ライフサイエンスコーパス: life stress

1 behavioral and neural consequences of early-life stress.

2 r guardians to collect data about cumulative life stress.

3 amily history who reported relatively severe life stress.

4 compared with subjects with moderate or low life stress.

5 ctivation in the hippocampus following early-life stress.

6 biological systems and increased exposure to life stress.

7 oupled with heightened experience of chronic life stress.

8 were present at baseline and following early-life stress.

9 gdala circuitry and function following early-life stress.

10 haps dose-dependent, relationship with early-life stress.

11 in the hippocampus of pups exposed to early life stress.

12 f the altered programming triggered by early life stress.

13 he pathological programming induced by early-life stress.

14 athological modifications triggered by early-life stress.

15 rect the "anxious phenotype" caused by early life stress.

16 embles that seen in animals exposed to early life stress.

17 be heightened in the context of more recent life stress.

18 ognitive deficits that can result from early life stress.

19 deficits in subjects with a history of early life stress.

20 cognitive impairments associated with early-life stress.

21 ed corticolimbic dysfunction caused by early life stress.

22 at which macaque infants experience an early-life stress.

23 behaviour associated with exposure to early-life stress.

24 ated with depression severity, but not early life stress.

25 ts with major depression and increased early life stress.

26 ychopathological conditions related to early-life stress.

27 raits, (4) social isolation, and (5) chronic life stress.

28 memory generalisation associated with early-life stress.

29 o become hyperactive immediately after early life stress.

30 fest as behavioural deficits following early-life stress.

31 lience by comparing varying "doses" of early life stress.

32 Cognitive Status and estimated increases in life stress.

33 ility in adolescents with a history of early life stress.

34 may buffer against depressogenic effects of life stress.

35 , or resembled patterns seen following early-life stress.

36 stress exposure and not by current levels of life stress.

37 overexpression reverses the effects of early life stress.

38 individuals also reporting higher levels of life stress.

39 articularly in cases linked to chronic early-life stress.

40 In the CNS, early-life stress (1) decreased 2-arachidonoyl glycerol and ar

41 in two samples that experienced substantial life stress: 1,011 first-year training physicians (inter

42 n mice (1) during development to model early-life stress, (2) in adulthood to model adult-onset stres

43 ient had major psychosocial impairment, high life stress, a low visceral pain threshold, and activati

44 ffect was abolished in mice exposed to early life stress, a prominent risk factor for developing adul

45 ession, which commonly arise following early life stress / adversity (ELA).

46 sure in humans to examine whether cumulative life stress affected brain morphometry and one type of e

47 atment of adult BALB/c mice exposed to early life stress affected neither their behavioral responses

48 Life stress also differentially affected, as a function

49 and nonenriched BALB/c mice exposed to early life stress also exhibited significantly increased expre

50 Accumulation of early life stress also increased the levels of late-adulthood

51 Because both this polymorphism and early-life stress alter serotonin levels, our findings support

52 therefore chose to investigate whether early life stress altered Line1 retrotransposition persists in

53 (MS) model of depression to study how early life stress alters LHb physiology and depressive behavio

54 s, and in female macaques, exposure to early-life stress alters LHPA-axis activation in response to a

55 ationships between multiple sources of early life stress and adult immune function in humans across s

56 on of a link between major depression, early life stress and adverse health outcomes in diseases asso

57 ered within the Htr2a gene promoter by early life stress and biological sex, and increased 6 mA is as

58 tor isoform are more resilient to both early-life stress and chronic psychosocial stress in adulthood

59 ronal activity as a critical target of early-life stress and demonstrate its function in controlling

60 ossible to model this relation between early life stress and depression in the rat through maternal d

61 s have revealed links between prenatal/early-life stress and elevated morbidity and risks of mortalit

62 Early-life stress and exposure to stressful stimuli play a maj

63 disrupted in individuals with PTSD and early-life stress and hence may mediate the effects of early-l

64 mptoms, parental depression, body fat, while life stress and household income have weak direct effect

65 jor depression patients with increased early life stress and independently correlated with depression

66 , this longitudinal study investigated early life stress and inherited variation in monkey hippocampa

67 Sustained life stress and low socioeconomic status are among the m

68 ween the neurobiological correlates of early-life stress and of inflammation.

69 ductions in PA that may occur in the wake of life stress and possibly vulnerability to depression pre

70 iduals' social isolation responses to recent life stress and potential severe pandemics.

