ライフサイエンスコーパス: lifespan

1 orrelation with relative age (age divided by lifespan).

2 ges in 0-2 years are most dynamic across the lifespan.

3 atocellular carcinomas and survive a shorter lifespan.

4 ional response of an NK cell varies over its lifespan.

5 lt in lower limb amputations and a shortened lifespan.

6 d persistent pumping throughout the mammal's lifespan.

7 and maintain genomic stability and a healthy lifespan.

8 y short stature, accelerated aging and short lifespan.

9 d cumulatively contribute to the short adult lifespan.

10 y soma-specific knockdown of nsun-1 extended lifespan.

11 eleration, indicative of a shorter predicted lifespan.

12 ignaling, resulting in their extremely short lifespan.

13 estine, leading to enhanced proteostasis and lifespan.

14 volume and training benefit across the human lifespan.

15 ease states, affecting both human health and lifespan.

16 ces LD accumulation during aging and extends lifespan.

17 individuals with type 1 diabetes across the lifespan.

18 disease incidence and prevalence across the lifespan.

19 ad normal Mendelian ratios, and had a normal lifespan.

20 ion of damage over the course of an animal's lifespan.

21 influence key human ageing traits, including lifespan.

22 flies exhibit severe seizures and a reduced lifespan.

23 essive motor impairment, but no reduction of lifespan.

24 eliorating disease-associated phenotypes and lifespan.

25 e-history traits such as seed mass and plant lifespan.

26 cross variables strata diverged with accrued lifespan.

27 Eczema has a bimodal distribution across the lifespan.

28 and tumorigenesis, thus potentially reducing lifespan.

29 y in dicing performance and extend the blade lifespan.

30 distinct trajectories in function across the lifespan.

31 INs are functionally identical with a 3-year lifespan.

32 ild-type flies with tyrosine increased their lifespan.

33 decline and disease to extend healthspan and lifespan.

34 iche cell pool depletion during the animal's lifespan.

35 en plays a critical role in boosting battery lifespan.

36 ncluding cognitive impairment, and shortened lifespan.

37 notypes ranging from metabolic efficiency to lifespan.

38 ntal and physical health problems across the lifespan.

39 iosynthesis and storage, progeny output, and lifespan.

40 ge-related metabolic diseases and can extend lifespan.

41 m or, more broadly, between reproduction and lifespan.

42 disease, and extend the human healthspan and lifespan.

43 ersely affecting baseline neural function or lifespan.

44 ter matching cognitive healthspan with human lifespan.

45 im) in male Drosophila significantly extends lifespan.

46 erates early disease onset without affecting lifespan.

47 ic rate increases that avoid trade-offs with lifespan.

48 argets for chronic airway disease across the lifespan.

49 de, which acts in the intestine to determine lifespan.

50 genetic variants is associated with a longer lifespan.

51 ost cost-effective LLIN product based on its lifespan.

52 o sex-specific changes in performance across lifespan.

53 as elevated in cdnf mutants throughout their lifespan.

54 tion between male puberty timing and shorter lifespan.

55 udy in a large sample of patients across the lifespan.

56 entify the driver biomarkers affecting human lifespan.

57 ive endurance affect capacity throughout the lifespan.

58 ive on immunity and immunotherapy across the lifespan.

59 relevant brain regions and shorter predicted lifespan.

60 to some common chronic diseases and reduces lifespan.

61 e and may explain interspecific variation in lifespan.

62 survival, and, for women, their reproductive lifespans.

63 female Daphnia magna with different average lifespans.

64 t crossover-destined D-loops may have longer lifespans.

65 variants outcompete individuals with longer lifespans.

66 gh capacity (1253 mA h g(-1) ) and ultralong lifespan (1000 cycles) with a low capacity fade rate of

67 ubfield volume and activity across the adult lifespan (20-70 years old).

