ライフサイエンスコーパス: licensing

1 Licensing consists of the loading of the hexameric MCM2-

2 Licensing is restricted to G1 phase of the cell cycle, b

3 Licensing of encapsulated MSCs with inflammatory cytokin

4 Licensing of eukaryotic origins of replication requires

5 -S progression, possibly by functioning as a licensing factor for DNA replication.

6 hen present on the chromatin, may serve as a licensing factor for estrogen-ESR1-mediated interactions

7 cus, the present results establish PTIP as a licensing factor for humoral immunity that acts at sever

8 As such, Htm1p-Pdi1p is suited to act as a licensing factor that monitors folding in the ER lumen a

9 l in which the cell cycle is controlled by a licensing process, the rate of which is related in a sim

10 This mutant Ly49A caused a licensing defect in NK cells, but the surface expression

11 o centrioles during anaphase is considered a licensing event for the next round of centriole duplicat

12 ), at Y32, which then phosphorylates MCM7, a licensing factor critical for DNA replication, at Y600 t

13 and inhibited by TCR-blockade, suggesting a licensing interaction involving the TCR and FcgammaR.

14 inhibition of mitosis coupled with aberrant licensing of S-phase entry.

15 tion necessary for Tcra locus accessibility, licensing mature thymocytes for trafficking and natural

16 Adaptive licensing for DR tuberculosis based on 2-month sputum cu

17 ed when analysing a longer time period after licensing.

18 Immunobridging studies allowed licensing of the vaccines for use starting at age 9 year

19 comply with the pertinent accreditation and licensing requirements.

20 ests globally, environmental assessments and licensing must considered both on- and off-lease sources

21 e varies according to their availability and licensing status.

22 ale usage maps can be used in consenting and licensing of anthropogenic developments to determine loc

23 ed an abbreviated pathway for developing and licensing biosimilar and interchangeable biological prod

24 creasingly reaching advanced development and licensing stages, providing new tools to fill previously

25 fficult, from the financing, development and licensing to programme implementation and public accepta

26 ecific department of motor vehicle (DMV) and licensing offices, where people register their vehicles

27 ng its transcription by recruiting HDAC1 and licensing the removal of activating histone acetylation

28 d IFN-gamma, accumulation of neutrophils and licensing and activation of other immune cell types in t

29 of tenure in the United States, patents, and licensing at universities, the current status of univers

30 examination, variation in state practice and licensing regulations, and issues surrounding the establ

31 S stimulation, and also in cross-priming and licensing cytotoxic T cell killers in vivo.

32 results in premature meiotic progression and licensing of homology-independent SC assembly.

33 we posit the need for medical societies and licensing boards to bring this issue to the forefront of

34 increasingly rigorous training, testing, and licensing processes introduced in top medical schools an

35 /f(-) was largely dependent on effective APC licensing via CD40 signaling.

36 MHC I also undergo education, referred to as licensing, which causes them to become more responsive t

37 activation events, a process referred to as licensing.

38 d target cell, a process that we refer to as licensing.

39 the weaker -Q(35) alleles, indicating better licensing of KIR2DL2/L3(+) NK cells with the stronger al

40 PV, detailed forecasting of tOPV needs, bOPV licensing, scaling up of bOPV production and procurement

41 infection with Staphylococcus aureus and, by licensing encephalitogenic Th17 cells, played a key role

42 cilitates restoration of genome integrity by licensing chromatin to concentrate genome caretaker prot

43 (+) T cells promote CD8(+) T cell priming by licensing dendritic cells (DCs) via CD40-CD154 interacti

44 rovide critical help within this process, by licensing dendritic cells to prime CD8Treg cells, howeve

45 nce (MCM) proteins facilitate replication by licensing origins and unwinding the DNA double strand.

46 Patients worldwide would be well served by licensing of new regimens for multidrug-resistant tuberc

47 s work alters our view of how ATP is used by licensing factors to assemble pre-RCs.

48 Under current Health Canada licensing requirements, a demonstration of bioequivalenc

49 triggers conformational changes in Cascade, licensing Cas3 to bind.

