ライフサイエンスコーパス: lineage commitment

1 atory networks that influence cell fates and lineage commitment.

2 ole in mammary gland development and luminal lineage commitment.

3 tein, which by contrast is dispensable for T-lineage commitment.

4 ity of MLL-Af4 was interlinked with lymphoid lineage commitment.

5 -scale chromatin folding during early neural lineage commitment.

6 gulated independently and can occur prior to lineage commitment.

7 are rate-limiting for metabolic activity and lineage commitment.

8 ing both myeloid and lymphoid haematopoietic lineage commitment.

9 n essential transcription factor for myeloid lineage commitment.

10 pulations, revealing a role in governing HSC lineage commitment.

11 ive feedback mechanisms control human T-cell lineage commitment.

12 favorable system to study developmental cell lineage commitment.

13 ams that enforce their identity and regulate lineage commitment.

14 led distinct effects on HSC self-renewal and lineage commitment.

15 orchestration of gene expression during cell lineage commitment.

16 tion factors and other genes associated with lineage commitment.

17 tion of TCR specificity into definite T cell lineage commitment.

18 into a cell cycle-independent pattern after lineage commitment.

19 bling precise coupling of TCR specificity to lineage commitment.

20 t are required by developing Tregs for their lineage commitment.

21 would indicate potential regulators of mSSC lineage commitment.

22 stages but then falls sharply during T-cell lineage commitment.

23 remodelling protein functions to facilitate lineage commitment.

24 chromatin accessibility may prime cells for lineage commitment.

25 n and is used as a biomarker to measure Treg lineage commitment.

26 tity and potency, promoting white adipogenic lineage commitment.

27 for all NK cell subsets or how it induces NK lineage commitment.

28 on and in epigenetic modifiers implicated in lineage commitment.

29 er induction of MEG-specific genes following lineage commitment.

30 perspectives for balancing self-renewal and lineage commitment.

31 nitor cell population at different stages of lineage commitment.

32 etry breaking during cell fate decisions and lineage commitment.

33 2-4%), indicative of early oligodendrocytic lineage commitment.

34 and basic research on pluripotency and early lineage commitment.

35 landscape is established during early T cell lineage commitment.

36 quired for primitive or definitive erythroid lineage commitment.

37 er, yet little is known about their roles in lineage commitment.

38 r that promotes HSC quiescence and represses lineage commitment.

39 hair cycle, stem cells of each type activate lineage commitment.

40 define a novel role for human CAR in hepatic lineage commitment.

41 abilizing ground-state pluripotency to allow lineage commitment.

42 including cell growth, differentiation, and lineage commitment.

43 tors YAP and TAZ, which serve to control SSC lineage commitment.

44 pression as a faithful molecular marker of T lineage commitment.

45 mesoderm differentiation and cardiovascular lineage commitment.

46 nal component of myeloid differentiation and lineage commitment.

47 nction with positive regulators to stabilize lineage commitment.

48 transcriptional circuit critical for B cell lineage commitment.

49 is best known as the master regulator of Th1 lineage commitment.

50 tor cell subsets at the earliest stages of T lineage commitment.

51 rmine the functional impact of T-bet on Th17 lineage commitment.

52 ulation and enhancers were at work directing lineage commitment.

53 ffect favors Foxp3 expression and T reg cell lineage commitment.

54 consistent with molecular characteristics of lineage commitment.

55 fate, whereas loss of esr2b impaired biliary lineage commitment.

56 nked to the balance between pluripotency and lineage commitment.

57 een stem and progenitor cell maintenance and lineage commitment.

58 uted to genomic position and the kinetics of lineage commitment.

59 ows proliferation, and biases MEPs toward Mk lineage commitment.

60 y mTORC1 in regulating the haemopoietic cell lineage commitment.

61 rentiation trajectory during early stages of lineage commitment.

62 cells (ESCs) must be reconfigured to enable lineage commitment.

63 ing a cytoplasmic role for Yap in epithelial lineage commitment.

64 d BMP-4-induced MSC differentiation prior to lineage commitment.

65 ignaled thymocytes leading to the CD4 helper lineage commitment.

66 nd RAR568 had no effect on cell stability or lineage commitment.

67 onizes WNT and FGF signaling to regulate MSC lineage commitment.

68 text-dependent support during activation and lineage commitment.

69 es multistep transitions in the early T cell lineage commitment.

70 ls, illuminating a mechanism of age-specific lineage commitment.

71 g against a direct role for CSF1R in myeloid lineage commitment.

72 r-deficient mice exhibited a block in B cell lineage commitment.

73 selection model of CD4(+) and CD8(+) T cell lineage commitment.

74 ocytes, blocking IL-21R does not restore CD4 lineage commitment.

75 promote stem cell self-renewal and/or direct lineage commitment.

76 iptional priming of HSCs/MPPs prior to their lineage commitment.

77 nscription factors from prematurely enacting lineage commitment.

78 the BM combined with reduced potential for T lineage commitment.

79 ssion of ThPOK and Runx3 and correct CD4/CD8 lineage commitment.

80 e-pronged blockage of T3 action during glial lineage commitment.

81 th Eos maturation (1199 genes) than with Eos-lineage commitment (490 genes), highlighting the greater

82 Cs exhibited impaired function and defective lineage commitment abilities.

83 dynamic changes in transcription and stalled lineage commitment, allowing cells to explore alternativ

84 STRAP in mediating the splicing networks of lineage commitment, alteration of which may be involved

85 nt stem cells may interfere with normal cell lineage commitment and cause the accumulation of undiffe

86 rks that control critical processes, such as lineage commitment and cellular differentiation.

87 differences in memory and activation status, lineage commitment and cytokine expression.