68 NMRs display an exceptionally long lifespan (~30 years), yet have been observed to display

69 atively associated with human healthspan and lifespan, accounting for 0.4 and 1.3 years of their vari

70 The insulin/IGF signalling pathway impacts lifespan across distant taxa, by controlling the activit

71 III is a determinant of cellular growth and lifespan across eukaryotes.

72 This extended lifespan allowed us to dynamically lineage trace and qua

73 investigate the evolutionary forces shaping lifespan among wild turquoise killifish populations.

74 lts, while neuronal DCP1 deficiency shortens lifespan and affects wing morphogenesis, cell non-autono

75 male and male species with different average lifespan and ageing rate.

76 In addition, sex differences in median adult lifespan and aging rates are both highly variable across

77 NPCs have a limited lifespan and are depleted near the time of birth.

78 eptor on adult muscles significantly reduces lifespan and causes local and systemic metabolic patholo

79 ains showed positive response to DR for both lifespan and climbing ability, 14% showed a negative res

80 tion (DR) is the most robust means to extend lifespan and delay age-related diseases across species.

81 On average, DR extended lifespan and delayed decline in climbing ability, but th

82 hat leads to low Coulombic efficiency, short lifespan and even safety concerns.

83 e significantly improved locomotor activity, lifespan and gene expression normalization.

84 homeostatic plasticity, extending organismal lifespan and health span.

85 nding of the role of lipids in regulation of lifespan and healthspan additional studies are required.

86 ction in the IIS pathway activity can extend lifespan and healthspan in various model organisms.

87 rization of Amyloid-beta were detrimental to lifespan and healthspan, we were able to separate the me

88 ge-related cell death and markedly increases lifespan and healthspan.

89 ring bacterial physiology as increasing both lifespan and healthspan.

90 he prevalence of sleep complaints across the lifespan and identify risk indicators of poor sleep.

91 nd behavior, and its modification across the lifespan and in response to pathology.

92 d transcriptomes of microglia throughout the lifespan and included a parallel comparison with periphe

93 , mitochondrial uncoupling drugs also extend lifespan and inhibit intestinal stem cell overproliferat

94 IRT6 regulates telomere maintenance and VSMC lifespan and inhibits atherogenesis, all dependent on it

95 in pillar-less microfluidic chambers reduces lifespan and introduces physiological stress by increasi

96 luence brain functions throughout the entire lifespan and may even be transmitted across generations

97 ety of mental health concerns throughout the lifespan and may present differently between adolescents

98 ment in multiple sclerosis varies across the lifespan and might be difficult to distinguish from othe

99 parents at reproduction can affect offspring lifespan and other fitness-related traits is important i

100 these genes produced independent effects on lifespan and physical activity decline, which suggests t

101 in the aging field is that DR enhances both lifespan and physical activity through similar mechanism

102 Overall, the capacity to generate reliable lifespan and physiological data underscores the potentia

103 lls and enteroblasts is sufficient to extend lifespan and preserve proliferative homeostasis in the g

104 the other parameters investigated (e.g., LFM lifespan and regeneration frequency) typically only lead

105 ne function and nutrition on an individual's lifespan and reproduction are well established, the inte

106 reduced mitochondrial translation to prolong lifespan and stimulate stress response such as the mitoc

107 ranslation machinery components can lengthen lifespan and stress survival.

108 iously described mutations in the C. elegans lifespan and stress-response pathways.

109 How lifespan and the rate of aging are set is a key problem

110 at increased growth rates may shorten trees' lifespan and thus recent increases in forest carbon stoc

111 itioner role was diverse, working across the lifespan and with different patient groups.

112 and cytoplasmic ADH5, have greatly shortened lifespans and develop leukemia.

113 good health (healthspan), total years lived (lifespan), and survival until an exceptional old age (lo

114 s associated with comorbidities, a shortened lifespan, and a poorer quality of life, but epidemiologi

115 Podxl(+/-) mice, in contrast, have a normal lifespan, and fail to develop kidney disease under norma

116 creases in power capability, energy density, lifespan, and flexibility.

