ライフサイエンスコーパス: leucyl-tRNA

1 eriments between the five captured wild-type leucyl-tRNAs and their synthetic counterparts, revealing

2 85% of RNAP III transcription activity using leucyl-tRNA as a template.

3 rom Methanobacterium thermoautotrophicum and leucyl tRNA derived from Halobacterium sp. NRC-1 as an o

4 sma KIC enrichment most accurately predicted leucyl-tRNA enrichment, whereas plasma Leu enrichment wa

5 f E. coli TruA in complex with two different leucyl tRNAs in conjunction with functional assays and c

6 convenient and reliable surrogate measure of leucyl-tRNA in liver.

7 lytic turnover, thus inhibiting synthesis of leucyl-tRNA(Leu) and consequentially blocking protein sy

8 s caused by decreased protein content of the leucyl tRNA synthetase (LRS) leucine sensor.

9 use HSPE71, Rat RhoGAP protein, S cerevisiae leucyl tRNA synthetase and S cerevisiae chromosome II OR

10 carboxy-terminal domain (Cterm) of human mt-leucyl tRNA synthetase rescues the pathologic phenotype

11 roach exploits an engineered E. coli-derived leucyl tRNA synthetase-tRNA pair that incorporates a pho

12 gnment we have analyzed the Candida albicans leucyl-tRNA synthetase (CaLeuRS) gene (CaCDC60).

13 Human mitochondrial leucyl-tRNA synthetase (hs mt LeuRS) achieves high amino

14 re we report the surprising observation that leucyl-tRNA synthetase (LARS) becomes repressed during m

15 kocyte-specific exon skipping event in human leucyl-tRNA synthetase (LARS).

16 er the overexpression of human mitochondrial leucyl-tRNA synthetase (LARS2) in the cytoplasmic hybrid

17 Escherichia coli leucyl-tRNA synthetase (LeuRS) aminoacylates up to six d

18 Yeast mitochondrial leucyl-tRNA synthetase (LeuRS) binds to the bI4 intron a

19 c and editing activities of Escherichia coli leucyl-tRNA synthetase (LeuRS) demonstrate that the enzy

20 rmatics analyses, we identified two distinct leucyl-tRNA synthetase (LeuRS) genes within all genomes

21 Leucyl-tRNA synthetase (LeuRS) has been identified as a

22 Leucyl-tRNA synthetase (LeuRS) has evolved an editing fu

23 Mitochondrial leucyl-tRNA synthetase (LeuRS) in the yeast Saccharomyce

24 Leucyl-tRNA synthetase (LeuRS) is a class I enzyme, whic

25 Leucyl-tRNA synthetase (LeuRS) is an essential RNA splic

26 In one case, Mycoplasma mobile leucyl-tRNA synthetase (LeuRS) is uniquely missing its e

27 Leucyl-tRNA synthetase (LeuRS) misactivates non-leucine

28 Leucyl-tRNA synthetase (LeuRS) performs dual essential r

29 Leucyl-tRNA synthetase (LeuRS) relies on its editing fun

30 Instead, leucyl-tRNA synthetase (LeuRS) was overexpressed in mdx

31 this biocontrol agent targets A. tumefaciens leucyl-tRNA synthetase (LeuRS), an essential enzyme for

32 In leucyl-tRNA synthetase (LeuRS), editing activities that

33 targeting an unprecedented Wolbachia enzyme, leucyl-tRNA synthetase (LeuRS), effectively inhibiting i

34 n-based compounds (benzoxaboroles) targeting leucyl-tRNA synthetase (LeuRS), including an antibiotic

35 Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetas

36 Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetas

37 a unique tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase (LeuRS), while the TM84-producer

38 thanogenesis, protein-modifying factors, and leucyl-tRNA synthetase (LeuRS).

39 synthetase (GluRS):tRNA(Glu) and an archaeal leucyl-tRNA synthetase (LeuRS):tRNA(Leu) complex.

40 lpha was found to form a stable complex with leucyl-tRNA synthetase (LeuRS; K(D) = 0.7 microM).

