ライフサイエンスコーパス: library

1 r 327,000 sequences in an inducible promoter library.

2 even if a correct compound is contained in a library.

3 2 papyrus fragments from the Tebtunis temple library.

4 s of visualizations using the NGL JavaScript library.

5 play panning strategies using a human immune library.

6 nthetic human single-chain fragment variable library.

7 he screening of combinatorial peptidomimetic library.

8 tic properties to cleave the hairpins in the library.

9 Kalpha against our in-house kinase inhibitor library.

10 hat are not generally included in commercial libraries.

11 techniques for enhanced amplification of DNA libraries.

12 improvement in overall performance of these libraries.

13 problems that arise when screening chemical libraries.

14 state of genes from replicate transcriptomic libraries.

15 generate pharmaceutically relevant compound libraries.

16 nal regulatory elements out of combinatorial libraries.

17 ng advantage of large existing Gateway clone libraries.

18 and an online tool to generate custom probe libraries.

19 as initiatives to implement mobile-specific libraries.

20 amplicons demonstrated that both full-length library (565 bp) and mini-barcodes (193 bp) contain enou

21 Screening of a GSK-proprietary library against intracellular Mycobacterium tuberculosis

22 e screened a naive human semisynthetic phage library against RBD, leading to the identification of a

23 chromatography of the fluorescently labeled library, allows the relative affinities of glycan ligand

24 , CINAHL, EMBASE, PsycINFO, CINHAL, Cochrane Library, AMED, SPORTDiscus, Web of Science and Clinical

25 employed progressively more complex genomic libraries and increased sequencing depths.

26 situ readout of dense combinatorial barcode libraries and single-base mutations produced by CRISPR b

27 portunities for the preparation of diversity libraries and will support efforts in both drug discover

28 7 compounds from the natural product set III library and 7 compounds from the approved oncology drugs

29 Searches of Medline, the Cochrane Library and CINAHL were used to identify recent primary

30 ScaffoldGraph (SG) is an open-source Python library and command-line tool for the generation and ana

31 y increases the difficulty of designing a DC library and leads to the creation of many undesired vari

32 675,000 sequences in a constitutive promoter library and over 327,000 sequences in an inducible promo

33 Using a naive llama single-domain antibody library and PCR-based maturation, we have produced two c

34 rted the high efficiency and accuracy of our library and revealed many so far uncharacterized genes e

35 nut, Pin p 1, were analyzed using a peptide library and sera from patients with clinical allergy to

36 derived from spectra in the NIST17 Tandem MS Library and those identified in urine, using the newly d

37 R experiment, a rationally designed fragment library, and a sample composition optimized for a maxima

38 (OVID Medline, OVID Embase, CINAHL, Cochrane Library, and Scopus) from 1964 to 2017 using relevant se

39 au, we performed a screen of a 1280-compound library, and tested a selective group of prescription dr

40 iew of MEDLINE, EMBASE, Scopus, the Cochrane Library, and the "gray literature" (conference proceedin

41 MEDLINE, EMBASE, PubMed, PsychINFO, Cochrane Library, and the TRIP Database, searched from January 1,

42 l genes, we demonstrate that SPINE-generated libraries are enriched for in-frame insertions, have dra

43 Libraries are screened biophysically and fragment:protei

44 , the screening and validation of a fragment library are described, and the development of the fragme

45 lavonoids) were identified from the Spectrum library as the most promising candidates to be tested on

46 Such speed is important for compound library, assay and future clinical screening of millions

47 )-initiated selection of components from the library assembles a parent CDN X, where the evolved cons

48 pounds based on screening of entire compound libraries based on desired phenotypes.

49 A synthetic phage display library based on the variable domain of new antigen rece

50 istinguished and quantified using solely the library-based method of 2D ultraviolet fragmentation spe

51 e, using covariates to correct for sex, age, library batches, and 1 surrogate variable component.