117 summary statistics for healthspan, parental lifespan, and longevity in a multivariate framework, inc

118 l stocks per capita, recycling rate, product lifespan, and manufacturing yield) in a dynamic material

119 rectly linked to faster growth reducing tree lifespan, and not due to covariance with climate or envi

120 eal that SUMO is an important determinant of lifespan, and provide novel insight, relevant to the com

121 trates the dual control of fat oxidation and lifespan, and shields the organism from life-shortening

122 lobin (HGB) levels were lower throughout the lifespan, and the occurrence of intestinal tumors was la

123 d WD-related vascular dysfunction across the lifespan, and this protection appeared to be mediated by

124 ons of metabolites associated with increased lifespan, and upregulates the levels of tyrosine-derived

125 regulate gene expression across the neuronal lifespan, and we suggest how emerging findings regarding

126 ts, through decreasing reproductive success, lifespan, and/or survival.

127 ibers, with short charging times, long cycle lifespans, and high power densities, hold promise for po

128 atopoietic progenitors resulted in a shorter lifespan associated with onset of thymic lymphomas, reve

129 able neurological, psychiatric, medical, and lifespan associations.

130 come a final telomere-mediated proliferative lifespan barrier called replicative crisis.

131 /or the consequence of the different average lifespans between the two genetically identical genders.

132 actors are key drivers regulating organismal lifespan but how these impact healthspan is less well un

133 uced tumorigenesis, while they had shortened lifespan, but did not show progeria-like phenotypes.

134 nd that accumulation of LDs does not shorten lifespan, but does protect aged cells against stress.

135 S likely contributes to maximum reproductive lifespan, but other unknown mechanisms could be importan

136 uences dauer entry, dauer recovery and adult lifespan by altering insulin sensitivity according to th

137 Although excess ROS reduces lifespan by causing extensive cellular dysfunction and d

138 tic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide asso

139 elevated calcium-cAMP signaling over a long lifespan can additionally drive tau phosphorylation, amy

140 ion pathway significantly extends Drosophila lifespan, causes alterations of metabolites associated w

141 ects including an extended post-reproductive lifespan combined with short interbirth intervals.

142 ts and achieve better BCVA during the drug's lifespan compared with PRP alone.

143 mental tooth cementum, that they had maximum lifespans considerably longer than comparably sized livi

144 Instead, lifespan correlation with CD33rSIGLEC gene number was ma

145 ditional battery technologies with a limited lifespan, creating a significant challenge for their dev

146 We show that the lifespan deficit induced by Amyloid-beta oligomers was r

147 d females had similar FECs across their long lifespan, despite distinct differences in life-history s

148 th mitochondrial translation and dynamics on lifespan, despite stimulating UPRMT, does not require it

149 n anabolism and catabolism, thus controlling lifespan, development and autophagy.

150 e mice nearing the end of their reproductive lifespan, DNA methylation fidelity is lost at a number o

151 ce, our data support the view that prolonged lifespan does not always coincide with extended healthsp

152 various progeroid phenotypes, such as short lifespan, dwarfism, lipodystrophy, sarcopenia, and low c

153 n vivo to modulate neurological function and lifespan, establishing a new pharmaceutical modality for

154 tients from small muscle imbalances over the lifespan, even enhanced VFV may be inadequate to avert d

155 With human median lifespan extending into the 80s in many developed countr

156 We also demonstrate that the lifespan-extending effect of this strain is positively c

157 edicts life expectancy and the efficacy of a lifespan-extending intervention up to a year in advance.

158 de-offs, it remains unclear whether systemic lifespan-extending interventions could ameliorate the de

159 Instead, this lifespan-extending synergy is exclusively dependent on t

160 Moreover, we find that lifespan-extending systemic down-regulation of insulin s

161 efine the downstream effects responsible for lifespan extension and often results in negative effects

162 ut Bacteroidales species are associated with lifespan extension in a novel HF model.

