ライフサイエンスコーパス: level of circulating

1 ferred to as fatigue, has been linked to low levels of circulating 25-hydroxyvitamin D (25OHD), a bio

2 ) mice exhibited reduced fat mass, decreased levels of circulating adipokines, improved insulin sensi

3 rmal white adipose tissue (dWAT) and reduced levels of circulating adiponectin.

4 and plasma cell development, as well as the levels of circulating Ag-specific Abs during a primary c

5 We found increased levels of circulating aged CD56(+) CD28(-) T cells in pa

6 Serum analysis demonstrated high levels of circulating alloantibodies with broad cross-re

7 ighest tertile of mammographic density, high levels of circulating alpha-carotene, beta-cryptoxanthin

8 nal bacteria modulate antiviral immunity and levels of circulating alphaviruses within hours of infec

9 pSTAT3(-/-) mice, with significantly reduced levels of circulating and airspace acute-phase proteins,

10 Cxcr3(-/-) mice revealed increased levels of circulating and brain CXCL10 after experimenta

11 sphorus due to abnormal bone metabolism; low levels of circulating and locally produced inhibitors; i

12 hormone (LH) and correspondingly attenuated levels of circulating androgens and estrogens.

13 These findings suggest that lower levels of circulating androgens and the potentiating eff

14 eceptor activation persists despite castrate levels of circulating androgens.

15 ogenesis may permit tumors to circumvent low levels of circulating androgens.

16 Increased levels of circulating angiopoietin-2 correlate with mark

17 Animal studies suggest that increased levels of circulating angiotensin II (AngII) could contr

18 using the ratio of urinary egg excretion to levels of circulating anodic antigen, a Schistosoma-spec

19 st levels of SLE disease activity and recent levels of circulating anti-double-stranded DNA.

20 Levels of circulating anti-flagellin IgG were induced in

21 umor-associated Neu5Gc can interact with low levels of circulating anti-Neu5Gc antibodies, thereby fa

22 gluten containing diet demonstrate that the levels of circulating anti-tTG IgA and anti-TGe IgA in D

23 The subsequent increase and decrease in levels of circulating anti-type VII collagen autoantibod

24 experimental tumor growth is enhanced by low levels of circulating antibodies directed against the no

25 Though basal levels of circulating antibodies were significantly elev

26 erculosis (TB) has been difficult due to low levels of circulating antigens or due to the lack of spe

27 on or synthesized in the kidney, but not the level of circulating APOL1, probably mediates APOL1-asso

28 d renal function in nondiabetic individuals, levels of circulating APOL1 did not associate with micro

29 with significant (P < 0.05) increases in the level of circulating apolipoprotein AI (Apo A-I) (4.0 ve

30 tes, both of which are characterized by high levels of circulating asprosin.

31 Elevated levels of circulating asymmetric and symmetric dimethyla

32 Elevated levels of circulating ATP and ADP are especially associa

33 s, orally administered PCI-32765 reduced the level of circulating autoantibodies and completely suppr

34 We evaluated T cell responses to insulin, levels of circulating autoantibodies against insulin, an

35 ory autoimmune disorder associated with high levels of circulating autoantibodies and immune complexe

36 utoimmunity is most commonly examined by the levels of circulating autoantibodies in clinical practic

37 DKO mice had high levels of circulating autoantibodies.

38 f action are in the neonate for these robust levels of circulating AVP at birth.

39 lymphoid tissues to maintain stable relative levels of circulating B cell subsets, and a potential me

40 s with chronic lymphocytic leukemia and high levels of circulating B cells can lead to removal of CD2

41 Because most patients with PAD have high levels of circulating BAFF, the increase in BAFF concent

42 Level of circulating bDNA before treatment could identif

43 althy, malaria-exposed children had elevated levels of circulating bicyclo-PGE2/TNF-alpha, compared w

44 d metabolomic profiling, we identified lower levels of circulating bile acid metabolites in multiple

45 Interestingly, we detected a high level of circulating BMP10 in WT and Bmp9-KO pups.

46 on tumor samples, and blood was analyzed for levels of circulating BRAF V600.

47 Metformin reduced levels of circulating branched-chain amino acids, which

48 e complex disease, whereas those with a high level of circulating C3 had well-preserved glomerular st

49 Therapeutic levels of circulating canine FIX activity (3.5%-8%) show

50 increased starvation sensitivity, and lower levels of circulating carbohydrate.

