lethality.

51 metabolic reprogramming, leads to synthetic lethality.

52 min E (VitE) deficiency results in embryonic lethality.

53 e cleavage (GCV) system caused the synthetic lethality.

54 elicit substantial impact in the absence of lethality.

55 with olaparib (a PARPi) to trigger synthetic lethality.

56 muscular atrophy in larval stages and pupal lethality.

57 evelopmental phenotypes, including embryonic lethality.

58 Specc1l in mouse results in early embryonic lethality.

59 mination of the Ubiad1 gene caused embryonic lethality.

60 ffects on respiratory sensitivity and opiate lethality.

61 riven MEK/ERK activity is necessary for this lethality.

62 hepatic biliary cells, and ultimately larval lethality.

63 ession from the developing SAN and embryonic lethality.

64 d knockdown of Cdk8 in flies results in semi-lethality.

65 onic acidemia, severe growth retardation and lethality.

66 overexpression in S2 cells resulted in cell lethality after 5-9 days, attributable to the nuclearly

67 rsist in these embryos, leading to embryonic lethality after implantation.

68 tro, and that Snx5 knockout in mice enhances lethality after infection with several human viruses.

69 also prevented Ripk1(D325A/D325A) embryonic lethality, although the mice died before weaning from mu

70 aking fully small-molecule-induced synthetic lethality an innovative approach toward unmet oncologica

71 Synthetic lethality-an interaction between two genetic events thro

72 IF2B2 in the zebrafish eif2b2 mutant rescues lethality and CNS apoptosis, demonstrating conservation

73 se (GPDH1) exhibit growth defects, synthetic lethality and decreased glycolytic flux.

74 of selected n-6 PUFAs rescued the embryonic lethality and defective permeability barrier.

75 mal Trr domain sufficient to rescue Trr-null lethality and demonstrate that this domain binds and sta

76 odels of NiVB infection, we achieved uniform lethality and disease pathogenesis reflective of that ob

77 the phenotype of pmt1 pmt3, showing seedling lethality and further reduced PC content without detecta

78 nt (flu) mutant, its release causes seedling lethality and inhibits mature plant growth.

79 strain, the DH6 strain shows stronger female lethality and lethality occurs at an earlier stage of de

80 35-42 mutant phenotype by inducing embryonic lethality and low fecundity.

81 in CED-3-dependent suppression of embryonic lethality and meiotic chromosome non-disjunction respect

82 tial therapeutic target to promote synthetic lethality and overcome chemoresistance.

83 ncern that the higher dose therapy increased lethality and QTc interval prolongation.

84 diting enzyme ADAR1 could induce higher cell lethality and render tumor cells more vulnerable to immu

85 t the At1g31870 locus and shows early embryo lethality and seed abortion.

86 (Gem + PRMT5 inhibition) creates conditional lethality and synergistic reduction of PDAC tumors in vi

87 ect-specific toxin (Hybrid) increased fungal lethality and the likelihood that insecticide-resistant

88 that correspond to the acquisition of tumor lethality and those of predictive and prognostic value i

89 Learning deficits scaled with attempt lethality and were partially explained by poor cognitive

90 rescued the disease phenotype and associated lethality, and normalized mTORC1 activity.

91 gC/D GTPases, conferred starvation-refeeding lethality, and RAGC-1 overexpression was sufficient to r

92 ected against inducible arrhythmias, related lethality, and the development of cardiomyopathy.

93 Thm1 loss causes perinatal lethality, and Thm2 loss allows survival into adulthood.

94 mage as the base for a conditional synthetic lethality approach.

95 ncies but the molecular events driving tumor lethality are not completely understood.

96 netic ablation of Ripk1 results in perinatal lethality arising from both RIPK3-mediated necroptosis a

97 f SNX14 in mice, which resulted in embryonic lethality around mid-gestation due to placental patholog

98 rophy allele of seip-1 resulted in embryonic lethality as well and could be rescued by PUFA supplemen

99 of severe global vascular defects and early lethality, as well as microphthalmia, periocular edema a

100 describe the concept of augmented synthetic lethality (ASL): depletion of a third gene product enhan

101 Besides, the brine shrimp lethality assay indicated that the roasted seed powder w

102 e latter was examined using the brine shrimp lethality assay.