52 ow-cost, multiplexed method that builds gene libraries by compartmentalizing and assembling microarra

53 isolate novel biocatalysts from metagenomic libraries by processing single cells as many as 10(8) pe

54 ckground levels, barcoded and pooled CUT&Tag libraries can be sequenced for as little as $25 per samp

55 ng DNA oligomers, million- to billion-member libraries can be synthesized for use in hundreds of heal

56 Two constitutional dynamic libraries (CDLs)-each containing two amines, two dialdeh

57 PsychINFO, PubMed, EMBASE, Scopus, Cochrane library/CENTRAL, Web of Science, and Google Scholar from

58 lls and screening of naive and memory T cell libraries, combined with T cell cloning and TCR sequenci

59 The protocols differed in library complexity and their ability to detect cell-type

60 two massively parallel reporter assay (MPRA) libraries composed of binding sites for SOX2, POU5F1 (OC

61 reactivity or require synthesis of precursor libraries comprising a large number of variants.

62 phage display screening of deep recombinant libraries consisting of as few as one major pathogen ant

63 performed a drug screening approach using a library consisting of epigenetic compounds and 'Donated

64 ze a NoV GI.1 Jun-Fos-assisted phage display library constructed from randomly fragmented genomic DNA

65 Given 3' enriched strategy in library construction, the most commonly used scRNA-seq p

66 ation and retention time prediction to build libraries containing every peptide in a proteome, and th

67 we present the Human TFome, a comprehensive library containing 1,564 TF genes and 1,732 TF splice is

68 We first apply Reel-seq to screen a library containing 4316 breast cancer-associated SNPs an

69 nstructing and screening a detailed lipidoid library containing imidazole or imidazole analogues to p

70 cient assembly of a high-quality and diverse library containing nearly 4000 fragments and screening f

71 ere a cell-based high-throughput screen of a library containing two-million molecules for the compoun

72 Notably, our DNA library contains the genome of a bacterium within the Rh

73 The equilibrated dynamic combinatorial library contains, amongst various macrocycles, two diffe

74 that all of the materials in the current 2D library could be rolled into their 1D counterparts and a

75 Pooled library CRISPR/Cas9 knockout screening across hundreds o

76 erpta Medica dataBASE (Embase), The Cochrane Library, Cumulative Index of Nursing and Allied Health L

77 ies published in English and in the Cochrane Library database with no restrictions.

78 h Literature), MEDLINE, Scopus, and Cochrane Library databases from inception to August 2019 were use

79 DNA encoded libraries (DEL) have shown promise as a valuable technol

80 DNA-encoded small molecule libraries (DELs) have enabled discovery of novel inhibit

81 amined PAR4-signaling responses to a peptide library derived from the canonical PAR4-agonist peptide,

82 new screening technologies, and advances in library design and chemical synthesis.

83 ranges generally guide DNA-encoded chemical library design, recent reports have highlighted the util

84 f enzyme stabilization through computational library design.

85 The Hybrid Automata Library (HAL) is a Java Library developed for use in mathematical oncology model

86 (PKIS) is a publicly-available chemogenomic library distributed to more than 300 laboratories by Gla

87 nal antibody are identified in proportion to library diversity, as diversity is increased from 10(6)-

88 scapes and high-quality, manually curated TE libraries: Drosophila melanogaster (fruit fly), Danio re

89 The TCRalphabeta-Jurkat libraries enabled repeated screening and panning for ant

90 This library enabled us to measure the effect of individual s

91 e round of ribosome display using the sybody libraries encoded by mRNA, followed by two rounds of pha

92 PCR is prone to create biased libraries - especially with the extremely high degrees o

93 for some genes, SPINE generated high-quality libraries for all genes tested.

94 We used Illumina RNA-Seq to analyse cDNA libraries for differential expression of genes from leav

95 ation of fluorine into proteins and fragment libraries for drug discovery has become increasingly com

96 Accordingly, we mined Quercus suber EST libraries for OSC fragments to use in a RACE PCR-based a

97 n of molecular structure to expand reference libraries for small molecule identification.

98 lective manner to synthesize large molecular libraries for studying structure-activity profiles.