71 Finally, we show that early life stress and psychopathology are each associated with

72 f the pathological phenotype caused by early life stress and represents an attractive pharmacological

73 t for a nonlinear relationship between early life stress and resilience by comparing varying "doses"

74 d structural), genotyping, and self-reported life stress and rumination.

75 C model revealed that both exposure to early-life stress and sociodemographic variables predicted the

76 in brain structure revealed that cumulative life stress and spatial working memory were related to s

77 unted for the association between cumulative life stress and spatial working memory.

78 Evidence supports the notion that early-life stress and trauma impact cortical development and i

79 ation of mitochondrial biogenesis with early life stress and with anxiety and substance use disorders

80 that are thought to be potentiated by early life stress and worsened by repeated depressive episodes

81 ce abuse conditions, health behavior change, life stresses and crises, and stress-related physical sy

82 measure generic and food specific quality of life, stress and anxiety prior to challenge, on the day

83 present clinical disorder, early and recent life stress, and anxiety symptoms, as well as the intera

84 ditional measures of disease activity, pain, life stress, and coping were collected for use in multip

85 ed hippocampal function resulting from early life stress, and due to multiple benefits (low cost, few

86 oid vulnerability hypothesis linked to early life stress, and epigenetic and genetic susceptibility m

87 ironmental factors such as microbiota, early life stress, and maternal immune activation can dysregul

88 diagnoses, including psychological distress, life stress, and well-being.

89 ast some of the behavioral sequelae of early life stress are mediated by reduced expression of LBP du

90 ions between VS activity and early or recent life stress as covariates.

91 ed if 6 mA is present and regulated by early life stress associated with predator odor exposure (POE)

92 and provide mechanistic links between early-life stress, astrocyte hypofunction, and behavioural def

93 Genetic inheritance and developmental life stress both contribute to major depressive disorder

94 adult-knockdown of Otx2 in VTA mimics early life stress by increasing stress susceptibility, whereas

95 Early life stress can disrupt development and negatively impac

96 These findings indicate that chronic early life stress can disrupt maturation of the gamma oscillat

97 Early-life stress can have lifelong consequences, enhancing st

98 These findings illustrate that early life stress can indeed affect specific cognitive functio

99 est a developmental mechanism by which early life stress can induce long-term changes in hippocampal

100 Together, these findings highlight how early-life stress can lead to altered brain circuitry and emot

101 pose that the psychoneuroimmunology of early-life stress can offer an innovative framework to underst

102 Early life stress can result in depression in humans and depre

103 In animals, early-life stress can result in programmed changes in gene exp

104 turbations during development, such as early-life stress, can also become encoded in the epigenome.

105 Accumulation of daily life stress (chronic stress) often causes functional gas

106 act of transcriptomic dysregulation on early-life stress, chronic stress, and transgenerational impac

107 tic brain injury, general and mental health, life stress, concussion symptoms, cognitive function, di

108 Thus, early-life stress could constitute a 'double-edged sword': mil

109 ical health status, early-life and perceived life stress, current animal contact, and subjective stra

110 Recent life stress, current depressive symptoms, and PA were as

111 We discovered that early-life stress decreases the activity of a specific class o

112 after stress exposure, suggesting that early life stress delays DG development.

113 e disorder and depressed women without early life stress demonstrated blunted ACTH responses.

114 t also CORT, and we questioned whether early-life stress disrupted attachment learning and its neural

115 Early life stress disrupts growth and creates horizontal groov

116 We asked whether chronic early life stress disrupts maturation of gamma oscillations, o

117 These results suggest that early-life stress disturbs attachment behavior via a unique ca

118 Here, we test for the first time how early-life stress drives developmental programming and transge

119 Our data suggest that early-life stress during a critical period of neuro developmen

120 Here, we explored how early-life stress (ELS) affects excitatory and inhibitory tran

121 It is currently unclear whether early life stress (ELS) affects males and females differently.

122 tened susceptibility to the effects of early life stress (ELS) and are twice as likely as men to deve

123 Both history of early-life stress (ELS) and female sex are associated with inc

124 Early life stress (ELS) and function of the hypothalamic-pitui

125 and gene expression can be altered by early life stress (ELS) and/or ethanol consumption.

