ライフサイエンスコーパス: leukosis

1 e and the causative agent of enzootic bovine leukosis.

2 us work characterizing ALV-J-induced myeloid leukosis.

3 is virus, and the chickens developed myeloid leukosis and hemangiomas within 2 months after hatching.

4 The transmembrane subunit (TM) of the avian leukosis and sarcoma virus (ALSV) envelope glycoprotein

5 tely defective in mediating subgroup A avian leukosis and sarcoma virus (ALSV-A) entry.

6 s the cellular receptor for subgroup A avian leukosis and sarcoma virus (ALSV-A).

7 The avian leukosis and sarcoma virus long terminal repeat (LTR) en

8 nown function with possible roles in myeloid leukosis associated with ALV-J.

9 ; pathologically, it appeared to mimic avian leukosis but is free of exogenous ALV infection; inocula

10 Enzootic bovine leukosis (EBL) is an economically important disease of c

11 eron and IL-10 and the progression of bovine leukosis in animals that develop more advanced disease s

12 ages may influence the progression of bovine leukosis in animals that develop persistent lymphocytosi

13 bgroups, ALV-J predominantly induces myeloid leukosis in meat-type chickens.

14 Pathogenicity and myeloid leukosis induction map to the env gene of ALV-J.

15 to reported viral genes.IMPORTANCE Lymphoid leukosis (LL)-like lymphoma is a low-incidence yet costl

16 lymphoma, also known as spontaneous lymphoid leukosis (LL)-like tumors, were identified in two commer

17 in chicken B-cell lymphomas induced by avian leukosis proviral integrations.

18 ne cis-acting determinants involved in avian leukosis sarcoma virus packaging RNA binding to Gag prot

19 ice that express TVA, the receptor for avian leukosis sarcoma virus subgroup A (ALSV-A), under the co

20 We are using avian leukosis-sarcoma virus (ALSV) vectors to generate mouse

21 The avian leukosis-sarcoma virus (ALV) group of retroviruses provi

22 t the amino acid level) to that of the avian leukosis-sarcoma virus family, it retains several sequen

23 portant for the efficient packaging of avian leukosis-sarcoma virus RNA.

24 In avian leukosis-sarcoma virus, however, we have shown that the

25 ed with infection by subgroups B and D avian leukosis-sarcoma viruses (ALVs).

26 substrates that are derivatives of the avian leukosis/sarcoma virus nucleocapsid-protease cleavage si

27 D cells were engineered to express the avian leukosis subtype A receptor, tv-a, to permit infection b

28 We have analyzed pol- mutants of avian leukosis virus (ALV) and murine leukemia virus (MuLV) fo

29 ind CCAAT/enhancer elements within the avian leukosis virus (ALV) and Rous sarcoma virus (RSV) LTR en

30 The avian leukosis virus (ALV) entry mechanism is controversial, w

31 d chicken embryos with the recombinant avian leukosis virus (ALV) EU-8 induces a high incidence of ra

32 Avian leukosis virus (ALV) has been used as a model system to

33 Avian leukosis virus (ALV) has endogenized prior to chicken do

34 ovide new evidence for the presence of avian leukosis virus (ALV) in both CEF supernatants and vaccin

35 Avian leukosis virus (ALV) induces bursal lymphoma in chickens

36 Avian leukosis virus (ALV) induces bursal lymphoma in tumor-su

37 Avian leukosis virus (ALV) induces tumors by integrating its p

38 cken strains are highly susceptible to avian leukosis virus (ALV) induction of bursal lymphoma, invol

39 Avian leukosis virus (ALV) infection induces bursal lymphomas

40 e factors that mediate alpharetroviral avian leukosis virus (ALV) integration are unknown.

41 Avian leukosis virus (ALV) is detrimental to poultry health an

42 The avian leukosis virus (ALV) long terminal repeat (LTR) contains

43 h different regions of the RSV and the avian leukosis virus (ALV) LTRs.