99 We have now screened each member of this library for growth in human serum and discovered 178 mut

100 We have developed PyIR, a Python wrapper and library for IgBLAST, which offers a minimal setup CLI an

101 In this work, a CCS library for IMS-HRMS, which is online and freely availab

102 DD and PDD with reference to a DNA reference library for local plants.

103 NumPy is the primary array programming library for the Python language.

104 SciPy is an open-source scientific computing library for the Python programming language.

105 ource, high speed and lightweight JavaScript library for visualization of large and complex networks.

106 le gRNA delivery, confirming its utility for library format applications.

107 Sequencing of automatically prepared libraries from T-cell receptor and immunoglobulin gene r

108 d Allied Health Literature, and the Cochrane Library from inception to 10th May 2019.

109 quencing can enhance the analysis of aptamer libraries generated by the Systematic Evolution of Ligan

110 l from tissue reception through whole-genome library generation can be accomplished in as little as 1

111 ough benchmarking to MuA transposon-mediated library generation on four ion channel genes, we demonst

112 DeCoDe to be broadly useful for a variety of library generation problems, ranging from protein engine

113 We demonstrate a library generation workflow that leverages fragmentation

114 s including immunodiagnostics, phage display library generation, and "humanness" assessment of BCR re

115 The Hybrid Automata Library (HAL) is a Java Library developed for use in mat

116 tion of biologically relevant small-molecule libraries, harnessing the unprecedented combination of N

117 Open-source web-based libraries help accelerate the creation of biologically b

118 ated from a C. perfringens transposon-mutant library, here we identified an immunoreactive antigen th

119 ubiquitin regulator-focused single-guide RNA library in HL lines carrying either wild-type or mutant

120 We screened a transposon (Tn) mutant library in the cop- background and isolated strains with

121 By screening the library in three hPSC lines, we discovered 290 TFs, incl

122 r a broad range of microplastics because our libraries include plastics containing a range of additiv

123 Our libraries increase the likelihood of spectral matching f

124 d any subset of signatures across the entire library independent from the originating source, project

125 the backbone of the phagemid vector and the library insert comprises only the variable regions of th

126 ensor of domain IV and stably integrated the library into HEK293T cells.

127 uced worldwide, the quality control of these libraries is lacking.

128 An important issue with screening compound libraries is that although an inhibitor suitable for the

129 The Cochrane Library, MEDLINE, and EMBASE databases were searched up

130 genetic methods, we describe a plasmid-based library methodology that affords bidirectional, graded m

131 ombinatorial approach can be used to analyze libraries obtained by different in vitro selection exper

132 ds grant us access to a vast sequence space (libraries of >1012 enzyme variants) that may hide yet un

133 tify binders from fully randomized synthetic libraries of 10(8) members-a 100-fold gain in diversity

134 signaling methods will require standardized libraries of biological parts and methods to assemble th

135 d synthetic chemistry approaches to generate libraries of compounds, with some ending as promising dr

136 iding an appropriate strategy for generating libraries of digital patients.

137 ific, molecular phenotype across genome-wide libraries of genetic perturbations.

138 We use high throughput screening of large libraries of materials with differing surface topographi

139 sed mutagenesis approach (TRIAD) to generate libraries of random variants with short in-frame InDels,

140 The method was demonstrated with libraries of randomly mutated cytochrome P411 variants t

141 uilt and analyzed high-throughput sequencing libraries of rNMPs derived from mitochondrial and nuclea

142 Libraries of single-stranded oligodeoxynucleotides (ssOD

143 evolutionary sequence data, design and build libraries of synthetic genes, and test them for activity

144 ene expression, permitting the assessment of libraries of transgenes that perturb cell growth and sur

145 EL provides relatively inexpensive access to libraries of unprecedented size, their production has be

146 of phenomic profiling assays, we assembled a library of 1,008 approved drugs and well-characterized t

147 In this study, we created a library of 135 barcoded coxsackieviruses to examine vira

148 r characterization platform, and establish a library of 15 mutually orthogonal split inteins for in v

149 Thus, we synthesized a library of 17 electron-rich alkenes (glycals) with varie

150 and cyclic dienes, we report a diverse click-library of 173 unique functional molecules in minimal sy

151 Generator), has algorithmically generated a library of 2,020,794,198 macrocycles that can result fro

152 Here, we screen a library of 2024 FDA-approved drugs or drug candidates, r

153 In this study, we synthesized a library of 36 peptoids containing fluorine, chlorine, br

154 ons in huwentoxin-IV sequence, we produced a library of 373 point mutants and tested them for Na(v)1.