50 Furthermore, the timing of the CD4Treg licensing of dendritic cells and the spatial competition

51 ell interactions and CD40 signalling in cDC1 licensing.

52 , strongly supports the hypothesis that Cdt1 licensing activity is regulated by periodic interaction

53 ndent on CD154-CD40-dependent dendritic cell licensing and resulted in a greater recall capacity of I

54 s, such as STAT signaling and dendritic cell licensing throughout the splenic parenchyma.

55 with distinct affinities, affecting NK cell licensing and inhibition.

56 seemingly conflicting input affects NK cell licensing and repertoire formation in mixed hematopoieti

57 Furthermore, regulation by NK cell licensing helps to safeguard against TNFSF14 production

58 ) cells and specifically the role of NK cell licensing is not well understood in ESC rejection.

59 luated the effect of human and mouse NK cell licensing on early stages of natural cytotoxicity.

60 ested a role for cis interaction for NK cell licensing, adoptive NK cell transfer experiments support

61 is and in trans, are both needed for NK cell licensing.

62 tion by other receptors and of prior NK cell licensing.

63 ss to NK cells by a process known as NK cell licensing/education.

64 hich of these interactions regulates NK-cell licensing is not yet clear.

65 ed pulp of the spleen during induced NK-cell licensing, and there were no differences in maturation o

66 s I on hematopoietic cells regulates NK-cell licensing, which is not associated with other obvious ph

67 dominant role of GrB in pDC-dependent T cell licensing.

68 lated TCR-mediated activation of MAIT cells, licensing them to dramatically increase Th1 cytokines an

69 RING-E2 approximately UBL catalytic center, licensing the acceptor lysine, and influencing E2 reacti

70 gression trigger the initiation of centriole licensing through centriole disengagement, at which poin

71 t that MVt undergoes a conformational change licensing the formation of a protruding sub-domain incor

72 llular homolog [Myc], cyclin D1/3, chromatin licensing and DNA replication factor 1 [Cdt1]), concomit

73 tion of Aurora kinases A and B and chromatin licensing and DNA replication factor 1 may explain the r

74 plaque-associated immune cells, consequently licensing their phagocytic activity and promoting plaque

75 Thus, ER-mitochondria contacts coordinate licensing of mtDNA synthesis with division to distribute

76 to kinetochores, mitotic exit, cytokinesis, licensing of DNA replication by re-activating pre-replic

77 ow helicase activity is regulated during DNA licensing, with implications for cell cycle control of D

78 which together provide new insights into DNA licensing.

79 nisms that redefine our understanding of DNA licensing.

80 the association between ADHD and both driver licensing and crash involvement and whether it varies by

81 enagers; nevertheless, most Graduated Driver Licensing programs have provisions that require supervis

82 en linked with New Jersey's statewide driver licensing and crash databases for 2004 through 2014.

83 E, PsycINFO, AMED, PSYNDEX, websites of drug licensing agencies and pharmaceutical companies, and tri

84 As part of the drug licensing process for new CDI therapies, a pediatric inv

85 We therefore propose a "dual-licensing" model of centriole duplication, in which Asl

86 ate of protection of 0.35 mug/mL used during licensing.

87 This commentary discusses the early licensing and deployment of a COVID-19 vaccine and how a

88 t, inhibition of Kin28 attenuates elongation-licensing signals, resulting in Pol II accumulation at t

89 unknown and thus neglected in environmental licensing.

90 knowledge gap and impediment to the eventual licensing of new antiviral drugs and vaccines for NIRVs.

91 ues, whereas they are more likely to exhibit licensing when they think concretely about what they hav

92 roved training of staff and routine facility licensing inspections that scrutinize infection control

93 nd Drug Administration industry guidance for licensing of antidiabetic drugs greatly increased the nu

94 used to estimate adjusted hazard ratios for licensing and crash outcomes through age 25 years.

95 hus can be used without any requirements for licensing or software purchase.

