ライフサイエンスコーパス: ligature

1 PD was induced by a ligature.

2 one of the first molars chosen to receive a ligature.

3 l as proteolytic enzyme activity, induced by ligature.

4 , and at the end of 1 hour of treatment with ligature.

5 t the proximal and distal sides of an axonal ligature.

6 ter left anterior descending coronary artery ligature.

7 wns was visualized by a metallic interdental ligature.

8 78 +/- 7.27, respectively) in the sides with ligature.

9 AF exhibited higher ABL in the sides without ligature.

10 /-)) and challenged them with acute coronary ligature.

11 mice using Porphyromonas gingivalis infected ligatures.

12 ion of periodontitis in rats by placement of ligatures.

13 peralgesic response in animals not receiving ligatures.

14 ntitis model induced by P. gingivalis-soaked ligatures.

15 mandibular and second maxillary molars using ligatures.

16 animals per group): 1) control rats (without ligature); 2) rats with ligature + placebo (saline; oral

17 ; 2) group L: periodontal disease induced by ligature; 3) group G-Pg: oral gavage with Porphyromonas

18 umulation of AT(1) receptors proximal to the ligature, a demonstration of anterograde receptor transp

19 Distance from the ligature, a variable common to all arterial ligation exp

20 After femoral neck ligature, ADC increased a mean of 27% after 6 hours and

21 Negative controls included ligature alone (14 animals) or ligature + P. gingivalis

22 Ligature alone caused a mean bone loss of 1.01 +/- 0.06

23 SIM/SIM-mPEG; 4) 1.5 mg SIM/SIM-mPEG; or 5) ligature alone.

24 The Lig + CsA group received silk ligature and CsA treatment.

25 or MRE (10, 30, and 90 mg/kg) 1 hour before ligature and daily until day 11.

26 The ligature and injection of heat-killed Pg models were the

27 (STZ+Mel, n = 8); 4) ligature (L, n = 6); 5) ligature and melatonin (L+Mel, n = 8); 6) STZ and ligatu

28 For the second model, rats received cecal ligature and puncture (CLP) surgery and fluid therapy wi

29 rmore, polymicrobial sepsis induced by cecal ligature and puncture resulted in early death of these a

30 Coecal ligature and puncture was performed to obtain nonlethal

31 rine model of polymicrobial infection (cecal ligature and puncture), adoptive transfer of Pink1-defic

32 yte and monocyte signals at 24 h post-coecal ligature and puncture, a response mediated by TNFalpha.

33 ctomy, one first mandibular molar received a ligature and the contralateral tooth was not ligated.

34 rimental periodontitis in the rat by placing ligatures and assessed the impact of AN0128 and positive

35 Wire ligatures and cotton pellets were left in place for 2 mo

36 l; periodontitis (periodontitis induced with ligature) and high-fat + periodontitis (received hyperca

37 STZ and ligature (STZ+L, n = 8); and 7) STZ, ligature, and melatonin (STZ+L+Mel, n = 8).

38 pha exacerbates the hyperalgesic response by ligatured animals, and induces a hyperalgesic response i

39 aration (carrier) only, and two animals with ligature application alone served as negative controls.

40 titis was induced by the placement of a silk ligature around mandibular incisors.

41 d by placing a sterilized nylon (000) thread ligature around the cervix of the second left upper mola

42 scaling procedures and placing braided silk ligature around the implants.

43 n of periodontitis via the installation of a ligature around the mandibular left first molar.

44 PD was induced by cotton ligature around the maxillary left first molars (PDSG an

45 , GIOP + EP, and ATV were submitted to EP by ligature around the maxillary left second molars for 11

46 inoculation of Porphyromonas gingivalis and ligature around the murine molar.

47 schemia was investigated with placement of a ligature around the neck of a femur (n = 7); the ADC of

48 Periodontitis was induced by ligature around the same molar in seven rats.

49 val inflammation was then initiated by tying ligatures around 12 study teeth per dog and by placing t

50 iodontal disease was induced by placing silk ligatures around both maxillary and mandibular teeth.

51 ls of groups EP and EP-HD100 received cotton ligatures around mandibular first molars (MFM).

52 ls of groups EP and EP-HN019 received cotton ligatures around mandibular first molars (MFMs).