103 ring fetal development resulted in perinatal lethality associated with structural and genomic evidenc

104 he alveolar airspaces to deploy an influenza lethality-associated response.

105 genotypes can also be tuned to cause hybrid lethality at different developmental life-stages.

106 iants identified in the probands rescue this lethality at lower efficiency than the reference.

107 Absence of CTHRC1 results in pronounced lethality attributable to ventricular rupture.

108 s required for performing a similar but cell lethality-based experiment to 25% of the normally requir

109 ncorporates genetic modifications to tighten lethality-based selection while simultaneously boosting

110 Mlkl(-/-)Casp1(-/-) mice also contributed to lethality because Casp8(C362A/C362A)Mlkl(-/-)Casp1(-/-)C

111 irs their self-renewal, leading to embryonic lethality before embryonic day 9.0, a developmental stag

112 Emx1-Cre recapitulated seizures and juvenile lethality between 1 and 2 months of age.

113 The screen revealed a striking synthetic lethality between Chk1 inhibition and cyclin F loss.

114 protein XPA markedly augments the synthetic lethality between MK2 and p53, enhancing anti-tumor resp

115 t cancers validated the concept of synthetic lethality between PARP inhibition and deleterious BRCA1/

116 Synthetic lethality between poly(ADP-ribose) polymerase (PARP) inh

117 Building on the observed synthetic lethality between Rb1 and Skp2, we found that small mole

118 rbance of the cardiac conduction system; and lethality between the second and fourth weeks after birt

119 novel protein partners and unravel synthetic lethality between XRN2 depletion and PARP1 inhibition.

120 Ifnar1(-/-) mice, whereas PRVABC59 caused no lethality; both strains caused 100% lethality in Ifnar1

121 d PI3K/mTOR pathways yields potent synthetic lethality by causing lethal replication stress and DNA d

122 ranscriptional squelching", while hid causes lethality by induction of apoptosis.

123 homozygous expression resulted in embryonic lethality by midgestation.

124 Ail and lipopolysaccharide (LPS)(6) enhance lethality by promoting resistance to human innate immuni

125 bipolar cells, thereby overcoming embryonic lethality caused by germline Frmpd1 deletion.

126 endogenous RD histone genes and rescues the lethality caused by homozygous deletion of the RD histon

127 the larval developmental delay and the pupal lethality caused by loss of KDM5.

128 in II mutant allele, was capable of rescuing lethality caused by partial defects in actin nucleation/

129 of autophagy with rapamycin also rescued the lethality caused by rrp4 inactivation.

130 Finally, lethality caused by sterile hemolysis in mice required T

131 Moreover, the embryonic lethality caused by the deficiency of mdm2 was fully res

132 f marimastat and varespladib prevents murine lethality caused by venom from the most medically-import

133 scue Ripk1 (mRHIM/mRHIM) mice from perinatal lethality caused by ZBP1-driven cell death and inflammat

134 This high lethality combined with the paucity of licensed medical

135 mucosal exposure resulted in remarkably high lethality compared to skin exposure.

136 mimicked the patients' phenotype with early lethality, defects in neurogenesis and cardiac dilation.

137 cific knockout of Lztr1 results in perinatal lethality due to cardiovascular dysfunction.

138 g that Acer2 deficiency results in embryonic lethality due to the atrophy of the fetal blood vessel n

139 icity against mammalian cells in culture and lethality during mouse bacteremia.

140 A mutation in mouse RIPK1 leads to embryonic lethality during mouse development(2,3).

141 rentiation, which further leads to embryonic lethality early in gestation.

142 WM, including impaired somatic growth, early lethality, effects on myelination, loss of oligodendrocy

143 ed that ATR inhibition can exploit synthetic lethality (eg, in cancer cells with impaired compensator

144 urvival remains unclear because of perinatal lethality exhibited by knockout mice lacking all three A

145 l (GI) tract is the principal determinant of lethality following allogeneic bone marrow transplantati

146 Using analysis of concordance for synthetic lethality for the yeast sphingolipid phospholipase ISC1,

147 udy provides the first evidence for cellular lethality from a PARP-1-targeted Auger emitter, calling

148 less, Myd88(-/-) mice were more sensitive to lethality from secondary septicemic plague.