126 Amygdala circuitry and early life stress (ELS) are both strongly and independently im

127 Animal models of early life stress (ELS) are characterized by augmented amygdal

128 Exposure and sensitivity to early-life stress (ELS) are related to increased risk for psyc

129 Early life stress (ELS) can be very harmful to an individual's

130 Early life stress (ELS) can compromise development, with highe

131 Adverse childhood experiences and early life stress (ELS) can impact these networks and behavior

132 al research indicates that exposure to early life stress (ELS) can moderate the relation between infl

133 Early life stress (ELS) experience is associated with persisti

134 Over the past few years, early life stress (ELS) has been established as a major risk f

135 Early-life stress (ELS) has been robustly associated with a ra

136 Early life stress (ELS) has been shown to have a significant i

137 act with retrospectively self-reported early life stress (ELS) in patients with psychiatric disorders

138 Early life stress (ELS) in the form of child abuse/neglect is

139 Early life stress (ELS) increases risk for psychiatric illness

140 Exposure to early life stress (ELS) increases the risk for developing psyc

141 developmental critical periods (CPs), early-life stress (ELS) induces cognitive deficits and alters

142 rent mechanisms.SIGNIFICANCE STATEMENT Early-life stress (ELS) induces long-lasting consequences on s

143 Early life stress (ELS) is a significant postnatal exposure, w

144 Early-life stress (ELS) is associated with increased vulnerabi

145 Early life stress (ELS) is common in the United States and wor

146 Early life stress (ELS) is highly related to the development o

147 Early life stress (ELS) is known to "scar" the brain and shape

148 Early-life stress (ELS) is one of the strongest lifetime risk

149 ATEMENT In children and animal models, early-life stress (ELS) leads to deficits in cognition, includ

150 Early-life stress (ELS) leaves signatures upon the brain that

151 Early life stress (ELS) may increase the risk of anxiety throu

152 later in adulthood, yet the effects of early life stress (ELS) on brain development remain poorly und

153 f this technique to examine effects of early life stress (ELS) on neurodevelopment in infancy, and hi

154 Specifically, mice susceptible to early life stress (ELS) or chronic social defeat stress (CSDS)

155 Early life stress (ELS) profoundly impacts the brain and corre

156 Early life stress (ELS) promotes susceptibility to CSDS in adu

157 Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for psychi

158 Individuals with a history of early-life stress (ELS) tend to have an altered course of depr

159 Early life stress (ELS) yields cognitive impairments of unknow

160 g chronic social defeat stress (CSDS), early life stress (ELS), and two-hit stress of combined CSDS a

161 Early life stress (ELS), such as abuse and neglect during chil

162 nderstand how the brain is affected by early life stress (ELS), which produces excessive activation o

163 nd environmental risk factors, such as early life stress (ELS).

164 work establishes a mechanism by which early life stress encodes lifelong susceptibility to stress vi

165 e previously found that the effects of early-life stress endure and worsen during adulthood, yet the

166 -documented in adult rats, but whether early life stress endures into adulthood to affect responsivit

167 g mechanism through which greater cumulative life stress engenders decrements in cognitive functionin

168 While early life stress evokes persistent changes in anxiety, it is

169 jor depression patients with increased early life stress exhibit enhanced inflammatory responsiveness

170 Adult animals exposed to early life stress exhibited a reduction in the number of DG st

171 on of brain activity and discuss the role of life stress experience in modifying 5-HTT function in th

172 d timing of a stressor to parallel the early-life stress experience of orphanage rearing, controlling

173 which demonstrated that the more severe the life stress experienced, the greater the risk of early H

174 Early-life stress experiences can produce lasting impacts on o

175 onlinear J-shaped relationship between early life stress exposure and subsequent resilience.

176 lescent fluoxetine treatment following early life stress exposure increased the proliferation and ear

177 Early life stress exposure increases risk for depression(2) an

178 oderate but not minimal or substantial early life stress exposure promotes the development of stress

179 nding protein 5 (FKBP5), interact with early-life stress exposure, such as exposure to intimate partn

180 s), while certain cytokine network analyses, life stress factors, and autonomic symptoms could.