96 India (DCGI), the Indian NRA responsible for licensing vaccines.

97 cial requirement of amino acid signaling for licensing and sustaining mTORC1 activation and functiona

98 ecule(s) restrict BCR signaling strength for licensing BCR-induced CSR and whether deficiency of such

99 while retaining subunits that maintain fork licensing and direct reassembly to the appropriate locat

100 The full licensing of replication origins in late G1 is normally

101 sruption of messenger RNA splicing; and (ii) licensing of expanded C9orf72 pre-messenger RNA for nucl

102 Impaired licensing of origins of replication during the G1 phase

103 egg extracts, Idas-Geminin is less active in licensing inhibition compared with a Geminin-Geminin hom

104 After this most recent change in licensing, we review the outcomes from clinical trials i

105 Geminin is thought to be involved in licensing replication by promoting the accumulation of C

106 ipated and novel requirement for CD200R1 in "licensing" pro-inflammatory functions of TLR2 and in lim

107 we review more recent developments including licensing of gene therapies, use of gene corrected autol

108 it (UreB) is required for NLRP3 inflammasome licensing.

109 is critical for NK-cell effector inhibition, licensing, and receptor repertoire development.

110 Since its initial licensing for use in adults and adolescents 12 years of

111 is presently limited in scale by interstate licensing restrictions and reimbursement barriers.

112 of geminin by DeltaCdt1_193-447, which lacks licensing activity and degradation sequences, causes cel

113 eins are loaded onto chromatin, with maximal licensing observed just prior to S phase onset.

114 Here, we uncover a novel mechanism licensing transcription in human mesenchymal stem cells

115 Mechanistically, licensing was largely imparted by changes in the posttra

116 We found that Ly49C-mediated licensing induced a split effect on NK cell functions, w

117 A new study suggests that small-RNA-mediated licensing of competitive interactions between transcript

118 x, age, medical school country, U.S. Medical Licensing Examination Step, and ABIM Internal Medicine C

119 status and were obtained from state medical licensing board sites and online medical facility and pr

120 h ABSITE scores: prior United States Medical Licensing Examination (USMLE) 1 and 2 scores (per 1-poin

121 IDSA ITE scores, prior United States Medical Licensing Examination (USMLE) scores, ABIM Internal Medi

122 r variables, including United States Medical Licensing Examination (USMLE) Step 1 score, Alpha Omega

123 were pass rates on the United States Medical Licensing Examination (USMLE) Step examinations and grad

124 d significantly higher United States Medical Licensing Examination scores (mean [SD] step 1 score, 23

125 Men had higher United States Medical Licensing Examination Step 1 scores (238.0 vs 230.1; P <

126 tion included a PGY-2, United States Medical Licensing Examination step 2 score, year 1 American Boar

127 Average US Medical Licensing Examination Step 1 scores were 239 +/- 14 and

128 We postulate that metabolic licensing of histone acetylation provides another layer

129 without inhibitory receptors for self-MHC ("licensing").

130 In cancer models, licensing of gammadelta T cells by tumor-reactive mAbs p

131 evidence for both moral contagion and moral licensing.

132 tion by their target Ag and a process named "licensing." In this study, we analyzed these processes i

133 accepted scored higher on Canadian national licensing examinations.

134 In conclusion, NK licensing mediated by KIR2DL2/3 and HLA-C1 elicits a nov

135 a neutralization resulted in detection of NK licensing effects.

136 Thus, NK licensing behavior to MCMV corresponds to the donor, and

137 by Cdc6 is required to release nonproductive licensing intermediates.

138 The absence of licensing is assumed to explain the block to DNA replica

139 essively to ensure that the disappearance of licensing inhibitors coincides exactly with a peak of Cd

140 The effect of licensing increased over time, and was largest in the se

141 This study unravels multifaceted effects of licensing on NK cell populations and their functions.

142 o confirmation of the physiologic effects of licensing with differential effects of NK subsets on ant

143 This evidence supports the expansion of licensing strategies to include more countries and more

144 transgenic mice to investigate the impact of licensing through this inhibitory receptor in precursor

145 ity theory by treating the implementation of Licensing Act (2003) as a natural experiment in alcohol

146 DNA rereplication can be induced by loss of licensing control at cellular replication origins, or by

147 ify Bmh1 as a key player in the mechanism of licensing of chromosome compaction in mitosis.