41 ulting from cancer-associated MTOR mutations.Leucyl-tRNA synthetase (LRS) is a leucine sensor of the

42 Leucyl-tRNA synthetase (LRS) is known to function as leu

43 The yeast mitochondrial leucyl-tRNA synthetase (ymLeuRS) performs dual essential

44 Binding of gold-labeled tRNA(Leu) places leucyl-tRNA synthetase and the bifunctional glutamyl-/pr

45 ein, different mutations in Escherichia coli leucyl-tRNA synthetase are combined to unmask the pretra

46 of onychomycosis, inhibits yeast cytoplasmic leucyl-tRNA synthetase by formation of a stable tRNA(Leu

47 he collective motion in Thermus thermophilus leucyl-tRNA synthetase by studying the low frequency nor

48 We present structures of leucyl-tRNA synthetase complexed with analogs of the dis

49 These mutations that altered or abolished leucyl-tRNA synthetase editing were introduced into comp

50 overcome this limitation, we have adapted a leucyl-tRNA synthetase from Methanobacterium thermoautot

51 n identified a mutation in the mitochondrial leucyl-tRNA synthetase gene (lrs-2) that impaired mitoch

52 ell, Bonfils et al. and Han et al. implicate leucyl-tRNA synthetase in this evolving story.

53 A point mutation in CP1 of class I leucyl-tRNA synthetase inactivates deacylase activity an

54 Epetraborole (EBO), a leucyl-tRNA synthetase inhibitor, represents a novel the

55 rving cells of leucine or treating them with leucyl-tRNA synthetase inhibitors did not elicit nuclear

56 ted that the transfer of human mitochondrial leucyl-tRNA synthetase into the cybrid cells carrying th

57 The inhibition of leucyl-tRNA synthetase represents a unique molecular tar

58 cid editing active site for Escherichia coli leucyl-tRNA synthetase resides within the CP1 domain tha

59 tational analysis within yeast mitochondrial leucyl-tRNA synthetase showed that the enzyme has mainta

60 ed conformational changes of T. thermophilus leucyl-tRNA synthetase upon substrate binding and analyz

61 red the refolding of the human mitochondrial leucyl-tRNA synthetase variant H324Q to that of wild typ

62 hreonine-rich region of the Escherichia coli leucyl-tRNA synthetase's CP1 domain that is hypothesized

63 4-Azaleucine, a competitive inhibitor of leucyl-tRNA synthetase, surprisingly triggered the heat

64 be aminoacylated by the human mitochondrial leucyl-tRNA synthetase, we examined the aminoacylation k

65 e mechanochemical motions in T. thermophilus leucyl-tRNA synthetase.

66 nate amino acids that can be misactivated by leucyl-tRNA synthetase.

67 he ser-tRNACAG and preventing binding of the leucyl-tRNA synthetase.

68 le inhibiting the Mycobacterium tuberculosis leucyl-tRNA synthetase.

69 Leu is a very poor substrate for full-length Leucyl-tRNA synthetase.

70 d mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase: homozygous c.1565C>A (p.Thr522As

71 y a constitutive protein complex composed of leucyl-tRNA-synthetase and folliculin, which regulates m

72 erminal domain extension is required by most leucyl-tRNA synthetases (LeuRS) for aminoacylation.

73 cluding a complex between prolyl-(ProRS) and leucyl-tRNA synthetases (LeuRS) in Methanothermobacter t

74 Aminoacylation and editing by leucyl-tRNA synthetases (LeuRS) require migration of the

75 Leucyl-tRNA synthetases (LeuRSs) have an essential role

76 Mycoplasma leucyl-tRNA synthetases (LeuRSs) have been identified in

77 ing pocket within the editing active site of leucyl-tRNA synthetases (LeuRSs).

78 Leucyl-tRNA synthetases have a hydrolytic active site th

79 is activated by methionyl-, isoleucyl-, and leucyl-tRNA synthetases in vivo.

80 editing of mischarged tRNA similar to other leucyl-tRNA synthetases.

81 out mischarging by glycyl-, glutaminyl-, and leucyl-tRNA synthetases.

82 pared the ability of wild-type and synthetic leucyl-tRNA to break the degeneracy of the leucine codon