ライフサイエンスコーパス: liability

1 but do appear to index schizophrenia genetic liability.

2 s explain only a tiny fraction of individual liability.

3 ome-wide evaluation of schizophrenia genetic liability.

4 on public health to one based on individual liability.

5 channel and pan-assay interference compounds liability.

6 efflux, and addressing a pregnane X-receptor liability.

7 l opioids, particularly ones with high abuse liability.

8 ere heritable, but not correlated to disease liability.

9 ht represent early manifestations of genetic liability.

10 ope of care, quality, and responsibility and liability.

11 s partially attributable to shared polygenic liability.

12 age of illness, symptom severity, or genetic liability.

13 etabolite levels are associated with illness liability.

14 that lacks tolerance, dependence, and abuse liability.

15 how the chemical modifications affect abuse liability.

16 ld contribute to altered gene expression and liability.

17 ume and cortical thickness, to schizophrenia liability.

18 hared with genetic variance in schizophrenia liability.

19 phrenia and FTND/CPD/COT shared some genetic liability.

20 ht represent early manifestations of genetic liability.

21 twins (24 pairs) informative for depression liability.

22 al factors on brain connectivity and disease liability.

23 for increasing ethanol intake and addiction liability.

24 encourage quality of care through threat of liability.

25 , data usage, and accountability for medical liability.

26 roperties of ketamine and may lack its abuse liability.

27 symptoms in HD, suggesting a common genetic liability.

28 disorders with partially overlapping genetic liability.

29 nt contributing to methamphetamine addiction liability.

30 SPR519 did not show any CYP or hERG liability.

31 ut not quantified-implications for offspring liability.

32 sk of adverse effects, particularly no abuse liability.

33 ffects of ketamine and appears to lack abuse liability.

34 daptations associated with reduced addiction liability.

35 Participants then assessed the physician's liability.

36 observed with a GRS for overall T2D genetic liability.

37 lted in playing a major role in the PROTACs' liability.

38 eterocycles devoid of covalent binding (CVB) liability.

39 ibitory activity while minimizing off-target liabilities.

40 ing variants and their resultant therapeutic liabilities.

41 ofiles and were devoid of the aforementioned liabilities.

42 of long half-life, however, carries with it liabilities.

43 d rational engineering to reduce hydrophobic liabilities.

44 es concerns about potential cross-resistance liabilities.

45 selectivity as well as a reduction in safety liabilities.

46 could offer equivalent efficacy with reduced liabilities.

47 ic-like effects with reduced sedative/ataxic liabilities.

48 tropisomerism, solubility, and Caco-2 efflux liabilities.

49 dometrioid carcinoma (OR per 50% higher odds liability: 0.89, 95% CI 0.82-0.96; P = 0.002).

50 cancer (odds ratio [OR] per 50% higher odds liability: 1.10, 95% CI 1.06-1.15; P = 6.94 x 10-7) and

51 e correlation between number of children and liability among females (B=0.011, 95% CI=0.006, 0.016),

52 y guidelines, and reports potential sequence liabilities and canonical forms.

53 ble to deliver novel drugs free from cardiac liabilities and guide personalized therapy.

54 acokinetic properties with minimal profiling liabilities and is efficacious in several murine models

55 haracterized by partially distinct polygenic liabilities and may represent more homogeneous phenotype

56 en widely used, sluggish kinetics, metabolic liabilities and potential off-target effects of CNO repr

57 st should provide an analgesic without abuse liability and an improved side-effect profile.

58 d reciprocal causation between schizophrenia liability and cognition (e.g. mutual influences in a cyc

59 s as well as twin studies suggest a familial liability and consequently different genes were investig

60 hose predisposing factors, including genetic liability and early family environment, that are shared

61 to test for the presence of a shared genetic liability and examined potential differences between low

62 suggest that a complex relationship between liability and fecundity is consistent with sexual select

63 ously unique properties, such as lower abuse liability and induced relief of withdrawal symptoms and

64 PK1 inhibitor 32, which does not have a hERG liability and possesses a favorable pharmacokinetic prof

65 estigated the associations between polygenic liability and progression to bipolar disorder or psychot

66 promising biomarkers for alcohol-consumption liability and related psychiatric and behavioral phenoty

67 lesterol auxotrophy of ALCLs is a targetable liability and, more broadly, that systematic approaches

68 ual or unmeasured confounding (e.g., genetic liability), and no causal inferences can be made based o

69 regate, did not exhibit other developability liabilities, and did not bind to any of the 5,300 human

70 hed tolerance, dependence/withdrawal, reward liability, and respiratory depression versus morphine.

