ライフサイエンスコーパス: ligand-gated

1 uCl was solved, the first for any eukaryotic ligand-gated anion channel, revealing a macrocyclic lact

2 luCls) in invertebrates, not affecting human ligand-gated anion channels.

3 le split nanobody (designated Chessbody) for ligand-gated antigen recognition in living cells.

4 We fused CaV1.2 to a ligand-gated Ca(2+)-permeable channel, enabling independ

5 eviously unknown endogenous activator of the ligand-gated calcium channels transient receptor potenti

6 are thus inactive but can be converted into ligand-gated catalytically active split-protein kinases.

7 ssed by mutations in acr-23, which encodes a ligand-gated cation channel of the cys-loop family.

8 NX1) opens and forms a pore complex with the ligand-gated cation channel P2X7, allowing the release o

9 ential vanilloid 1 (TRPV1) is a nonselective ligand-gated cation channel responding to noxious heat,

10 TRPV1 is a ligand-gated cation channel that is expressed on a major

11 ic P2X3 and heteromeric P2X2/3 receptors are ligand-gated cation channels activated by ATP.

12 ber of the P2X purinergic receptor family of ligand-gated cation channels and has recently been shown

13 AMPA-type glutamate receptors are ligand-gated cation channels responsible for a majority

14 rs (NMDARs) constitute an important class of ligand-gated cation channels that are involved in the ma

15 line (ACh) receptors (nAChRs) are pentameric ligand-gated cation channels that include at least two a

16 N-methyl-D-aspartate receptors (NMDARs) are ligand-gated cation channels that mediate excitatory syn

17 ubfamily (TPC1-3) of eukaryotic voltage- and ligand-gated cation channels with two non-equivalent tan

18 e propose that, while P2X receptors are fast ligand-gated cation channels, they are most adept at med

19 N-methyl-d-aspartate (NMDA) receptors are ligand-gated, cation-selective channels that mediate a s

20 ormational changes predicted to occur during ligand-gated channel activation and desensitization.

21 TR gating is distinct from that of a typical ligand-gated channel because its ligand (ATP) is usually

22 zation remain unavailable for the pentameric ligand-gated channel family.

23 RPV1 or vanilloid receptor is a nonselective ligand-gated channel highly expressed in primary sensory

24 f ADPR or AMPCPR, identify TRPM2 as a simple ligand-gated channel that obeys an equilibrium gating me

25 TR gating that combines the allosterism of a ligand-gated channel with its unique enzymatic activity.

26 ngly and contrary to what is expected from a ligand-gated channel, these activations occur in a seemi

27 As a ligand-gated channel, TRPA1 can be activated by electrop

28 c properties that are common to conventional ligand-gated channels (e.g. unliganded openings and cons

29 allostery that are shared with conventional ligand-gated channels and (ii) the R domain modulates CF

30 ides a framework for understanding gating in ligand-gated channels and how mutations in the acetylcho

31 erpretation of protein allostery for general ligand-gated channels and receptors.

32 For ligand-gated channels each state can represent a differe

33 forms are a family of ubiquitously expressed ligand-gated channels encoded by three individual genes.

34 GABAARs are heteropentameric ligand-gated channels formed by the combination of 19 po

35 Despite their widespread nature, no ligand-gated channels have yet been found within the out

36 This increases Ca2+ binding to ligand-gated channels known as ryanodine receptors (RyR2

37 AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4

38 GABAA receptors are pentameric ligand-gated channels mediating inhibitory neurotransmis

39 type A receptors (GABA(A)Rs), which are the ligand-gated channels target of the major inhibitory neu

40 loop receptors (CLRs) are commonly known as ligand-gated channels that transiently open upon binding

41 tamate receptors are postsynaptic tetrameric ligand-gated channels whose activity mediates fast excit

42 Ligand-gated channels, in which a substrate transport pa

43 cognized that this small molecule influences ligand-gated channels, including the GABAA receptor and

44 For ligand-gated channels, it is challenging to separate lig

45 In certain ligand-gated channels, such as BK channels and MthK, a C

46 Akin to ligand-gated channels, the dilated state of the midplane

47 channels, but not sodium (Na(+)) channels or ligand-gated channels.

48 mechanisms for the superfamily of pentameric ligand-gated channels.