53 tiated in 18 New Zealand White rabbits using ligatures around mandibular second premolars, followed b

54 sing an isolated frog heart preparation with ligatures around the atria, Luigi Luciani, an Italian ph

55 PED was induced by placing ligatures around the cervix of the maxillary second mola

56 was induced by wrapping P. gingivalis-soaked ligatures around the left maxillary second molar and cha

57 Periodontitis was induced by ligatures around the lower first molars for 2 weeks.

58 ntal disease was induced by placing 2.0 silk ligatures around the mandibular first molar and premolar

59 PED was simulated by placing ligatures around the neck of teeth for 5 weeks.

60 ic BOO was induced by placing lumen reducing ligatures around the proximal urethra.

61 One-half of the animals received silk ligatures around their mandibular premolars followed by

62 Inflammatory responses to subgingival ligatures, assessed by changes in peripheral blood diffe

63 DM and EP was induced by the placement of a ligature at the fist mandibular and the second maxillary

64 induced by placing and maintaining 3.0 silk ligatures at a peri marginal position on the left and ri

65 s monkeys (Macaca mulatta) by tying 2.0 silk ligatures at the gingival margins of maxillary premolar/

66 ver, in gingival tissue sampled 3 days after ligature attachment, fluoxetine administration reduced I

67 inucleated TRAP+ cells in mice that received ligature attachment.

68 sponse to periodontitis-inducing subgingival ligatures compared with wild-types.

69 t affecting MMP-9 mRNA expression induced by ligature, compared to the ligature + placebo group (P <0

70 mG); maxillary right molars were used as non-ligature controls.

71 r bone loss was significantly reduced in the ligature + desipramine group (P < 0.05), whereas gingiva

72 duced periodontitis treated with vehicle; 3) ligature + desipramine: rats with ligature-induced perio

73 periodontitis and placebo treatment; and 3) ligature + doxycycline group: ligature-induced periodont

74 This non-human primate study indicates that ligature-enhanced plaque accumulation is a precursor of

75 left maxillary second molar and changing the ligatures every other day.

76 cebo (saline; oral gavage); and 3) rats with ligature + fluoxetine (20 mg/kg/day in saline; oral gava

77 IR = ischemia-reperfusion) and releasing the ligature for 30 min.

78 ary artery for 90 min and then releasing the ligature for 30 min.

79 an, after which periodontitis was induced by ligature for 4 weeks.

80 nduced by either Porphyromonas gingivalis or ligature, gamma-proteobacteria accumulate and stimulate

81 s gingival collagen degradation was like the ligature group (P > 0.05).

82 TIMP-1 when compared to vehicle alone in the ligature group (P < 0.05).

83 and and osteoprotegerin) was observed in the ligature group on day 7.

84 e-induced periodontitis and no treatment; 2) ligature group: ligature-induced periodontitis and place

85 ables within 20 minutes after release of the ligature in the 10 rats which had immediate reflow.

86 was induced in groups PERIO and CAF+PERIO by ligatures in the upper second molar.

87 The 11 days of ligature induced bone resorption, low levels of BALP, le

88 Attachment of ligature induced significantly elevated tumor necrosis f

89 Ligature-induced alveolar bone loss was diminished in ch

90 ation of anti-DC-STAMP-mAb downregulated the ligature-induced alveolar bone loss.

91 ent and radiographic alveolar bone loss in a ligature-induced beagle dog model.

92 ts of caffeine and/or estrogen deficiency on ligature-induced bone loss (BL), trabecular bone area (T

93 on controls (n = 10); (2) sham-operation and ligature-induced bone loss (n = 10); (3) orchiectomy wit

94 of the TRPV1 agonist, capsaicin, suppressed ligature-induced bone loss in mice with fewer tartrate-r

95 and subphysiologic levels of testosterone on ligature-induced bone loss in rats.

96 esented increased gingival area accompanying ligature-induced bone loss.

97 subphysiologic levels significantly increase ligature-induced bone loss.

98 titis at baseline and during the 6 months of ligature-induced disease.

