ライフサイエンスコーパス: limb

1 es between the thrust produced by each upper-limb).

2 workload in RT exercises of upper and lower limbs).

3 ects the flexible usage of the primate upper limb.

4 ion in the distal and ventral portion of the limb.

5 er interface that spreads targets across all limbs.

6 volved via changes in the thorax, pelvis and limbs.

7 evels were upregulated in skin of allogeneic limbs.

8 volve anti-phase coordination among the four limbs.

9 between the dominant and non-dominant upper-limbs.

10 when instructed by sensory signals from the limbs.

11 affecting the heart, kidney, vertebrae, and limbs.

12 trial locomotion occurred with the origin of limbs.

13 perfusion and angiogenesis in ischemic hind limbs.

14 stic high-dimensional articulated prosthetic limbs.

15 ous were predominantly involved in the upper limbs.

16 hen performing simultaneous movements of the limbs?

17 ness that subsequently expanded to the upper limbs, (2) cerebellar ataxia, (3) psychosis and/or sever

18 magnitude during the bimanual loads for both limbs (25%).

19 e in the preferred loads for the ipsilateral limb (~25%) than the contralateral limb (~9%).

20 31.1% reduction in volume difference between limbs, 33.9% at 6 months, 25.7% at 12 months, 47.4% at 2

21 r detecting MI and is difficulty to apply to limb 6-lead ECG based life type or wearable devices.

22 at reconstructed precordial 6-lead ECG using limb 6-lead ECG.

23 ontralateral limb (97%) than the ipsilateral limb (66%).

24 silateral limb (~25%) than the contralateral limb (~9%).

25 manual variance related to the contralateral limb (97%) than the ipsilateral limb (66%).

26 performance of the contralateral, untrained limb, a phenomenon known as cross transfer.

27 ific characteristics, including the cause of limb absence (acquired or congenital) and hours of daily

28 would offer insight on how individuals with limb absence could modify their behavior to more fully e

29 sample of nine individuals with transradial limb absence, embodiment was quantified using a survey r

30 nctional recovery for individuals with upper limb absence.

31 extracted to characterize balance, the lower limb accelerometry-based metrics proved to be most infor

32 , 1.51 [95% CI, 1.13 - 2.03], P=0.0058), and limb adverse events (adjusted HR, 8.37, P<0.001).

33 riction and recirculation of blood flow to a limb after traumatic brain injury (TBI), can modify leve

34 and other salamanders can regenerate entire limbs after amputation as adults, and much recent effort

35 characterized by kinetic tremor of the upper limbs, although other clinical features can also occur.

36 ications induced by these wounds can lead to limb amputation or even death and urgently require more

37 re, we demonstrate in four people with upper-limb amputation that epidural spinal cord stimulation (S

38 Adjusted for history of PVD, death or limb amputation was more common in patients with COVID-1

39 dynamic improvement, quality of life, target limb amputation, and all-cause mortality.

40 al limb ischemia patients undergoing a lower-limb amputation.

41 ft recipients and victims of traumatic major limb amputation.

42 reatening disease that often result in lower limb amputations and a shortened lifespan.

43 toring somatosensory feedback to people with limb amputations is crucial to improve prosthetic contro

44 In individuals with lower-limb amputations, robotic prostheses can increase walkin

45 owards restoring sensory perception to upper-limb amputees, which includes the whole spectrum from ge

46 eal-time control experiments involving upper-limb amputees.

47 nisms for directional movements mediated via limb and axial spinal circuits.

48 Examining whether and how the rhythms of limb and breathing movements interact is highly informat

49 nd how this affects postintervention adverse limb and cardiovascular events.

50 arization are at high risk for major adverse limb and cardiovascular events.

51 ipheral artery disease patients face earlier limb and later cardiovascular ischemic risk that is heig

52 resistance of locomotor muscle during single-limb and whole-body exercise modalities.

53 e in females compared to males during single-limb and whole-body exercise.

54 Limb and/or trunk restraints were used "daily" in the la

55 n turning, and that activations in different limbs and body regions produce distinct behaviors.