155 lators in A. fumigatus and construction of a library of 484 transcription factor null mutants.

156 this we screened the E90K GnRHR mutant vs. a library of 645,000 compounds using a cell-based calcium

157 We describe the creation of a mass spectral library of acylcarnitines and conjugated acylcarnitines

158 Here we further evolve ABE7.10 using a library of adenosine deaminase variants to create ABE8s.

159 In a screen of an insertional mutant library of all 14 annotated PTS permease (EIIC) genes in

160 A library of analogs was synthesized and studied in vitro

161 odel, we screened a combinatorially complete library of antitoxin variants at three key positions aga

162 d evolution, the site-saturation mutagenesis library of Bacillus sp. MN chitosanase consisting of 167

163 n, we report a newly developed combinatorial library of cholesteryl-based disulfide bond-containing b

164 optimized and applied in the synthesis of a library of chromophore-amino acid conjugates with slight

165 that creates an in silico three-dimensional library of composite peptidic macrocycles.

166 sis using X-ray crystallography of a diverse library of compounds prepared using microscale parallel

167 This was achieved by the generation of a library of Cys mutations in Env glycoprotein on the vira

168 est mechanical properties when compared to a library of dipeptide analogues, thus validating the uniq

169 Here we profiled a library of drugs encompassing approximately 12,000 clini

170 Using a library of fluorinated glucose (Glc), mannose (Man), and

171 In brief, our approach involves creating a library of fragments derived from an open reading frame

172 s next selectively reacted to give rise to a library of galectin-3 inhibitors.

173 Herein, a library of heterostructured, multimetallic (Pt, Pd, Rh,

174 tibodies against gluten from a non-immunized library of human single-domain antibodies (dAbs).

175 The Library of Integrated Network-Based Cellular Signatures

176 and split-pool decoding, we created a large library of isogenic reporter clones and identified repor

177 The protocol allowed the construction of a library of isoindolinones bearing a congested carbon in

178 Correspondingly, we constructed a library of isotopically labeled bottlebrush molecules an

179 We have previously designed a library of lentiviral vectors to generate somatic-transg

180 The National Library of Medicine (MEDLINE/PubMed) was systematically

181 ng literature screening via the U.S National Library of Medicine bibliographic database (MEDLINE) and

182 In this study, we investigated a small library of melanoma antigens and the effects of several

183 Screening a library of microscale reactions and selected resynthesiz

184 l studies, we investigate the influence of a library of molecules, derived by electro-dimerization of

185 A library of more than 30 macrocyclic peptidomimetic inhib

186 Our European sequence-indexed library of Mu insertions provides an important resource

187 Here, we screen a library of nearly 400 interferon-stimulated genes (ISGs)

188 We created a library of nearly all possible variants in a 36 base reg

189 We present a versatile method that applies a library of nucleic acids coupled to biocatalytic DNA mac

190 we use nucleosome affinity proteomics with a library of nucleosomes that disrupts all exposed histone

191 ersatility and vast potential of an expanded library of orthogonal split inteins for their use in the

192 oughput screen was performed with an arrayed library of over 13,000 K. pneumoniae transposon insertio

193 previously unknown inhibitors of GMII from a library of over 350 iminosugars and investigated their b

194 ABits (PhotoAffinity Bits), which utilizes a library of photoreactive fragments to covalently capture

195 nges to Raman spectra, we present a spectral library of plastic particles aged in the environment (SL

196 e structure-activity relationship (SAR) of a library of pyrimidine-4-carboxamides as inhibitors of NA

197 A library of random GreA variants has been used to isolate

198 A library of recombinant non-pathogenic Escherichia coli s

199 We build a library of sgRNA variants with different expression acti

200 Relative to the rich library of small-molecule organics, few examples of orde

201 By screening a yeast surface-displayed library of synthetic nanobody sequences, we developed na

202 on of SSP genes; and (4) information about a library of synthetic peptides and root and nodule phenot

203 Screening a deep mutant library of the bla(ampC) beta-lactamase gene of Escheric

204 unsuitable for the practical synthesis of a library of these derivatives.