181 In rodent models of early-life stress, fragmentation and unpredictability of mater

182 Life stress frequently occurs within the context of home

183 thers who experienced higher levels of early life stress had significantly increased pro-inflammatory

184 Early-life stress has been linked to multiple neurodevelopment

185 human and non-human animal studies of early-life stress has converged on long-lasting epigenetic cha

186 ies of humans suggest that exposure to early life stress has long-term effects on neural circuits inv

187 Here we investigated whether a severe early-life stress (i.e., maternal deprivation, MD) promotes DA

188 of this and other studies suggest that early life stress impairs fear conditioning in adult rats wher

189 ress models, a heavy burden of recent common life stress in community-dwelling adolescent girls was a

190 neuroinflammation may improve resilience to life stress in patients with depression.

191 me, we used a simple visual analog scale for life stress in psychiatric patients, a high-risk group.

192 ant maternal separation, a paradigm of early life stress in rodents, elicits long-lasting changes in

193 Early life stress in the form of infant abuse or neglect const

194 Specifically, early-life stress in the form of maternal separation (MS) in r

195 viability of the hippocampus following early life stress in VFD-reared versus normally-reared subject

196 asia, a growth disruption indicator of early life stress, in the largest sample of Neanderthal and Up

197 ong adolescents as a mechanism through which life stress, including neighborhood conditions, may affe

198 egression analyses showed that higher severe life stress increased the odds of developing HIV disease

199 Chronic early life stress increases adult risk for depression, bipolar

200 osing rodents or non-human primates to early life stress increases anxiety-like behaviors and impairs

201 Early-life stress increases NE but also CORT, and we questione

202 Early life stress increases one's risk for health problems lat

203 Early life stress increases risk for depression.

204 Chronic early-life stress increases vulnerability to alcoholism and an

205 Exposure to early-life stress increases vulnerability to psychiatric disor

206 to investigate the associations among early life stress-induced anxiety and hyperactivity with vHIP

207 ings provide mechanistic insights into early life stress-induced intestinal changes that may translat

208 Early-life stress induces a persistent elevation of IL-6, hype

209 ng male and female mice we report that early-life stress induces anxiety-like behaviour and fear gene

210 mmune network hypothesis suggests that early-life stress initiates a positive feedback loop between p

211 Recent life stress interacted with VS reactivity to predict sel

212 data, we found support for a model by which life stress interacts with the effect of serotonin trans

213 nts completed assessments of chronic stress (Life Stress Interview), and trained personnel collected

214 Early life stress is a prominent risk factor for the developme

215 Although early-life stress is a significant risk factor for developing

216 Early life stress is associated with the development of psychi

217 Relatedly, life stress is cited as one of the major risk factors fo

218 Because early-life stress is common and constitutes a strong risk fact

219 Although early-life stress is known to alter health, its long-term cons

220 Chronic or early-life stress is one of the key risk factors for depressio

221 raise the interesting possibility that early-life stress is protective against extrapyramidal motor e

222 We found that early life stress leads to a more immature, proliferative DG t

223 This study provides evidence that early life stress leads to long-term changes in the density of

224 Numerous studies have shown that early life stress leads to persistent changes in behavioral an

225 Although early life stress (MALT) did not significantly impact measures

226 growing body of research suggests that early life stress may contribute to adverse health partly thro

227 and parenting with increased perceived work-life stress may disproportionately decrease the long-ter

228 a critical period for development, and early life stress may increase the risk of gastrointestinal di

229 : Maternal depression and prenatal and early life stress may influence childhood wheezing illnesses,

230 port clinical evidence suggesting that early-life stress may predispose individuals to increased anxi

231 e long-term behavioral consequences of early life stress may therefore be due in part to interference

232 Our results indicate that early life stress may tip the neural balance toward acute thre

233 -life-dependent manner, independent of early life stress mechanisms, underscoring the importance of t

234 nd temporal differences in response to early-life stress might provide unique insight into the cause

235 Here, we used a rodent early-life stress model that leads to robust and longlasting i

236 nutrition, education, and exposure to (early-life) stress modify the onset, incidence, and progressio

237 (10-12)) in adolescents at risk due to early life stress (n = 427, age 14 years)(8).

238 and women with major depression but no early life stress (N=11).

239 current major depression and increased early life stress (N=14) versus nondepressed male comparison s

240 were measured in healthy women without early life stress (N=20), women with childhood abuse without m

241 ivity predict psychological vulnerability to life stress occurring as much as 1 to 4 years later.