71 e more effective, safer, and devoid of abuse liabilities are desperately needed.

72 cetyltransferase (HAT) inhibitors with these liabilities are now routinely used to probe epigenetic p

73 Vasoactive liabilities are typically assayed using wire myography,

74 of the RNA interference (RNAi) pathway, but liabilities arising from the native RNA structure necess

75 nd breast-cancer-resistant protein substrate liability as indicated by an efflux ratio of 0.8 in the

76 h in turn moderates the emergence of general liability as individual risk for mental illness.

77 tive does not display the same level of hERG liability as observed with 1 and represents a promising

78 safety, efficacy and equity, validation, and liability, as well as how its data were obtained.

79 traits, and a causal effect of schizophrenia liability," as well as in Supplementary Figures 1-10 and

80 up program was initiated to remove metabolic liabilities associated with 1.

81 g good functional activity but displayed new liabilities associated with metabolism and hERG inhibiti

82 ardiovascular drug but lacking its metabolic liability associated with CYP2D6 metabolism.

83 rties with their EPS and prolactin-elevating liabilities at therapeutic doses.

84 ailable findings suggested that greater tort liability, at least in its current form, was not associa

85 (2) Can metabolic liabilities be modulated in a favorable way?

86 edness decreased, suggesting shared familial liability between ADHD and EDs.

87 ese PRSs suggest a broader effect of genetic liability beyond traditional diagnostic boundaries.

88 enthusiasm because these scores explain more liability, but predictions are small and not yet actiona

89 is often not desirable and can create safety liabilities by activating native host immune defenses ag

90 provide standard care can reduce the risk of liability by accepting, rather than rejecting, that advi

91 ay also serve as a metabolic and therapeutic liability by indicating cancer cell susceptibility to FA

92 effects on general dimensions of cross-trait liability, calculate more predictive polygenic scores an

93 imits their use with high power lasers: this liability can be overcome by employing materials with hi

94 solates but also exhibited limited cytotoxic liability (CC50 > 100 muM).

95 These results suggest familial liability contributes to the association between eating

96 We tested the hypothesis that shared genetic liability contributes to the high rates of comorbidity b

97 In some settings, medical liability costs are enormous, human resource shortages a

98 in severity on the same continuum of genetic liability could be rejected.

99 GDH2 may be essential to mitigate metabolic liabilities created by IDH1 mutations in glioma, with po

100 However, such liability depends in part on lay judgments by jurors: wh

101 iratory suppression, constipation, and abuse liability detract from the general activation of these r

102 therapeutic mAb such as tryptophan oxidation liabilities during the mAb's development.

103 development and identification of potential liabilities earlier in development could significantly i

104 effects could add to identification of these liabilities earlier.

105 analysis found support for causal and graded liability effects of cannabis on precuneus structure.

106 Is as anti-HIV-1 agents with fewer long-term liabilities, efficacy on new drug-resistant HIV-1 strain

107 We show that genetic liability estimates are primarily driven by SNPs identif

108 ,628), we found that the variance in disease liability explained by common variants is higher for COA

109 ficantly increased the amount of variance in liability explained by GRPS.

110 mechanisms that may contribute to drug-abuse liability, exploring evidence from opioids, alcohol, and

111 ft, recent studies have identified a general liability factor for psychopathology-sometimes called th

112 We found that genetic liabilities for ASD and ADHD covary with neuromotor deve

113 The genetic liabilities for MDD and schizophrenia were associated wi

114 egulated transcriptional programs can become liabilities for melanoma cells due to their acquired dep

115 denoting the sum of an individual's genetic liability for a disorder are a promising biomarker for p

116 We studied whether genetic liability for AD predicts sleep duration using a genetic

117 strate may (in part) underpin shared genetic liability for ADHD and BMI and the manifestation of thei

118 cence, and to examine whether higher genetic liability for ADHD is correlated with total number of ad

119 ligands as effective analgesics with reduced liability for adverse effects.

120 ons may plausibly reflect a predispositional liability for alcohol use or a causal consequence of alc

121 asting epigenetic signatures associated with liability for attention and cognition, and limited poten

122 e for mechanistic interpretations of genetic liability for brain diseases.

123 icans and African-Americans, but the genetic liability for CD converged on many similar tissue types

124 g of information may contribute to a general liability for common mental disorders.

125 fication of NPA101.3, lacking the structural liability for demethylation.

126 ditive contributions of these factors to the liability for depression, supporting the multiplicative

127 abnormalities are influenced by the genetic liability for developing the disease.

128 has become clear that Fiu also represents a liability for E. coli because its activity allows import

129 c associations and demonstrates that genetic liability for major depression increases risk for suicid

130 ommon genetic variants may result in general liability for many later psychiatric outcomes.