51 This study sought to investigate plasma levels of circulating cardiac natriuretic peptides, atri

52 Taken together, our results suggest that the level of circulating catalytic IgG under pathological co

53 ice display increased adiposity despite high levels of circulating catecholamines and leptin.

54 issue mass or activation because of elevated levels of circulating catecholamines.

55 and consequently Blimp1 CKO mice had higher levels of circulating CCL8, resulting in increased neutr

56 Our results suggest that higher levels of circulating CD11b(+) cells and neutrophils are

57 lammatory response characterized by elevated levels of circulating CD14(+), CD16(+), CD4(+), and CD8(

58 Levels of circulating CD34+ CD133+ bone marrow-derived p

59 On average, 6-fold elevated levels of circulating CD34+ cells and colony-forming uni

60 tically, can induce AGMs to sustain very low levels of circulating CD4(+) T cells without showing sig

61 c decay in viremia and a significant rise in levels of circulating CD4(+) T cells.

62 We can show that detectable levels of circulating cell-free tumor DNA correlate with

63 Increasing levels of circulating cell-free tumor DNA during melanom

64 meta-analysis shows that a reduction in the levels of circulating cells putatively provided with vas

65 ate in these mice was associated with higher levels of circulating chemokine (C-C motif) ligand 2 (CC

66 ung involvement, patients with ILD show high levels of circulating Chit1 activity that correlate with

67 Western diet rich in saturated fat is a high level of circulating cholesterol.

68 ssibility of an inverse relationship between levels of circulating cholesterol in neonates and IHPS r

69 cellular effects of elevated and suppressed levels of circulating cholesterol on the normal prostate

70 SNPs previously found to be associated with levels of circulating cholesterol.

71 We found that physiologic levels of circulating chromogranin A (CgA), a protein se

72 Lower levels of circulating club cell secretory protein (CC16)

73 V-seropositive subjects developed detectable levels of circulating CMV DNA (DNAemia), and 5 of 17 VZV

74 atients with active retinitis, had increased levels of circulating CMV-specific CD8(+) T cells with "

75 wild-type and Per3(-/-) mice showed elevated levels of circulating corticosterone and increased hippo

76 glucose intolerance and constitutively high levels of circulating corticosterone, suggesting reduced

77 dback inhibition and manifested as increased levels of circulating cortisol.

78 r results support the hypothesis that higher levels of circulating CRP are associated with increased

79 lomerular immune complex deposits and higher levels of circulating cryoglobulins, IgG2a, IgG2b, and I

80 This is based on high levels of circulating CSF-1 in patient sera with aggress

81 ith chronic and acute HF may have measurable levels of circulating cTn, whose detection and magnitude

82 Levels of circulating CXCL13 were higher in those vaccin

83 Increased levels of circulating CXCL4 are associated with immune-m

84 Together our data support that increased levels of circulating CXCL4 may contribute to immune dys

85 evels of soluble Abeta are elevated and that levels of circulating cytokine and chemokine signatures

86 oinflammatory RNA transcripts, and increased levels of circulating cytokines and chemokines.

87 nflammatory status, both peripherally (lower levels of circulating cytokines) and centrally (less act

88 e, Toxoplasma appears to specifically impact levels of circulating cytokines, and our results may par

89 y-life DENV vaccine in populations with high levels of circulating DENV antibodies and suggests the u

90 n of Wnt inhibitor family members and higher levels of circulating Dickkopf-1 (Dkk1), sclerostin, and

91 Higher levels of circulating DJ-1 were associated with increase

92 Although the levels of circulating DNA and nucleosomes (indicative of

93 Plasma levels of circulating donor strain-reactive IgG antibodi

94 erular basement membrane thickening, reduced levels of circulating dsDNA autoantibodies and total ser

95 The authors detected 3- to 4-fold higher levels of circulating EDA in cord blood than in adult se

96 kely to be the functional allele influencing levels of circulating endogenous sex hormones and outcom

97 s study was to investigate whether increased levels of circulating endothelial cells (CECs) might be

98 acute vasculitis (n=12) had markedly higher levels of circulating endothelial microvesicles, identif

99 Subclinical levels of circulating endotoxin are associated with the

100 oductive age and has been linked to elevated levels of circulating endotoxin in nonpregnant individua

101 We observed high sustained levels of circulating, engineered cells at 1 year after

102 n capillaries are exposed to prolonged, high levels of circulating enzyme.

