ライフサイエンスコーパス: leucine residue

1 mino acid at position 65 (either a serine or leucine residue).

2 s -2 to +6 relative to the primary conserved leucine residue.

3 enzymes at a completely conserved C-terminal leucine residue.

4 RNA(Ser) amber suppressor from a serine to a leucine residue.

5 superantigens should focus on this critical leucine residue.

6 though this sequence preserved only a single leucine residue.

7 ivates P-factor by removal of the C-terminal leucine residue.

8 a methionine residue in place of the native leucine residue.

9 in SOAR1, which in SOAR2 is substituted by a leucine residue.

10 strated proteolytic processing at a specific leucine residue.

11 ine residue at position 19 was replaced by a leucine residue.

12 t the tryptophan pocket is now occupied by a leucine residue.

13 he heptad leucine repeat region, rather than leucine residues.

14 and atypical processing sites C-terminal to leucine residues.

15 the LamB hydrophobic core were converted to leucine residues.

16 x was replaced with isologous asparagine and leucine residues.

17 rs retained the hydrophobic character of the leucine residues.

18 on of the entire sequence through the lysine-leucine residues.

19 butions from conserved aromatic, acidic, and leucine residues.

20 lly contain an essential tyrosine or pair of leucine residues.

21 Mutation of leucine residues 1010 and 1011 motif in the EGF receptor

22 d X-ray structures indicate that a conserved leucine, residue 103 in the Themiste zostericola Mhr seq

23 Mutation of leucine residue 238 of this NES motif abolished the inte

24 Leucine residues 357, 358, and 361 of nCLU were necessar

25 monomeric mutant of phospholamban, in which leucine residue 37 was changed to alanine.

26 All four leucine residues (a position) and three valine residues

27 imerization and that mutation of a conserved leucine residue abolishes self-association.

28 in the meprin alphaT domain GXXXG motif with leucine residues, alanine insertions in the meprin alpha

29 In addition, specific leucine residues along the length of these proteins are

30 ed to substitute a glutamine for a conserved leucine residue and may hinder processing of SP-C precur

31 onversion of a conserved proline (1173) to a leucine residue and the other a deletion of an isoleucin

32 ent NF-kappaB activation are mediated by two leucine residues and a tryptophan-containing motif in th

33 he deduced PICBP protein sequence is rich in leucine residues and contains three classes of repeats.

34 In addition, the two leucine residues and four of the five negatively charged

35 e initially replaced the core region with 12 leucine residues and then constructed recovery-of-functi

36 mally altered tRNA(Ser) exclusively inserted leucine residues and was an excellent in vitro substrate

37 n not as the canonical methionine but as the leucine residue, and its activity was independent of ups

38 One face displays hydrophobic leucine residues, and the opposite face displays hydroph

39 of off-rotamer conformations are largest for leucine residues (approximately 6 % versus 16.6 %).

40 sults suggest that helix 4 and the conserved leucine residue are part of a pRBR-binding interface in

41 not observed in other mutants and all other leucine residues are ordered in this structure, it is li

42 naturally occurring HBV variant containing a leucine residue at amino acid 97 of the core protein was

43 Although HSV-1 and HSV-2 UL52s contain a leucine residue at position 986, most other herpesvirus

44 e residues (605, 617, and 620), and that the leucine residue at the +2 position from the pTyr interac

45 Importantly, the leucine residue at this position is highly conserved amo

46 rowth factor receptor (EGFR) contains two di-leucine residues at 658 (TLRRLLQER) and 679 (NQALLRIL).

47 acing valine residues at each a position and leucine residues at each d position of the heptad repeat

48 Whereas the introduction of CalphaMe-leucine residues at positions 27 and either 18 (11), 37

49 Mamu-A*01 because they contained proline and leucine residues at positions 3 and 9, respectively.

50 were mutated singly to alanines, and the two leucine residues at positions 539 and 548 were mutated d

51 ivity, or ligand-induced degradation, the di-leucine residues at positions 658 or 679 were mutated to

52 the sequence isomer in which the lysine and leucine residues at positions R6 and R7 are swapped has

53 agonists, we introduced two or more CalphaMe-leucine residues at positions shown in earlier studies t

54 three "classical" heptad repeat motifs with leucine residues at the "d position," and a distinctive

55 quence repeat, abcdefg , with isoleucine and leucine residues at the a and d sites to ensure dimeriza

56 modified these trimer designs by introducing leucine residues at V3 positions 306 and 308 to create h

57 MARTX toxin at other sites, specifically at leucine residues between the effector domains.

58 The major recognition events are the two leucine residues binding in hydrophobic pockets on sigma

59 Substitution of leucine residues by 5,5,5-trifluoroleucine at the d-posi

60 the distal histidine has been replaced by a leucine residue, CcP(H52L), has been investigated as a f

61 entire syndecan-1 transmembrane domain with leucine residues completely blocks the cell spreading.