148 d autoreactive T cells required a process of licensing in the lung revealed an unexpected relationshi

149 rticipation in WHO-convened joint reviews of licensing dossiers, as well as pragmatic application of

150 function is better characterized in terms of licensing inferences to opaque generic content than in t

151 hat naive CD8(+) T cells remain dependent on licensing by APCs and CD4(+) T cells, and it may therefo

152 n of graft survival, a function dependent on licensing by gut microflora.

153 s collected before and during the 4-year OPO licensing office contract.

154 etimes it liberates them to do the opposite (licensing)?

155 al NK cell repertoire, known as education or licensing, is a complex process mediated through inhibit

156 ynamic process known as NK cell education or licensing.

157 al requirements both before and after origin licensing.

158 rmally high levels of replication and origin licensing factors and are likely poised for genome re-re

159 d onto DNA in G1-phase (also known as origin licensing).

160 gins to prepare for S phase, known as origin licensing.

161 These sites are selected by origin licensing, during which the core enzyme of the eukaryoti

162 M loading with a severely compromised origin licensing checkpoint.

163 A p53-dependent origin licensing checkpoint normally ensures sufficient MCM loa

164 ccharomyces cerevisiae by deregulated origin licensing is non-random and defined by broad domains tha

165 ltransferases may be recruited during origin licensing.

166 e in ATP hydrolysis are competent for origin licensing.

167 of the DNA sequence requirements for origin licensing.

168 itive to replication stress, and full origin licensing ensures their correct differentiation and func

169 replication, suggesting increment in origin licensing and re-replication.

170 some maintenance (MCM)3 that limiting origin licensing in vivo affects the functionality of hematopoi

171 However, the mechanisms of origin licensing and helicase activation are poorly understood.

172 While the biochemistry of origin licensing is understood, the mechanisms that promote an

173 Thus, Sir2-mediated attenuation of origin licensing within both euchromatin and telomeric heteroch

174 dings elucidate dynamic mechanisms of origin licensing, and identify the transition between initial D

175 y promotes bud formation and prevents origin licensing so that DNA cannot rereplicate between bud for

176 Thus, rapid origin licensing is an intrinsic characteristic of stem cells t

177 The separation of DNA replication origin licensing and activation in the cell cycle is essential

178 signaling may control DNA replication origin licensing and replisome stability thereby cell cycle pro

179 xpected to compromise DNA replication origin licensing and result in elevated rates of genome damage

180 o be achieved by limiting replication origin licensing and thereby restricting the firing of each rep

181 ouble hexamers during DNA replication origin licensing is crucial for ensuring once-per-cell-cycle DN

182 proteins involved in DNA replication origin licensing may explain the deleterious consequences of CS

183 essential for eukaryotic replication origin licensing, however, it is poorly understood how CDC6 act

184 origins, an essential process termed origin licensing.

185 in with hypomorphic expression of the origin licensing factor mini-chromosome maintenance (MCM)3 that

186 egulate the G1/S transition after the origin licensing is complete.

187 This origin licensing requires loading two Mcm2-7 helicases around o

188 n timing can be reset subsequently to origin licensing.

189 but the molecular mechanism of this origin 'licensing' is still poorly understood.

190 Knockdown of the replication origin-licensing factor CDT1 eliminates both stress-induced rer

191 terms, and we have added a statement to our licensing policy stipulating that anyone, including comm

192 ould expand their criteria to treat patents, licensing, and commercialization activity by faculty as

193 European Medicines Agency recommended a post-licensing study assessing the cardiovascular safety of f

194 ddressed, as well as current practice in pre-licensing trials, the increasing problems of polypharmac

195 DNA replication depends on a preceding licensing event by Cdt1 and Cdc6.

196 ists, tax and real estate data, professional licensing lists, and ancestry websites, and exposure mea

197 tion that invokes a mechanism we term quorum licensing.

198 Rapid licensing in stem cells is caused by accumulation of the

199 ponsiveness of activating NK cell receptors (licensing) and modifies the repertoire of MHC-I receptor

200 ngements and non-participation in reciprocal licensing networks.

