ライフサイエンスコーパス: leucine

1 or amino acid oxidation (IAAO; with l-[1-13C]leucine).

2 obligate source of the essential amino acid leucine.

3 expand the selectivity to include valine and leucine.

4 ne into the brain, mice were injected with L-leucine (300 mg/kg, IP) immediately before kynurenine (3

5 y in nutrient emptying, slower digestion and leucine absorption kinetics.

6 intestinal hydrolysis, and higher and faster leucine absorption.

7 uced by amino acids, especially arginine and leucine, accompanied by the dynamic lysosomal localizati

8 To confirm that leucine acts by interfering with the transport of kynure

9 , PHD1 ensures an optimal mTORC1 response to leucine after episodes of metabolic scarcity.

10 ailability of amino acids, in particular the leucine, after the ingestion of two solid and isocaloric

11 Leucine aminopeptidase (LAP) is an essential proteolytic

12 The activity of leucine aminopeptidase was positively correlated with EC

13 Both ERAP2 and leucine aminopeptidase, an enzyme unrelated to antigen p

14 n of NV-5138, a recently developed synthetic leucine analog, has a rapid and sustained antidepressant

15 ons of phenylalanine, glutamine, isoleucine, leucine and glycerophosphocholine.

16 ne, l-[ring-3,5-2H2]-tyrosine, and l-[1-13C]-leucine and ingested 45 g carbohydrate with either 0 (0

17 Leucine and MTORC1 metabolism may be involved in the mec

18 sites included positive associations between leucine and postmenopausal breast cancer, and isoleucine

19 In agreement with leucine and proline being the most frequently methylated

20 Replacement of R401W with leucine and then lysine progressively restores HMGB1 bin

21 d scoring (FAO, 2013) indicated, isoleucine, leucine and valine as the limiting amino acids.

22 However, this is hindered by overlapped leucine and valine frequencies.

23 ch) of alanine, choline compounds, creatine, leucine and valine.

24 ariants in the elk prion protein gene: L132 (leucine) and M132 (methionine).

25 ched-chain amino acids (BCAAs, i.e., valine, leucine, and isoleucine) function as nitrogen donors to

26 evels of branched-chain amino acids (valine, leucine, and isoleucine), aromatic amino acids (tryptoph

27 leucine, histidine, but limiting for lysine, leucine, and threonine.

28 f soil bacterial and fungal growth using the leucine- and acetate-incorporation methods, respectively

29 A variety of inputs including the amino acid leucine are required for full mTORC1 activation.

30 associating protein with a high frequency of leucine) are the best-characterized members of a group o

31 Microcystin-leucine arginine (MC-LR), associated with the most toxic

32 Leucine, arginine, and methionine signal to mTORC1 throu

33 fraction with (13) C-bicarbonate and (15) N-leucine as tracers.

34 s and the mutation of the FXIII-A Isoleucine-Leucine-Aspartate-Threonine (ILDT) motif prevented Lys67

35 rier confirmed that kynurenine competes with leucine at the level of the amino acid transporter LAT1

36 the circulating concentrations of the BCAAs leucine (BCAA: 9.0% +/- 12%; low-BCAA: 9.2% +/- 11%), va

37 an activity based electrochemical substrate leucine-benzyl ferrocene carbamate (Leu-FC) for selectiv

38 ed in a concentration of postprandial plasma leucine between 2 h and 5 h30 twice higher than that pro

39 emptying would not explain the difference in leucine bioavailability.

40 volved from the isopropylmalate synthases of leucine biosynthesis.

41 did not inhibit the uptake of extracellular leucine but instead facilitated the efflux of intracellu

42 Substitution of a leucine by threonine in helix 8 of the ligand-binding do

43 f activator peptides, such as benzoyl-leucyl-leucine (Bz-LL), for function.

44 (KIC), the alpha-keto acid corresponding to leucine, can assess both BCAA aminotransferase (BCAT) an

45 aconate resistance mechanism in Mtb and an l-leucine catabolic pathway that proceeds via an unprecede

46 his pathway, Rv2498c, also participates in l-leucine catabolism.