49 Bestrophin (BEST1-4) ligand-gated chloride (Cl(-)) channels are activated by

50 Glycine receptors (GlyRs) are ligand-gated chloride channels that mediate inhibitory n

51 cid type A receptors (GABA(A) receptors) are ligand-gated chloride channels that play a central role

52 A gamma-aminobutyric (GABA(A)) receptors are ligand-gated chloride channels with a very rich pharmaco

53 ransmission via the allosteric modulation of ligand-gated chloride channels, such as hetero-oligomeri

54 ino acid and neurotransmitter that activates ligand-gated Cl(-) currents, to insulin secretion from i

55 s position within M2 is conserved throughout ligand-gated excitatory cys-loop channel subunits, delet

56 urotoxicity by noncompetitively blocking the ligand-gated GABA(A) receptor ion channel, leading to al

57 We present iTango, a light- and ligand-gated gene expression system based on a light-ind

58 Ligand-gated heteropentameric GlyRs form chloride ion ch

59 tional and molecular properties of two major ligand-gated inhibitory receptor systems, the GABA(A) re

60 tor (GABA(A)R) is a member of the pentameric ligand gated ion channel (pLGIC) family that mediates io

61 al closely related members of the pentameric ligand gated ion channel family.

62 s the first report showing the key role of a ligand gated ion channel, the purinergic P2X7 receptor i

63 Pentameric ligand gated ion channels (pLGICs) mediate signal transd

64 acting ionotropic Glu receptors (iGluRs) are ligand gated ion channels and are believed to be involve

65 eptors (adrenoceptors) and P2X1-purinoceptor ligand gated ion channels in male mice, thereby blocking

66 desensitization gate in this novel class of ligand gated ion channels.

67 rystal structure of the Erwinia chrysanthemi ligand-gated ion channel (ELIC) in complex with a deriva

68 y binds to and stabilizes the pLGIC, Erwinia ligand-gated ion channel (ELIC), and decreases ELIC dese

69 rom prokaryote homologs-Erwinia chrysanthemi ligand-gated ion channel (ELIC), Gloeobacter violaceus l

70 nts of chlorpromazine binding in the Erwinia ligand-gated ion channel (ELIC).

71 e reduction in the membrane protein, Erwinia ligand-gated ion channel (ELIC).

72 rokaryotic homolog, the Erwinia chrysanthemi ligand-gated ion channel (ELIC).

73 prokaryotic homologs, Gloebacter and Erwinia ligand-gated ion channel (GLIC and ELIC, respectively),

74 membrane domain of the Gloeobacter violaceus ligand-gated ion channel (GLIC) channel, characterize th

75 Gloeobacter violaceus ligand-gated ion channel (GLIC) has served as a valuable

76 etic propofol bound to Gloeobacter violaceus ligand-gated ion channel (GLIC), a bacterial homolog of

77 Crystal structures of Gloeobacter violaceus ligand-gated ion channel (GLIC), a proton-gated prokaryo

78 /C) receptors, and the Gloeobacter violaceus ligand-gated ion channel (GLIC), are receptors that cont

79 tameric ligand-gated ion channel, Gloebacter ligand-gated ion channel (GLIC), represents an excellent

80 e bacterial Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC), which is sensitive to a

81 ed ion channel (ELIC), Gloeobacter violaceus ligand-gated ion channel (GLIC)-and crystallized eukaryo

82 yotic proton-activated Gloeobacter violaceus ligand-gated ion channel (GLIC).

83 on-gated prokaryotic homologue of pentameric ligand-gated ion channel (LGIC) from G. violaceus, have

84 GLIC, a prokaryotic member of the pentameric ligand-gated ion channel (pLGIC) family, provides a uniq

85 The glycine receptor (GlyR) is a pentameric ligand-gated ion channel (pLGIC) mediating inhibitory tr

86 ic cation-selective member of the pentameric ligand-gated ion channel (pLGIC) superfamily.

87 The 5-HT(3) receptor, a pentameric ligand-gated ion channel (pLGIC), is an important therap

88 y stimulation of the purinergic receptor P2X ligand-gated ion channel 7 (P2X7) by millimolar concentr

89 The P2X7 receptor is a trimeric ligand-gated ion channel activated by ATP.

90 The 5-HT(3) receptor is an important ligand-gated ion channel and drug target in the central

91 iew, we discuss our current understanding of ligand-gated ion channel and G protein-coupled receptor

92 ic GABA(A)Rs and in the Erwinia chrysanthemi ligand-gated ion channel and may be essential for the ab

93 allosteric modulators (PAMs) for the GABA(A) ligand-gated ion channel are described.