201 Therefore, MHC polymorphism regulates licensing and detection of viral targets by distinct sub

202 because of availability, cost, or regulatory licensing.

203 Barriers include reimbursement, licensing, and fear of litigation.

204 s during G1 phase, suggestive of reiterative licensing.

205 nsation, DNA damage response and replication licensing.

206 activation defects, differential replication licensing or X versus Y chromosome size, but rather to '

207 BO1) plays a crucial role in DNA replication licensing and cell proliferation, yet its molecular regu

208 dramatically decreased MCM7 DNA replication licensing and induced cell growth arrest.

209 is an essential component of DNA replication licensing complex.

210 to chromatin and upregulates DNA replication licensing factor CDC6.

211 h predominantly inhibits the DNA replication licensing factor Cdt1, preventing genome over-replicatio

212 Cdt1 DNA replication licensing factor is part of the pre-replication complex

213 easomal degradation of Cdt1 (DNA replication licensing factor), p21 (cyclin-dependent kinase [CDK] in

214 MCM7 is one of the pivotal DNA replication licensing factors in controlling DNA synthesis and cell

215 DNA replication licensing is now understood to be the pathway that leads

216 , but its role in regulating DNA replication licensing is unclear.

217 t does not bind RACK1 has no DNA replication licensing or oncogenic transformation activity.

218 teins play critical roles in DNA replication licensing, initiation and elongation.

219 complex), which mediates pre-DNA replication licensing--contains a bromo adjacent homology (BAH) doma

220 by depleting Cdt1, an essential replication licensing factor, partially rescued emi1 deficiency-indu

221 DT2 targets proteins involved in replication licensing (CDT1), cell cycle control (p21), and chromati

222 the first comprehensive view of replication licensing in vivo, using video microscopy of Caenorhabdi

223 g DNA rereplication upon loss of replication licensing through the activation of the S-phase checkpoi

224 latory mechanisms of prokaryotic replication licensing.

225 l cycle progression that targets replication licensing factors, also targets the p12 subunit of Pol d

226 The replication licensing factor CDC6 recruits the MCM2-7 replicative he

227 ex genotype group is a defective replication-licensing complex.

228 ene proximity relies on both DNA replication-licensing and actual DNA replication activity.

229 e (Mcm) proteins are part of the replication-licensing complex that is loaded onto chromatin during t

230 MAPC suppression required licensing and proceeded via IDO-mediated tryptophan cata

231 ologic activity may not be innate, requiring licensing by their microenvironment.

232 ained hidden behind proprietary, restrictive licensing agreements, which raises barriers to entry for

233 sh involvement and whether it varies by sex, licensing age, and/or being prescribed ADHD medication a

234 (95% CI, 1.25-1.48) and did not vary by sex, licensing age, or over time.

235 ting public access, the new policies specify licensing terms for reuse of content by third parties, i

236 ll, and no ambiguity was found about states' licensing powers.

237 ability to study NK cells with synchronized licensing.

238 tor function by an education process termed "licensing" mediated by inhibitory Ly49 receptors which r

239 ompetence through an unclear process termed "licensing." Ly49C is the main self-specific inhibitory L

240 Thus, we demonstrated that licensing of dysbiotic microbiota is a critical componen

241 Importantly, we found that licensing of cytokine production was mediated by paracri

242 ystem of mouse CMV infection, indicated that licensing did not play a major role in the NK cell antiv

243 lication cycle, raising the possibility that licensing of centrosome duplication occurs by modulating

244 The licensing of direct-acting antivirals heralds a new era

245 The licensing of herpes zoster vaccine has demonstrated that

246 The licensing of ipilimumab and sipuleucel-T for cancer, and

247 Compared with individuals without ADHD, the licensing probability of individuals with ADHD 6 months

248 igins in late G1 is normally enforced by the licensing checkpoint.

249 gainst replicative stress is provided by the licensing of thousands of origins in G1 that are not nec

250 population of NK cells as determined by the licensing patterns of donor MHC-I haplotypes, resulted i

251 Sfi1 C-terminal (Sfi1-CT) dimerization, the licensing step for SPB duplication.

252 of protection of 0.35 mug/mL has enabled the licensing of effective new PCVs, serotype-specific corre

253 lizing drug activity, and would expedite the licensing of new treatment regimens.