205 itors, based on (a) one-pot preparation of a library of thiosemicarbazide compounds, (b) biological e

206 hese components, we screened the genome-wide library of viable yeast deletion mutants for defects in

207 Screening this library of well-annotated, published kinase inhibitors h

208 uates, and proposes cyclizations utilizing a library of well-established chemical reactions and reage

209 we detail technology for the generation of 'libraries' of clonogenic cells from 1-mm-diamter endosco

210 e previously selected phage antibody display libraries on live mesothelioma cells and tissues followi

211 his method-termed SpliMLiB for Split-and-Mix Library on Beads-was applied towards the directed evolut

212 we utilized a sequential panning of a phage library on cultured rat EpiSCs and then subtracted phage

213 ating a 160,000-membered, 4-site, saturation library on the surface of 8 million monoclonal beads.

214 a highly reactive, intrinsically disordered library peptide before and after conjugation.

215 unts while accounting for effects from input library preparation and sequencing depth.

216 to artifacts generated in PCR-based RNA-Seq library preparation and the lack of normal RNA-Seq data,

217 The fully automated library preparation by centrifugal microfluidics thus of

218 depletion to the rRNA-depletion protocol for library preparation from blood RNA effectively reduces h

219 stmortem cortex using poly(A)+ and Ribo-Zero library preparation methods.

220 formation traditionally lost in standard NGS library preparation methods.

221 Overall, this library preparation process allows for highly accurate s

222 In this study, we developed a novel library preparation process using randomized splint liga

223 esequenced on MinION after applying a custom library preparation.

224 not generate enough ChIP DNA for sequencing library preparation.

225 hoices for the best sequencing platforms and library preparations.

226 ccessibility and methylation from single DNA library preparations.

227 Although there are many spectral libraries produced worldwide, the quality control of the

228 and captured using streptavidin beads before library production and high-throughput sequencing.

229 systematic search of PubMed and the Cochrane Library (Prospective Register of Systematic Reviews ID:

230 PubMed, EMBASE, Web of Science, and Cochrane Library (PROSPERO #CRD42019121862) for original studies

231 of globin gene counts in non-hgbRNA depleted libraries provides improvement in overall performance of

232 canning synthetic glycopeptide combinatorial library (PS-SGCL) that vary in number and location of ca

233 ence, Science Direct, AMED, CINAHL, Cochrane Library, PsychInfo, Google Scholar, Delphis) was initial

234 es as low as 0.11% for single reads, without library purification.

235 ed to gauge the effect of each template upon library redistribution.

236 ral substance drugs included in two NCI drug libraries representing a variety of chemical structures.

237 ced gene expression profiles from large drug libraries, researchers can prioritize small molecules th

238 Recently, sequencing of salivary-gland mRNA libraries revealed increasingly complex and complete tra

239 Ahigh-throughput shRNA library screen in IRF8 expression-restrictive cells enab

240 as identified using an intracellular peptide library screen, and subsequently shown to both inhibit f

241 In the two libraries screened, 17 compounds from the natural produc

242 in terms of the number of guides depleted in library screening and the extent of the induced transcri

243 higher than unoptimized peptides from naive library screening.

244 ns and holds promise for performing chemical library screens and improving our understanding of the h

245 peutics based on naturally derived substance library screens for the treatment of cardiac fibrosis.

246 In many cases, a library search procedure returns a wrong answer even if

247 of selenium-containing DNA-encoded chemical libraries (SeDELs), and lays the foundation for the deve

248 tial scanning fluorimetry (DSF), DNA-encoded library selection, and in silico screening.

249 ction design and deployment in combinatorial library settings, providing a framework for the design o

250 sembly systems (CAS) targeting compounds and libraries sharing structural cores.

251 To generate scMNase-seq libraries, single cells are isolated by FACS sorting, ly

252 fferent settings with different sample size, library size and effect size.