47 ingestion results in systemic amino acid and leucine concentrations similar to that following milk pr

48 nstrated a remarkable ability to survive low leucine concentrations.

49 Stearic acid decreased while the leucine content increased upon storage, but palm oil FMP

50 re of nutritional interest due to their high leucine content, but little data are available on their

51 , including plasma leucine, despite its high leucine content.

52 Substitution of the glycine with leucine converted the resting-state R2lox cofactor to an

53 dent of LAT1 and leucine, which explains why leucine could block brain uptake of kynurenine without a

54 Associating Protein with a high frequency of LEucines (DAPLE) belongs to a group of unconventional ac

55 of Yap/Taz prevented growth of PDA cells in leucine-deficient medium, but not in complete medium.

56 ced NH(3) and NADH were reacted in situ with leucine dehydrogenase (LeuDH) to generate l-norleucine w

57 nds is the incorporation of l-tyrosine- or l-leucine-derived 4-alkyl-l-proline derivatives (APDs) in

58 aminoacidemia was observed, including plasma leucine, despite its high leucine content.

59 ctivity, and the positions of these required leucines differ based on the identity and position of th

60 y promotes CR-triggered hypothermia and that leucine enkephalin directly controls core body temperatu

61 Bile acid composition and leucine fermentation defined a prototype metabolomic mod

62 Leucine had no effect of its own on sickness behavior an

63 These findings demonstrate that leucine has antidepressant properties vis-a-vis inflamma

64 itro, we found that conversion of Phe-202 to leucine in either Mfn1 or Mfn2 diminishes the fusion act

65 ing rats verified the increased oxidation of leucine in glioma tissue.

66 u Microscopy confirmed that these C-terminal leucines in clade C Vpu, like W76 in clade B, contribute

67 e, phenylalanine, glutamic acid, valine, and leucine increased in samples exposed to eustress and wer

68 mically similar amino acids (e.g. valine vs. leucine), indicating that LCDs composed of related amino

69 Together with valine and leucine interdigitation, these cause a dehydrated pore c

70 Lactobacilli produced leucine, isoleucine and valine as branched chain amino a

71 Branched chain amino acids (leucine, isoleucine and valine) were also present in sub

72 nt differences for some metabolites (valine, leucine, isoleucine, proline, and malic acid).

73 to systematically replace 29 membrane-facing leucine, isoleucine, valine, and phenylalanine residues

74 ha (ER) transcriptional co-repressor through leucine/isoleucine-rich motifs that are functionally ind

75 nificant changes in the metabolism of valine/leucine/isoleucine; the jejunum, skeletal muscle, and li

76 the hemagglutinin (HA) from glutamine (Q) to leucine (L) has been shown to play a key role in recepto

77 B) domain, namely the TPP1 glutamate (E) and leucine (L)-rich (TEL) patch and the N terminus of TPP1-

78 ty with a total of four amino acid variants (leucine [L], proline [P], serine [S], and threonine [T])

79 ically l-[1-13C]-phenylalanine and l-[1-13C]-leucine labeled milk protein after endurance exercise.

80 While leucine (Leu) is a critical mTORC1 regulator under AA-st

81 Among the 20 amino acids, three of them-leucine (Leu), arginine (Arg), and serine (Ser)-are enco

82 lower-limb immobilization, with thrice-daily leucine (LEU; n = 8) or placebo (PLA; n = 8) supplementa

83 presence of a conserved aspartate-glutamate-leucine-leucine-alanine motif) competitively inhibit the

84 thesis rates, and to a greater extent than a leucine-matched bolus of milk protein, in resistance-tra

85 single bolus of mycoprotein compared with a leucine-matched bolus of milk protein, in rested and exe

86 by DIA using mass defect-based N,N-dimethyl leucine (mdDiLeu) tags and high-resolution tandem mass s

87 - and host-derived metabolites including the leucine metabolite beta-hydroxy-beta-methylbutyrate, whi

88 In contrast, the KU43 TE domain selects leucine methyl ester and performs a direct amidation of

89 is referred to as VILMHA (valine isoleucine leucine methyl hydrogen analysis), was tested on three p

90 ingested either 31 g (26.2 g protein: 2.5 g leucine) milk protein (MILK) or 70 g (31.5 g protein: 2.