62 Glycine substitution for selective leucine residues confirmed that MYOC-MYOC interactions o

63 associating protein with a high frequency of leucine residues (Daple) interacts with PCP and cell-int

64 associating protein with a high frequency of leucine residues (DAPLE), this review will cover (i) the

65 s leptomycin B-sensitive and mutation of the leucine residues decreased or eliminated nuclear export

66 that involved either of the two end heptadic leucine residues did not significantly affect fusion.

67 pairs of closely spaced phenylalanines and a leucine residue distributed throughout the N-terminal 10

68 Nonetheless, mutations of a quartet of leucine residues (either single or multiple mutants) in

69 digitating hexa- and penta-heptad repeats of leucine residues flanked by a very basic region.

70 yl thiol pro-nucleophile, while the two tert-leucine residues flanking a central thiourea hydrogen-bo

71 cterized by an amino-terminal domain rich in leucine residues followed by a carboxy-terminal acidic t

72 putative bZIP-like domains and corresponding leucine residues for interaction and modulation of the t

73 ine-rich region, we targeted all neighboring leucine residues for mutagenesis.

74 3)H]TDBzcholine incorporated into homologous leucine residues, gammaLeu-109 and deltaLeu-111.

75 ble positions of methyl groups in valine and leucine residues have been linked to molecular motions a

76 ion of a proline residue in position 80 to a leucine residue in a small endomembrane protein encoded

77 hyl group dynamics of a key hydrophobic core leucine residue in chicken villin headpiece subdomain pr

78 Mutation of the leucine residue in helix 4 of CaLCuV AL1 reduced binding

79 S2 revealed the importance of its C-terminal leucine residue in infectious particle production.

80 Mutation of a single leucine residue in Sas6's Gorab-binding domain generates

81 Substitution of the conserved leucine residue in the BH3 domain of BimEL for alanine (

82 nhanced radiative pathway due to an adjacent leucine residue in the emissive population.

83 This is the first example of a leucine residue in the hinge loop that blocks the ATP bi

84 phobic interactions of LRT and depended on a leucine residue in the L1 loop between the first two hel

85 are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in

86 A conserved leucine residue in the midpoint of the second transmembr

87 fied P35delL mutation leads to the loss of a leucine residue in the protein.

88 s in the substitution of a tryptophan with a leucine residue in the ubiquitination domain.

89 ubstitutions in place of the tyrosine or the leucine residue in the YxxL motif demonstrated small, as

90 study, we substituted a proposed stabilizing leucine residue in the zipper domain with a helix-disrup

91 al shielding tensors of alanine, valine, and leucine residues in a series of crystalline peptides of

92 ther, our observations suggest that the four leucine residues in Ca(V)beta3 form a hydrophobic pocket

93 Furthermore, double mutants in these leucine residues in each of A3F's two CD domains (A3F L3

94 e replacements at any of three isoleucine or leucine residues in either alpha1, beta2 or beta3 comple

95 By contrast, alanine replacements for leucine residues in either beta4 or beta6 destabilize bu

96 Alterations to one of these specific leucine residues in either of the two A3F CD domains (A3

97 Mutational analysis of key leucine residues in helix alpha1 demonstrated a role for

98 ding frame encodes a 7-kDa protein with five leucine residues in heptad repeats followed by a basic r

99 Additionally, we introduced CalphaMe-leucine residues in lieu of leucine at positions 14, 15,

100 imple method to observe the methyl groups of leucine residues in proteins expressed in bacterial, euk

101 m solution NMR data for alanine, valine, and leucine residues in proteins show major differences, wit

102 In addition, two leucine residues in the C-terminal leucine-rich repeat r

103 ovel allele of ZIP1, zip1-4LA, in which four leucine residues in the central coiled-coil domain have

