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2 o characterize the abundance and identity of limpets along the south-eastern Pacific coast from 18 de
3 ch as the more obvious outgroup, the keyhole limpet, an observation common to other DNA sequence anal
5 rt a notable example of CGP in the Antarctic limpet, an unusually tractable system where multiple con
6 species of the genus Haliotis plus a keyhole limpet and a more distantly related gastropod, the Chile
7 Complementary, ancient and modern shells of limpets and mussels were isotopically analysed to explor
8 The highest concentrations detected were in limpets and sea urchins, followed by sea stars, ascidian
9 rms of 4 closely related intertidal Nacellid limpets, Antarctic (Nacella concinna), New Zealand (Cell
10 ation, ranging from tiny pigment-cup eyes in limpets, compound eyes in ark clams and pinhole eyes in
11 unctatus), trematode parasites for a keyhole limpet (Fissurella latimarginata), and pinnotherid pea c
13 ritional and techno-functional properties of limpets, found attached to rocks on the shores of Cornwa
14 conomically important Cape turban shells and limpets from MSA layers along the south and west coasts
17 150 mug GM-CSF) or control (100 mug keyhole limpet haemocyanin) via monthly intradermal injection un
20 njugated to immunocyanin monomers of keyhole limpet hemocyanin (IC(KLH)) to create the MCV ICKLH-SOO9
23 n conjugated to the carrier protein, keyhole limpet hemocyanin (KLH) - to be capable of inducing broa
24 Fc stimulated the production of anti-keyhole limpet hemocyanin (KLH) Ab, increasing anti-KLH IgG, IgG
26 lin (Ig) idiotype (Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with granulocyt
27 derivative was covalently linked to keyhole limpet hemocyanin (KLH) and monophosphoryl lipid A (MPLA
28 were pulsed with 2 foreign proteins, keyhole limpet hemocyanin (KLH) and tetanus toxoid (TT), as well
29 unization with two conjugates, Tn(c)-keyhole limpet hemocyanin (KLH) and Tn(c)-palmitic acid (PAM) wi
30 -idiotypic mAb MK2-23, conjugated to keyhole limpet hemocyanin (KLH) as a carrier and given with Baci
33 ogenicity, we bound thiolated MEP to keyhole limpet hemocyanin (KLH) by using succinimidyl-4-(N-malei
34 bodies generated to the glycoprotein keyhole limpet hemocyanin (KLH) can cross-link with reactive car
35 njugation of the glycopeptide to the keyhole limpet hemocyanin (KLH) carrier protein completed the pr
36 and conjugated to maleimide-modified keyhole limpet hemocyanin (KLH) carrier protein through backbone
37 t regions plus GM-CSF, or linkage to keyhole limpet hemocyanin (KLH) carrier protein were increasingl
39 Delta71-82 alphaS, human betaS, and keyhole limpet hemocyanin (KLH) control proteins induced no symp
42 cally synthesized, and conjugated to keyhole limpet hemocyanin (KLH) for examining its immunogenicity
43 ition (6OXY(Gly)(4)OH) conjugated to keyhole limpet hemocyanin (KLH) has shown early proof-of-efficac
45 ,4,6-trinitrophenol (TNP)-conjugated keyhole limpet hemocyanin (KLH) in a specific pathogen-free envi
46 ation with the cocaine immunogen GNC-keyhole limpet hemocyanin (KLH) in preventing cocaine self-admin
49 neration cocaine immunoconjugate GND-keyhole limpet hemocyanin (KLH) or with the anti-cocaine mAb GNC
50 comprising Id chemically coupled to keyhole limpet hemocyanin (KLH) plus granulocyte macrophage colo
51 onjugated to the immunogenic protein keyhole limpet hemocyanin (KLH) protects mice from tumor challen
52 e PI3P hapten to maleimide-activated keyhole limpet hemocyanin (KLH) provided a PI3P immunogen, which
53 hallenge of the transgenic mice with keyhole limpet hemocyanin (KLH) resulted in a decrease in anti-K
54 l models of inflammation including a keyhole limpet hemocyanin (KLH) study and a collagen-induced art
55 compounds demonstrated efficacy in a Keyhole Limpet Hemocyanin (KLH) study in rats, where the blockad
58 immunogenic foreign carrier protein keyhole limpet hemocyanin (KLH) using glutaraldehyde has shown p
59 by adding antimyeloma idiotype (Id)-keyhole limpet hemocyanin (KLH) vaccine to vaccine-specific cost
61 ptides and to peptides conjugated to keyhole limpet hemocyanin (KLH) were characterized by their abil
63 eptide mimetics of GXM conjugated to keyhole limpet hemocyanin (KLH) with glutaraldehyde developed Ab