103 -5; and p < 0.001, r = 0.4901 for IL-13) and levels of circulating eosinophils (p < 0.0116, r = 0.565

104 ve suggested an inverse relationship between levels of circulating EPCs/CACs and the presence of CAD

105 Increased levels of circulating Epo lead to reticulocytosis, polyc

106 (EpoR) are required for maintaining adequate levels of circulating erythrocytes during embryogenesis

107 bone marrow, despite significantly elevated levels of circulating erythropoietin.

108 are strongly implicated in sensing the high levels of circulating estradiol on proestrus to activate

109 phase of the estrous cycle with the highest levels of circulating estradiol, and produced a dose-dep

110 Moreover, increasing the levels of circulating estrogens sufficed to promote the

111 We measured levels of circulating EVTF activity, fibrinogen, activat

112 We measured levels of circulating EVTF activity, fibrinogen, activat

113 ients with more advanced disease show higher levels of circulating exosomal miR-193a.

114 dystrophy, exhibit a substantial decrease in levels of circulating exosomal miRNAs.

115 ultures, and in vivo injections enhanced the levels of circulating exosomes.

116 Although levels of circulating factor VIII in untreated VWF(-/-)

117 ucose levels, often in combination with high levels of circulating fatty acids.

118 hondrial glutathione in liver, and decreased levels of circulating fatty acyl-carnitines.

119 er pregnancy to test the hypothesis that the levels of circulating fetal DNA correlate with arthritis

120 Elevated levels of circulating FFAs are associated with obesity,

121 trains, each with distinct etiology for high levels of circulating FGF23, onto a Cyp24-null backgroun

122 Elevated levels of circulating fibrinogen are associated with an

123 b(AEK) mice were generated that carry normal levels of circulating fibrinogen but lack the capacity f

124 mic population that increases in response to levels of circulating Flt3L.

125 Low levels of circulating free eculizumab (<50 microg/mL) co

126 characterized by hepatic steatosis, elevated levels of circulating free fatty acids (FFA), endoplasmi

127 duction, but this increase also elevates the levels of circulating free fatty acids and thus causes I

128 pyruvate derived from glycine that increases levels of circulating free fatty acids through extra-NE

129 Increased levels of circulating free heme, a by-product of Plasmod

130 JDP2 null females had increased levels of circulating FSH and higher expression of the F

131 Therefore, modestly increasing the levels of circulating full-length adiponectin completely

132 eishmanial Th1-cell-type response: increased levels of circulating gamma interferon, accelerated gran

133 n of Ghr and MBOAT in the stomach, and lower levels of circulating Ghr compared to WT-controls.

134 Elevated levels of circulating glucocorticoid therefore promote a

135 hat hypothalamic malonyl-CoA responds to the level of circulating glucose and leptin, both of which a

136 Capsaicin treatment also increased the levels of circulating glucose and triglycerides and nega

137 Levels of circulating glucose are tightly regulated.

138 re subjected to blood analysis to detect the level of circulating glutathione in its reduced (GSH) an

139 Patients with glaucoma exhibit low levels of circulating glutathione, suggesting a general

140 tastasis in athymic mice accompanied by high levels of circulating GM-CSF and TGFbeta1.

141 inactivating IRIS in TNBC cells lowered the levels of circulating GM-CSF, suppressed TAM recruitment

142 ctase (MTHFR) gene lead to markedly elevated levels of circulating Hcy-thiolactone.

143 Anemia is defined by low levels of circulating hemoglobin, resulting in insuffici

144 lation of Erfe in Th3/+ mice restored normal levels of circulating hepcidin at 6 weeks of age, sugges

145 High levels of circulating high density lipoprotein (HDL) and

146 hemia/reperfusion (I/R) injury, we show that levels of circulating histones are significantly higher

147 we observed a direct correlation between the levels of circulating histones in patients and the abili

148 Low levels of circulating HMW adiponectin appear to increase

149 Lower levels of circulating hProinsulin-B10 were obtained from

150 the CD49d-blocking antibody natalizumab) on levels of circulating HSPCs after a single dose of antib

151 Finally, high levels of circulating HSV-2-specific CD8(+) T cells, but

152 oteinuria, glomerular C3 deposition, and the level of circulating ICs.

