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1 breaks in aged animals near the end of their life span.
2 the offspring with low FM and FO diets along life span.
3 mphasis on maintaining health throughout the life span.
4 mitigate adverse health outcomes across the life span.
5 one gene expression and extend chronological life span.
6 ze, and body-composition outcomes across the life span.
7 n and retention of complex skills across the life span.
8 and regulators of neutrophil recruitment and life span.
9 ositive, affiliative interactions over their life span.
10 th alone, is a powerful predictor of species life span.
11 ramework for enhancing resilience across the life span.
12 nce health and disease prevention across the life span.
13 scription and maintains normal chronological life span.
14 validation for continuity of PLEs across the life span.
15 ultiple mouse models, prolonging the healthy life span.
16 of aging-associated phenotypes and extended life span.
17 reasing histone supply extends chronological life span.
18 fective erythropoiesis and RBCs with a short life span.
19 per second for the duration of the sensors' life span.
20 life adversity and sleep quality across the life span.
21 itical role in homeostasis, health span, and life span.
22 DENV transmission and shortens the mosquito life span.
23 escence are a general determinant of species life span.
24 5% confidence interval, 11.9 to 18.0) longer life span.
25 exposed biology" consequential to the entire life span.
26 genous bacteria impacts organismal aging and life span.
27 ance (IR) adversely affects human health and life span.
28 PR(ER) decline with age, and increases adult life span.
29 improves cardiac function and increases mice life span.
30 ress responsivity and anxiety throughout the life span.
31 al senescence, resulting in reduced residual life span.
32 f temporally controlled strategies to extend life span.
33 cessfully, but experience a relatively short life span.
34 ity of recruitment and extended reproductive life span.
35 ning is correlated with reduced survival and life span.
36 o lower chronic disease incidence and longer life span.
37 r function with an unprecedented increase in life span.
38 ta plays a key role in modulating vertebrate life span.
39 to 30% in women and 15% in men during their life span.
40 rochromatin silencing loss regulate cellular life span.
41 cing or sustained loss of silencing shortens life span.
42 gut motility, feeding defects, and decreased life span.
43 hip among oxidative stress, health span, and life span.
44 ar)3-9 or Dicer-2 also led to an increase in life span.
45 o optic and peripheral neuropathy across the life span.
46 ession led to increased cellular replicative life span.
47 ease prevention and the extension of healthy life span.
48 h leads to reduced body weight and shortened life span.
49 undergo senescence independent of organismal life span.
50 rt rate is a heritable trait correlated with life span.
51 ill be available to support the reproductive life span.
52 ded SOD1 levels and significant extension of life span.
53 o overt morphologic phenotype throughout the life span.
54 petence and developmental changes across the life span.
55 composition in all brain regions across the life span.
56 ators for human clinical outcomes and health/life span.
57 s a wide range of stressors to TL across the life span.
58 translatome of mouse tissues over the entire life span.
59 xposure to psychosocial stressors across the life span.
60 or high-risk HPV18 E7 to extend keratinocyte life span.
61 expression of CyTP genes, ensuring extended life span.
62 agonistic functions on energy metabolism and life span.
63 ion, resulted in significantly longer filter life span.
64 nd promotion of wellness in women across the life span.
65 tite system jointly determines longevity and life span.
66 ageing and because of its minimal impact on life span.
67 tigation of reproductive effort and residual life span.
68 t may be acquired at different points in the life span.
69 for subsequent adult growth, fertility, and life span.
70 for the acute loss of Lkb1 and extend mouse life span.
71 nt and MC-associated disease risk across the life span.
72 uilibrium state characterized by an extended life span.
73 demiological and clinical studies across the life-span.
74 integrity and consequently limiting the host life-span.
75 ulmonary complications, resulting in shorter life-span.
76 we consider developmental change across the life-span.
77 e span, the 9H;C* and 4L;C* mice had shorter life spans.
78 ing phase that largely determine their final life spans.