242 However, the long term impact of early-life stress on chromatin architecture in the VTA was not

243 The effect of life stress on depression is moderated by a repeat lengt

244 distinction is also made between effects of life stress on first onset of depression and on the subs

245 To determine effects of chronic early life stress on gamma oscillations, we separated pups fro

246 We examined the impact of early-life stress on haloperidol-induced catalepsy using the r

247 ms underlying the long-term effects of early-life stress on hippocampal integrity and function.

248 ediated the effects of genetic variation and life stress on limbic brain volumes, particularly on lef

249 ational transmission of the effects of early life stress on mental and physical health.

250 s and hence may mediate the effects of early-life stress on PTSD risk.

251 tional effects of maternal exposure to early-life stress on several phenotypic traits in their offspr

252 roinflammation moderates the impact of daily life stress on suicidal ideation and negative affect, th

253 Notably, the impact of early-life stress on the mechanisms that govern BLA excitabili

254 ned more variance (1.7%, P = 0.005) than the life stress-only model.

255 n adult neurogenesis after exposure to early life stress or adult chronic fluoxetine treatment.

256 strong or moderate direct relationships with life stress, pain conditions, falls, age, insomnia, weig

257 Early life stress, personality traits, and levels of negative

258 eraction of genetic profile scores and early life stress predicted left hippocampal and left amygdala

259 Early-life stress predicts later inflammation, and there are s

260 Early life stress predisposes to mental illness and behavioral

261 We investigated how early life stress produces long-term alterations in DG structu

262 The highest level of perceived everyday life stress raised the risk of either receiving triple t

263 pmental shifts in personality in response to life stress rather than neuropathological ones related t

264 ularly parenting behaviors, influences later-life stress reactivity.

265 re rats reproduced the consequences of early-life stress, reducing memory functions throughout life.

266 family history regardless of the severity of life stress reported, and it increased in adolescents wi

267 re and function and their relevance to daily-life stress responsivity.

268 Early-life stress sensitizes individuals to subsequent stresso

269 n, potential mediating factors such as early life stress, sex, personality traits, and negative memor

270 Some individuals exposed to early life stress show evidence of enhanced systemic inflammat

271 viduals who experienced high levels of early life stress showed lower levels of brain activation when

272 vironmental factors of depression, including life stress, social and lifestyle factors, using the UK

273 and depression (all Ps < 0.05) but not early life stress, social status, social support, neuroticism,

274 concept regarding the origin of toxic early-life stress, stating that it may derive from specific pa

275 During development, early-life stress, such as abuse or trauma, induces long-lasti

276 pecific differences, malleable through early-life stress, suggesting the role of endocannabinoids and

277 tic stress disorder and reported more recent life stress than abused women without major depressive d

278 dge, we used a rodent model of chronic early-life stress that engenders robust and enduring increases

279 hronic PTSD constitutes a form of persistent life stress that potentiates oxidative stress (OXS) and

280 rocesses are set into motion that link early life stress to health disorders in the later years?

281 en limited in estimating the contribution of life stress to the development of accelerated immune agi

282 history of childhood maltreatment, or early life stress, to delineate the ecophenotypic variant.

283 In our model of early-life stress (variable foraging demand [VFD]), food insec

284 oped after prolonged abstinence and if early life stress was a risk factor.

285 udy examined whether high perceived everyday life stress was associated with an increased risk of eit

286 Greater burden of recent life stress was associated with less left precuneus and

287 Early life stress was not associated with elevated CRP.

288 gical momentary assessment showed that daily-life stress was partly decoupled from opioid craving in

289 Increased life stress was significantly associated with a rise in

290 eported state PA, such that higher levels of life stress were associated with lower PA for participan

291 , cognition, behavior, and exposure to early-life stress were collected as part of a screening and na

292 Moreover, when BALB/c mice exposed to early life stress were raised in an enriched postweaning envir

293 ase progression was also predicted by severe life stress when a proportional odds logistic regression

294 f the altered programming triggered by early life stress, which enhances the vulnerability to stress-

295 frontal cortex (PFC) in the effects of early-life stress, which often emerge in adolescence or young

296 show low PA levels in the context of recent life stress, while those with relatively high VS reactiv

297 nsporter protein gene on the likelihood that life stress will precipitate depression may help to unde

298 port for the notion that the interactions of life stress with biopsychosocial variables have an impac

299 We tested the hypothesis that early life stress would persistently compromise neuronal viabi

300 s (CRHR1, NR3C2, NR3C1, and FKBP5) and early life stress would predict increases in cortisol levels d