91 rotein (MILK) or 70 g (31.5 g protein: 2.5 g leucine) mycoprotein (MYCO) following a bout of unilater

92 BCKDC) activities via production of [1-(13)C]leucine or (13)CO(2) (and thus H(13)CO(3)(-)), respectiv

93 fication of peaks as either from isoleucine, leucine, or valine reduces the search space by many orde

94 utes a highly conserved proline residue with leucine (p.P72L) that, based on the high-resolution stru

95 tead facilitated the efflux of intracellular leucine pools.

96 Leucine, proline, cysteine, and tryptophan concentration

97 e most affected with an important descend in leucine release.

98 duction, and NLR (nucleotide-binding domain, leucine repeat domain-containing protein).

99 te proteolysis and that mutation of a single leucine residue (L6) to aspartic acid inhibits proteolys

100 ine residue at position 19 was replaced by a leucine residue.

101 In addition, specific leucine residues along the length of these proteins are

102 Moreover, insertion of leucine residues into the TMD helix induced a ligand-ind

103 n and AN3365, to mimic starvation of Trp and leucine, respectively.

104 eukin-18 (IL-18), nucleotide-binding domain, leucine rich family (NLR) pyrin domain containing 3 (NLR

105 While the small leucine rich proteoglycans (SLRPs), including decorin an

106 cleotide variant (SNV) within the C-terminal leucine rich repeat (LRR) domain is responsible for the

107 ous work has shown that Elfn1 (extracellular leucine rich repeat and fibronectin Type III domain cont

108 orrelated with reduced expression of LRRC26 (leucine rich repeat containing 26), the gamma subunit ma

109 d activation of pathways of beta-catenin and leucine rich repeat containing G protein-coupled recepto

110 Both possess conserved leucine rich repeat domains (LRR) as proposed sites of m

111 Leucine rich repeat kinase 2 (LRRK2) is an enigmatic enz

112 Pase domain Ras of complex proteins (ROC) of leucine rich repeat kinase 2 (LRRK2) result in an abnorm

113 The LRRK2 gene, coding for leucine rich repeat kinase 2 (LRRK2), is a key player in

114 epigenetic regulation of nucleotide-binding leucine rich repeat or Nod-Like Receptor (NLR) genes as

115 Here, we show that leucine rich repeat receptor and nogo-interacting protei

116 Leucine rich repeat transmembrane (LRRTM) proteins are s

117 Nucleotide binding site-leucine rich repeats (NLRs), receptor-like kinases (RLKs

118 h NLRP10 is the only NLR protein lacking the leucine rich repeats, it has been implicated in multiple

119 Leucine-rich alpha-2 glycoprotein (LRG) is a novel acute

120 Here, we investigated the role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in normal and

121 embrane models that were prone to generating leucine-rich designs.

122 -specific tRNA binding protein that inhibits leucine-rich ETC complexes.

123 Autoantibodies against leucine-rich glioma inactivated 1 (LGI1) are found in pa

124 BEX3 possess a conserved leucine-rich nuclear export signal and experimental data

125 minant negative binder of Beclin-1, known as leucine-rich pentatricopeptide repeat-containing protein

126 cal, but unconnected, functions of the small leucine-rich proteoglycan, decorin.

127 e to salicylic acid (SA), and protein kinase leucine-rich receptors (PK-LRR).