56 tively small scales the bending movements of limbs and ctenes conform to the patterns observed for mu

57 ght hand, progressive weakness in both lower limbs and weight loss.

58 t of the kidney, skin, neural tube, lung and limb, and many other organs and tissues.

59 rative joints are a hallmark of the tetrapod limb, and their positioning is a key step during limb de

60 sorder characterized by short stature, short limbs, and craniofacial anomalies.

61 tiple malformations of the vertebrae, heart, limbs, and kidney, and no affected individual survived f

62 an exercise-induced muscle stiffness of the limbs, and often of the eyelids.

63 In particular, limb angles and symmetry appeared to be the most relevan

64 e speed achieved while performing each upper-limb arm-pull.

65 or the swim speed achieved during each upper-limb arm-pull.

66 he speed achieved by each one of their upper-limbs arm-pull.

67 f the human brain to represent an artificial limb as a body part (embodiment) has been inspiring engi

68 Here, we used the developing limb as a model system to compare the binding specificit

69 nd-guided treatments of varices in the lower limbs, as well as to provide a brief overview of the mai

70 ned touch location in external space affects limb assignment: the crossed right hand is localized in

71 duplex US for vascular mapping before upper limb AVF creation in participants with CKD.

72 limb bud, the establishment of the principal limb axes, the specification of pattern, the integration

73 Effective limb-based locomotion did not arise until loss of the an

74 modules (Nature) to accommodate the changing limb biomechanics and influences from sensorimotor train

75 ance of a comprehensive description of lower-limb biomechanics that includes consideration of joint m

76 Utilizing limb blood flow occlusion, we demonstrate that critical

77 se hindlimb ischemia model, with accelerated limb blood flow recovery compared to controls.

78 the ectodermal compartment, using the mouse limb bud as a model.

79 findings imply that IRX3/5 coordinate early limb bud morphogenesis with skeletal pattern formation.

80 pattern formation, IRX3/5 help to shape the limb bud primordium by promoting the separation and inte

81 ike cells, the developmental ontology of the limb bud, or definitive endoderm.

82 sitioning of the limbs, the formation of the limb bud, the establishment of the principal limb axes,

83 nt along which cells move to shape the early limb bud.

84 They also retain H3K27ac enrichment in limb buds devoid of GLI activator and repressor, indicat

85 In the emerging limb buds, different subgroups of Hoxd genes respond fir

86 find that upon ectopic expression in distal limb buds, HOXA11 binds sites normally HOX13-specific.

87 spliceosome function in the developing mouse limb by ablating one of its essential components, U11 sm

88 emains unknown whether training of the upper limb can induce the cross-transfer effect to the trunk m

89 The vertebrate limb continues to serve as an influential model of growt

90 mall stature with proximal shortening of the limbs, contractures, facial dysmorphism, congenital cata

91 y rostrocaudal patterning to the assembly of limb control circuits.

92 otor network, with sensory feedback from the limbs controlling the direction.SIGNIFICANCE STATEMENT A

93 Using this method, we have characterized limb coordination and walking behavior in response to tr

94 y produces the rhythmic output necessary for limb coordination during locomotion.

95 dages of L. illecebrosa indicates that these limbs correspond to the deutocerebral segment and are th

96 icantly improved fine motor movements of the limb corresponding to the sensorimotor stroke lesion sit

97 During cortical reorganization that follows limb deafferentation, neurons in deafferented forelimb S

98 phila coordinate the movements of individual limbs (DeAngelis et al., 2019).

99 a critical window of development results in limb defects in humans and non-human primates while mice

100 am syndrome (HOS), which is characterized by limb defects in humans, but the underlying mechanistic b

101 polymorphisms phenocopy thalidomide-induced limb defects in humans.

102 o-mutation in Tbx5 heterozygotes rescued the limb defects, thus placing Tbx5 upstream of Hh-signaling

103 hus placing Tbx5 upstream of Hh-signaling in limb defects.

104 ac, vertebral, tracheo-esophageal, renal and limb defects.

105 by measuring changes in DNA synthesis after limb denervation.

106 xhibit significant differences between upper-limbs determinants.