94 P2X7 is an important ligand-gated ion channel expressed in multiple immune ce

95 As members of the Cys loop ligand-gated ion channel family, neuronal nAChRs are pen

96 ELIC, the pentameric ligand-gated ion channel from Erwinia chrysanthemi, is a

97 rain's major inhibitory neuroreceptor is the ligand-gated ion channel gamma-aminobutyric acid (GABA)

98 ein motions underlying Gloeobacter violaceus ligand-gated ion channel gating in a membrane environmen

99 inhibits the currents of the homopentameric ligand-gated ion channel GLIC, yet the crystal structure

100 icroscopy Torpedo model; the only pentameric ligand-gated ion channel imaged in a native lipid membra

101 ntext of the alpha4beta2 nAChR, a widespread ligand-gated ion channel in the brain and a target for n

102 e receptor (alpha7nAChR) is a homopentameric ligand-gated ion channel mediating fast synaptic transmi

103 The ligand-gated ion channel P2X7 receptor attracts special

104 t be incorporated into functional pentameric ligand-gated ion channel receptors.

105 GlyRs are members of the pentameric ligand-gated ion channel superfamily (pLGIC) that mediat

106 anniversary of the discovery of the Cys loop ligand-gated ion channel superfamily of neurotransmitter

107 Prokaryotic members of the Cys-loop receptor ligand-gated ion channel superfamily were recently ident

108 tion to our knowledge of the entire Cys loop ligand-gated ion channel superfamily.

109 tors (GABAARs) are members of the pentameric ligand-gated ion channel superfamily.

110 ransient Receptor Potential A 1 (TRPA1) is a ligand-gated ion channel that contributes to inflammator

111 The serotonin type 3 receptor (5-HT(3)) is a ligand-gated ion channel that converts the binding of th

112 ane conductance regulator (CFTR) is the only ligand-gated ion channel that hydrolyzes its agonist, AT

113 The P2X4 receptor is a ligand-gated ion channel that is expressed on a variety

114 The NMDA-sensitive glutamate receptor is a ligand-gated ion channel that mediates excitatory synapt

115 the structure of the prototypical pentameric ligand-gated ion channel the Torpedo nicotinic acetylcho

116 ents show that G2A activation sensitizes the ligand-gated ion channel TRPV1 in sensory neurons via ac

117 This study provides an example of a ligand-gated ion channel whose deactivation is sensitive

118 the N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel with essential roles in brain d

119 bacterial homolog ELIC (Erwinia chrysanthemi ligand-gated ion channel) has a similar lipid sensitivit

120 ious association of purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7), with asthma exacerb

121 in macrophages via purinergic receptor P2X, ligand-gated ion channel, 7 (P2X(7)), may play a role in

122 d signaling through purinergic receptor P2X, ligand-gated ion channel, 7 (P2X7 receptor; encoded by P

123 cotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the free energy of bi

124 The homologous prokaryotic pentameric ligand-gated ion channel, Gloebacter ligand-gated ion ch

125 the serotonin type 3A receptor, a pentameric ligand-gated ion channel, is crucial for regulating cond

126 f function of the ATP-gated P2X(2) receptor (ligand-gated ion channel, purinergic receptor 2) that is

127 One such ligand-gated ion channel, the NMDAR, impacts nearly all

128 the gating mechanism in the same pentameric ligand-gated ion channel.

129 receptor, three of the key features of this ligand-gated ion channel.

130 indicate that switches in ion selectivity of ligand-gated ion channels (LGICs) do not affect network

131 Presynaptic ligand-gated ion channels (LGICs) have long been propose

132 Ligand-gated ion channels (LGICs) mediate fast synaptic

133 Pentameric ligand-gated ion channels (LGICs) play an important role

134 able the systematic creation of a toolbox of ligand-gated ion channels (LGICs) with orthogonal pharma

135 ellular excitation or inhibition by Cys-loop ligand-gated ion channels (LGICs), and is essential for

136 dulation is a general phenomenon of Cys-loop ligand-gated ion channels (LGICs), and whether this modu

137 ray cocrystal structure within this class of ligand-gated ion channels (LGICs).

138 Pentameric ligand-gated ion channels (pLGICs) are allosteric recept

139 Pentameric ligand-gated ion channels (pLGICs) are essential determi

140 Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-

141 Pentameric ligand-gated ion channels (pLGICs) are targets of genera

142 ructure of full-length eukaryotic pentameric ligand-gated ion channels (pLGICs) is still lacking.