99 th extraction of healthy teeth or teeth with ligature-induced EP and ZA-treated animals with extracti

100 periodontal attachment loss associated with ligature-induced experimental periodontal disease in rat

101 ur groups: 1) no periodontitis induction; 2) ligature-induced experimental periodontitis (group PR);

102 female Sprague Dawley rats were subjected to ligature-induced experimental periodontitis between maxi

103 on periodontal inflammation and bone loss in ligature-induced experimental periodontitis in vivo Puri

104 uccessfully improved periodontal health in a ligature-induced experimental periodontitis model in Wis

105 aded membranes was investigated in rats with ligature-induced experimental periodontitis, and the out

106 iched diet to ABL was not found in rats with ligature-induced experimental periodontitis, these findi

107 ially prevented the periodontal breakdown in ligature-induced experimental periodontitis.

108 The effects of CsA on ligature-induced expressions of gelatinases and EMMPRIN

109 s, CR resulted in a significant reduction in ligature-induced GI (P <0.0001), BOP (P <0.0015), PD (P

110 etate (SBHA) with 0.3% (w/v) NaOH (SBHAN) on ligature-induced gingival inflammation in the beagle dog

111 Using a ligature-induced model in type-2 Zucker diabetic fatty (

112 ition on alveolar bone loss, an experimental ligature-induced model of periodontitis was used.

113 In a ligature-induced model of periodontitis, we demonstrate

114 These findings were confirmed in an in vivo ligature-induced mouse periodontitis model in which adop

115 show evidence that the P. gingivalis-soaked ligature-induced murine model mounts an adequate inflamm

116 GFbeta, Rapamycin, and IL2 microspheres in a ligature-induced murine periodontitis model.

117 We tested the impact of ligature-induced PD on 5xFAD mice and WT littermates.

118 iodontal pathogens in plaque associated with ligature-induced peri-implantitis and ligature-induced p

119 Melatonin significantly restricted ligature-induced periodontal bone loss (P <0 .01) and su

120 In vivo studies revealed that ligature-induced periodontal bone loss is significantly

121 The inhibitory effects of CsA on the ligature-induced periodontal breakdown was examined with

122 d) were divided into two groups, with either ligature-induced periodontal disease (LPD) or control co

123 achment loss and radiographic bone loss in a ligature-induced periodontal disease beagle dog model.

124 and alveolar bone resorption associated with ligature-induced periodontal disease in female rats.

125 (OM) on the periodontal tissues of rats with ligature-induced periodontal disease.

126 t molars of rats sacrificed at 15 days after ligature-induced periodontal disease.

127 mmatory tissue destruction in a rat model of ligature-induced periodontal disease.

128 local treatment of NHPs with Cp40 inhibited ligature-induced periodontal inflammation and bone loss,

129 owed that melatonin significantly limits the ligature-induced periodontal tissue destruction (P <0.01

130 ntibody (mAb) was tested in a mouse model of ligature-induced periodontitis ( n = 6-7/group) where Pa

131 uence of probiotic (PROB) supplementation on ligature-induced periodontitis (LIP) and intestinal morp

132 bition of bone resorption in the presence of ligature-induced periodontitis (LIP).

133 -9/TIMP-1 ratio were similar among rats with ligature-induced periodontitis (P > 0.05); however, MMP-

134 domly to the following: 1) control group: no ligature-induced periodontitis and no treatment; 2) liga

135 ontitis and no treatment; 2) ligature group: ligature-induced periodontitis and placebo treatment; an

136 Using a mouse model of ligature-induced periodontitis and resolution, we tested

137 atment; and 3) ligature + doxycycline group: ligature-induced periodontitis and SDD treatment.

138 immune-modulatory activity, whose effects on ligature-induced periodontitis are yet to be investigate

139 fects of probiotic therapy (PT) in rats with ligature-induced periodontitis associated with restraint

140 nologic characteristics of a baboon model of ligature-induced periodontitis during pregnancy.

141 ected to experimental gingivitis followed by ligature-induced periodontitis in a split-mouth design.

142 Our findings suggest that ligature-induced periodontitis in animals with diabetes

143 formulation (fabricated with human CCL22) in ligature-induced periodontitis in beagle dogs leads to r

144 duction, progression, and recovery phases of ligature-induced periodontitis in rats, with the results

145 te the effects of electroacupuncture (EA) on ligature-induced periodontitis in rats.

146 s an adjuvant to the mechanical treatment of ligature-induced periodontitis in rats.

147 he effects of local administration of TIL on ligature-induced periodontitis in rats.