149 The lethality from tTA overexpression is thought to be due t

150 placenta and heart over-growth and perinatal lethality (>90%) due to raised extra-cellular IGF2 secon

151 In Escherichia coli, antibiotic lethality has been linked to oxidative stress and the do

152 ivating variant which was predicted to cause lethality if expressed ubiquitously.

153 e-strand breaks (DSBs), which can cause cell lethality if unrepaired or cancers if improperly repaire

154 AsCas12a toolkit by screening for synthetic lethalities in OVCAR8 and A375 cancer cells, discovering

155 e oligomerization of hCSPalpha and premature lethality in a dose-dependent manner.

156 The finding of early embryonic lethality in a Tonsl(-/-) murine model and the discovery

157 s, reduced numbers of neutrophils, and early lethality in a tonsl(-/-) zebrafish model both support t

158 NX1, inhibited cell growth, and induced cell lethality in AML cells expressing mtRUNX1.

159 reduced c-Myc levels and exerted synergistic lethality in BETi-P/R sAML cells.

160 Inhibition of RAD52 leads to lethality in BRCA-deficient cells.

161 53BP1 activity drives genome instability and lethality in BRCA1-deficient mice by inhibiting homologo

162 that centrosome depletion induces synthetic lethality in cancer cells that contain the 17q23 amplico

163 onnection between G4 formation and synthetic lethality in cancer cells, and recent progress towards c

164 romote intestinal injury and sepsis-mediated lethality in Cebpd(-/-) mice.

165 defects in the fertilized embryo and ensuing lethality in crosses between symbiotic males and either

166 Loss of cpa leads to lethality in early development and expression of the hum

167 eroxic injury, which result in high rates of lethality in experimental models, are thought to include

168 aused no lethality; both strains caused 100% lethality in Ifnar1 (-/-) Ifngr1 (-/-) double-knockout (

169 We found that strain H/PF/2013 caused 100% lethality in Ifnar1(-/-) mice, whereas PRVABC59 caused n

170 ene residing on the X chromosome resulted in lethality in male flies.

171 causes chromosome instability and embryonic lethality in mammals.

172 nous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ri

173 s-induced PANoptosis and underlies perinatal lethality in mice in which the RIP homotypic interaction

174 full virulence, bacterial dissemination, and lethality in mice infected by the intragastric route.

175 l elongation rate results in early embryonic lethality in mice.

176 sulting in cellular senescence and embryonic lethality in mice.

177 of which may be involved in early embryonic lethality in mice.

178 cript by 25 to 50% delayed seizure onset and lethality in mouse models of SCN8A encephalopathy and Dr

179 re of alveolar inflation and early postnatal lethality in mouse.

180 function of this gene is unknown, embryonic lethality in Mrpl3 knock-out mice suggests it is critica

181 PI/PER triple-combination achieved synthetic lethality in multiple myeloma cells in culture and preve

182 mice provided significant protection against lethality in passive transfer studies.

183 of IFN-driven RIPK3 activation and perinatal lethality in the absence of RIPK1.

184 of four escape mutant viruses had increased lethality in the DBA2/J mouse model.

185 6 strain displayed robust virulence and 100% lethality in the hamster model of acute CDI.

186 oglycerate dehydrogenase) were conditionally lethality in the M9-glucose medium supplemented with Gly

187 Sepsis is commonly present with high lethality in the severe forms of the disease.

188 NFalpha and IL-1beta and highly resistant to lethality in these models, disclosing a complementary, b

189 of single stranded breaks, causing synthetic lethality in tumors with loss of high-fidelity double-st

190 orineural deafness, enterocolitis, and early lethality in two pedigrees: males with DKC1 p.Glu206Lys

191 serum or anti-NS1 mAb, prevent NS1-mediated lethality in vivo.

192 OH-metabolites and suppressed PCB 28 induced lethality including dCYP1A2.

193 , and murine Nmnat1 knockouts show embryonic lethality, indicating that complete absence of NMNAT1 ac

194 via sex ratio distortion or female-specific lethality is also explored.

195 Synthetic lethality is an innovative framework for discovering nov

196 mice have revealed that variation in opiate lethality is associated with strain differences, suggest

197 n order to combat this phenomenon, synthetic lethality is being investigated, making use of existing

198 If lethality is complete, releasing this strain should only

199 Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination.

200 l metabolic threshold below which antibiotic lethality is negligible.