143 ion channels, the superfamily of pentameric ligand-gated ion channels (pLGICs) is unique in that its

144 Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical

145 Pentameric ligand-gated ion channels (pLGICs) mediate fast chemoele

146 Pentameric ligand-gated ion channels (pLGICs) mediate numerous phys

147 Pentameric ligand-gated ion channels (pLGICs) mediate signal transm

148 Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors

149 Pentameric ligand-gated ion channels (pLGICs) play a central role i

150 Rapid opening and closing of pentameric ligand-gated ion channels (pLGICs) regulate information

151 Ketamine inhibits pentameric ligand-gated ion channels (pLGICs), including the bacter

152 Pentameric ligand-gated ion channels (pLGICs), such as nicotinic ac

153 y modulating agonist responses of pentameric ligand-gated ion channels (pLGICs).

154 ptors (GlyRs) are anion-permeable pentameric ligand-gated ion channels (pLGICs).

155 ucture-based ligand discovery for pentameric ligand-gated ion channels (pLGICs).

156 and modulating membrane-embedded pentameric ligand-gated ion channels (pLGICs).

157 tructure-function relationship of pentameric ligand-gated ion channels (pLGICs).

158 activity of anionic and cationic pentameric ligand-gated ion channels (pLGICs).

159 P2X receptors (P2XRs) are ligand-gated ion channels activated by extracellular ATP

160 NMDA receptors (NMDARs) are Ca(2+)-permeant, ligand-gated ion channels activated by the excitatory ne

161 Glycine receptors are chloride-permeable, ligand-gated ion channels and contribute to the inhibiti

162 into the signalling mechanisms of pentameric ligand-gated ion channels and enhance current understand

163 understanding the mechanisms of operation of ligand-gated ion channels and fast chemical synapses.

164 Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled receptor

165 (nAChR) belongs to the family of pentameric ligand-gated ion channels and is involved in fast synapt

166 (nAChRs) belong to the family of pentameric ligand-gated ion channels and mediate fast excitatory tr

167 are over-represented in membrane receptors, ligand-gated ion channels and nuclear receptor targets,

168 yric acid (GABA(A)) receptors are pentameric ligand-gated ion channels and the main drivers of fast i

169 , which is vestigial in bacterial pentameric ligand-gated ion channels and was largely removed for cr

170 elical receptors are proposed to function as ligand-gated ion channels and/or to act metabotropically

171 Ligand-gated ion channels are allosteric membrane protei

172 Allosteric modulators of ligand-gated ion channels are of particular interest as

173 Ligand-gated ion channels are prototypic oligomeric memb

174 Pentameric ligand-gated ion channels are targets of general anesthe

175 Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements

176 N-methyl-d-aspartate (NMDA) receptors are ligand-gated ion channels assembled from GluN1 and GluN2

177 the expression of gephyrin, an organizer of ligand-gated ion channels at inhibitory synapses in hipp

178 and modulate a large number of voltage- and ligand-gated ion channels at the plasma membrane.

179 alpha7 receptors are ligand-gated ion channels composed of five identical sub

180 NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and

181 Pentameric ligand-gated ion channels control synaptic neurotransmis

182 s), including the NMDA receptor subtype, are ligand-gated ion channels critical to fast signaling in

183 Of the ligand-gated ion channels examined, 20% showed patterned

184 Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spi

185 Voltage- and ligand-gated ion channels form the molecular basis of ce

186 Purinergic P2X receptors are a family of ligand-gated ion channels gated by extracellular adenosi

187 To examine the function of ligand-gated ion channels in a defined membrane environm

188 modulator that activates GPCRs in mammals or ligand-gated ion channels in invertebrates.

189 or TRPV1 is an outstanding representative of ligand-gated ion channels in ligand selectivity and sens

190 Glutamate receptors are essential ligand-gated ion channels in the central nervous system

191 The ligand-gated ion channels in the Cys-loop receptor super

192 hetics are known to modulate the activity of ligand-gated ion channels in the Cys-loop superfamily, t

193 the mRNA expression patterns of voltage- and ligand-gated ion channels in the DR using the Allen Mous

194 cysteine (Cys)-loop receptor super family of ligand-gated ion channels in the nervous system and is a

195 nAChRs are cholinergic receptors forming ligand-gated ion channels in the plasma membranes of cer

196 ng at the extracellular domain of pentameric ligand-gated ion channels initiates a relay of conformat

197 GABA(A) receptors are pentameric ligand-gated ion channels involved in fast inhibitory ne

198 AChR) belongs to a superfamily of pentameric ligand-gated ion channels involved in many physiologic a

199 this review article, an auxiliary subunit of ligand-gated ion channels is defined using four criteria

200 Pentameric ligand-gated ion channels mediate fast chemical transmis

201 nker but also the M1-M2 linker of pentameric ligand-gated ion channels modulates function in vivo.