148 et can aggravate the liver disease caused by ligature-induced periodontitis in rats.

149 diet aggravates the liver disease caused by ligature-induced periodontitis in rats.

150 ase of pericytes and liver disease caused by ligature-induced periodontitis in rats.

151 on of antimicrobial peptides and ameliorates ligature-induced periodontitis in wild-type but not in G

152 al treatment with sFRP5 in mice subjected to ligature-induced periodontitis inhibited inflammation an

153 using a Porphyromonas gingivalis-associated ligature-induced periodontitis model in mice.

154 Subsequent experiments using a murine ligature-induced periodontitis model showed that even a

155 reduce periodontal disease severity in a rat ligature-induced periodontitis model.

156 and increased the alveolar bone loss in the ligature-induced periodontitis model.

157 Ligature-induced periodontitis resulted in significantly

158 esial/distal periodontal bone support at the ligature-induced periodontitis tooth areas.

159 ehicle; 3) ligature + desipramine: rats with ligature-induced periodontitis treated with desipramine

160 ith vehicle (saline); 2) ligature: rats with ligature-induced periodontitis treated with vehicle; 3)

161 Ligature-induced periodontitis was established in rats a

162 Ligature-induced periodontitis was examined in Goto-Kaki

163 Mice with ligature-induced periodontitis were orally treated with

164 d with ligature-induced peri-implantitis and ligature-induced periodontitis were similar.

165 rformed in rats: prevention and treatment of ligature-induced periodontitis with RvE1 topical treatme

166 phyromonas gingivalis-induced periodontitis, ligature-induced periodontitis, and aging-associated per

167 ngival plaque microbiota in the Nhp model of ligature-induced periodontitis, and that active immuniza

168 In ligature-induced periodontitis, knockout of taste signal

169 One week after ligature-induced periodontitis, the percentage of TLR4-p

170 ling and inflammatory mediators in rats with ligature-induced periodontitis.

171 duction, progression, and recovery phases of ligature-induced periodontitis.

172 sion using a nonhuman primate model of teeth ligature-induced periodontitis.

173 meters or proinflammatory cytokine levels in ligature-induced periodontitis.

174 zed with a P. gingivalis vaccine followed by ligature-induced periodontitis.

175 the gingival tissues of mice with or without ligature-induced periodontitis.

176 n promoting liver fibrosis in a rat model of ligature-induced periodontitis.

177 d from healthy sites and at sites undergoing ligature-induced periodontitis.

178 RvE1 treatment prevented bone loss in ligature-induced periodontitis.

179 l in in rats with diabetes mellitus (DM) and ligature-induced periodontitis.

180 at baseline; 0.5, 1, and 3 months following ligature-induced periodontitis; and following naturally

181 tudy suggests that P. gingivalis exacerbates ligature-induced, RANKL-dependent periodontal bone resor

182 al tissues were collected 3 or 15 days after ligature insertion (or no ligature insertion for control

183 3 or 15 days after ligature insertion (or no ligature insertion for controls) and treatments.

184 inhibitor) during periodontitis induction by ligature insertion in rats.

185 ); 3) STZ and melatonin (STZ+Mel, n = 8); 4) ligature (L, n = 6); 5) ligature and melatonin (L+Mel, n

186 ded into four groups: 1) control; 2) CsA; 3) ligature (Lig); and 4) ligature plus CsA (Lig + CsA).

187 In response to persistent subgingival ligature-mediated challenge, Rac-null mice had increased

188 Afterward, following the removal of ligatures, melatonin (10 mg/body weight) to Ep-Mel group

189 Experimental periodontitis was induced via ligature method around lower right first molar teeth.

190 Only the ligature model displayed significant alveolar bone loss

191 mRNA expression in the CCL2 MP group in the ligature model.

192 Furthermore, the blood cytokine response to ligature models showed their relevance for evaluating th

193 igature (Ocx+T; n = 10); and (6) Ocx, T, and ligature (n = 10).

194 without ligature (Ocx; n = 10); (4) Ocx and ligature (n = 10); (5) Ocx plus 250 mg/kg body weight in

195 ats in the healthy control group received no ligatures (n = 10).