163 This lifespan extension is not mediated by canonical diet-res

164 Lifespan extension of per mutants depends on mitochondri

165 ore, nutrient response genes responsible for lifespan extension or age-related decline in functionali

166 mechanisms have an effect on healthspan and lifespan extension, and outlines questions to guide futu

167 of host-microbe homeostasis, and organismic lifespan extension.

168 both Cyp26a1 and Cyp26b1 also had a reduced lifespan, failed to gain weight, and showed fat atrophy.

169 are required to generate evidence about UAS lifespan, failure rates, and performance under different

170 ess, including development time, adult size, lifespan, fecundity, and neonate production.

171 s central for coherent perception across the lifespan from infancy onwards.

172 iguingly, we find that ovariectomy uncouples lifespan from metabolic health, with ovariectomized fema

173 The worldwide average human lifespan has increased over the past century.

174 sociated biological responses throughout the lifespan, has emerged in recent years as a cornerstone i

175 but the evolutionary driving forces limiting lifespan have not been defined.

176 s trans-ethnically associated with a shorter lifespan (hazard ratio = 1.03[1.02-1.04], P(meta) = 3.9

177 1.04], P(meta) = 3.9 x 10(-13)) and parental lifespan (hazard ratio = 1.06[1.06-1.07], P = 2.0 x 10(-

178 ons in PLWH will have an important effect on lifespan, healthspan and quality of life as patients age

179 so far can explain only a small fraction of lifespan heritability in humans.

180 isplay various assets such as extended blood lifespan, high drug loading and reduced cytotoxicity lea

181 of morbidity and a significant extension of lifespan; however, at the molecular level this rescue ap

182 to developmental delay, pupal death, reduced lifespan, impaired synaptic transmission, and glial and

183 and avoiding the swim-induced stress across lifespan in animals reared in liquid.

184 preservation of vascular function across the lifespan in both the presence and absence of a Western d

185 tochondrial translation is known to increase lifespan in C. elegans, and is accompanied by a fragment

186 susceptibility to complex traits with human lifespan in collaboration with three worldwide biobanks

187 lving neuroinflammatory phenotype across the lifespan in Down syndrome, a knowledge that is relevant

188 The obesity PRS showed distinct effects on lifespan in Japanese and European individuals (P(heterog

189 Although lifespan in mammals varies over 100-fold, the precise ev

190 tabolic health is not inextricably linked to lifespan in mammals, and highlight the importance of eva

191 ral impairment of vascular function over the lifespan in mice, acceleration and exacerbation of that

192 roved drug rapamycin slows aging and extends lifespan in multiple organisms, including mice.

193 tevia (erythritol) have been shown to affect lifespan in other flies.

194 eliorate age-associated hallmarks and extend lifespan in progeroid mice.

195 elated vascular dysfunction across the adult lifespan in sedentary mice consuming a non-Western diet,

196 s and exacerbates vascular ageing across the lifespan in sedentary mice They also show that lifelong

197 roved a composite symptom score and extended lifespan in the Mecp2 KO mice.

198 timulated reversals can be scored across the lifespan in the NemaLife chip.

199 lassical anti-inflammatory cytokine, extends lifespan in the SOD1-G93A mouse model of familial ALS.

200 , and peripheral organs, but did not prolong lifespan in these mice.

201 fore to improve metabolic profile and extend lifespan in various model organisms.

202 on, improved cardiac function, and prolonged lifespan in vivo.

203 effects on vascular function throughout the lifespan, in the setting of ageing alone, as well as age

204 elerated GrimAge, an epigenetic predictor of lifespan, in traumatized civilians.

205 y-life adversity led to dramatically shorter lifespans, individuals who experienced early adversity d

206 e NemaLife chip to accelerate healthspan and lifespan investigations in C. elegans.