79 ated hearts and showed significantly shorter life spans.
80 ng processes and extends average and maximal life spans.
81 ree different measures of the variability of life spans.
82 ered from high-dose radiation to live normal life spans.
83 ticipants (humans), sampled across the adult life span (20-89 years), to reveal that RSFC-based netwo
84 roup of individuals sampled across the adult life span (20-89 years), we measured correlations at res
85 on (DR), which positively affects health and life span across species, leads to metabolic reprogrammi
87 on key indicators of arthropathy across the life-span among participants with severe hemophilia A.
91 re the magnitude and drivers of variation in life span and examine the mechanisms enabling peculiar m
93 ated rNMPs on mtDNA stability over the mouse life span and found that the mtDNA rNMP content increase
94 r higher optimism was associated with longer life span and greater likelihood of exceptional longevit
99 essing the relationship between reproductive life span and later inflammatory profiles, Huang et al.
101 and the balance of macronutrients determine life span and patterns of age-specific mortality (ASM).
102 acid (OA), substantially mitigates the short life span and proteotoxicity in mdt-15(-) animals at low
103 he connection between AD risk factors across life span and provide mechanistic insight to the process
104 striction has been associated with increased life span and reduced aging-related disorders and reduce
107 ts implicate novel candidate genes affecting life span and suggest that variation for life span may b
108 A of infrastructures or products with a long life span and tangible water use during use or end-of-li
109 he interplay between V(c,max) at maturation, life span and the decline in photosynthetic capacity wit
110 larly challenging to model, due to its short life span and the dispersive effects of constant water m
112 a cell census of the human thymus across the life span and to reconstruct T cell differentiation traj
113 educed CD47 surface expression and a reduced life span and were phagocytosed in the liver of infected
114 ingly, mice heterozygous in Fdxr had a short life span and were prone to spontaneous tumors and liver
115 using RNA interference (RNAi): all affected life span and/or micro-environmental variance of life sp
116 cies (birds and mammals) with very different life spans and body sizes, including mouse (Mus musculus
117 f how telomere dynamics vary over individual life spans and cohorts, and with spatio-temporal variati
119 uggle with motor difficulties throughout the life span, and these motor difficulties may affect indep
120 that the testing effect decreases across the life span, and they suggest that changes in alpha-beta o
122 nd environmental interventions that modulate life-span, and operates across species as distant as hum
124 phrocyte functional impairment and shortened life span, as well as collapse of nephrocyte lacunar cha
125 failure time models to assess differences in life span associated with optimism; models adjusted for
126 spect to development, 2) the time across the life span at which effects are measured, and 3) the beha
127 ost of developmental disabilities across the life span, better methods are needed to detect the risk
128 nt stomatal conductance, leaf sizes and stem life span between dominant clades would have shifted the
129 Significant differences were observed in life span between genders, where females survived longer
131 using a conditional knockout did not affect life span but impaired synaptic plasticity and memory.
132 ical trials suggests the ability to increase life span by 1-5 years with an improvement in health spa
133 dentify pathways that regulate chronological life span by controlling intracellular histone levels.
135 mouse models of late-onset HPP with extended life spans by engineering a floxed Alpl allele, allowing
136 aning (1.2 x 1012GC), exhibited an increased life span, characterized by delayed weight loss and dimi
138 trait loci (QTLs) that control chronological life span (CLS) in calorie-rich and calorie-restricted e
143 cued from autoinflammation and have improved life span compared with Stat1(+/-)Pdgfrb(+/D849V) mice.