107 Despite being vital for limb development and size regulation, its role remains u

108 mponent necessary for understanding not only limb development but also the molecular and genetic mech

109 w that the minor spliceosome is required for limb development via size control potentially shared in

110 , and their positioning is a key step during limb development.

111 ed to: (1) verify a hypothetical inter-upper limb difference in the determinants related to front-cra

112 Limb displacement causes muscle stretch; the corrective

113 ges from an axial-driven mode in larvae to a limb-driven one in adult frogs.

114 t with the loss of sensory feedback from the limbs due to peripheral neuropathy to result in motor im

115 The reference test was a full lower limb duplex ultrasound.

116 The reaching task with assistive limb dynamics was associated with the most muscle co-con

117 was co-opted to be transcribed in the distal limb ectoderm, where it is activated following the rule

118 In contrast, risk for major adverse limb events (2.6% vs. 3.0%) and hospitalization for acut

119 patency rate and Freedom from major adverse limb events (F-MALE).

120 prognosis after post-procedure major adverse limb events (MALE) are not well-studied.

121 diovascular events (MACEs) and major adverse limb events (MALEs).

122 aspirin to reduce major cardiac and ischemic limb events after lower extremity revascularization.

123 tion confers very high risk of major adverse limb events early postprocedure.

124 valuate sex-specific differences in MACE and limb events in the EUCLID (Examining Use of Ticagrelor i

125 , 0.92 (95% CI, 0.85-1.00) for major adverse limb events, 0.60 (95% CI, 0.48-0.74) for myocardial inf

126 cardial infarction, stroke, or major adverse limb events, including amputation).

127 ssociated with an increased risk of ischemic limb events.

128 ociated with greatest risk for major adverse limb events.

129 ence between dominant and non-dominant upper-limbs (except for the hand surface area).

130 uctured limbs-exercise program (3 supervised limb exercise sessions /week, 60 min /session for the fi

131 For single-limb exercise, the intensity-duration relationship is di

132 general cognitive function in the structured limbs-exercise intervention were identified.

133 ne of the two arms: (1) a 24-week structured limbs-exercise program (3 supervised limb exercise sessi

134 ated to cognitive function in the structured limbs-exercise program (Z= 9.294, p<0.01); (3) Processin

135 w as following: (1) The effect of structured limbs-exercise program on cognitive function was partial

136 The structured limbs-exercise program was beneficial for maintaining ge

137 e effectiveness and mechanisms of structured limbs-exercise-induced cognitive improvement respectivel

138 e disease score (SCORAD), involvement of the limbs, flexural lesion distribution at the age of 3 year

139 is a highfidelity replicate of the original limb (Flowers et al. 2017).

140 lied to the planta pedis of the transplanted limb for 10 days, 4 times daily for 10 minutes.

141 he 3D kinematics of a rat's head, trunk, and limbs for week-long timescales in freely behaving animal

142 The HoxD gene cluster is critical for proper limb formation in tetrapods.

143 ready known to be required for body axis and limb formation, thus validating our approach; plus, many

144 s or older who underwent surgery for a lower limb fracture caused by major trauma from July 7, 2016,

145 After excluding patients whose limb fractures increased ISS above 15, the group decreas

146 ffects contribute to further the recovery of limb function following SCI.SIGNIFICANCE STATEMENT Accum

147 Improvements in upper limb function occurred at 3, 6 and 12 months, but not in

148 omprise four subtypes of autosomal recessive limb-girdle muscular dystrophies (LGMDR3, LGMDR4, LGMDR5

149 JB6 cause a late-onset muscle disease termed limb-girdle muscular dystrophy type D1 (LGMDD1), which i

150 The injured limb had greater vertical peak forces, with improved dut

151 regression, the speed achieved by each upper-limb identified a set of variables, with the peak speed

152 3 +/- 1 y) underwent 7 d of unilateral lower-limb immobilization, with thrice-daily leucine (LEU; n =

153 Training of one limb improves performance of the contralateral, untraine

154 ient T cells in the skin of the transplanted limb in the absence of clinical or histological evidence

155 afferents are absent in the upper and lower limbs in HSAN III, and we have argued that this may acco

156 ften referred to as one of the most flexible limbs in nature, yet this assumption requires detailed i

157 nerated tails in the tuatara and regenerated limbs in Xenopus adult frogs, which have a cartilaginous

158 imaging study with people born without upper limbs-individuals with dysplasia-who use the feet to act

159 implicit treatment of the elasticity of the limbs, inelastic collision between a soft body and rigid

160 ABSTRACT: Chronic pain and disability after limb injury are major public health problems.

161 lting from defective survival of a subset of limb-innervating motor neurons and abnormal migration of

162 inant cervical, bulbar, orofacial, and upper limb involvement.