66 y) is conjugated to ovalbumin (OVA), keyhole limpet hemocyanin (KLH), and a bis-maleimide; KLH conjug
68 ainst an exogenous, nonself antigen, keyhole limpet hemocyanin (KLH), by releasing IL-4 in the microe
69 ddition of a foreign helper protein, keyhole limpet hemocyanin (KLH), can augment the efficacy of tum
70 vaged with a single dose of 20 mg of keyhole limpet hemocyanin (KLH), followed by s.c. immunization w
71 H antigen conjugated to the protein keyhole limpet hemocyanin (KLH), has been in clinical evaluation
72 d 4-6 weeks later by DCs pulsed with keyhole limpet hemocyanin (KLH), HLA-A*0201-positive restricted
73 primary response to PC conjugated to keyhole limpet hemocyanin (KLH), T15 Id(+) Abs constitute >90% o
74 typic mAb immunization protocol (mAb-keyhole limpet hemocyanin (KLH)-Calmette-Guerin bacillus (BCG),
76 ere cocultured with HDK-1 T cells (a keyhole limpet hemocyanin (KLH)-specific CD4+ Th1 clone) in the
84 recombinant HPV16/18 E7 antigens and keyhole limpet hemocyanin (KLH; an immunological tracer molecule
85 droxy-3-nitrophenyl(5) conjugated to keyhole limpet hemocyanin (NP(5)- KLH) or infected with HSV-1, a
86 se to 4-hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin (NP-KLH) and NP-OVA develops within ec
87 3-nitrophenyl acetyl (NP)-conjugated keyhole limpet hemocyanin (NP-KLH) or ovalbumin(323-337) peptide
90 to disease-inducing (TNP-conjugated keyhole limpet hemocyanin [TNP-KLH]) and disease-inhibiting (ant
92 d with nitrophenol hapten-conjugated keyhole limpet hemocyanin adsorbed to Imject aluminum hydroxide-
93 mounted a substantial Ab response to keyhole limpet hemocyanin after completion of anti-CD40L Ab trea
94 Moreover, mDCs(ICOS) pulsed with the keyhole limpet hemocyanin Ag during the maturation phase were be
96 s vaccination with GM2 conjugated to keyhole limpet hemocyanin and administered with QS-21 (GMK) for
97 ginata hemocyanin in comparison with keyhole limpet hemocyanin and C. concholepas hemocyanin, which w
98 dy responses against protein antigen keyhole limpet hemocyanin and carbohydrate antigen sTn, respecti
100 -hydroxykynurenine (3OHKYN)-modified keyhole limpet hemocyanin and characterized it using 3OHKYN-modi
102 sting of tumor Ig protein coupled to keyhole limpet hemocyanin and emulsified in an immunologic adjuv
103 Th2 immune deviation induced with keyhole limpet hemocyanin and IFA did not affect corneal allogra
104 ith cytokine-matured DCs loaded with keyhole limpet hemocyanin and MHC-I alone or MHC-I/II-restricted
105 two different immunogenic carriers, keyhole limpet hemocyanin and N-alpha-palmitoyl-S-[2,3-bis(palmi
106 ral responses to the T-dependent Ags keyhole limpet hemocyanin and OVA, as well as reduced Ag-specifi
107 its production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicating that
108 In response to trinitrophenol (TNP)-keyhole limpet hemocyanin and tetanus/diphtheria vaccine, CD40Lt
109 mocyanin or trinitrophenylated (TNP) keyhole limpet hemocyanin and the type 2 T-independent Ags TNP-F
110 rom the hybridoma, was conjugated to keyhole limpet hemocyanin and used to immunize Balb/c mice by ad
112 assay and immunoblots using anti-AGE-keyhole limpet hemocyanin antibody, aminoguanidine inhibited glu
113 nses of L-selectin-deficient mice to keyhole limpet hemocyanin are indistinguishable from wild-type c
114 e induced after immunization with PC-keyhole limpet hemocyanin but at significantly lower levels than
115 eactive CTL, and development of anti-keyhole limpet hemocyanin CD4+ T cells, rejection of allogeneic
116 ccine, MH6, was then contrasted with keyhole limpet hemocyanin conjugate vaccine in a subsequent expe
119 ice vaccinated with the CD20 peptide keyhole limpet hemocyanin conjugates had a 25% decrease in CD19(
120 ogenicity of three synthetic globo H-keyhole limpet hemocyanin conjugates plus the immunologic adjuva
121 ice immunized with PA1 conjugated to keyhole limpet hemocyanin developed high anti-peptide (1/13,000)
122 ) propeptide [SLS(10-30)] coupled to keyhole limpet hemocyanin evoked antibodies in rabbits that comp
123 naive mice with 3H1 conjugated with keyhole limpet hemocyanin Freund's adjuvant induced humoral and
125 -trinitrophenyl hapten conjugated to keyhole limpet hemocyanin immunization and nephritis induction.