145 reased retrieval practice effects across the life span contribute to, and may reflect, age-related de
147 ergo productive Ag encounter and have finite life spans dependent on survival signals propagated by t
150 those: increasing organism body size and/or life span, disrupting processes within the organism, and
151 ging is a global burden, and the increase in life span does not increase in parallel with health span
152 ange in sexual function during an individual life span driven by environmental cues - is an exceeding
153 DR), that has a conserved positive effect on life span, employs this mechanism of ER hormesis for lon
154 ate that both changes in life expectancy and life span equality are weighted totals of rates of progr
157 fying framework to study life expectancy and life span equality over time, relying on concepts about
158 mic relationship between life expectancy and life span equality with reliable data from the Human Mor
159 ons to the joint rise of life expectancy and life span equality, however, make it difficult to determ
161 ns in mortality increase life expectancy and life span equality: the more progress at the youngest ag
162 s, the longest living rodent, with a maximum life span exceeding 30 years, and found that injury resp
163 which likely contributes to the health- and life-span extending effect of IIS pathway downregulation
166 Cas9 knockout of PTPN14 rescued keratinocyte life span extension in the presence of the PTPN14 bindin
169 collected fine structural information on the life span, formation, and disappearance of LSEC fenestra
170 rsors and maintain it unchanged during their life span, gene expression profiling at the time of an a
171 ing in Neighborhoods of Diversity across the Life Span (HANDLS) study [2004-2013, Age(base):30-64 y,
174 eas heterozygous knock-in mice have a normal life span, homozygous animals die at 3 months of age bec
175 hey have to persist throughout an organism's life span, HSCs tightly regulate the balance between pro
177 own about the inter-specific distribution of life span in a wide diversity of vertebrates and in adul
178 span and/or micro-environmental variance of life span in at least one sex and environment and exhibi
180 t of astrocyte-like glia, which extended the life span in Caenorhabditis elegans Glial XBP-1s initiat
181 Here we show that RAGE exhibits an extended life span in lung epithelia (t(1/2) 6 h), is monoubiquit
187 span and the micro-environmental variance of life span in the DGRP revealed significant genetic varia
188 all cases, whether for maximum known in situ life span in the soil seed bank (417 species), or for ha
189 Calorie restriction and rapamycin extended life span in virtually all genotypes but through differe
190 ritical length can trigger aging and shorter life spans in mice and humans by a mechanism that involv
191 n vertebrates, and usually result in shorter life spans in the larger sex, although the underlying me
192 eterious environmental events throughout the life span, including gestational and early life insults.
193 allenges in research on women's reproductive life spans, including how to appropriately capture lifet
194 perature or added oxidant concentration, and life span increases in mutants having more chaperones or
195 activity was not compensated for by reduced life span, indicating that increased daylength leads to
198 erstanding the genetic basis of variation in life span is a major challenge that is difficult to addr
200 ng cycling is efficiently suppressed and the life span is significantly prolonged (three times longer
202 seeds of > 50% of species are likely to have life spans <= 20% of the longest recorded under the same
203 ing life span and suggest that variation for life span may be maintained by variable allelic effects
204 ms for stress risk and resilience across the life span must consider the nature and timing of stress
205 unmet needs, which include normalization of life span (myelofibrosis and some patients with PV), red
209 We used this model to project the effective life span of antibiotics and the number of gonorrhea cas
211 , this strategy could increase the effective life span of antibiotics by 0.94 years, which is equival
213 Compared with Atg7 (Delta/Delta) mice, the life span of Atg7 (Delta/Delta) p53 (Delta/Delta) mice w
218 h of cytopathic RNA viruses by extending the life span of infected cells, which serve as the replicat
220 proved the quality of life and increased the life span of many HIV-infected individuals, this therape
222 ngevity as no difference was observed in the life span of mosquitoes with different genotypes (chi(2)
223 ic restriction (CR) improves health span and life span of organisms ranging from yeast to mammals.