163 regeneration and found that the regenerated limb is a highfidelity replicate of the original limb (F

164 h rate-dependent unidirectional block in one limb, is associated with atrial fibrillation (AF) induct

165 2.6% vs. 3.0%) and hospitalization for acute limb ischemia (1.6% vs. 1.7%) were not different by sex.

166 optimal revascularization strategy for acute limb ischemia (ALI) remains unclear, and contemporary co

167 stantial cohort of patients without critical limb ischemia (CLI) have not been described.

168 Critical limb ischemia (CLI) is the most advanced stage of periph

169 on cannula was associated with lower odds of limb ischemia (odds ratio, 1.93; 95% CI, 1.17-2.47; p =

170 une-related complication that often leads to limb ischemia and thromboembolism, is proposed.

171 a to identify patients admitted for critical limb ischemia between 2005 and 2014.

172 In mouse hind limb ischemia model, local intramuscular delivery of CSC

173 and on blood vessels from diabetic critical limb ischemia patients undergoing a lower-limb amputatio

174 A total of 20 938 veterans with critical limb ischemia were hospitalized between 2005 and 2014.

175 lar complications like significant bleeding, limb ischemia, and cannula site bleeding were 15.4% (95%

176 prespecified analysis, PAD events (critical limb ischemia, limb revascularization, or amputation for

177 ry efficacy outcome was a composite of acute limb ischemia, major amputation of a vascular cause, myo

178 jor amputation were obtained including acute limb ischemia, revascularization, and all-cause mortalit

179 ation increased among veterans with critical limb ischemia, which was accompanied by a reduction in m

180 C consisted of 4 x 5 min cycles of left hind limb ischemia.

181 with dapagliflozin versus placebo including limb ischemic adverse events (HR, 1.07 [95% CI, 0.90-1.2

182 putations, peripheral revascularization, and limb ischemic adverse events were site-reported and cate

183 There were 560 patients who had at least 1 limb ischemic event, 454 patients with at least 1 periph

184 stain a greater relative intensity of single-limb, isometric exercise than males, limited investigati

185 e triggered in the chondral surface of adult limb joints in mice by stimulating a regenerative respon

186 y in the liver, kidneys, and upper and lower limb joints.

187 Detailed assessment of joint movements and limb kinetics during overground locomotion in female adu

188 of the body's dimensions, was assessed using limb length estimation.

189 height based on unaffected leg and residual limb length.

190 rhythmic oscillation involving distal upper limbs, linked to increased sensorimotor cortex excitabil

191 Greater risk of limb loss among patients with beta-hemolytic streptococc

192 were followed up for the outcomes of death, limb loss, and streptococcal toxic shock syndrome.

193 disease, associated with significant risk of limb loss, morbidity and mortality; however, there remai

194 istics that predispose to both infection and limb loss.

195 bs recovered quickly; however, in allogeneic limbs, macroscopic skin alterations were significantly m

196 erwent full clinical characterization, lower limb magnetic resonance imaging (MRI), muscle biopsy, an

197 s required for digit identity in a subset of limb mesenchymal cells.

198 g single-limb or combined upper and/or lower limb motions.

199 nts of recurrent inhibition in primate upper limb motoneurons, revealing that it is more flexibly org

200 ystem for investigating neural mechanisms of limb motor control.

201 eclined during the 18-year period, including limb motor deficit (from 77% [95% CI 74%-81%] to 62% [56

202 a complexity of acute impairments, of which limb motor deficit, dysphagia, and incontinence have dec

203 had low levels of all impairments except for limb motor impairment and dysarthria.