104 Mutation of the leucine residues in the common motif of MBP-1 also abrog

105 h CAP's N-terminal domain involving critical leucine residues in the conserved RLE motifs and adenyly

106 ch mutations by randomizing three contiguous leucine residues in the DNA-binding domain, and then by

107 er ovary cells frequently alter a cluster of leucine residues in the H6-H7 loop region of beta-tubuli

108 ggested to form intermolecular contacts with leucine residues in the hydrophobic groove (L155, L158,

109 Leucine residues in the leucine-rich region of RFX5(N) (

110 in the repressor domains indicated that the leucine residues in the LXVXL motif are required for tra

111 Moreover, we confirm that some leucine residues in the M domain participate in the in-r

112 exception of the substitution of serine and leucine residues in the W3A1 ETF protein for the human r

113 The leucine residues in this motif are required for the down

114 The leucine residues in this motif were required for the int

115 4beta2 nicotinic acetylcholine receptor by a leucine residue insertion in the M2 transmembrane domain

116 the effector domains reveal aromatic and/or leucine residues interspersed with acidic, proline, seri

117 g preference of the protease for proline and leucine residues into a cathepsin L-like preference for

118 Moreover, insertion of leucine residues into the TMD helix induced a ligand-ind

119 the hydrophobic core comprises six layers of leucine residues introduced at the "a" and "d" positions

120 The hydrophobic nature of the leucine residue is a primary determinant of its function

121 A conserved leucine residue is found at the P1 position of all four

122 of V3L, electron density corresponding to a leucine residue is present in a position that stabilizes

123 In the second series, a leucine residue is replaced with five-, six-, and seven-

124 Deuterating the individual leucine residues (isopropyl-d(7)) permits the use of sol

125 Furthermore, mutation of leucine residues (L-->A) within a nuclear exclusion sign

126 rectifier by substitution of a proline for a leucine residue (L147P).

127 ophobic sequence stretches (with the central leucine residues L20 and L66) in the first and second TM

128 system-mediated degradation, among which two leucine residues (L268 and L269) were critical for the p

129 tations reveals that double mutations of the leucine residues (L317D+L335D) may disrupt the interacti

130 sidues 38 to 55 and contains three conserved leucine residues, L38, L45, and L52, conforming to the h

131 r single-site substitutions at the conserved leucine residues (L45 and L52), caused a significant dec

132 te proteolysis and that mutation of a single leucine residue (L6) to aspartic acid inhibits proteolys

133 utational analyses revealed that a conserved leucine residue (Leu-64) on the third helix that would n

134 ning mutagenesis of this region identified a leucine residue (Leu-678), which is required for hAhR ac

135 A leucine residue, Leu-98, lines the O(2)-binding pocket i

136 analyses, we examined the importance of two leucine residues, Leu-112 and Leu-156, in the ECD of the

137 A leucine residue, Leu278, further stabilizes nonphospho b

138 n the peptide helix, onto which are appended leucine residue-like substituents.

139 For example, a leucine residue located as far as 1 nm into the hydropho

140 Point mutation at three conserved leucine residues located on the predicted dimer interfac

141 r all conditions examined, indicating that a leucine residue may effectively replace tyrosine for int

142 of the monohalogenated phenols, including a leucine residue near the back edge of the heme (L100).

143 ts with beta-branched residues and conserved leucine residues occupying the a and d positions of the

144 this pocket more deeply than the equivalent leucine residue of pKID.

145 that although the cytoplasmic domain and the leucine residue of the "LSXWS" box are not critical for

146 ckground levels by global replacement of the leucine residues of GFPm by 5,5,5-trifluoroleucine.

147 e studies presented here we demonstrate that leucine residues of helix I (alphaI) regulate tyrosine a

148 which Leu 9, Leu 13, and all four intrinsic leucine residues of melittin were replaced by 5,5,5-trif

149 ckets in the MIT domain bind three conserved leucine residues of the CHMP motif, and mutations that i

150 Individual mutation of the two leucine residues of the endocytic dileucine motif in the

151 role of this motif for channel function, the leucine residues of the zipper were individually mutated

152 oducing point mutations in either one or two leucine residues of this NES sequence abolished the nucl

153 by the ligand binding domains, and the three leucine residues on helix 10 of TR2 are critical for thi

154 lass II reporter gene, confirming that these leucine residues play an essential role in RFX activity

155 ixth membrane-spanning domains have multiple leucine residues potentially similar to leucine-heptad m

156 -directed mutation of Leu-219, the conserved leucine residue present in all BH3 domains, markedly sup

157 Pases replacement of phenylalanine 28 with a leucine residue produces a "fast cycling" mutant that ca

158 aaX motif is altered to contain a C-terminal leucine residue (Ras-CVLL).

