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1 available in one step on 10 gram scale, as a linchpin.
2 te to valuable, rigid, sp(3)-rich amino acid linchpins.
3 lity of thianthrenium salts as electrophilic linchpins.
4 d functional outcomes in these metalloenzyme linchpins.
5                                   A diketone linchpin 1,5-dichloropentane-2,4-dione converts peptide
6 using a novel multifunctional C(2)-symmetric linchpin, 3,5-bis(bromomethyl)benzaldehyde (termed KYL),
7 se pathway and autophagy machinery as both a linchpin and an Achilles' heel in B. neotomae's ability
8 ansient but key N-H---F-C hydrogen bond as a linchpin and secondary "dual" charge-induced n -> pai* i
9  Thus, we conclude that Mg(2+) ions act as a linchpin and that at least one ion must be removed prior
10  application of a novel bifunctional oxazole linchpin; and Stille coupling of a C(28) trimethyl stann
11 yclo[1.1.1.0(1,3)]pentane (TCP) as a radical linchpin, as well as other diverse alkyl groups, on-DNA
12 n, and the use of a 1,4-pentadiyne unit as a linchpin building block.
13 ubcomplex, with the latter also serving as a linchpin connecting distal parts of the complex.
14           A copper-catalyzed three-component linchpin coupling method for the stereoselective union o
15 tages of a one-flask multicomponent dithiane linchpin coupling protocol, over the more conventional s
16 itching the order of epoxide addition in the linchpin coupling step, two analogous dihydropyranones w
17 tin A and B are reported and were based on a linchpin coupling strategy using a boron/tin hetero-bis-
18  based on the Smith three-component dithiane linchpin coupling strategy.
19             [Chemical reaction: See text] A "linchpin" coupling strategy is described for the constru
20 charge migration, this class of bifunctional linchpins employs initial through-bond ARC by an SN 2' r
21                 In a number of proteins, the linchpin features are in regions found experimentally to
22 ng for many proteins is limited by critical "linchpin" features, often the backbone torsion angles of
23 res of active RING/U-Box E3/E2 pairs, as the linchpin for allosteric activation of E2~Ub.
24 recise hydrophobic connection that acts as a linchpin for assembly and trafficking of P-gp.
25 maining carboxyl group serves as a versatile linchpin for further synthetic applications, as demonstr
26 ic disorders, indicating that AP-1 acts as a linchpin for intracellular CCV formation.
27                                          The linchpin for repacking in the adenosine binding site is
28  findings suggest that Golgin-45 serves as a linchpin for the maintenance of Golgi complex structure,
29 ns of tightly spaced M1 sites, which was the linchpin for uncovering organizational principles.
30 the utility of N-Boc alpha-amino nitriles as linchpins for alkaloid synthesis.
31 reactive beta-lactone products are versatile linchpins for the mono-selective installation of diverse
32 thesis, and validation of three vinylepoxide linchpins for through-bond/through-space ARC are now rep
33 idation of new highly effective bifunctional linchpins for type II anion relay chemistry (ARC) has be
34                   Enones are widely utilized linchpin functional groups in chemical synthesis and mol
35         The introduction of thianthrene as a linchpin has proven to be a versatile strategy for the C
36                     Surgeons were considered linchpins if their linchpin score was in the top 15%.
37 rom (R)-glycidyl tosylate, which served as a linchpin in a one-flask, sequential three-components cou
38 nscriptional activation pathway represents a linchpin in C. glabrata multidrug resistance.
39  mutant aggregates, as a critical pathogenic linchpin in CLN4-associated neurodegeneration.
40 the proximal N-terminus of the channels as a linchpin in coalescing different parts of the channels i
41              This hypothesis is a conceptual linchpin in helix-coil theories and protein folding.
42 icating that the kleisin subunit acts as the linchpin in holocomplex assembly.
43                     It may thus constitute a linchpin in multiple aspects of infections with Lyme dis
44 lterations in mitochondrial function are the linchpin in numerous disease states including in the dev
45 atidylinositol 3-kinase delta (PI3Kdelta), a linchpin in the pre-B-cell receptor and interleukin 7 re
46 sh causality through post hoc reviews is the linchpin in the recommendation for widespread adoption o
47 actions between the D- and T-arms as the key linchpin in the tertiary structure of tRNAs.
48                           c-di-GMP acts as a linchpin in this transition by binding and regulating th
49 nd the utility of N-pyridinium aziridines as linchpins in chemical synthesis.
50 synthesize novel 2-substituted BCP synthetic linchpins in one pot.
51   The use of alpha-boryl enamine and enamide linchpins in the synthesis of nitrogen heterocycles has
52                  These products can serve as linchpins in the synthesis of pharmaceutically valuable
53                  Presumably, this remarkable linchpin insertion is enhanced by the linear hydrogen bo
54 e-stage heteroarene transmutation provides a linchpin intermediate used to access three stemoamide al
55                                        These linchpin intermediates can be generated selectively and
56                                          The linchpin is assignment of a durable power of attorney in
57 his reagent as a more broadly applicable NCO linchpin is demonstrated by the formation of lactams and
58    Facile derivatization of these ambiphilic linchpins is demonstrated, providing access to high-valu
59 trical iodonium salts as versatile synthetic linchpins is presented.
60 f this approach, with alkyl boronic acids as linchpins, is demonstrated through various downstream fu
61 cell lysis, supporting a role for ppGpp as a linchpin linking expansion of cytoplasmic volume to the
62 e AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simu
63                   We propose that this "zinc linchpin" motif serves to structurally organize the IDC
64 -bearing carbonyl linchpin reagent (carbonyl linchpin N,O-dimethylhydroxylamine pyrrole; CLAmP) is re
65     We conclude that this hydrogen bond is a linchpin of backbone structure around the triple.
66 died model of homeostatic cell turnover, the linchpin of cell equilibrium is feedback control of the
67                Ligand-binding assays are the linchpin of drug discovery and medicinal chemistry.
68 te a long-standing but equivocally supported linchpin of evolutionary theory.