201 Although synthetic lethality is not a new idea, recent advances, including

202 systems in genomic integrity and antibiotic lethality is not understood, in part because mycobacteri

203 However, the cause of lethality is obscure.

204 Homozygous mutant animals die as pupae, but lethality is rescued by the mini-GAL4-driven expression

205 The cause of this lethality is unknown.

206 Biliary dysgenesis, but not larval lethality, is driven primarily by Yap signaling.

207 of Mfsd7c in mice resulted in late-gestation lethality, likely due to CNS phenotypes.

208 embryonic over-growth with reduced neonatal lethality (<60%), and long-term survival.

209 This synthetic lethality may eventually be exploited to improve outcome

210 sruption of the Lrrc32 gene results in early lethality, mice lacking the enhancer are viable but lack

211 tKO mice demonstrate partial embryonic lethality, most likely due to the role of miR-1a in card

212 DARC on the endothelium, contributing to the lethality observed during bloodstream infection in mice.

213 ion of the GCV system causes the conditional lethality observed in the glyA yggS or serA yggS mutants

214 ant mechanistic contributor to the synthetic lethality observed.

215 oth components in a single construct, female lethality occurred at the embryonic and/or first instar

216 6 strain shows stronger female lethality and lethality occurs at an earlier stage of development.

217 ed-3(-) mutant, and suppresses the embryonic lethality of a mutant defective for the apoptotic suppre

218 eting of these pathways does not explain the lethality of anthrax toxin(1,2).

219 In contrast to the early embryonic lethality of Atm(KD/KD) mice, AtmR3016H (Atm(R/R) ) mice

220 t DNA2-dependent end resection to rescue the lethality of BRCA1(Delta11) mice, despite increasing RIF

221 tergenerational relationships and spread and lethality of COVID-19 in a critical way.

222 er cases considerably warps estimates of the lethality of COVID-19 within populations and comparisons

223 these spiders, and consequently the primate lethality of delta-HXTXs remains enigmatic.

224 additional Lshid(Ala2) effector, the female lethality of DH6 is 100% dominant and cannot be represse

225 rrant up-regulation contributes to embryonic lethality of Dnmt3b knockout embryos.

226 Here, we bypassed the embryonic lethality of dually PARP-1/PARP-2-deficient mice by usin

227 rmalities in the vasculature causing partial lethality of embryos and neonates.

228 Additionally, the female lethality of FL3#2 was partially repressed by supplying

229 y the lack of animal models due to embryonic lethality of GPI biosynthesis gene null mutants.

230 The mutant larvae exhibited increased lethality of incomplete penetrance.

231 we currently lack theory for predicting the lethality of multihost parasites.

232 activation of MepS was found to suppress the lethality of mutations in essential division genes.

233 ssociated early-onset intestinal failure and lethality of Spint2-deficient mice is caused by unchecke

234 on splicing further resulted in preferential lethality of spliceosomal mutant AML, providing a strate

235 coagulation and thrombosis contribute to the lethality of subjects infected with severe acute respira

236 east cancer model, tumor-selective synthetic lethality of the combination of bioavailable ATR and Wee

237 tries, leading to uncertainty about the true lethality of the disease.

238 ns, which was previously hampered due to the lethality of the gene.

239 Given the early lethality of the only published global Slc7a7 knockout m

240 In Escherichia coli, conditional lethality of the yggS and glyA (encoding serine hydroxym

241 Thus, embryonic lethality of Ubiad1 deficiency results from depletion of

242 tive control agent (which might mitigate the lethality of venous thromboembolism) and those for which

243 Synthetic lethality offers a promising but largely unexploited str

244 Approaches to estimating a group's future lethality often require data on the group's capabilities

245 c losses of genes that result in early mouse lethality or are associated with severe human congenital

246 highlights exciting targets within synthetic lethality, (PARP, ATR, ATM, DNA-PKcs, WEE1, CDK12, RAD51

247 Association analysis on the lethality phenotype, as well as an evolutionary rate cov

248 dd alleles from these mice resulted in early lethality prior to post-natal day 15 (P15), which was pr

249 ng based on the genetic concept of synthetic lethality provides an avenue to discover drug targets in

250 dium) sordellii and responsible for the high lethality rate associated with P. sordellii infection.