202 Pentameric ligand-gated ion channels or Cys-loop receptors are resp

203 Desensitization in pentameric ligand-gated ion channels plays an important role in reg

204 P2X7 receptors (P2X7Rs) are ligand-gated ion channels sensitive to extracellular ATP

205 ed calcium channels (VGCCs) and postsynaptic ligand-gated ion channels such as AMPA receptors (AMPARs

206 and for and modulator of ryanodine receptors-ligand-gated ion channels that are critical for intracel

207 tivation, as illustrated here for pentameric ligand-gated ion channels that are principal to nervous

208 cotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that consist of pentameric com

209 NMDA-type glutamate receptors are ligand-gated ion channels that contribute to excitatory

210 AMPA receptors (AMPARs) are tetrameric ligand-gated ion channels that couple the energy of glut

211 Insect olfactory receptors operate as ligand-gated ion channels that directly transduce odor s

212 NMDA receptors are ligand-gated ion channels that mediate excitatory neurot

213 NMDA receptors are ligand-gated ion channels that mediate excitatory neurot

214 Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synapt

215 Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synapt

216 Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neu

217 Glutamate receptors are ligand-gated ion channels that mediate fast excitatory s

218 id type A (GABA(A)) receptors are pentameric ligand-gated ion channels that mediate fast inhibition i

219 GABA(A) receptors (GABA(A)Rs) are pentameric ligand-gated ion channels that mediate synaptic inhibiti

220 oxazolepropionic acid receptors (AMPARs) are ligand-gated ion channels that mediate the majority of f

221 Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that open their ion-conducting

222 MDA) receptors are obligate heterotetrameric ligand-gated ion channels that play critical roles in le

223 oxytryptamine type 3 (5-HT(3)) receptors are ligand-gated ion channels that play important roles in d

224 5-HT(3) receptors are pentameric ligand-gated ion channels that regulate synaptic activit

225 AMPA receptors are ligand-gated ion channels that show multiple conductance

226 NMDA receptors are ligand-gated ion channels that underlie transmission at

227 M3 to reduce the sensitivities of pentameric ligand-gated ion channels to their surrounding membrane

228 (P2XRs) are ATP-activated calcium-permeable ligand-gated ion channels traditionally viewed as sensor

229 Ligand-gated ion channels undergo conformational changes

230 Inhibitory glycine receptors are pentameric ligand-gated ion channels with a definitive and clinical

231 Ionotropic glutamate receptors (GluRs) are ligand-gated ion channels with a modular structure.

232 NMDA receptors are ligand-gated ion channels with a regulatory intracellula

233 aves the way for engineering light-sensitive ligand-gated ion channels with subtype specificity throu

234 ors, nuclear hormone receptors, voltage- and ligand-gated ion channels) and approximately 3180 bioact

235 members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamine type 3 re

236 lobular proteins, the opening and closing of ligand-gated ion channels, and ligand binding to hydroph

237 Bacteria have many voltage- and ligand-gated ion channels, and population-level measurem

238 PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity tw

239 3 nonselectively inhibits several excitatory ligand-gated ion channels, and we recently showed that i

240 l shares gating principles with conventional ligand-gated ion channels, but the allosteric network th

241 Desensitization is a canonical property of ligand-gated ion channels, causing progressive current d

242 onnection including ligand-receptor binding, ligand-gated ion channels, chemotaxis, chromatin structu

243 of the effect of agonist and anesthetics on ligand-gated ion channels, developed in earlier work, is

244 cell-surface receptors, and specifically for ligand-gated ion channels, for well over a century.