131 We show that significant genetic liability for neuropsychiatric disease lies within prena

132 Thus, CDO1 is a metabolic liability for NSCLC cells with high intracellular cystei

133 nd functional alterations as well as genetic liability for psychosis in individuals experiencing psyc

134 gene ELFN1 as conferring significant genetic liability for PTSD.

135 Network analysis revealed that genetic liability for schizophrenia is primarily associated with

136 ere heritable and positively correlated with liability for schizophrenia spectrum disorders (phenotyp

137 influencing both the levels of glutamate and liability for schizophrenia spectrum disorders.

138 ntermediate phenotype related to the genetic liability for schizophrenia that manifests as altered re

139 The estimated heritability of liability for SCZ (h(2) = 0.62, 95% confidence interval

140 of familial coaggregation suggests familial liability for the association between eating disorders a

141 e study was underpowered to explore familial liability for this association.

142 or workers' compensation reduces industries' liability for worker health, illustrating racial capital

143 tion DPP1 inhibitors free from aorta binding liabilities found for earlier compound series was discov

144 ewiring, little is known about the metabolic liabilities generated by this reprogramming.

145 A shared genetic liability has been proposed as one possible mechanism.

146 contributor to phenotypic variation-genetic liability-has led to the routine application of PRSs acr

147 y examples where reactive metabolite-related liabilities have been resolved through structure-metabol

148 isk even among individuals with high genetic liability (HR: 0.82; 95% CI: 0.68 to 0.998).

149 nal gene interactions and genotype-dependent liabilities in cancer.

150 We also uncovered cancer-selective metabolic liabilities in central carbon, amino acid, and lipid met

151 methylammonium cation does not introduce new liabilities in common pharmacological properties of the

152 ext specificity of metabolic preferences and liabilities in malignant cells.

153 tivation capacity in mice, leading to safety liabilities in murine studies.

154 y the early childhood manifestations of this liability in a UK population-based cohort.

155 1 and CNTNAP2 to likely increase the genetic liability in an idiopathic ASD case.

156 al connectivity may explain heightened abuse liability in individuals with a history of chronic drug

157 dard treatment recommendations will increase liability in medical malpractice, undermining the use of

158 development but to later become a metabolic liability in metastasizing cells that is counteracted by

159 ntiated safe opioid analgesics without abuse liability in primates.

160 Higher schizophrenia liability in study subjects without manifest disorder wa

161 steroidogenesis, and interference can pose a liability in terms of side effects.

162 become the standard for quantifying genetic liability in the prediction of disease risks.

163 of ischemic events with no apparent bleeding liability in this high-risk group.

164 ERG activity and frequencies of other safety liabilities included those that investigated mammalian c

165 1.7 leads that address a number of metabolic liabilities including bioactivation, PXR activation, as

166 genetic variance components of schizophrenia liability indicated that 26.87% (CI 21.45-32.57%) was as

167 d be provided and should not rely on carrier liability insurance policies.

168 omising analgesic activity and reduced abuse liabilities into a more stable series of benzylic core a

169 ion of these synonymous mutations to disease liability is comparable to de novo protein-truncating mu

170 This shared liability is most consistent with a general risk for sub

171 Substantial genetic liability is shared across psychiatric disorders but les

172 ated variants, yet how these variants confer liability is uncertain.

173 er these childhood antecedents index genetic liability is unknown.

174 hizophrenia, most of the currently explained liability is within common variation, suggesting that va

175 of an understanding of potential privacy and liability issues lead to questions about the dominant pa

176 Although docking retains important liabilities (it cannot calculate affinities accurately n

177 res identified strategies to obviate the DDI liability, leading to compound 16, which exhibits robust

178 pattern of a weak positive correlation with liability may contribute to the persistence of schizophr

179 Shared genetic liability might partly explain the association between n

180 ity estimate of 17.4% (s.e. 1.7%) based on a liability model.

181 e the in vivo profile and address off-target liabilities of a series of BACE1 inhibitors represented

182 d pharmacodynamic features that overcome the liabilities of artemisinin derivatives.

183 inical studies reveal beneficial effects and liabilities of manipulating immune pathways in various n

184 sion is that to reduce cardiovascular safety liabilities of new therapeutic agents, there is an urgen

185 8 overcomes the metabolic liabilities of PQR620 (52), the first-in-class brain pen

186 It also lacks some of the pharmacokinetic liabilities of the clinical agents and appears to have a

187 To assess cross-resistance liabilities of the Complex I inhibitors, we profiled the

188 The merits and liabilities of these approaches will be discussed in the

189 to increase the potency and reduce metabolic liabilities of this series.