251 TcsL-induced damage to lung tissues and the lethality rate in mice.

252 se hosts also develop systemic pathology and lethality, reducing confidence in the translatability of

253 een achieved concerning neonatal sepsis, its lethality remains considerably high, and further insight

254 and radical debridement of necrotic tissue, lethality remains high.

255 In this study, a respiratory synthetic lethality screen revealed a role for an evolutionarily c

256 Using a synthetic lethality screen, we identified important regulators of

257 ll dependencies by high-throughput synthetic lethality screens, integration of clinico-genomic data a

258 Synthetic lethality (SL) is a promising form of gene interaction f

259 ly interacting proteins results in synthetic lethality (SL).

260 Synthetic lethality strategies for cancer therapy exploit cancer-s

261 are amenable to chemically induced synthetic lethality strategies upon association with inhibitors of

262 uitin pathway may, therefore, be a synthetic lethality strategy for BRCA1-deficient cancers.

263 H3K27me3 engagement causes partial postnatal lethality, supporting a role in development.

264 These lethality suppressor mutants may provide valuable tools

265 andom GreA variants has been used to isolate lethality suppressors to assess important residues for G

266 osophila tetracycline-suppressible embryonic lethality system by analyzing the frequency and structur

267 g the potential for the genetic breakdown of lethality systems by rare spontaneous mutations, or sele

268 al redundant, albeit functionally unrelated, lethality systems.

269 ed to algal growth inhibition and springtail lethality tests with terpenes, alkanes, and cyclic silox

270 expression of MDM2 I438K leads to embryonic lethality that is rescued by p53 deletion, suggesting MD

271 st a general concept of inducing cancer cell lethality through activation of mitochondrial proteolysi

272 uncover that mycobacteria resist antibiotic lethality through nucleotide sanitization by MutTs, and

273 ses severe conotruncal defects and perinatal lethality, thus providing mouse genetic evidence demonst

274 erapeutic opportunity and a unique synthetic lethality to exploit the distinctive metabolic state of

275 sence of RNase H1 and RNase H2 leads to cell lethality under Rnr1 depletion.

276 thering Sli15 to Ame1/Okp1 rescued synthetic lethality upon Ctf19 depletion in a Sli15 centromere-tar

277 model for estimating a terror group's future lethality using latent-variable modeling techniques to i

278 d on the possibility of triggering synthetic lethality using only small organic molecules (dubbed "fu

279 Remarkably, LPS-induced lethality was almost completely abrogated in neuronal Mf

280 (KQ/KQ) mice were perinatal lethal, yet this lethality was averted in p53(KQ/-) mice, which displayed

281 Embryonic lethality was completely prevented by the combined loss

282 Neratinib lethality was enhanced by knock down of YAP.

283 D(50) of (2R,6R)-HNK to prevent NMDA-induced lethality was found to be 228 mg/kg, compared with 6.4 m

284 se) has been described, but the mechanism of lethality was not determined.

285 Perinatal lethality was observed in Slc7a7Lbu/Lbu and Slc7a7Bay/Ba

286 ific deletion to prevent double-KO embryonic lethality, we developed two mouse models of a conditiona

287 ency and is non-toxic to mice but can regain lethality when combined with PI3K pathway inhibitors.

288 TRADD rescues Ripk1(-/-) mice from perinatal lethality when RIPK3-mediated necroptosis is disabled.

289 seip-1 mutants displayed penetrant embryonic lethality, which is caused by the disruption of the lipi

290 dk8, the fly homolog of CDK19, causes larval lethality, which is suppressed by expression of human CD

291 delayed repair and ultimately injury-induced lethality, while loss of Wnt production from endothelial

292 Subsequently, we assessed parameters such as lethality, wing and eye morphology, neuromuscular juncti

293 RAD21, and STAG2 and screened for synthetic lethality with 3009 FDA-approved compounds.

294 n of both Crk and CrkL resulted in perinatal lethality with defects in desmosome morphology and kerat

295 ally used drugs showed significant synthetic lethality with loss or inhibition of GSTO1.

296 d regulatory mechanisms that cause synthetic lethality with PARPis.

297 KAR3), and they all share the same synthetic lethality with the first group.

298 entify genes whose depletion shows synthetic lethality with VX-680.

299 atic endoderm stage, leading to necrosis and lethality within days.

300 lation, cause cardiomyopathies and embryonic lethality, yet how tissue symmetry is broken to specify