126 -Trinitrophenyl hapten conjugated to keyhole limpet hemocyanin immunization resulted in higher affini
127 , antigen-specific IgG1 responses to keyhole limpet hemocyanin immunization, regulated CD4(+) T-cell
129 nd in 4-hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin immunized animals; recall responses we
130 a T helper 2 response (ovalbumin or keyhole limpet hemocyanin in alum) and is only seen with T cell-
132 , or 100,000-mug doses of intranasal keyhole limpet hemocyanin in conjunction with adjuvant intranasa
135 ent with a secondary Th2 response to keyhole limpet hemocyanin or A. fumagatus extract, or by intrana
136 loading immature DCs with the neoAgs keyhole limpet hemocyanin or human immunodeficiency virus-1 p24
137 ent, secondary Th2 lung responses to keyhole limpet hemocyanin or primary responses to Nippostrongylu
138 nt (TD) Ags fluorescein-labeled (FL) keyhole limpet hemocyanin or trinitrophenylated (TNP) keyhole li
139 normal and B cell-deficient mice to keyhole limpet hemocyanin over 6 mo and observed diminished IL-2
141 ve prepared a conjugate vaccine (GD2-keyhole limpet hemocyanin plus immunological adjuvant QS-21) tha
142 the original tumor, including (1) Id-keyhole limpet hemocyanin protein, (2) Id single-chain variable
143 s with an F(2)Pab peptide coupled to keyhole limpet hemocyanin recognized a p53(1-39) peptide phospho
144 ermore, CLEC12A-mediated delivery of keyhole limpet hemocyanin resulted in enhanced proliferation and
145 with peptide 184- 198 conjugated to keyhole limpet hemocyanin showed significant pulmonary eosinophi
148 city of coupling the glycopeptide to keyhole limpet hemocyanin was examined; although both IgM and Ig
149 Abs following immunization with DNP-keyhole limpet hemocyanin was significantly decreased for all Ig
150 networks, the primary Ab response to keyhole limpet hemocyanin was unaltered over a 20-day period.
151 s to 2,4,6-trinitrophenyl-conjugated keyhole limpet hemocyanin were measured by ELISA, and presence o
152 n of high-affinity antibodies to TNP-keyhole limpet hemocyanin were severely impaired, even after ado
154 o CR3 counterligands (fibrinogen and keyhole limpet hemocyanin) by 50%, but did not affect adhesion t
155 iophage phiX 174 and nuclear protein-keyhole limpet hemocyanin) characterized by a reduction in numbe
157 moral immunity to model Ags (OVA and keyhole limpet hemocyanin), affecting all major T-dependent Ig c
158 imarginata, and Megathura crenulata (keyhole limpet hemocyanin), on cultures of peritoneal macrophage
160 by day 3 after immunization with Ars-keyhole limpet hemocyanin, (KLH) and at day 6, large clusters of
161 has been synthesized, conjugated to keyhole limpet hemocyanin, and administered with the immunologic
162 d with caffeine covalently linked to keyhole limpet hemocyanin, and recombinant antibody techniques w
163 eptides were synthesized, coupled to keyhole limpet hemocyanin, and used to produce rabbit antisera.