44 In this study, we identified avian leukosis virus (ALV) proviral integration sites in rapid

45 omosome-transgenic mice expressing the avian leukosis virus (ALV) receptor TVB, fused to monomeric re

46 ated that bridge proteins comprised of avian leukosis virus (ALV) receptors fused to epidermal growth

47 We also found that endogenous avian leukosis virus (ALV) retroviral insertions were not mobi

48 A new subgroup of avian leukosis virus (ALV) that includes a unique env gene, de

49 An avian leukosis virus (ALV) was found in some chicken embryos a

50 A new subgroup of avian leukosis virus (ALV), designated subgroup J, was identif

51 cteristics of a eukaryotic retrovirus, avian leukosis virus (ALV), offers a robust, eukaryotic versio

52 Avian leukosis virus (ALV), previously shown to be noninfectio

53 ficient retroviral vector based on the avian leukosis virus (ALV), we inserted into the chicken genom

54 An avian leukosis virus (ALV)-based retroviral vector system was

55 erence experiments have indicated that avian leukosis virus (ALV)-E may utilize a cellular receptor r

56 common retroviral integration site in avian leukosis virus (ALV)-induced B-cell lymphomas originally

57 In 2010, sporadic cases of avian leukosis virus (ALV)-like bursal lymphoma, also known as

58 n virus (EAV) family or to the avian sarcoma-leukosis virus (ALV)-related subgroup E endogenous virus

59 or the cytopathic subgroups B and D of avian leukosis virus (ALV-B and ALV-D), as a tumor necrosis fa

60 an retrovirus (EAV) and the endogenous avian leukosis virus (ALV-E), which originate from the chicken

61 Subgroup J avian leukosis virus (ALV-J) is a recently identified avian on

62 er-host transmission of the subgroup J avian leukosis virus (ALV-J) may be the most important issues

63 e glycoprotein (Env) of the subgroup J avian leukosis virus (ALV-J) play an essential role in the vir

64 a cellular receptor of the subgroup J avian leukosis virus (ALV-J).

65 equence of 5'-ACGACAACA-3' for avian sarcoma-leukosis virus (ASLV) and 5'-AACA(A/C)AGCA-3' for human

66 ent of sites of integration of avian sarcoma-leukosis virus (ASLV) and human immunodeficiency virus (

67 the viral entry process of avian sarcoma and leukosis virus (ASLV) and human immunodeficiency virus t

68 model for the avian retrovirus avian sarcoma/leukosis virus (ASLV) and the filovirus ebolavirus Zaire

69 protein (Env) of the oncovirus avian sarcoma/leukosis virus (ASLV) contains an internal fusion peptid

70 The retrovirus avian sarcoma and leukosis virus (ASLV) enters cells via pH-independent me

71 een single virions bearing avian sarcoma and leukosis virus (ASLV) envelope glycoprotein (Env) and th

72 The fusion peptide of the avian sarcoma/leukosis virus (ASLV) envelope protein (Env) is internal

73 The entry process of the avian sarcoma and leukosis virus (ASLV) family of retroviruses requires fi

74 a previous study, we found avian sarcoma and leukosis virus (ASLV) gag genes in 19 species of birds i

75 ian retroviruses, we found avian sarcoma and leukosis virus (ASLV) gag genes in 26 species of gallifo

76 The avian sarcoma/leukosis virus (ASLV) is activated for fusion by a two-s

77 een with some subgroups of avian sarcoma and leukosis virus (ASLV) is associated with viral Env activ

78 vian or mammalian cells by avian sarcoma and leukosis virus (ASLV) or EnvA-pseudotyped murine leukemi

79 or entry of the retrovirus avian sarcoma and leukosis virus (ASLV) predicts that upon binding cell su

80 defect associated with an avian sarcoma and leukosis virus (ASLV) receptor resistance allele, tvb(r)

81 the other hand, integration of avian sarcoma-leukosis virus (ASLV) shows little preference either for

82 Binding of avian sarcoma and leukosis virus (ASLV) to its cognate receptor on the cel

83 and LTR expression from an avian sarcoma and leukosis virus (ASLV) vector.

84 Some retroviruses, such as avian sarcoma/leukosis virus (ASLV), employ a two-step mechanism in wh

85 has been proposed for the avian sarcoma and leukosis virus (ASLV), whereby interaction with specific

86 id-dependent fusion of the avian sarcoma and leukosis virus (ASLV), with endosomes.