153 c disease (CD) patients usually present high levels of circulating IgA antibodies directed to differe

154 s study, we report that 129/Sv mice had high levels of circulating IgE, increased expression of the h

155 y detected disease, suggesting that reducing levels of circulating IGF-I might not prevent the initia

156 Increased level of circulating IGFBP-4 may be responsible of pro-a

157 logical and clinical nephritis with elevated levels of circulating IgG anti-dsDNA autoantibodies and

158 acquired PS-specific memory B cells, but not levels of circulating IgG at time of pneumococcal exposu

159 The marked increases in levels of circulating IgG(4) and IgE observed clinically

160 3(-/-) MRL/MpJ-Fas(lp) mice showed increased levels of circulating IgG-IgA immune complexes at 20 wee

161 in FcgammaRIII-KO was accompanied by higher levels of circulating IgM/IgG alloantibodies and SAP tha

162 ased IL-17-producing cells and increased the level of circulating IL-10.

163 Elevated levels of circulating IL-10 were also detected in sera f

164 neutrophilia that correlated with increased levels of circulating IL-17 and granulocyte colony-stimu

165 patients with active pemphigus had elevated levels of circulating IL-17(+)(,) T(H)17, T(FH)17, and T

166 Elevated levels of circulating IL-18 were also seen in patients w

167 Patients with cystinosis had higher levels of circulating IL-1beta and IL-18 compared with c

168 Patients had increased levels of circulating IL6 (3.86 [2.84-4.95] vs. 1.66 [1.

169 showed poorer survival in patients with high levels of circulating IL6.

170 , no significant differences in preoperative levels of circulating immune cells were detected between

171 A 10-fold increase in the mean level of circulating immunoglobulins against protein-bou

172 The levels of circulating immunoglobulins against 3-nitrotyr

173 were associated with a marked diminution of levels of circulating inflammatory cytokines that are co

174 oblast ablation was associated with elevated levels of circulating inflammatory cytokines, including

175 he 13 wks following ICU discharge had higher levels of circulating inflammatory markers (IL-6 and C-r

176 , we assessed the association between weekly levels of circulating influenza virus and counts of outc

177 compatible with an observed increase in the level of circulating insulin.

178 linical trials that have aimed to reduce the levels of circulating insulin and to abrogate insulin si

179 Higher levels of circulating insulin have been associated with

180 increased circulating insulin and depressed levels of circulating insulin-like growth factor binding

181 SS) immunopathology because of the increased levels of circulating interleukin (IL)-17 in pSS.

182 vior, reduction of body weight, and elevated levels of circulating interleukin 6.

183 ients with visceral leishmaniasis, increased levels of circulating interleukin-6 (IL-6) regularly acc

184 rdiovascular disease (CVD) and have elevated levels of circulating intermediate (CD14(++)CD16(+)) mon

185 tivation, involves a marked reduction in the levels of circulating iron, coupled with iron sequestrat

186 BLEO-injured il17a(-/-) mice had diminished levels of circulating Krebs Von Den Lungen 6 (alveolar e

187 It regulates the levels of circulating LDL cholesterol and is considered

188 sing data from the UK Biobank, we found that levels of circulating LDL-C were negatively associated w

189 and it is associated with elevated baseline levels of circulating leptin in normal, nonseptic patien

190 These high levels of circulating leptin receptor bind leptin and li

191 asting, there is a dramatic reduction of the levels of circulating leptin, an adipokine with proinfla

192 AgRP neurons are more responsive to low levels of circulating leptin, but they are also more pro

193 In addition, higher levels of circulating let-7b miRNA were associated with

194 AI (CSL111, 80 mg/kg) similarly reduced the level of circulating leukocytes by 12+/-5% (all P<5.0x10

195 ice lacking GalNAc-4-ST1 exhibited increased levels of circulating LH.

196 s with PDAC pathogenesis, and changes in the levels of circulating LIF correlate well with tumour res

197 studies have attempted to determine whether levels of circulating lipids are associated with risks o

198 Our data showed that high levels of circulating lipids for a prolonged period elev

199 Despite high levels of circulating lipids, the postprandial python he

200 olymorphisms (SNPs) associated with abnormal levels of circulating lipids.