164 del Ag 4-hydroxy-3-nitrophenylacetyl-keyhole limpet hemocyanin, but GrB-deficient mice produced norma
165 ted from plasma of mice immunized to keyhole limpet hemocyanin, but not from naive or OVA-immunized m
166 when immunized with nitrophenylated-keyhole limpet hemocyanin, Dbc1(-/-) mice produce significantly
167 When immunized with trinitrophenyl-keyhole limpet hemocyanin, dbh-/- mice produced less Th1 cytokin
169 response to the T cell-dependent Ag, keyhole limpet hemocyanin, in the PDE7A(-/-) mice was found to b
172 ent Ag, phosphocholine conjugated to keyhole limpet hemocyanin, ppc1-5 NAA B cells mounted a quick Ig
173 DCs with the foreign helper protein, keyhole limpet hemocyanin, prior to intratumoral delivery and co
174 g vaccination with the TCR linked to keyhole limpet hemocyanin, specific anti-TCR humoral responses w
175 ter immunization with trinitrophenyl-keyhole limpet hemocyanin, specific ASC could be isolated from a
176 y response to the T-dependent Ag DNP-keyhole limpet hemocyanin, the Tg mice exhibited severely impair
177 ergic sensitization to a neoantigen, keyhole limpet hemocyanin, using a unique model of human nasal a
179 recombinant filarial protein Ags and keyhole limpet hemocyanin, we sensitized T cells from uninfected
180 xylase (GAD), but not the control Ag keyhole limpet hemocyanin, were eliminated in NODJg mu(null) mic
181 lly administered soluble protein Ag, keyhole limpet hemocyanin, were enhanced when mice were treated
182 -I, with or without conjugation with keyhole limpet hemocyanin, were fused with P3/NS1/1-Ag4-1 myelom
183 Ig fusion protein, however, enhances keyhole limpet hemocyanin- specific T-cell proliferation and 2,4
184 Mac-1 were defective in adherence to keyhole limpet hemocyanin-coated glass, iC3b-mediated phagocytos
185 ce were immunized with a cocktail of keyhole limpet hemocyanin-conjugated peptides corresponding to t
188 cific Th2 cells, lymphoid cells from keyhole limpet hemocyanin-immune mice bearing healthy corneal al
189 various preclinical models, such as keyhole limpet hemocyanin-induced Ab responses, alloantigen-indu
190 a pigs immunized intranasally with a keyhole limpet hemocyanin-linked peptide, corresponding to the p
191 ized mice, were able to suppress the keyhole limpet hemocyanin-specific delayed-type hypersensitivity
192 avalin A-stimulated spleen cells nor keyhole limpet hemocyanin-specific proliferation of spleen cells
193 h LPS or upon 6-h coculture with the keyhole limpet hemocyanin-specific Th1 clone HDK-1 in the presen
194 h of incubation with HDK-1 T cells (keyhole limpet hemocyanin-specific TH1 clone) or with 5S8 T cell
195 t were reconstituted with a clone of keyhole limpet hemocyanin-specific Th2 cells and trinitrophenyl-
218 uppression of IgE in response to DNP-keyhole limpet hemocyanin/alum and Nippostrongylus brasiliensis
219 ing MoDC with conjugates of primary (keyhole limpet hemocyanin; KLH) and recall (Bet v 1) Ags (H4B4*K
220 d GH to a carrier protein, including keyhole limpet hemocyanion, diphtheria toxoid cross-reactive mat
221 phase III clinical trial vaccine, GH-keyhole limpet hemocyanion/QS21, the GH-DT/C34 vaccine elicited
223 significantly larger than turban shells and limpets in succeeding Later Stone Age (LSA) layers that
224 ely studied bioluminescent systems (those of limpet Latia, earthworms Diplocardia and Fridericia and
225 striking increases in the recruitment of owl limpets (Lottia gigantea) and volcano barnacles (Tetracl
226 the unmineralized teeth of the giant keyhole limpet (Megathura crenulata) are shown to attain a stiff
229 he extinction of three consumer species (the limpet Patella, the periwinkle Littorina and the topshel
234 Our study highlighted that the addition of limpet protein improved the rheological properties and g
236 ecific locations within the continuum of the limpet's translucent protective shell ensures the vivid
237 ing or facilitating the establishment of the limpet Scurria viridula along the south-eastern Pacific
240 e artificial intelligence techniques to four limpet species that display well-defined phylogeographic
241 aving molluscs, the chiton Chaetopleura, the limpet Tectura, and the snail Lymnaea, the MAPK pathway
242 al stage of the radula, the organ from which limpet teeth originate, identifies sequential changes in
243 d modeling, we show that the leading part of limpet teeth successfully achieves this combination of p
244 elopmental processes ex vivo, where isolated limpet tissue and cells in culture generate new biomimet
245 molecular processes behind the generation of limpet tooth and establish a platform for development of