ライフサイエンスコーパス: licensing factor

1 ication origins as a coactivator of the Cdt1 licensing factor.

2 ing frame of a gene encoding DNA replication licensing factor.

3 ts that led to the proposal of a replication licensing factor.

4 family of proteins that comprise replication licensing factor.

5 rigin binding of the Mcm4 subunit of the MCM licensing factor.

6 UL-4 independently controls both replication-licensing factors.

7 nd Rdh54 fulfill a role of prorecombinogenic licensing factors.

8 is an essential component of DNA replication licensing factor, a hexameric protein complex that regul

9 s on the temporal restriction of replication licensing factor activity.

10 l cycle progression that targets replication licensing factors, also targets the p12 subunit of Pol d

11 x (also known as MCM2-MCM7), the replication licensing factor and presumptive replicative helicase.

12 rmally high levels of replication and origin licensing factors and are likely poised for genome re-re

13 plex, replication factor C proteins, MCM DNA-licensing factors and the bacterial DnaA, RuvB, and McrB

14 ulate DNA replication and that components of licensing factor are targets of the products of tumor su

15 tration that cellular replication and origin licensing factors are required for KSHV latent cycle rep

16 Replication-licensing factors are required to form prereplicative co

17 nome encodes two homologs of the replication licensing factor CDC10 Target1 (CDT1), and overexpressio

18 events the nuclear export of the replication-licensing factor Cdc6 during S phase, and the block on n

19 The replication licensing factor CDC6 recruits the MCM2-7 replicative he

20 ow that CDK phosphorylation of the essential licensing factor Cdc6 stabilizes it by preventing its as

21 to chromatin and upregulates DNA replication licensing factor CDC6.

22 ted by concomitant downregulation of the DNA licensing factor cdc6.

23 rase inhibitor, or by deregulation of origin licensing factor CDC6.

24 The replication-licensing factors Cdc6 and Cdt1 are required for the ass

25 nated activation of both an essential origin licensing factor, CDC6, and an activity required for ori

26 UBXN-3/FAF1 binds to the licensing factor CDT-1 and additional ubiquitylated prot

27 ligase CRL4(Cdt2) only starts to degrade the licensing factor CDT1 after origin firing, raising the q

28 E3 ubiquitin ligase include the replication licensing factor Cdt1 and the cyclin-dependent kinase (C

29 Several proteins, including the replication licensing factor CDT1 and the histone methyltransferase

30 ation, in part, by degrading the replication-licensing factor Cdt1 during S phase.

31 Knockdown of the replication origin-licensing factor CDT1 eliminates both stress-induced rer

32 have been reported to target the replication licensing factor Cdt1 for ubiquitin-mediated proteolysis

33 The DNA replication licensing factor Cdt1 is degraded by the ubiquitin-prote

34 Proper expression of the replication licensing factor Cdt1 is primarily regulated post-transl

35 The C. elegans orthologue of the replication-licensing factor Cdt1 is required for DNA replication.

36 cle-regulated degradation of the replication licensing factor Cdt1 plays important roles in preventin

37 Geminin interacts with the licensing factor Cdt1 to prevent untimely replication an

38 in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 re

39 h predominantly inhibits the DNA replication licensing factor Cdt1, preventing genome over-replicatio

40 atin during G1 phase and is dependent on the licensing factor Cdt1.

41 ession, including a critical DNA replication licensing factor CDT1.

42 ase, is a coactivator of the DNA replication licensing factor Cdt1.

43 replication induced by overexpression of the licensing factor Cdt1.

44 -, G2- and M-phases by binding the essential licensing factor CDT1.

45 ing the Ska1 complex and the DNA replication licensing factor, Cdt1, enable the kinetochore-localized

46 the recruiting transcription and replication licensing factors coordinates the transcriptional and DN

47 ), at Y32, which then phosphorylates MCM7, a licensing factor critical for DNA replication, at Y600 t

48 in the endocycle have reduced levels of the licensing factor Double Parked/Cdt1 (Dup/Cdt1), as well

49 inhibits the accumulation of the replication-licensing factor Doubleparked/Cdt1 (Dup/Cdt1).

50 s, nucleocytoplasmic compartmentalization of licensing factors ensures that DNA replication occurs on

51 ental observations suggest that AR becomes a licensing factor for DNA replication in AS prostate canc

52 in vivo, consistent with AR functioning as a licensing factor for DNA replication in AS prostate canc

53 regulator of G1-S progression and possibly a licensing factor for DNA replication yet the mechanisms

54 -S progression, possibly by functioning as a licensing factor for DNA replication.

55 al cells, in which AR does not function as a licensing factor for DNA replication.

56 nsor for siRNA thermodynamic asymmetry and a licensing factor for entry of authentic siRNAs into the

57 hen present on the chromatin, may serve as a licensing factor for estrogen-ESR1-mediated interactions

58 cus, the present results establish PTIP as a licensing factor for humoral immunity that acts at sever

59 se mutations in core domains of human origin licensing factors in a fully reconstituted in vitro MCM

60 MCM7 is one of the pivotal DNA replication licensing factors in controlling DNA synthesis and cell

61 Cdt1 DNA replication licensing factor is part of the pre-replication complex

62 covered a single phosphorylation site in the licensing factor M18BP1 and a cyclin A binding site in t

63 ) encodes a homologue of the DNA replication licensing factor Mcm7, a highly conserved protein found

64 in with hypomorphic expression of the origin licensing factor mini-chromosome maintenance (MCM)3 that

65 unreplicated from replicated DNA, as in the licensing factor model.

66 Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene e

67 easomal degradation of Cdt1 (DNA replication licensing factor), p21 (cyclin-dependent kinase [CDK] in

68 by depleting Cdt1, an essential replication licensing factor, partially rescued emi1 deficiency-indu

69 resence of a soluble form of the replication-licensing factor (RLF) Cdc6, inhibits initiation of cell

70 Replication licensing factor (RLF) is an essential initiation factor

71 Replication licensing factor (RLF) is involved in preventing re-repl

72 that prevent the association of replication licensing factor(s) with the DNA.

73 -activated JNK kinases and also for the Cdt1 licensing factor that ensures that DNA is replicated exa

74 As such, Htm1p-Pdi1p is suited to act as a licensing factor that monitors folding in the ER lumen a

75 s work alters our view of how ATP is used by licensing factors to assemble pre-RCs.

76 The enforced expression of these two licensing factors was sufficient to restore the assembly

77 ion (MBT), including a marked decline of the licensing factor XCdc6.