201 obial translocation as indicated by elevated levels of circulating lipopolysaccharide (LPS), LPS-bind

202 trafficking and metabolism, and in modulated levels of circulating lipoprotein-cholesterol and trigly

203 vents, including death, in persons with high levels of circulating Loa loa microfilariae.

204 Elevated levels of circulating low-density lipoprotein cholestero

205 cells, and this occurs in the face of lower levels of circulating low-density lipoprotein cholestero

206 ytes with an IFNalpha phenotype and elevated levels of circulating LPS.

207 ensitive to endotoxin and exhibited elevated levels of circulating Ly6C(+) monocytes and macrophage-d

208 ase activity, elevated S1P levels, and lower levels of circulating lymphocytes.

209 ir in these infants is associated with lower levels of circulating markers of oxidative stress than r

210 eep deprivation and assessed inflammation by levels of circulating markers.

211 thies is a possible consequence of increased levels of circulating mature reticulocytes expressing in

212 Finally, in humans, lower levels of circulating MBL were accompanied by enhanced m

213 tralizing antibodies show 2.3-fold decreased levels of circulating MCP-1.

214 There was a trend toward lower levels of circulating mDC2s with increasing allergy and

215 meostatic mechanism maintains a steady-state level of circulating MDSC in tumor-bearing individuals.

216 tabolites, and the risk of formation of high levels of circulating metabolites in preclinical species

217 designing interventions for manipulating the levels of circulating metabolites.

218 immune tolerance to the parasite, with high levels of circulating microfilariae, few clinical sympto

219 Elevated levels of circulating microparticles are associated with

220 nts with unstable carotid plaque have higher levels of circulating microparticles compared to patient

221 valis, a keystone pathogen and to assess the levels of circulating miR-146a and associated proinflamm

222 ents and AngII-infused mice exhibit elevated levels of circulating miR103a-3p.

223 Increased CPB duration yielded in higher levels of circulating mitochondrial (mt)DNA, soluble thr

224 The levels of circulating mitochondrial DNA (mtDNA) in patie

225 ative period, there were significantly lower levels of circulating mitochondrial DNA in recipients re

226 within 24 hours after ICU admission, and the levels of circulating mitochondrial DNA were quantified

227 Here, we investigated if the levels of circulating molecular lipids are related to ad

228 antiangiogenic plasma profile, and elevated levels of circulating monocytes and T, but not B, lympho

229 The patients had reduced levels of circulating NAD.

230 at elderly macaques have significantly lower levels of circulating naive CD4(+) T cells, naive CD8(+)

231 Notably, because high levels of circulating NAMPT are found in obese and diabe

232 Hantavirus infection induced high systemic levels of circulating NETs in patients and this systemic

233 Here we report that levels of circulating neutrophil microvesicles are enhan

234 The level of circulating NO-related products probably determ

235 ocoa was associated with acute elevations in levels of circulating NO species, an enhanced FMD respon

236 Acute EVD was characterized by reduced levels of circulating nonclassical CD16(+) monocytes wit

237 lerance to central hypovolemia and increased levels of circulating norepinephrine levels.

238 tes led to an approximately 80% reduction in levels of circulating normal AAT, demonstrating potentia

239 e exposed to cold temperatures had increased levels of circulating NPs as well as higher expression o

240 We observed a 27% reduction in the levels of circulating NT-proANP (p < 0.001, maximal at 6

241 Low levels of circulating or brain DHA are associated with v

242 Higher levels of circulating osteopontin were also correlated w

243 e, we show that CD157 knockout mice have low levels of circulating OT in cerebrospinal fluid, which c

244 R) was suppressed by anti-G-CSFR, as was the level of circulating P-selectin and ICAM-1.

245 icient in the IL-1 receptor also had reduced levels of circulating P-selectin, similar to those obser

246 We found high levels of circulating PDGF-BB in platelet-poor plasma sa

247 y 24 hours postinoculation, a time when high levels of circulating pegylated IFN-alpha were still pre

248 ated in male HFD-Hhip +/- mice that had high levels of circulating plasma insulin, but not in female

249 s indicated by high Mx1 expression), and low levels of circulating plasmacytoid dendritic cells (as o

250 This study examined whether reduced levels of circulating PPi, an antimineralization factor,

251 Levels of circulating PRIME cells decreased during flare

252 conditions, and MDD patients exhibit higher levels of circulating pro-inflammatory cytokines.