245 Likewise, mutations in the inhibitory ligand-gated ion channels, GABAA receptors (GABAARs), ca

246 n and function of the prokaryotic pentameric ligand-gated ion channels, GLIC and ELIC, was examined b

247 ntameric ion channel analogous to pentameric ligand-gated ion channels, however, future patch clamp e

248 ently and allosterically modulate pentameric ligand-gated ion channels, including GABA(A) receptors (

249 e receptors, G-protein coupled receptors and ligand-gated ion channels, including the NMDA glutamate

250 NMDA receptors (NMDARs), ligand-gated ion channels, play important roles in vario

251 They belong to the family of pentameric ligand-gated ion channels, sharing a highly conserved mo

252 numerous studies have focused on pentameric ligand-gated ion channels, the details of anesthetic bin

253 ilies such as G-protein-coupled receptors or ligand-gated ion channels, the sigma1 receptor is an evo

254 Similar to other ligand-gated ion channels, their gating cycle begins wit

255 or interactions of this structural family on ligand-gated ion channels, we employed HEK cells transfe

256 Using the Cys-loop superfamily of ligand-gated ion channels, we show that functional studi

257 type glutamate receptors act as voltage- and ligand-gated ion channels, with functional properties de

258 NMDA receptors are tetrameric ligand-gated ion channels.

259 RPV1 represents an excellent model system of ligand-gated ion channels.

260 nsporters can operate as anion-selective and ligand-gated ion channels.

261 t efficacy in heteromeric nAChRs and related ligand-gated ion channels.

262 lent cation binding site in other pentameric ligand-gated ion channels.

263 ing selective G-protein-coupled receptors or ligand-gated ion channels.

264 regulation between excitatory and inhibitory ligand-gated ion channels.

265 tylcholine receptors (nAChRs) are pentameric ligand-gated ion channels.

266 xt of current models of anesthetic action on ligand-gated ion channels.

267 similar to synaptic activation of classical ligand-gated ion channels.

268 ng the agonism, coagonism, and modulation of ligand-gated ion channels.

269 ditis elegans glutamate-activated pentameric ligand-gated ion channels.

270 and with their potency in inhibiting certain ligand-gated ion channels.

271 neral pathway to photosensitizing pentameric ligand-gated ion channels.

272 ating candidate agonists and antagonists for ligand-gated ion channels.

273 a complete understanding of drug actions on ligand-gated ion channels.

274 her represent one of the largest families of ligand-gated ion channels.

275 rally and functionally from simple bacterial ligand-gated ion channels.

276 LIC and possibly other homologous pentameric ligand-gated ion channels.

277 ing of the ion-conducting pore in pentameric ligand-gated ion channels.

278 ne a new molecular paradigm for gating among ligand-gated ion channels.

279 ) are members of the Cys-loop superfamily of ligand-gated ion channels.

280 fast synaptic transmission by functioning as ligand-gated ion channels.

281 GABAA) receptors, which are Cl(-)-permeable, ligand-gated ion channels.

282 ritical for channel gating in all pentameric ligand-gated ion channels.

283 ing on ion channels, most notably pentameric ligand-gated ion channels.

284 ghts on ethanol allosteric interactions with ligand-gated ion channels; and (iii) a first step for de

285 have led to the identification of MPTL-1, a ligand-gated ion-channel subunit of the parasitic nemato

286 N-methyl d-aspartate receptors are ligand-gated ionotropic receptors mediating a slow, calc

287 onal studies of a dual RCK-containing, multi-ligand gated K(+) channel from Geobacter sulfurreducens,

288 On the other hand, numerous ligand-gated K(+) channels lack such gate, suggesting th

289 In some eukaryotic and most bacterial ligand-gated K(+) channels, RCK domains regulate ion flu

290 Together, our data identify a unique ligand-gated mechanism to control receptor shedding by A

291 whereas activating an exogenously expressed ligand-gated Na(+) channel, which depolarizes horizontal

292 arly those reactive with ion channels of the ligand-gated nicotinic acetylcholine receptor superfamil

293 (K(v)) and Ca(2+) channel (L-type) families, ligand-gated P2X receptors (P2X2 and P2X4), tandem P dom

294 r the activity of, the wild-type alpha7nAChR ligand-gated pentameric ion channel, the findings point

295 tic Slo channel families and the majority of ligand-gated prokaryotic K(+) channels and transporters.

296 active peptides that allosterically modulate ligand-gated receptor function.

297 the specific binding of neurotransmitters to ligand-gated receptor ion channels.

298 ng of the transmembrane ion channel of these ligand-gated receptors is driven by conformational trans

299 Glutamate receptors are ligand-gated tetrameric ion channels that mediate synapt

300 d comprise a structurally distinct family of ligand-gated trimeric ion channels.