128 We recently identified the leucine-rich repeat (LRR) adhesion protein, trophoblast

129 All sera and 9/11 CSFs bound both the leucine-rich repeat (LRR) and the epitempin repeat (EPTP

130 SHR4z has significant homology to the short leucine-rich repeat (LRR) domain of SOMATIC EMBRYOGENESI

131 In addition to its leucine-rich repeat (LRR) domain that has been previousl

132 PI)-ANCHORED PROTEINS (LLG) complexes, or by leucine-rich repeat (LRR) extensin proteins (LRXs).

133 In particular, leucine-rich repeat (LRR) genes make the largest contrib

134 As proof-of-concept, we used a leucine-rich repeat (LRR) protein binder, called a repeb

135 Plant nucleotide-binding (NB) leucine-rich repeat (LRR) receptor (NLR) proteins functi

136 n in the nucleotide-binding domain (NBD) and leucine-rich repeat (LRR)-containing (NLR) inflammasome

137 subgroup of nucleotide-binding domain (NBD), leucine-rich repeat (LRR)-containing proteins (NLRs) att

138 ated promoter::GUS transgenic plants for all leucine-rich repeat (LRR)-RLKs in Arabidopsis and analyz

139 Plant nucleotide-binding leucine-rich repeat (NLR) disease resistance proteins re

140 ost most of the conserved nucleotide-binding leucine-rich repeat (NLR) genes that are known to be inv

141 A nucleotide-binding, leucine-rich repeat (NLR) immune receptor gene was isola

142 Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors activate cell

143 Plant nucleotide binding/leucine-rich repeat (NLR) immune receptors are activated

144 that are monitored by nucleotide-binding and leucine-rich repeat (NLR) immune receptors.

145 e of four genes encoding nucleotide-binding, leucine-rich repeat (NLR) immune receptors.

146 stance genes encoding nucleotide-binding and leucine-rich repeat (NLR) intracellular immune receptor

147 in the gene encoding the nucleotide binding, leucine-rich repeat (NLR) protein NbZAR1.

148 autoimmunity through the nucleotide-binding leucine-rich repeat (NLR) protein SUMM2 and the MAPK kin

149 RPS5, a nucleotide-binding leucine-rich repeat (NLR) protein, is activated by the p

150 Nucleotide-binding leucine-rich repeat (NLR) proteins play critical roles i

151 nes encode intracellular nucleotide-binding, leucine-rich repeat (NLR) proteins.

152 coding a coiled-coil nucleotide binding site Leucine-rich repeat (NLR) receptor protein that was alte

153 f TIR domain-containing, nucleotide binding, leucine-rich repeat (TNL) immune receptors.

154 NLR (nucleotide-binding [NB] leucine-rich repeat [LRR] receptor) proteins are critica

155 o a pair of amino acids, 106 and 156, in the leucine-rich repeat and central domains and show these m

156 ate mapping of nucleotide-binding domain and leucine-rich repeat containing (NLR) genes.

157 VASP, extended-synaptotagmin 2 [ESYT2], and leucine-rich repeat containing 15 [LRRC15]), and "isomer

158 xplore the role of nucleotide-binding domain leucine-rich repeat containing receptor family member NL

159 Nucleotide-binding, leucine-rich repeat containing X1 (NLRX1) is a mitochond

160 Five nucleotide binding leucine-rich repeat contigs distinguished resistant and

161 n asymmetric dimer bridged by the N-terminal leucine-rich repeat domain of ANP32A.

162 nt interface specifically formed between the leucine-rich repeat domain of FBXL2 and PTAR1, which unm

163 tartan (trn), which encodes a transmembrane leucine-rich repeat domain protein that mediates cell-ce

164 this study, we show that Scrib, through its leucine-rich repeat domain, forms a complex in vivo with

165 Receptor kinases with extracellular leucine-rich repeat domains (LRR-RKs) form the largest g

166 in NLRP1, encoding Nucleotide-Binding Domain Leucine-Rich Repeat Family Pyrin Domain-Containing 1.

167 hibitor Flightless-1 and its binding partner leucine-rich repeat flightless-interacting protein 2.