207 Progressive telomere shortening during lifespan is associated with restriction of cell prolifer

208 e show that repeat de-repression and average lifespan is correlated with the number of Y chromosomes.

209 However, their lifespan is limited by irreversible Zn anodes owing to w

210 However, their lifespan is limited by the water decomposition and Zn de

211 rammed, the conservation of their effects on lifespan is most likely a reflection of the conservation

212 Temporal scaling of lifespan is not evident when ferroptosis is inhibited, c

213 ether they can accurately predict health and lifespan is not known.

214 rain structure crucial for memory across the lifespan, is highly sensitive to adverse life events.

215 n regimes and genetic pathways that increase lifespan lead to radically different healthspan outcomes

216 y be due to mutation accumulation across the lifespan, leading to tissue dysfunction, disease, and de

217 Shorter lifespan limits infection spread and accelerates pathoge

218 etary restriction, which promotes health and lifespan, may enhance cancer immunity.

219 ps, 30 products, and use the revised Weibull lifespan model to map the generation of anthropogenic mi

220 n of DCAP-1/DCP1 in developmental events and lifespan modulation.

221 /Anxa6(-/-)) were generated and examined for lifespan, neurologic and hepatic functions, as well as l

222 Throughout our lifespan, new sensory experiences and learning continual

223 p modify preexisting memories throughout the lifespan of an organism.

224 and anti-aging compounds, by increasing the lifespan of C. elegans up to 16.82%, 16.65%, 16.53%, and

225 capacity for RSC-mediated repair extends the lifespan of flies carrying kidney stones.

226 , tyrosine supplementation partially rescued lifespan of flies with ETC complex I suppression.

227 engthened by excluding the post-reproductive lifespan of humans and orcas (R(2) = 0.83; P < .0001).

228 egression to predict age, remaining life and lifespan of individual C. elegans.

229 ed the brain inflammatory profile across the lifespan of individuals with Down syndrome.

230 growth and motor function and increases the lifespan of male and female SMA mice.

231 C2 (mTOR Complex 2) specifically reduces the lifespan of males.

232 iptional and epigenomic landscape across the lifespan of memory formation and recall in the hippocamp

233 riptional landscape of engram cells over the lifespan of memory formation and recall.

234 miR-155 in T cells contributes to shortened lifespan of miR-146a(-/-) mice.

235 and plasma proteomics at 10 ages across the lifespan of Mus musculus, and integrated these findings

236 ves, which can be released during the entire lifespan of plastics and pose a threat to the environmen

237 also accelerate disease onset but extend the lifespan of SOD1 mice.

238 tal issue influencing the safety and cycling lifespan of sodium batteries.

239 erve conduction velocity, motor function and lifespan of the mice to wild-type levels.

240 blocked neurodegeneration, and increased the lifespan of Top1 cKO mice by 30%.

241 cantly reduced tumor burden and extended the lifespan of tumor-bearing mice.

242 udies have revealed that alphaKG extends the lifespan of worms and maintains the pluripotency of embr

243 Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation sp

244 m, and 100 km (UAS30, UAS65, and UAS100) and lifespans of 1000 to 10 000 h, and compared the costs an

245 We measured the lifespans of 3 LLIN products, and calculated their cost

246 ameters can then be estimated, including the lifespans of short and long-lived infected cells, and th

247 ng an additional time frame based on accrued lifespan, offers dynamic survival projections as compare

248 By examining the impact of lifespan on pathogen spread in a population, we propose

249 known to be diet responsive nor to influence lifespan or climbing ability.

250 stems follow similar trajectories across the lifespan or sustain the impacts of brain aging independe

251 learning (VPL)(1-4) remain stable across the lifespan or undergo developmental changes.

252 man brain functional architecture across the lifespan pave the way for future clinical studies invest

253 cies that have a prolonged post-reproductive lifespan (PRLS), during which the aging process continue

254 ns (age R2 = 0.79; remaining life R2 = 0.77; lifespan R2 = 0.72) increased with the number of feature

255 d probabilistic sensitivity analyses for UAS lifespans, range, and accident or failures.