69 of valuable 3-hydroxy-2-methyl carbazoles, a linchpin of more than 25 carbazole-based alkaloids, is u
70      The neuromuscular junction (NMJ) is the linchpin of nerve-evoked muscle contraction.
71  Mechanosensitive sensory hair cells are the linchpin of our senses of hearing and balance.
72 h live-cell imaging to dissect the molecular linchpin of TAQC.
73                              STK19 acts as a linchpin of the assembly, orienting the incoming TFIIH a
74                                          The linchpin of the mechanism is the generation of submesosc
75                                            A linchpin of this network is gataE which as we show is a
76  mitochondria and the endoplasmic reticulum (linchpins of current theories about the origins of PD) i
77  mature rRNA with ribosomal proteins are the linchpins of ribosome biogenesis.
78 ols for more efficient radiosyntheses and as linchpins of technologies that have the potential to imp
79 apamycin (mTOR) and mTOR complex 1 (mTORC1), linchpins of the nutrient sensing and protein synthesis
80 rability, which distinguished HRRs with more linchpin oncologists than expected based on oncologist d
81                             As a result, the linchpin preserves the carbonyl functionality in the ARC
82 ed and the trans-trisubstituted vinylepoxide linchpins proceed to deliver three-component adducts wit
83            The resultant Z-alkenyl sulfonium linchpins provide access to a wide array of Z-alkene tar
84 g, single base pair A40-U48 acts as the main linchpin, rather than the multiple base pairs comprising
85 ketones utilizing a pyrrole-bearing carbonyl linchpin reagent (carbonyl linchpin N,O-dimethylhydroxyl
86 evelopment and validation of the first amide linchpin reagent and demonstrate its use as a doubly ele
87 ivity, demonstrating the ability of this new linchpin reagent to form amides through atypical bond co
88                                          The linchpin reagent was first functionalized via rhodium-ca
89                                              Linchpin reagents are building blocks that can be chemos
90 ofold orthogonal acyl-difluoroalkylations of linchpin reagents.
91 esults indicate that the P4/P6 junction is a linchpin region, where even small nucleotide substitutio
92 3 direct interface, including the so-called "linchpin" residue conserved in RING E3s and required for
93 chment, mediated by a universally conserved 'linchpin' residue in kinesin (N255), triggers a clamshel
94                          A critical role for linchpin residues in nucleocytoplasmic coagulation and o
95                                 Mutations at linchpin residues that help organize the baseplate impai
96                                      Surgeon linchpin score (a measure of local uniqueness or scarcit
97  Surgeons were considered linchpins if their linchpin score was in the top 15%.
98                                   Oncologist linchpin score, which examined the extent to which a phy
99 ships between oncologist characteristics and linchpin score.
100 21 using backbone-backbone hydrogen bonds, a linchpin serine residue, and hydrophobic side-chain pack
101                                  Moreover, a linchpin strategy enables preprogrammed installation of
102    Here, we report a generalizable synthetic linchpin strategy for bridge functionalization via radic
103 ne-aniline crosslinking through a minimalist linchpin strategy that affords macrocyclic urea or carba
104                              Patients with a linchpin surgeon had greater odds of adjuvant delay comp
105                                              Linchpin surgeon status (locally unique surgeon) was not
106 The present report is the first example of a linchpin tetraester construct that utilizes ester linkag
107 t identifies a protein called RGS-PX1 as the linchpin that connects signal transduction activated by
108 d BglII, is a sensor for DNA binding and the linchpin that couples base recognition and DNA cleavage.
109 nting rigid structures, zinc actually is the linchpin that orchestrates dynamic changes in response t
110 he anion thus located forms a 4-fold ligated linchpin that tethers the surface domain to the central
111          The development of new bifunctional linchpins that permit the union of diverse building bloc
112 versatile bifunctional dithiane-vinyl iodide linchpin, the unorthodox use of the Evans-Tishchenko rea
113                              These synthetic linchpins then serve as common precursors to complex 2-s
114 s, carbon monoxide functions as a one-carbon linchpin to facilitate building structural complexity an
115 ular design, the acetylene motif served as a linchpin to introduce a broad range of carbonyl-containi
116 tional allylboron reagent serves as a useful linchpin to join two distinct carbonyl compounds to prov
117 raints and element-ligand cooperation as the linchpin to this reaction path and its selectivity.
118                                   Instead, a linchpin to true portability is software that works on m
119 n APIs, prodrugs, and as valuable synthetic "linchpins" to access an array of sulfur-derived function
120 gher-order relational reasoning" is one such linchpin trait in the evolution of human tool use, socia
121 ansfer radical addition (ATRA) reactions are linchpin transformations in synthetic chemistry enabling
122 es in the solvent controlled three-component linchpin union of silyl dithianes for the stereocontroll
123 validation of a unique class of bifunctional linchpins, uniting benzyne reactivity initiated by type
124                    Physicians are considered linchpins when fewer of their peers are connected to oth
125           Hence, methionine 46 represents a "linchpin" whereby its oxidation is a primary event permi
126 ectivity under mild conditions, and generate linchpins with distinct physiochemical properties.
127 conjunctive olefination that uses an alkene 'linchpin' with a defined geometry to cross-couple comple
128         The trans-disubstituted vinylepoxide linchpin yields a mixture of E/Z isomers, whereas the ci

 
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