204 one of the largest overall datasets of upper limb motor recovery.

205 correlated with MEP amplitudes in the upper limb motor region.

206 2 months, but not in those with absent upper limb movement at baseline, suggesting a possible target

207 that mylpf impairment most severely affects limb movement.

208 feasibility of decoding kinematics for lower limb movements during walking.

209 t to significant stretch deformations during limb movements or sudden head movements, especially duri

210 isease as they executed cued upper and lower limb movements.

211 The medullary thick ascending limb (mTAL) plays a key role in urinary acid and NaCl ex

212 This study aimed to investigate lower-limb muscle activities in gait phases and co-contraction

213 est" postures require higher levels of lower limb muscle activity than chair sitting.

214 e anesthetized and exposed to bilateral hind limb muscle contractions (both concentric and eccentric)

215 l-motor neuronal synapses of upper- or lower-limb muscles (depending on the injury level), 1-2 ms bef

216 n each day, motor-evoked potentials in upper limb muscles were first measured after stimulation of th

217 mly assigned adult patients undergoing lower-limb nonmajor orthopedic surgery who were considered to

218 nucleus, putamen, corpus callosum, posterior limb of internal capsule), level of brainstem, grey- whi

219 he Faroe Bank Channel and supplies the lower limb of the Atlantic Meridional Overturning Circulation,

220 model A gave a better fit to the lengthening limb of the force-velocity relation than model B.

221 (N = 50) that underwent DBS to the anterior limb of the internal capsule (ALIC), the nucleus accumbe

222 Only the posterior limb of the internal capsule (IC), comprised primarily o

223 hemisphere, 1.17 x10(3)mum(2)/sec), anterior limb of the internal capsule (left, 1.11 x10(3)mum(2)/se

224 Results The posterior limb of the internal capsule (mean ADC: left hemisphere,

225 These include the anterior limb of the internal capsule, the ventral striatum, the

226 orin 1-negative cells of the thin descending limb of the loop of Henle, and principal cells of the co

227 Clearly, the two limbs of autonomic control over the stomach are influenc

228 to manipulate neural activity in individual limbs of freely moving animals.

229 ified CRISPR/Cas9-generated mutations in the limbs of mosaic mutant axolotls before and after regener

230 of mRNAs encoding components of the negative limbs of the core circadian clock, most notably REV-ERBa

231 To this end, we have studied the limbs of the Hoxa13 mouse mutant that specifically fail

232 ter areas near the hippocampus and posterior limbs of the internal capsule.

233 to visually cued stimuli representing single-limb or combined upper and/or lower limb motions.

234 tential of musculoskeletal tissues following limb or digit loss.

235 ng animals who use multiple propulsors, e.g. limbs or ctenes, which move with antiplectic metachronal

236 there were no significant differences in any limb outcome with dapagliflozin versus placebo including

237 Long-term cardiovascular and limb outcomes after revascularization for peripheral art

238 ally, atorvastatin promoted favorable venous limb outward remodeling, preserved arteriovenous fistula

239 eloped spasticity predominantly of the lower limbs over the course of the disease.

240 thesized to underlie phenotypes like phantom limb pain and hinder recovery.

241 irs move synchronously while the ipsilateral limb pairs move out-of-phase during stepping.

242 orelimb coordination, ensuring that diagonal limb pairs move synchronously while the ipsilateral limb

243 factors including HOXA9/A10/D13 involved in limb patterning and RELA, JUN and NFAT5, which have targ

244 tissue sarcoma (STS) to neoadjuvant isolated limb perfusion (ILP).

245 skilled reaching, spontaneous limb use, and limb placement over a 7 week period after stroke.

246 at integrates cortical commands to stabilize limb posture.

247 As a result, limb progenitor cells experience delayed prometaphase-to

248 While limb proportions and zygapophyseal facets vary among Eus

249 ng a real-time pain reaction system in upper-limb prostheses.

250 erebellum that is ipsilateral to the passive limb receiving the touch.