253 sis, splenomegaly, BM failure, and decreased levels of circulating proatherogenic cells in mice fed a

254 Dialysis patients have higher levels of circulating procoagulant MVs than healthy cont

255 In patients with risk factors, high levels of circulating progenitor cells increase event-fr

256 lethality, growth retardation, and elevated level of circulating proinflammatory cytokines.

257 erosclerosis, despite having highly elevated levels of circulating proinflammatory cytokines.

258 f this study was to investigate whether high levels of circulating proprotein convertase subtilisin k

259 lipoprotein receptor expression, and higher levels of circulating proprotein convertase subtilisin/k

260 protein C due to genetic mutations or a low level of circulating protein C increase the risk of veno

261 Given elevated levels of circulating sAPP-alpha in some patients with a

262 Dyslipidemia is characterized by elevated levels of circulating saturated fatty acids (SFAs) that

263 ted with low-grade inflammation and elevated levels of circulating saturated fatty acids, which trigg

264 Under normal levels of circulating serotonin, the proliferative activ

265 e Stat5 during late pregnancy despite normal levels of circulating serum prolactin and pituitary prol

266 tes in the large intestine, along with lower levels of circulating short-chain fatty acids (SCFA).

267 High levels of circulating soluble CD40 ligand (sCD40L) are f

268 Clinically, the levels of circulating soluble ST2, commonly considered a

269 phenotype and that mutants display increased levels of circulating sugar, along with augmented expres

270 d before their seasonal enlargement) and the levels of circulating T during their rut, suggesting tha

271 ing the tissue-specific responses to similar levels of circulating T(3).

272 Higher levels of circulating testosterone were associated with

273 and no reproductive behavior, and have basal levels of circulating testosterone.

274 and no reproductive behavior, and have basal levels of circulating testosterone.

275 To investigate the effect of low levels of circulating TF, whole blood (+/-100 fM added T

276 Mice with TF-positive tumors and elevated levels of circulating TF-positive MPs had increased thro

277 ound that patients with cancer have elevated levels of circulating TF-positive MPs.

278 uppressed TAM recruitment, and decreased the levels of circulating TGFbeta1.

279 brin content, and there was no difference in levels of circulating thrombin-antithrombin complexes.

280 pulmonary fibrosis had significantly higher levels of circulating TN-C compared with SSc patients wi

281 High levels of circulating TNF and its receptors, TNFR1 and T

282 And the level of circulating Treg was as an independent factor a

283 animals are able to counteract the increased levels of circulating trehalose induced by a high sugar

284 Higher-than-normal levels of circulating triglycerides are a risk factor fo

285 ght, having higher blood pressure and higher levels of circulating triglycerides, and having lower le

286 n-like 4 (ANGPTL4), has been shown to reduce levels of circulating triglycerides.

287 l transition in the primary tumors, elevated levels of circulating tumor cells, and increased spontan

288 mph node involvement, yet did not affect the levels of circulating tumor cells, suggesting that reduc

289 and exhibited severe lung injury and higher levels of circulating tumor necrosis factor-alpha (TNFal

290 that SLE patients had significantly elevated levels of circulating U1 and/or Y1 RNA compared with hea

291 ant sedation with midazolam, and reduced the levels of circulating unbound venom.

292 We evaluated whether alterations in levels of circulating uric acid (UA), a systemic antioxi

293 is physiologically consistent with increased levels of circulating vasopressin and up-regulation of v

294 There were significantly higher levels of circulating vaspin (P < 0.05), vaspin mRNA (P

295 iator of this effect was an elevation in the levels of circulating VEGF.

296 CLYBL that has been associated with reduced levels of circulating vitamin B12.

297 Low levels of circulating vitamin D are associated with dive

298 Although high levels of circulating VP can increase blood pressure, th

299 but not control animals, revealed normalized levels of circulating VWF that persisted for at least 1

300 s predisposing to liver disease, whereas low levels of circulating Z alpha1-antitrypsin lead to emphy