168 d genes included 639 nucleotide-binding site leucine-rich repeat genes (NBS-LRRs), 290 receptor-like

169 and 56% (343) of 616 nucleotide-binding site-leucine-rich repeat genes harbored at least one Tnt1 ins

170 Nucleotide-binding and leucine-rich repeat immune receptors (NLRs) provide resi

171 ponse proteins, including nucleotide-binding leucine-rich repeat immune receptors, oxidative and DNA

172 Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common

173 Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most freque

174 Leucine-rich repeat kinase 2 (LRRK2) encodes a complex p

175 Leucine-rich repeat kinase 2 (LRRK2) G2019S is a relativ

176 Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most c

177 ortem PD patients' substantia nigra; and (b) leucine-rich repeat kinase 2 (LRRK2) gene identified pat

178 The Parkinson's disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied ex

179 The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause o

180 The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause o

181 Leucine-rich repeat kinase 2 (LRRK2) is a large multidom

182 Leucine-rich repeat kinase 2 (LRRK2) is a promising ther

183 Leucine-rich repeat kinase 2 (LRRK2) is the most commonl

184 A broad role for leucine-rich repeat kinase 2 (LRRK2) mutations in famili

185 We found that the Parkinson's disease gene, leucine-rich repeat kinase 2 (LRRK2), has an unexpected

186 1 exacerbated death of PQ-exposed cells in a leucine-rich repeat kinase 2-mediated manner.

187 Inhibition of leucine-rich repeat kinase using PFE360 failed to rescue

188 s a coiled-coil, nucleotide-binding site and leucine-rich repeat protein (CNL).

189 Ptr1 candidates to eight nucleotide-binding leucine-rich repeat protein (NLR)-encoding genes.

190 F-box and leucine-rich repeat protein 16 (FBXL16) is a poorly stud

191 ISLR2 (immunoglobulin superfamily containing leucine-rich repeat protein 2) and STRA6 (stimulated by

192 that deletion of the gene encoding PH domain Leucine-rich repeat Protein Phosphatase 1 (PHLPP1) prote

193 Pleckstrin homology (PH) domain and leucine-rich repeat protein phosphatase 1 (Phlpp1) regul

194 iled multi-genome-derived nucleotide-binding leucine-rich repeat protein repertoire involved in disea

195 rod bipolar cell terminals is regulated by a leucine-rich repeat protein, LRRTM4.

196 ns, immunoglobulin superfamily proteins, and leucine-rich repeat proteins, as well as their associate

197 The leucine-rich repeat receptor kinases (LRR-RK) FLS2 and E

198 Plants use leucine-rich repeat receptor kinases (LRR-RKs) to sense

199 ant responses, we identified a corresponding leucine-rich repeat receptor, termed INR, specific to se

200 SCM, a leucine-rich repeat receptor-like kinase, is required fo

201 In embryophytes, the leucine-rich repeat receptor-like kinases (LRR-RLKs) are

202 Both pathways involve leucine-rich repeat receptor-like kinases acting in shoo

203 Nucleotide-binding leucine-rich repeat receptors (NLRs) monitor the plant i

204 ction using intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) that directly or in

205 innate immunity relies on nucleotide binding leucine-rich repeat receptors (NLRs) that recognize path

206 cluding genes putatively encoding NB-ARC and leucine-rich repeat sequences, protein kinases and defen

207 members of the immunoglobulin, cadherin, and leucine-rich repeat superfamilies.

208 ere, we show that nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein

209 , nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin protein 3 complex, CASP1,

210 d nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin protein 3 complex.

211 between 2 candidate genes, EMSY and LRRC32 (leucine-rich repeat-containing 32) but the functional me

212 (i.e. SEC61) and ER proteins (ribophorin I, leucine-rich repeat-containing 59 (LRRC59), and SEC62) p

213 ly defined, revealing that it belongs to the leucine-rich repeat-containing 8 (LRRC8) protein family.