190 passive permeability and efflux transporter liability of a compound must be addressed.

191 Individual variation in the addiction liability of amphetamines has a heritable genetic compon

192 cedented opportunity to evaluate the genetic liability of complex disease using polygenic risk scores

193 -directed T3 action offsets the diabetogenic liability of glucagon, and glucagon-mediated delivery sp

194 e, novel strategies to predict the potential liability of new entities toward the AOX enzyme are urge

195 gs demonstrate that ACC mediates a metabolic liability of NSCLC and that ACC inhibition by ND-646 is

196 rize the oncogenic potential and therapeutic liability of one eRNA, NET1e, supporting the clinical fe

197 f opioids that may lead to a lower addictive liability of opioids with selective low potency for the

198 iscovery sample as indicators of the genetic liability of schizophrenia.

199 activity at DAT and NET, and decreases abuse liability of the compounds.

200 t are common contribute substantially to the liability of the disorder.

201 The addiction liability of these drugs has led to the current epidemic

202 umerated compounds, biological activity, and liabilities, over 17 years.

203 OPS (Copy-number alterations Yielding Cancer Liabilities Owing to Partial losS) genes, and spliceosom

204 it can also be an interpersonal and societal liability, partly remediable with narcissism-reduction i

205 ntly correlated with increased schizophrenia liability (phenotypic correlation, -0.25; 95% CI, -0.38

206 TMLM, LT-Fam is computed from posterior mean liabilities (PML) under a liability threshold model; how

207 admixed African (Nagelkerke's R(2) = 0.032; liability R(2) = 0.017; P < 10(-52)), Latino (Nagelkerke

208 10(-52)), Latino (Nagelkerke's R(2) = 0.089; liability R(2) = 0.021; P < 10(-58)), and European indiv

209 pean individuals (Nagelkerke's R(2) = 0.089; liability R(2) = 0.037; P < 10(-113)), further highlight

210 deviation increase in PRS and corresponding liability r(2) values of approximately 1%, suggesting at

211 The R(2)(liability) (R(2) adjusted for the rate of disease risk i

212 s rational," Cushman downplays its signature liability: Rationalization exposes a person to the hazar

213 Physicians with poor malpractice liability records may pose a risk to patient safety.

214 Efforts to constrain emerging liabilities related to the citizenship of transplant can

215 15 found no evidence of an association with liability risk and 5 found limited evidence.

216 association between measures of malpractice liability risk and health care quality and outcomes.

217 , 9 found no significant association between liability risk and outcomes (such as Apgar score and bir

218 one found evidence of an association between liability risk and outcomes.

219 atisfaction), 7 found no association between liability risk and these outcomes and 5 identified signi

220 gher proportion of variance explained on the liability scale (improvementtarget= 50%; improvementrepl

221 component and non-additive residuals on the liability scale and (2) the Levene's test to assess equa

222 non-additive environmental residuals on the liability scale and secondly using the Levene's (Brown-F

223 The liability scale common variant heritability estimate for

224 ke pseudo-R(2) and variance explained on the liability scale were calculated.

225 value of 0.16 (SE=0.02) when converted to a liability scale.

226 uld be explained by the effect of GRS on the liability scale.

227 ng multiplicative interactive effects on the liability scale.

228 erties such as enumerated compounds, but not liabilities, show statistically significant increasing t

229 mmarize the structure-activity and structure-liability studies leading to the discovery of 31 and the

230 The tort liability system is intended to serve 3 functions: compe

231 r improved mode of action, but also revealed liabilities that allowed us to discern two properties of

232 ing and its potential to induce biosynthetic liabilities that can be exploited for glioma therapy.

233 x natural products often exhibit a number of liabilities that hinder their development as therapeutic

234 for desirable ADMET properties or suspected liabilities that may require significant optimization.

235 compounds that, like 2, were free of the CV liabilities that resulted in the discontinuation of BMS-

236 M1 activation contributes to the cholinergic liabilities that were previously attributed to activatio

237 Tourette syndrome (rather than OCD) genetic liability that is not captured by traditional DSM-based

238 the presence of an immunity from malpractice liability, the Centers for Medicare & Medicaid Services'

239 relative risks (RRs) were evaluated, and the liability threshold model was used to examine the effect

240 n posterior mean genetic liabilities under a liability threshold model, conditional on case-control s

241 rom posterior mean liabilities (PML) under a liability threshold model; however, LT-Fam uses publishe

242 The data were analyzed using univariate liability threshold modeling, stratified by sex and age,

243 Liability threshold models adjusting for censoring with

244 Previously, we introduced a liability threshold-based mixed model association statis

245 Polygenic risk score increases schizophrenia liability through cognition-relevant pathways', by Toulo

246 lity to limit IDH1(R132H)-mediated metabolic liabilities, thus promoting glioma growth in this contex

247 These risk factors included genetic liability to 3 factors (endometriosis, polycystic ovary

248 etermine potential causal effects of genetic liability to a morning preference on food intake.