159 d that substitution of isoleucine-100 with a leucine residue resulted in trimethoprim resistance.

160 stitutions in the single and double heptadic leucine residue(s) of melittin, respectively, whereas th

161 retch of basic residues followed by a run of leucine residues spaced seven amino acids apart.

162 56A, where in the P. denitrificans oxidase a leucine residue substituted for the corresponding residu

163 gineered mutations to generate proteins with leucine residues substituted individually for each of th

164 r, S(2), was 0.83-0.96 for all (15)N-labeled leucine residues, suggesting a restricted internal motio

165 ), was unaffected by mutation of the REG/MTS leucine residues, suggesting that activity loss was not

166 binding and bending, and have mutagenized a leucine residue that contacts an adenine nucleotide at t

167 ed protein sequences to identify a conserved leucine residue that is present in nearly all known PCI

168 ly, we investigated the methyl groups of two leucine residues that belong to the hydrophobic core (L1

169 Two conserved leucine residues that contact each face of the adenine r

170 in (DBD) and a mutant lacking two C-terminal leucine residues that form part of the hydrophobic core

171 as altered by site-directed mutagenesis to a leucine residue, the mutant enzyme showed increased subs

172 Mutations at the two conserved leucine residues to alanine at the NES motif (L98A,L100A

173 he tertiary structure from three nonadjacent leucine residues to form a motif reminiscent of establis

174 At higher temperatures, all three labeled leucine residues undergo rapid reorientation about the C

175 This novel NES does not contain multiple leucine residues unlike other CRM1-interacting NES, is c

176 s mapped PCSK7 processing of Syncytin-2 to a leucine residue upstream of the polybasic cleavage site.

177 l deuteration of the isopropyl group in each leucine residue was used to probe the orientation and dy

178 zed order parameters for 11 methyl groups of leucine residues were also determined.

179 These leucine residues were also required for optimal viral in

180 ositive rate of only 6%, when isoleucine and leucine residues were not distinguished.

181 ed the hydrogen bonds, disulfide bond, and a leucine residue which may restrict solvent access, by mu

182 A is corroborated by mutagenesis of selected leucine residues, which leads to the abrogation of oligo

183 se factor 1, the UAGA quadruplet specifies a leucine residue with an efficiency of 13 to 26 %.

184 leads to replacement of a strictly conserved leucine residue with arginine (aL156R).

185 based molecular bridge joins the methyl of a leucine residue with the methyl of its closest lactic ac

186 this region, replacement of any of the three leucine residues with alanine destroyed the function of

187 Replacing six hydrophobic core leucine residues with alanines results in a destabilizat

188 se residues are replaced with isoleucine and leucine residues with branched side chains that are intr

189 s for Fmoc-selenomethionine and substituting leucine residues with selenomethionine.

190 family have been synthesized, replacing core leucine residues with smaller and less hydrophobic resid

191 This missense variant changes a leucine residue within a conserved region of EXOSC4 to p

192 e mutation, L125V, which affects a conserved leucine residue within the bHLH region.

193 eus localized, and a mutation in a conserved leucine residue within the first helix of the protein in

194 Mutagenesis of two leucine residues within a conventional di-leucine motif

195 genesis studies uncovered that two conserved leucine residues within the CAD play a pivotal role.

196 Mutation of the conserved tyrosine or leucine residues within the FcepsilonRI beta or gamma IT

197 The conserved leucine residues within the L(D/E)XLLXXL motif were esse

198 genesis was used to selectively mutate eight leucine residues within the leucine zipper motif.

199 Point mutations of specific leucine residues within the NES disrupt the normal subce

200 parin or the receptor, but rather the lysine-leucine residues within the sequence indirectly stabiliz

201 cally, the introduction of helix-stabilizing leucine residues within the TMD region spanning the vesi

202 ther elucidate the role of this region, four leucine residues within this region of Tat were mutated.