256 ability and olfactory perception, as well as lifespan reduction.

257 egions at the gene level and associated with lifespan regulation and neuronal functions.

258 ion with M3, resulted in modest extension of lifespan relative to control SOD1-G93A cohort.

259 extent to which it may attenuate or augment lifespan remain important unanswered questions.

260 n during a multilimb reaction time task in a lifespan sample of healthy human adults (N = 89; 20-75 y

261 population, we propose that epidemics drive lifespan setpoints' evolution.

262 tribute to control the evolution of species' lifespan setpoints.

263 the NE system supports attention across the lifespan.SIGNIFICANCE STATEMENT In old age, the ability

264 h high-dose AAV9 also significantly extended lifespan, signifying a treatment option for patients for

265 However, a lack of lifespan studies has precluded verification of these the

266 The identification of mutations extending lifespan suggests that aging is under genetic control, b

267 g partially mediates the association between lifespan systolic blood pressure burden and adult cognit

268 ies exhibiting greater fecundity and shorter lifespans tend to host more zoonoses; however, the cause

269 lity of crowding is a stronger predictor for lifespan than the absolute crowding levels.

270 of the epigenetic mark H3K9me2 have a longer lifespan that can be passed down to future generations.

271 egative effects of parental age on offspring lifespan (the 'Lansing effect') is examined.

272 ransmission is maintained throughout the ATI lifespan through a potent homeostatic reduction in presy

273 n neurons of worms is sufficient to increase lifespan through the function of the insulin/IGF-like si

274 ific miRNAs play pivotal roles in regulating lifespan through their influences on inflammaging.

275 A second model is trained on remaining lifespan to generate the AFRAID (Analysis of Frailty and

276 shifts among the substances used across the lifespan to simultaneous co-use of substances that span

277 meiosis, mapping their binding locations and lifespans to individual homologous chromosomes using a g

278 Here we show that growth-lifespan trade-offs are indeed near universal, occurring

279 ses to sexual stimuli could account for some lifespan trade-offs normally attributed to pregnancy and

280 antitative traits and demonstrate that these lifespan traits affect the evolutionary constraint on hu

281 is question by linking particular alleles to lifespan traits.

282 normalized respiratory function and extended lifespan up to an eight-month end point.

283 atter, FA was significantly lower across the lifespan (up to 7%; p < 0.0033) and reached peak maturat

284 omoting resistance to H(2)O(2) and extending lifespan upon caloric restriction.

285 The genetic mechanisms contributing to lifespan variation remain unresolved.

286 turally occurring OsSGR promoter and related lifespan variations can be exploited in breeding program

287 sex-specific plasticity over an individual's lifespan varies in wild populations and influences popul

288 antly comprise the same materials, but their lifespans vary widely: in stark contrast to mammals, sha

289 usal effect of blood pressure and obesity on lifespan was further supported by Mendelian randomizatio

290 Importantly, lifespan was reduced by a loss of general fitness and in

291 Median lifespan was significantly reduced by 20% from 709 days

292 manifests only during a unique period of the lifespan where dynamic hormonal changes occur.

293 use skeletal muscle were profiled across the lifespan, which revealed the presence of distinct myonuc

294 sterile male early in life came at a cost to lifespan, which was observed in the absence of females e

295 ding to both the effect-sizes and pattern of lifespan white matter FA differences.

296 herewith demonstrate a strong correlation of lifespan with CD33rSIGLEC gene number in 26 species, ind

297 ive stress and allows flies to have a normal lifespan with little to no sleep.

298 The corresponding decrease in lifespan within 5 years when compared with patients free

299 and relative risk of death, and decrease in lifespan within 5 years, when compared with development

300 cline of the individuals was scaled to their lifespan without significant deviation from the average