87 o extend the host range of the avian sarcoma/leukosis virus (ASLV)-based RCASBP vectors produced two

88 trate its activity against avian sarcoma and leukosis virus (ASLV).

89 otypical avian retrovirus, avian sarcoma and leukosis virus (ASLV).

90 iral infection mediated by the avian sarcoma-leukosis virus (ASLV-A) envelope glycoproteins can be ne

91 ar receptor for subgroup A avian sarcoma and leukosis virus (ASLV-A), in viral entry.

92 he receptor for subgroup A avian sarcoma and leukosis virus (ASLV-A), induces conformational changes

93 VA receptor for subgroup A avian sarcoma and leukosis virus (ASLV-A), the five cell lines were resist

94 coprotein of the subtype A avian sarcoma and leukosis virus (ASLV-A).

95 ar receptor for subgroup A avian sarcoma and leukosis virus (ASLV-A).

96 ar receptor for subgroup A avian sarcoma and leukosis virus (TVA) mice expressing S31A also form diff

97 he interactions between the subgroup A avian leukosis virus [ALV(A)] envelope glycoproteins and solub

98 ed the interactions between subgroup A avian leukosis virus [ALV(A)] envelope glycoproteins and Tva,

99 this hypothesis, the requirements for avian leukosis virus A (ALV-A) infection were examined.

100 e encoding the receptor for subgroup A avian leukosis virus and controlled by the astrocyte-specific

101 The budding of avian sarcoma leukosis virus and HIV-1 Gag virus-like particles contai

102 fecting both clones and subclones with avian leukosis virus and using a PCR-based assay to determine

103 viral replication by using avian sarcoma and leukosis virus as a model retrovirus.

104 action was found for HIV-1 and avian sarcoma/leukosis virus but not murine leukemia virus, suggesting

105 The avian leukosis virus DeltaLR-9 causes a high frequency of B-ce

106 The avian sarcoma and leukosis virus envelope glycoproteins, trimers composed

107 cell lymphomas induced by the nonacute avian leukosis virus EU-8.

108 ain of the TVB receptor for subgroup B avian leukosis virus fused to epidermal growth factor (EGF).

109 rovirus, subgroup A of the Avian Sarcoma and Leukosis Virus genus (ASLV-A), was studied by examining

110 ments (dr1) of avian sarcoma virus (ASV) and leukosis virus have the properties of constitutive trans

111 Avian leukosis virus induces lymphoma in chickens after provir

112 -1, murine leukemia virus, and avian sarcoma/leukosis virus integrations.

113 The fusion protein of avian sarcoma and leukosis virus is likely to fold into a six-helix bundle

114 etroviral [i.e., replication-competent avian leukosis virus long terminal repeat with splice acceptor

115 g the retroviral replication-competent avian leukosis virus long terminal repeat, splice acceptor (RC

116 g the A1 CCAAT/enhancer motif from the avian leukosis virus long terminal repeat.

117 us RCAS (replication-competent avian sarcoma-leukosis virus LTR splice acceptor)-mediated somatic gen

118 ed selection from a subgroup B avian sarcoma-leukosis virus of an extended-host-range variant (LT/SI)

119 in does not associate with the avian sarcoma leukosis virus or the HIV-1 budding complexes when ISG15

120 -a, to permit infection by recombinant avian leukosis virus produced by the replication-competent avi

121 We have adapted the avian leukosis virus RCAS (replication-competent avian sarcoma

122 e-lineage expression of the subgroup A avian leukosis virus receptor, TVA.