224 that knockin mutant p53-R270H shortened the life span of p73 (+/-) mice and subjected TAp63 (+/-) or
226 d that the ability of HPV18 E7 to extend the life span of primary human keratinocytes required PTPN14
229 severely affect development, locomotion, and life span of the animal and disrupt the distribution and
231 the forebrain than the hindbrain across the life span of the Tg mice, suggesting that sortilin, at l
233 In contrast, dCMP+dTMP+THU therapy decreased life span of Tk2(-/-) animals compared to dCMP+dTMP.
234 thymidine monophosphate (dTMP), prolongs the life span of Tk2-deficient (Tk2(-/-) ) mice by 2- to 3-f
235 that dC+dT delayed disease onset, prolonged life span of Tk2-deficient mice and restored mtDNA copy
239 infected butterflies, they also reduced the life span of uninfected butterflies, resulting in a hump
240 t of alternative strategies on the effective life spans of antibiotics and the overall burden of gono
245 d cells, HCMV must subvert the natural short life-span of these blood cells by inducing a distinct ac
246 easures, not even crude ones such as maximum life span or typical litter/clutch size, for 65% of thre
247 ts, on subjects at different ages across the life span, or on temporal trajectories of phenotypes aft
249 timing are associated with a longer parental life span (P 6.2 x 10-6 for fathers and P 2.0 x 10-3 for
250 normous health benefits, including increased life span, protection against age-associated disorders,
251 ften limiting and/or troublesome (i.e. short life-span reduced metabolic activity, lacking important
252 by a bottom-up approach showed higher blood life span, reduced tumor growth and higher tolerance in
256 R; Heterocephalus glaber) exhibits prolonged life span relative to its body size, is unusually cancer
257 owever, strategies to extend health span and life span require understanding of interindividual diffe
258 es that women who have a longer reproductive life span-roughly determined as the period from menarche
259 similar exposures in the home, have shorter life spans, share many clinical/biological features, and
262 norhabditis elegans that show the following: Life span shortens nonlinearly with increased temperatur
263 of health and economic advantages across the life-span should be dynamically integrated to better und
264 tential distribution, small size and limited life span, such sites are hard to find and characterize,
265 ally, genetic ablation of MFS2 increased fly life span, suggesting that Malpighian tubule stones are
266 rates, despite their small numbers and short life span, suggesting that they have beneficial roles in
267 Lamin C, albeit promoting obesity, increases life span, suggesting that this isoform is crucial for m
268 e with an SHP2 inhibitor and found increased life span, suppressed crescentic glomerulonephritis, red
269 accumulate harmful modifications over their life span that render them prone to aggregation, which,
270 We found a threefold geographic variation in life span that was strongly linked to temperature, but n
272 H and 4L mice that have normal histology and life span, the 9H;C* and 4L;C* mice had shorter life spa
277 in adult mice causes liver damage, shortens life span to 3 mo due to neurodegeneration, and is letha
278 emantic changes that happen during the adult life span to uncover the structure of the mental lexicon
280 ecture of the brain potentially accounts for life-span transitions in intellectual ability, memory, a
281 not for seeds, yet the functional trait seed life span underpins global agriculture, plant species co
282 oup vs systemic heparin group, median filter life span was 47 hours (interquartile range [IQR], 19-70
284 ng rates of cell birth and growth across the life span, we estimate that adult neurogenesis ultimatel
288 tream (tPA-MG53) have a healthier and longer life-span when compared with littermate wild type mice.
289 illations are altered over the course of the life span, which could contribute to hippocampus-depende
291 that alleles affecting natural variation in life span will have properties that enable them to persi
292 ing memory, WM) tends to decrease across the life span with large inter-individual variability; the u
293 hensive atlas of the human thymus across the life span with new insights into human T cell developmen
294 invading S. aureus, yet they have a limited life span with replacement by bone marrow derived monocy
295 eemingly incongruent combination of extended life spans with high mortality rates was enabled by coex
296 to mutant knockin LRRK2 mice over half their life span, with observable and measurable phenotype, is
298 ficiency virus (HIV) to live a near expected life span, without progressing to AIDS or transmitting H
299 interactions of space and number through the life span, yet propose a theory with several weaknesses.
300 th excitatory/inhibitory imbalance and short life-span, yielded a remarkable survival benefit when br