249 Genetic liability to a morning preference was associated with in

250 S) is an estimate of an individual's genetic liability to a trait or disease, calculated according to

251 bjects with schizophrenia might increase the liability to adverse outcomes with cannabis use is consi

252 d are believed to reflect underlying genetic liability to ASD.

253 armonization to properly capture the genetic liability to AUD.

254 nce of YAP1/TAZ-TEAD signaling as a specific liability to be considered as a new target for therapeut

255 in a femtosecond laser is not necessarily a liability to be mitigated, but can act as a unique and p

256 However, the genetic liability to cognitive impairment and apathy appears to

257 test may be used as a method to predict the liability to deamidation of therapeutic antibodies in vi

258 alysis supports a potential causal effect of liability to depression on brain white matter microstruc

259 e differences may be a causal consequence of liability to depression.

260 l communication between brain regions in the liability to develop AUD.

261 ne, GRIK5, that contributes to the polygenic liability to develop eye diseases have helped to illumin

262 with expectations from a polygenic model of liability to disease risk.

263 iabetes) scaled to reflect a 50% higher odds liability to disease.

264 There was strong evidence that genetic liability to endometriosis was associated with an increa

265 an randomization suggested causal effects on liability to PAU of substance use, psychiatric status, r

266 9, 95% CI 1.02-1.16; P = 0.007); and genetic liability to polycystic ovary syndrome and endometrioid

267 neuropathy termed hereditary neuropathy with liability to pressure palsies (HNPP).

268 opathies, such as hereditary neuropathy with liability to pressure palsies or demyelinating forms of

269 and represents both a potential benefit and liability to rapidly dividing cells; however, the precis

270 Genetic risk for liability to recurrent MDD was partitioned using sparse

271 pulsive phenotype may reflect a quantitative liability to related mental health disorders that indexe

272 word 'schizophrenia' have been re-worded as 'liability to schizophrenia' or 'schizophrenia risk', inc

273 ucleotide polymorphisms (SNPs) contribute to liability to schizophrenia, but their etiological relati

274 c risk factors act and interact to influence liability to schizophrenia.

275 ural phenotype underlying individual genetic liability to schizophrenia.

276 st line of evidence that these DNVs increase liability to schizophrenia.

277 ent groups of tooth surfaces and that innate liability to some patterns of caries presentation may pa

278 ittle evidence for an association of genetic liability to type 2 diabetes, parity, or circulating lev

279 t up-to-date computational method to predict liability toward human AOX (hAOX), for applications in d

280 gy of schizophrenia; however, shared genetic liability toward infections and schizophrenia could infl

281 red by PRS, also influence a general genetic liability towards broad childhood psychopathology in the

282 ons of their therapeutic potential and abuse liability, two specific areas that are of significant pu

283 Mitigation of a potential Ames and hERG liability ultimately led to two promising compounds, one

284 ation method based on posterior mean genetic liabilities under a liability threshold model, condition

285 The proportion of liability variance explained by GPRSs for each MDD subgr

286 new round of optimization addressing the key liabilities was performed and led to discovery of compou

287 e acyclic amines inactivated CYP3A4 and this liability was addressed by modifications that sterically

288 I=0.006, 0.016), whereas among males, higher liability was associated with being childless (odds rati

289 To determine potential jurors' judgments of liability, we conducted an online experimental study of

290 Based on this shared liability, we identified multiple long non-coding RNAs a

291 To overcome this potential liability, we introduced an alkyne moiety as a latent el

292 int effects of PRS and CNVs on schizophrenia liability were modeled by using logistic regression.

293 ion of electrotonic coupling and lower abuse liability, which may be exploited in future therapeutic

294 brain exposure by decreasing P-glycoprotein liability while maintaining potency and selectivity.

295 are downstream of the disease or its genetic liability, while 15 proteins were supported as having a

296 airments in 4 domains known to share genetic liability with ADHD: IQ, social communication, pragmatic

297 ing behavior patterns share a common genetic liability with obesity measures and are moderately herit

298 e genome contributing to this shared genetic liability with other conditions than for strictly define

299 emale protective effect is that familial ASD liability would be expected to aggregate asymptomaticall

300 dentifying neural correlates of this general liability would substantiate its importance in character