196 Ligature occlusion of the artery did not decrease inulin

197 scular testosterone esters injection without ligature (Ocx+T; n = 10); and (6) Ocx, T, and ligature (

198 bone loss (n = 10); (3) orchiectomy without ligature (Ocx; n = 10); (4) Ocx and ligature (n = 10); (

199 ese include articles by Sir Astley Cooper on ligature of the common carotid artery for aneurysm, John

200 nd ischemic conditions 7 days after complete ligature of the left anterior descending coronary artery

201 usion (I/R), and mouse hearts that underwent ligature of the left anterior descending coronary artery

202 The Lig group received silk ligature on selected molars.

203 gingival inflammation 42% compared with the ligature only (P < 0.05), whereas vehicle alone had no e

204 Diathermy DCH was performed without pedicle ligature or anal-canal dressing, and a diclofenac suppos

205 clinical models: partial hepatectomy, portal ligature or embolization, and radiotherapy or chemothera

206 Surgical ligatures or fibrin sealants may be indicated in case of

207 issue compared with the control site without ligature ( P < 0.05), which was unaffected by local inje

208 rols included ligature alone (14 animals) or ligature + P. gingivalis (non-treatment; 15 animals).

209 75%; P <0.05) compared to the non-treatment (ligature + P. gingivalis) group, where significant perio

210 er canine teeth and fixed in place with wire ligature passing through holes in the flange and around

211 ntal breakdown was induced in a pre-clinical ligature periodontal inflammatory disease model.

212 ontrol rats (without ligature); 2) rats with ligature + placebo (saline; oral gavage); and 3) rats wi

213 ression induced by ligature, compared to the ligature + placebo group (P <0.05).

214 Compared to the ligature + placebo group, alveolar bone loss was reduced

215 of 18 adult Macaca mulatta (12-22 years) had ligatures placed (premolar, 1st molar teeth) in all 4 qu

216 Plaque was allowed to accumulate around wire ligatures placed into the defects.

217 Plaque was allowed to accumulate around ligatures placed into the defects.

218 crestal bone height at 3 and 6 months after ligature placement (P < .001 after 6 months).

219 ographic measurements at 3 and 6 months post-ligature placement and cessation of scaling.

220 Periodontitis was induced by ligature placement around the maxillary left second mola

221 olipoprotein E-deficient mice receiving silk ligature placement around the maxillary second molars.

222 wley) that have undergone loose, chromic gut ligature placement around the sciatic nerve.

223 HES was administered immediately after ligature placement at a dose of 75 or 150 mg/kg by intra

224 ng at four days, but not six days, following ligature placement completely abolishes the hyperalgesic

225 Mice with the ligature placement developed severe periodontitis and va

226 Periodontitis was induced by ligature placement for 7 days, and vitamin K2 (30 mg/kg)

227 laque accumulation were encouraged with wire ligature placement for 8 weeks.

228 asts and percent eroded bone after 7 days of ligature placement was similar, while four days after re

229 tion, and periodontitis was induced via silk ligature placement with Porphyromonas gingivalis lipopol

230 in TNFalpha in the hippocampus at day 8 post-ligature placement, coincident with hyperalgesia.

231 ining the locus coeruleus (LC) at day 4 post-ligature placement, followed by an increase in TNFalpha

232 ere euthanized on days 0, 3, 7, and 10 after ligature placement, for a total of 12 experimental and 1

233 -2 expression increased at 21 days following ligature placement, in conjunction with MT1-MMP expressi

234 After ligature placement, increases were observed in PI, GI, P

235 Following ligature placement, the microbiota included a large prop

236 r 10 days, G1 and G3 were subjected to EP by ligature placement.

237 were performed in both groups 28 days after ligature placement.

238 ded at baseline and 1, 2, and 3 months after ligature placement.

239 Periodontitis was induced by ligature placement.

240 ed hippocampal slices isolated at day 8 post-ligature placement.

241 spinal cord are also increased at day 8 post-ligature placement.

242 ) control; 2) CsA; 3) ligature (Lig); and 4) ligature plus CsA (Lig + CsA).