254 empt to subvert this block by expressing the licensing control factors Cdc18 and Cdt1 during the inte

255 Following the licensing of an injectable vaccine, we consider the rela

256 covered a single phosphorylation site in the licensing factor M18BP1 and a cyclin A binding site in t

257 well as de novo stabilizing mutations in the licensing inhibitor, GMNN, cause MGS.

258 cells and HLA-DQ8 have a crucial role in the licensing of cytotoxic T cells to mediate intestinal epi

259 ctive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intesti

260 These steps include the licensing of DCs by the microbiota, their activation and

261 ion (MBT), including a marked decline of the licensing factor XCdc6.

262 its known functions in the regulation of the licensing of replication origins and expanding the scope

263 y the helper macrophages, reminiscent of the licensing role of helper T cells in antiviral adaptive i

264 atin during G1 phase and is dependent on the licensing factor Cdt1.

265 f proinflammatory conditions to override the licensing mechanism.

266 ng IL-18-mediated inflammation overrides the licensing function of neutrophils, instead inducing iNKT

267 Analysis found no evidence that the Licensing Act (2003) affected the overall volume of viol

268 UBXN-3/FAF1 binds to the licensing factor CDT-1 and additional ubiquitylated prot

269 eatments can be found to either speed up the licensing process, or increase the spatial competitivene

270 Geminin interacts with the licensing factor Cdt1 to prevent untimely replication an

271 In this study, we show that the "licensing" of NK cells, determined by the presence of KI

272 ent long-range resection altogether, thereby licensing NHEJ at collapsed forks.

273 all expected value of control (EVC), thereby licensing the associated cognitive effort.

274 spase-8-dependent cleavage of N4BP1, thereby licensing TRIF-independent TLRs to produce higher levels

275 sequence site on the CTLA4 promoter, thereby licensing CBP/p300-mediated histone acetylation and loca

276 11 endonuclease initiates resection, thereby licensing HR followed by MRE11 exonuclease and EXO1/BLM

277 er its interaction with mature TACE, thereby licensing its proteolytic activity.

278 This licensing mechanism enables the cell to discriminate chr

279 , mediating protective immunity both through licensing of cellular effectors of the innate immune sys

280 induction of oral tolerance to DNFB through licensing tolerogenic gut DCs.

281 diminishes its interaction with STING, thus licensing an IFN-I response.

282 Thus, licensing controls signals as proximal as inside-out sig

283 ient peripheral T cells have a defect in TNF licensing after TCR/CD28 stimulation.

284 igen and prime CD8 T cells after exposure to licensing stimuli, such as an agonistic anti-CD40 antibo

285 Loss of 53BP1 caused hypersensitivity to licensing inhibition when replication origins were remov

286 improvements in overall survival leading to licensing for the treatment of metastatic castration-res

287 03 and December 2004 prospectively linked to licensing and police-reported crash data, with an averag

288 nd whether the drugs prescribed reflected UK licensing and guidelines.

289 In all, tested organs donor cells undergo "licensing" for pathogenicity, consisting of vigorous inc

290 induced CD8(+) memory T-cell expansions upon licensing by CD4(+) T cells, and primed naive CD8(+) T c

291 re on moderators of moral consistency versus licensing effects using five conceptual themes: construa

292 loading in live human cells using an in vivo licensing assay on the basis of fluorescence recovery af

293 Voluntary licensing initiatives appear to substantially improve HC

294 untries, to identify the effect of voluntary licensing agreements on treatment uptake.

295 ered and selective introduction of voluntary licensing in different countries, to identify the effect

296 the notion that the lung is the organ where "licensing" for pathogenicity takes place is based on bia

297 the notion that the lung is the organ where "licensing" takes place.

298 onut" designs), leaving it ambiguous whether licensing was observed.

299 ility of binding to self-MHC consistent with licensing.

300 SU1 and pPSU2 plasmids are available without licensing restrictions to nonprofit academic users, affo