251 Minor skin alterations in syngeneic limbs recovered quickly; however, in allogeneic limbs, m

252 ation (CMR) is a promising therapy for upper limb recovery in stroke, but the brain mechanisms are un

253 ill contribute to the understanding of upper limb recovery patterns in the first 6 months after strok

254 ges have been described as being crucial for limb regeneration and in certain circumstances have been

255 ur yeast osmotic stress response and axolotl limb regeneration case studies.

256 within the proliferating progenitors during limb regeneration.

257 epidermis is required to initiate salamander limb regeneration.

258 g in animals to identify genes essential for limb regeneration.

259 vascular and kidney efficacy and the risk of limb-related events in patients with and without PAD in

260 prosthesis is a novel concept of artificial limb replacement that allows to extract control signals

261 romatin accessibility specific to the distal limb requires HOX13 function.

262 tructured questionnaire whether trunk and/or limb restraints were used on that resident during the la

263 With Rivaroxaban in Endovascular or Surgical Limb Revascularization for Peripheral Artery Disease) de

264 Estimating the likely success of limb revascularization in patients with lower-extremity

265 nalysis, PAD events (critical limb ischemia, limb revascularization, or amputation for ischemia) and

266 90 days, amputation-free survival (AFS) and Limb salvage (LS) were noticeably worse in P2 compared t

267 a is central to decisions between attempting limb salvage and amputation.

268 cal management to maximize the potential for limb salvage.

269 009-2014, we enrolled 30 patients with trunk/limb sarcomas, melanoma, Merkel-cell carcinoma, and colo

270 nown about how downstream circuits transform limb sensory information to guide motor output.

271 onary phase and tethering of the lipoprotein LimB similar throughout the cell cycle.

272 Focusing on the developing limb, single-cell RNA data identified 25 candidate cell

273 We find that limb size is reduced owing to elevated minor intron rete

274 m, blood, kidneys, smooth muscle lineage and limb skeleton in the developing vertebrate embryo.

275 stinct disease progression profiles based on limb-specific paresis and paralysis, tremors and seizure

276 s, an energy-consuming process that enhances limb stability.

277 ses disabling and incurable contractures, or limb stiffness, which result from proteasome-mediated pr

278 o restrict distal early (DE)/thick ascending limb (TAL) segment lineage assignment in the developing

279 comprehensive atlas of the transcriptome of limb tendons in adult mice and rats using systems biolog

280 while retaining sensitivity to another known limb teratogen, all-trans retinoic acid (atRA).

281 es, we concentrate on the positioning of the limbs, the formation of the limb bud, the establishment

282 bolism, and a minority of them have proximal limb-threatening deep vein thrombosis (DVT).

283 on the basis of whether patients had chronic limb-threatening ischemia (1480 patients) or intermitten

284 treatment groups among patients with chronic limb-threatening ischemia (33.4% [249 patients] in the d

285 For chronic limb-threatening ischemia, the mortality difference was

286 immers may exhibit imbalances in their upper-limbs' thrust (differences between the thrust produced b

287 of amputation performed because of nonviable limb tissue were 12.2% and 19.6% in the US joint trauma

288 nificantly compromised the prediction of the limb to be moved.

289 l integration of the commands that moved the limb to that location.

290 extinct tetrapodomorphs that span the fin-to-limb transition and use functionally informed ecological

291 evaluated for skilled reaching, spontaneous limb use, and limb placement over a 7 week period after

292 teral to CFA reduced recovery of spontaneous limb use.

293 noxious stimulation of an amputee's phantom limb using transcutaneous nerve stimulation (TENS).

294 hing frequency is inherently proportional to limb velocity and imposed by a synchronization of breath

295 oring somatosensation related to the missing limb via direct activation of the sensory nerves in the

296 mpact Scale (LLIS) scores, and postoperative limb volume calculations were analyzed.

297 The reduction in limb volume difference followed a similar pattern but wa

298 pear to have a more substantial reduction in limb volume differential compared to LEL patients.

299 uron disorder responsible for proximal lower limb weakness that subsequently expanded to the upper li

300 sparse for the control of the primate upper limb, where no direct measurements have been made to dat

301 first and most affected muscle in the lower limbs, whereas the triceps and interosseous were predomi