214 The recent identification of Leucine-Rich Repeat-Containing 8 (LRRC8A-E) proteins as

215 Human organoids derived from leucine-rich repeat-containing G protein-coupled recepto

216 lycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled recepto

217 WNT/beta-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled recepto

218 ciated CpG was cg03566881 located within the leucine-rich repeat-containing G-protein coupled recepto

219 R-spondins (Rspos) are endogenous ligands of leucine-rich repeat-containing G-protein-coupled recepto

220 d nucleotide-binding oligomerization domain, leucine-rich repeat-containing protein (NLRP) 3 and pro-

221 Here, we report a DNA repair suppressor, leucine-rich repeat-containing protein 31 (LRRC31), that

222 These channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family

223 ator of reactive oxygen species (NRROS) is a leucine-rich repeat-containing protein that uniquely ass

224 Nucleotide-binding and leucine-rich repeat-containing receptors (NLRs) encompas

225 ionships between relaxin family peptides and leucine-rich repeat-containing, G protein-coupled recept

226 Herein, we introduce leucine-rich repeats (LRRs) and calponin homology contai

227 with its substrate C-MYC via its C-terminal leucine-rich repeats (LRRs) domain.

228 tion is linked to carcinogenesis, and Lrig1 (leucine-rich repeats and Ig-like domains 1) marks a dist

229 sistant seizures are common in patients with leucine-rich, glioma-inactivated 1 (LGI1)-IgG associated

230 vated receptor 2, nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-

231 vated receptor 2, nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-

232 te-receptor-antibody (pCSF(NMDAR), n = 7) or Leucine-rich-glioma-inactivated-1-Ab (pCSF(LGI1), n = 6)

233 I), an actin-binding protein that contains a leucine-rich-repeat (LRR), which binds R-ras and may reg

234 existing phytohormone and nucleotide-binding-leucine-rich-repeat (NLR) networks, to regulate immunity

235 The earring-shaped NLRP3 consists of curved leucine-rich-repeat and globular NACHT domains, and the

236 ts in Arabidopsis, and identified HPCA1 as a leucine-rich-repeat receptor kinase belonging to a previ

237 Here we demonstrate that the leucine-rich-repeat receptor Tartan and the teneurin Ten

238 s, RGF1 INSENSITIVEs (RGIs), a clade of five leucine-rich-repeat receptor-like kinases, in promoting

239 The NLRs or NBS-LRRs (nucleotide-binding, leucine-rich-repeat) form the largest resistance gene fa

240 eptor-related alpha, flightless-1 (FLII) and leucine-rich-repeat-(in FLII)-interacting-protein-1 as a

241 the contributions of two recently identified leucine-rich-repeat-containing (LRRC) regulatory gamma s

242 Pm5e encodes a nucleotide-binding domain leucine-rich-repeat-containing (NLR) protein.

243 content of the leucyl tRNA synthetase (LRS) leucine sensor.

244 at domain 1 (PTCD1) protein, a mitochondrial leucine-specific tRNA binding protein that inhibits leuc

245 duces intracellular depletion of methionine, leucine, spermidine, and spermine, but not putrescine.

246 We also show that the leucine-substituted variant no longer functions as a two

247 tively rare mutation leading to a proline to leucine substitution (P152L) in TP53 at the very end of

248 to determine the effectiveness of high-dose leucine supplementation on muscle morphology and strengt

249 The whey-based cheese contained 25% more leucine than Mozzarella, however its digestion by pigs r

250 We hypothesized that administration of leucine that has a high affinity for LAT1 should prevent

251 Using (3)H-leucine (the gold standard for LAT-1 transport studies)

252 following steady-state infusion of [U-(13)C]leucine to glioma-bearing rats verified the increased ox

253 at residues 125 (A125T) and 151 (A151T) and leucine to glutamine at residue 217 (L217Q) in the hemag

254 tial tRNA synthetase that accurately charges leucine to tRNA(Leu) for protein translation.

255 1 mutations in the patient V(L), only one, a leucine to valine mutation, is responsible for fibril fo

256 Importantly, the leucine-to-arginine substitution at amino acid residue 2

257 nd Galpha(12) was imbued largely by a single leucine-to-isoleucine variation at position G.H5.23.

258 s-Cl(-)/H(+) exchange transporter (ClC-ec1), leucine transporter (LeuT), dopamine transporter (DAT),

259 t lipids bound at the dimer interface in the leucine transporter show decreased k(off) rates in molec

260 JPH203 inhibited leucine uptake by > 90%.

261 Rhodobacteraceae were more active in (15) N-leucine uptake.

262 ignificant differences were found for (15) N-leucine uptake.