123 urthermore, later steps of avian sarcoma and leukosis virus reverse transcription were stimulated by

124 Replication-competent avian leukosis virus splice-acceptor (RCAS)/cellular receptor

125 (tva), which encodes the receptor for avian leukosis virus subgroup A (ALV/A), we provide direct evi

126 Avian sarcoma and leukosis virus subgroup A (ASLV-A) entry is mediated by

127 ptad repeat domains of the avian sarcoma and leukosis virus subgroup A (ASLV-A) TM subunit of the env

128 envelope protein (Env) of avian sarcoma and leukosis virus subgroup A folds into a bundle during low

129 and its specific receptor for avian sarcoma leukosis virus subgroup A or B) system allow cell type-s

130 Cell killing by avian leukosis virus subgroup B (ALV-B) in cultures has been e

131 Avian leukosis virus subgroup J (ALV-J) is a simple retrovirus

132 Avian leukosis virus subgroup J (ALV-J) is an important concer

133 egion, termed the E element or XSR, of avian leukosis virus subgroup J (ALV-J), a member of avian ret

134 Avian leukosis virus subgroup J (ALV-J), an avian oncogenic re

135 ferrin, a serine/threonine kinase, and avian leukosis virus subgroup J glycoprotein.

136 Among all subgroups, avian leukosis virus subgroup J is one of the most pathogenic,

137 ences in receptor usage among the many avian leukosis virus subgroups.

138 nvelope glycoprotein (EnvA) of avian sarcoma/leukosis virus subtype A (ASLV-A) binds to liposomes at

139 internal fusion peptide of the avian sarcoma/leukosis virus subtype A (ASLV-A) Env (EnvA) are importa

140 The receptor for avian sarcoma/leukosis virus subtype A (ASLV-A), Tva, is the simplest

141 murine leukemia virus (A-MLV), avian sarcoma/leukosis virus type A (ASLV-A), and influenza A virus.

142 lineages by infection with subgroup A avian leukosis virus vectors in lines of transgenic mice that

143 ransfer of genes carried by subgroup A avian leukosis virus vectors.

144 roviral vector derived from an avian sarcoma/leukosis virus which has been modified so that it uses t

145 Moloney murine leukemia virus, avian sarcoma leukosis virus, and foamy virus.

146 us, murine leukemia virus, and avian sarcoma-leukosis virus, and found that a statistical palindromic

147 human immunodeficiency virus, avian sarcoma leukosis virus, and influenza virus was independent of t

148 ations while other viruses such as the avian leukosis virus, MAYV and several unclassified viruses ha

149 erminal domain of the alpharetrovirus, avian leukosis virus, revealing a previously undetected evolut

150 two new replication-competent avian sarcoma/leukosis virus-based retroviral vectors with amphotropic

151 ing mice susceptible to infection with avian leukosis virus-derived gene vectors.

152 common retroviral integration site in avian leukosis virus-induced lymphomas and has been implicated

153 novel envelope gene of the subgroup J avian leukosis virus.

154 on site in B cell lymphomas induced by avian leukosis virus.

155 lar receptors for subgroup B, D, and E avian leukosis viruses (ALV) encoded by the s1 allele of the c

156 susceptibility to subgroup B, D, and E avian leukosis viruses (ALV) is determined by specific alleles

157 , the cellular receptor for subgroup A avian leukosis viruses (ALV-A) can mediate viral entry when ex

158 ain of the TVA receptor for subgroup A avian leukosis viruses (ALV-A), fused to the MR1 single-chain

159 Subgroups B, D, and E avian leukosis viruses (ALV-B, -D, and -E) share the same chic

160 ning RNA of both subgroup E endogenous avian leukosis viruses (ALV-E) and endogenous avian viruses (E

161 d genomic RNAs of wild-type and mutant avian leukosis viruses (ALVs) in an attempt to (i) better unde

162 D and noncytopathic subgroup E of the avian leukosis viruses (ALVs).

163 Avian sarcoma and leukosis viruses (ASLV) are unusual among retroviruses i

164 Receptor specificity in avian sarcoma and leukosis viruses (ASLV) maps to the central region of th

165 sceptibility to subgroup A avian sarcoma and leukosis viruses (ASLV-A) was recently identified by a g

166 r for subgroup B, D, and E avian sarcoma and leukosis viruses (ASLVs) is a tumor necrosis factor rece

167 eceptor for the subgroup A avian sarcoma and leukosis viruses [ASLV(A)] is the cellular glycoprotein

168 he receptor for subgroup C avian sarcoma and leukosis viruses [ASLV(C)], i.e., Tvc, a protein most cl

169 r region of the subgroup A avian sarcoma and leukosis viruses envelope glycoproteins, SUATM129 produc