243 eriodontitis was induced in C57BL/6J mice by ligatures previously incubated with Pg (LIGPG group) or

244 t ligature treated with vehicle (saline); 2) ligature: rats with ligature-induced periodontitis treat

245 When REP was induced by removal of a CCA ligature, RCBF initially increased to 185% of baseline.

246 The mPI, and GI scores decreased after ligature removal (P < 0.001).

247 PD values were reduced following ligature removal (P < 0.05).

248 Ligature removal had a limited effect on the composition

249 initiation of gingival inflammation (before ligature removal), and 2 weeks and 4 weeks after ligatur

250 After ligature removal, rats in the Mel-Ped group were treated

251 After ligature removal, scaling, and a 2- to 4-week healing pe

252 After ligature removal, spontaneous resolution of gingival inf

253 After ligature removal, the PED group was given a single intra

254 e and 24 hours and 8 days after repair after ligature removal.

255 ture removal), and 2 weeks and 4 weeks after ligature removal: 1) plaque index (PI); 2) gingival inde

256 ore left anterior descending coronary artery ligature restored titin-based myocyte tension after MI,

257 mine effective IL-10 induction in vitro Silk ligatures (size 7-0) were tied around the mouse maxillar

258 ure and melatonin (L+Mel, n = 8); 6) STZ and ligature (STZ+L, n = 8); and 7) STZ, ligature, and melat

259 r periodontitis induction, first molars were ligatured submarginally for 4 weeks.

260 g at 6 weeks (ie, the time at which the tube-ligature suture dissolves) were used for statistical ana

261 mes a week for a 6-week period to previously ligatured teeth.

262 first molar of the animals received a cotton ligature that was left in the same position for 14 days.

263 After removal of the ligature, the rats in the melatonin groups (EP-MEL, DM-M

264 as similar, while four days after removal of ligatures, the type 2 diabetic group had significantly h

265 In the control group without the ligatures, TLR4 was detected in 19% of the neurons in th

266 Attachment of ligature to a second maxillary molar induced DC-STAMP me

267 ls also underwent unilateral L5 spinal nerve ligature to induce sustained neuropathic pain behavior.

268 Plaque was allowed to accumulate around wire ligatures to create chronic disease.

269 mation in the diabetic periodontium by using ligatures to induce periodontitis in type-2 diabetic Got

270 into three groups: 1) control: rats without ligature treated with vehicle (saline); 2) ligature: rat

271 In EP, a ligature was placed around maxillary second molars.

272 to the right lateral liver lobe, and a loose ligature was placed around the portal venous branch supp

273 For the EP groups, a ligature was placed around the right mandibular first mo

274 This stain disappeared if a ligature was placed on the dorsal root to block axonal t

275 doxycycline (6 mg/kg) for 21 days after the ligature was placed.

276 After 7 days, the ligature was removed, and the animals were distributed i

277 After 7 days, the ligature was removed, and the rats were randomly divided

278 imental peri-implantitis by the use of three ligatures (weeks 31, 34, 37) followed by open flap debri

279 Silk ligatures were applied to the maxillary second molars in

280 create experimental periodontitis, 4/0 silk ligatures were inserted submarginally around first molar

281 Cotton ligatures were next placed around the healing-abutments

282 The ligatures were placed 30 days postorchiectomy (or sham-o

283 Silk ligatures were placed around the cervical area of the ma

284 Wire ligatures were placed into these defects for plaque accu

285 Silk ligatures were placed subgingivally around the mandibula

286 At the same time, P. gingivalis-soaked ligatures were placed subgingivally around the maxillary

287 s of the right hind limb was ligated and the ligatures were released after a predetermined period of

288 Ligatures were removed after 7 days, and rats were then

289 Three weeks later, the ligatures were removed and 4 different treatment modalit

290 Ligatures were removed from the second molars on day 14,

291 After 2 mos, the ligatures were removed, and a notch was placed at the ba

292 After 30 days, ligatures were removed, dogs were placed on a hard diet

293 After 2 months, the wire ligatures were removed, the teeth and roots scaled and r

294 After 2 months, the ligatures were removed, the teeth were scaled and root p

295 r all experimental teeth after delivery, and ligatures were removed.

296 ere repeated at 10 months post-baseline, and ligatures were removed.

297 Ligatures were tied around selected teeth to initiate or

298 cal evaluation was performed, and additional ligatures were tied on teeth in the contralateral quadra

299 We showed that after the removal of ligatures, which induces resolution of periodontal infla

300 Wistar rats were subjected to ABR by ligature with nylon thread in the second upper-left mola