253 ve of the current study was to determine how library size selection, read length and format, protein

254 Library sizes of up to 10(9) variants can be screened, t

255 for the rapid generation of block copolymer libraries spanning a wide range of compositions starting

256 l chemical space by empowering combinatorial library synthesis with a "few good reactions".

257 designed a focused high-coverage CRISPR-Cas9 library targeting 332 members of a recently published SA

258 thelial cells using a focused dual guide RNA library targeting 852 DDR-associated genes.

259 We screened an RNAi library targeting ubiquitin E3 ligases and observed that

260 nzimidazole series, identified using encoded library technology, with an N-methyl pyridone series ide

261 the utility of focused DNA-encoded chemical libraries that are structurally biased for a class of pr

262 from naive and synthetic humanized VHH phage libraries that specifically bind the S1 SARS-CoV-2 spike

263 of 1280 compounds in the Prestwick Chemical Library that could suppress seizures.

264 We developed Epiviz File Server, a Python library that implements an in situ data query system for

265 found ability to generate and curate digital libraries, the field of machine vision can now be effect

266 he effective depth of synthesized vector DNA libraries, thereby raising the discovery cost of novel v

267 tructural information to engineer AAV capsid libraries through saturation mutagenesis of different an

268 eened, thus allowing campaigns of naive scFv libraries to be selected against membrane protein antige

269 with short in-frame InDels, and screen TRIAD libraries to evolve a promiscuous arylesterase activity

270 ies from high latitudes to provide essential libraries to improve the conservation, monitoring, and m

271 igh-throughput screening (HTS) of a chemical library to identify binders of mircoRNA-15b which is ide

272 ened a low-complexity transposon (Tn) mutant library to identify novel genes important for E. faecali

273 scovered from a one-bead-one compound (OBOC) library to inhibit Abeta(40) aggregation, we investigate

274 short barcodes are counted by sequencing DNA libraries transfected into cells and the cell's output R

275 ssential for the generation of pMHC-multimer libraries used to probe diverse, polyclonal TCR repertoi

276 positive results, depending on the chemical library used.

277 We also analyse selected pseudo-NP libraries using chemoinformatic tools, to assess their m

278 ctional screening of a human gut metagenomic library using Lactococcus lactis MG1363 as heterologous

279 ein, a protease-focused DNA-encoded chemical library was designed that utilizes chemotypes known to e

280 chain variable fragment (scFv) phage display library was screened for binding, internalization, and t

281 and, using a single-chain peptide-HLA phage library, we generated peptide specificity profiles for t

282 interferon-stimulated gene short-hairpin RNA library, we identified a viral restriction factor, TDRD7

283 our BonnMu (B73) data to the UniformMu (W22) library, we identified conserved insertion hotspots betw

284 ASE, PubMed/Medline, CINAHL, EBSCO, Cochrane Library, Web of Science, Iranian online databases and th

285 MEDLINE; CINAHL; PsycINFO; Cochrane Library; Web of Science Current Contents Connect; Web of

286 pproximately 400 000 compounds from existing libraries were screened.

287 ounds from the approved oncology drugs set V library were found to exhibit anticlostridial activity.

288 Reads from each library were mapped back into the assembled transcriptom

289 PubMed and the Cochrane Library were searched for randomized controlled trials (

290 PubMed and the Cochrane Library were searched for randomized controlled trials (

291 MEDLINE, EMBASE, and the Cochrane library were searched through 24 July, 2019.

292 ware is developed to design CRISPR guide RNA libraries, which can be used for genome editing of codin

293 allows facile chemical modification of phage libraries, which greatly expands the chemical space amen

294 eptide in a proteome, and then refines those libraries with empirical data.

295 Targeted metagenomics using strand-specific libraries with target enrichment is a sensitive, general

296 We initially screened a library with a large structural variety of lipidoids ex

297 rce is available as a well-documented python library with a simple command-line interface.

298 rtaken, and the interaction of the resulting library with the protein was measured by techniques incl

299 es with exoglycosidase digestion to create a library with their complete structures, accurate masses,

300 Affinity selection of the library with thrombin, a common protease, revealed a num