263 ranched-chain amino acid (BCAAs; isoleucine, leucine, valine) metabolism in obesity, insulin resistan

264 eselenization chemistry at phenylalanine and leucine was demonstrated through the rapid synthesis of

265 d from 3,5-substituted-N-salicylidene-l-tert-leucine were used as catalysts in asymmetric reduction o

266 ow impaired mTORC1 activation in response to leucine whereas mTORC1 activation by growth factors or e

267 port and was largely independent of LAT1 and leucine, which explains why leucine could block brain up

268 transporting essential amino acids including leucine, which regulates the mTOR signaling pathway.

269 By replacing leucine with glycine in the zebrafish MetRS-binding pock

270 nce although an association was observed for leucine with incident obesity-related cancer.

271 tabolites suggested a modest association for leucine with obesity-related cancers (1.04 [1.00-1.08]),

272 Here, a novel basic leucine zipper (bZIP) family transcription factor TubZIP

273 ELONGATED HYPOCOTYL 5 (HY5), a basic domain/leucine zipper (bZIP) transcription factor, acts as a ma

274 Flowering Locus T 1 (RFT1), OsFD-like basic leucine zipper (bZIP) transcription factors, and Gf14 pr

275 -resolved ICIRD spectroscopy on basic-region leucine zipper (bZIP)-LOV of aureochrome 1a from the dia

276 Members of the class III homeodomain-leucine zipper (HD-ZIPIII) gene family are critical play

277 such as a C(2) H(2) -zinc finger (ZF), and a leucine zipper (LZ), whose roles in FOXP2 remain largely

278 to +33 bp) of Frmpd1 binds to neural retina leucine zipper (NRL) and cone-rod homeobox protein (CRX)

279 scription factors: ERF/AP2 class I, homeobox-leucine zipper and R2R3 MYB.

280 ression alleles of wallenda (wnd, encoding a leucine zipper bearing kinase similar to human DLK and L

281 Dual leucine zipper kinase (DLK) has emerged as a key mediato

282 microtubule dynamics was independent of dual leucine zipper kinase (DLK)-mediated stress but was resc

283 The maternal embryonic leucine zipper kinase (MELK) has been implicated in the

284 /Thr protein kinase MELK (maternal embryonic leucine zipper kinase) has been considered an attractive

285 ATF4 is a member of the basic leucine zipper transcription factor (bZIP) superfamily.

286 The basic leucine zipper transcription factor ATF-like 3 (BATF3) i

287 5) is an essential and conserved plant basic leucine zipper transcription factor whose level controls

288 Here we show that basic LEUCINE ZIPPER TRANSCRIPTION FACTOR67 (bZIP67) acts down

289 ATF6 and BBF2H7 are transmembrane basic leucine zipper transcription factors and are subjected t

290 ol the activity of the class-III homeodomain-leucine zipper transcription factors(6-8)-and thereby re

291 a parallel homodimer linked by an N-terminal leucine zipper, and we show that the WT chain in WT-RQ h

292 tom caused by biallelic mutations within the leucine zipper-like transcription regulator 1 (LZTR1).

293 tients with NS harboring mutations of LZTR1 (leucine zipper-like transcription regulator 1), an adapt

294 binds to the LTCC C-terminus via a modified leucine-zipper (LZ) interaction.

295 ation in human fibroblasts, we uncovered the leucine-zipper protein LUZP1 as an interactor of truncat

296 screen hits is MLX, a basic helix-loop-helix leucine-zipper transcription factor that regulates metab

297 ification-dependent CpA recognition by basic leucine-zipper transcription factors.

298 -specific transcription factors: bZIP (basic leucine-zipper) proteins, exemplified by the AP-1 and CE

299 mays) involving the production of the BASIC LEUCINE ZIPPER60 (bZIP60) transcription factor, a pivota

300 SIVE ELEMENT BINDING PROTEIN3 (AREB3), BASIC LEUCINE ZIPPER67 (bZIP67), and ABA INSENSITIVE3 (ABI3) w