88 r not Setd1a controls specific hematopoietic lineage commitment and differentiation during animal dev

89 Transcriptional programs control cellular lineage commitment and differentiation during developmen

90 ugh Notch signaling plays important roles in lineage commitment and differentiation of multiple cell

91 n other species, suggesting greater neuronal lineage commitment and differentiation of self-renewing

92 tion factors (MRFs) are well known to govern lineage commitment and differentiation, exactly how the

93 xpression of genes controlling hematopoietic lineage commitment and differentiation, including Hox fa

94 ee of transcriptional diversification during lineage commitment and differentiation.

95 in mammalian cells and eventually determines lineage commitment and differentiation.

96 ontribution of transcription factors to cell lineage commitment and differentiation.

97 ic controls and that pave the way for proper lineage commitment and differentiation.

98 s a major regulator of mESC self-renewal and lineage commitment and document a multilayer regulatory

99 signal leading to differential hematopoietic lineage commitment and enhanced thrombopoiesis.

100 al NSCs, Pnky knockdown potentiates neuronal lineage commitment and expands the transit-amplifying ce

101 We generated a single cell map of early lineage commitment and found that SDS hematopoiesis was

102 e several disagreements related to tuft cell lineage commitment and function.

103 e chromatin marks between genes induced with lineage commitment and genes induced with cell maturatio

104 novel molecular determinants that reinforce lineage commitment and help resist cell fate changes.

105 RUNX1a, an isoform of RUNX1, parallels with lineage commitment and hematopoietic emergence from hPSC

106 r hierarchy in human megakaryocyte/erythroid lineage commitment and highlights the importance of usin

107 ematopoiesis that begins expression during T-lineage commitment and is required for this process.

108 cations for the role of ligand in gammadelta lineage commitment and its relationship to the specifica

109 critical developmental stages, including Eos-lineage commitment and lineage maturation.

110 al roles in stringent gene regulation during lineage commitment and maintenance.

111 semi-invariant TCR, which triggers NKT cell lineage commitment and maturation.

112 t Trib1 regulates both granulocyte precursor lineage commitment and mature eosinophil identity.

113 cal Wnt signaling is critical for melanocyte lineage commitment and melanoma development.

114 y suppressed expression of key regulators of lineage commitment and neurogenesis (REST and ASCL1/hASH

115 n this study, we defined the role of IRF8 in lineage commitment and neutrophil vs monocyte differenti

116 er stem and progenitor cell differentiation, lineage commitment and organogenesis during mammalian de

117 that super-enhancers underlie the identity, lineage commitment and plasticity of adult stem cells in

118 mic epithelial cells (cTECs) regulate T cell lineage commitment and positive selection, while medulla

119 intained after the initial specification and lineage commitment and possibly throughout life.

120 provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumo

121 tumor cells, could revert corneal epithelial lineage commitment and reinstate a normal p63-related si

122 e find that enhancer potential is reset upon lineage commitment and show how pervasive epigenetic pri

123 nderstanding of NONO in stem cell functions, lineage commitment and specification.

124 ranscription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 s

125 n hypothalamic progenitors and contribute to lineage commitment and subtype-specific neuronal identif

126 role for Car enzymes in regulating mast cell lineage commitment and suggest that Car enzyme inhibitor

127 Cell-lineage commitment and terminal differentiation are disr

128 tally regulated chromatin transitions during lineage commitment and the molecular etiology of congeni

129 However, its function in neuronal lineage commitment and the molecular mechanisms of its a

130 ness to Hippo signaling, the exact timing of lineage commitment and the overall relationship between

131 -MSCs than in BM-MSCs is responsible for the lineage commitment and tumorigenesis differences in both

132 Lineage commitment and tumorigenesis, traits distinguish

133 ow several epigenetic factors broadly affect lineage commitment and tumorigenesis, which should be co

134 unexplored pathway that controls liver cell lineage commitment and whose dysregulation may play a ro

135 th which to interrogate HSC self-renewal and lineage commitment and, more broadly, to study and chara

136 So what do terms like 'lineage commitment' and helper T-cell 'specification' me

137 ypes that together direct stem cell renewal, lineage commitment, and differentiation.

138 ling can influence stem cell homeostasis and lineage commitment, and discuss the implications of this

139 as potent regulators of stem cell function, lineage commitment, and epigenetic status.

140 ibed to play a role in vascular development, lineage commitment, and in mesoderm differentiation into

141 opoietic stem and progenitor cell expansion, lineage commitment, and maturation have been investigate

142 7R(+) compartment, show a partial block in B lineage commitment, and produce proB cells with aberrant

143 bryonic stem cells and is important both for lineage commitment, and reprogramming to naive pluripote

144 medicine, techniques which control stem cell lineage commitment are a rapidly expanding field of inte

145 ontributions to early tissue development and lineage commitment are profound.

146 ence to suggest that molecular signatures of lineage commitment are reflected in apoptotic cascades a

147 imens, our understanding of how the earliest lineage commitments are regulated remains narrow.

148 many PcG proteins are fundamental for proper lineage commitment, as highlighted by the fact that a la

149 diate two distinct roles played by GATA-3 in lineage commitment, as revealed by removing wild-type or

150 through distinct pluripotent states, before lineage commitment at gastrulation.

151 otal role for H3K9me3 heterochromatin during lineage commitment at the onset of organogenesis and for

152 e analysis of the exit from pluripotency and lineage commitment at the single cell level, a potential

153 ation of Ccr7 does not occur early during DC lineage commitment because monocytes and pre-DCs both ha

154 hematopoietic cells, contributes to the MEP lineage commitment bias observed in Tmprss6-/- mice.

155 phils, whereas deletion following eosinophil lineage commitment blunted the decrease in EoPs without

156 ERalpha cell autonomously regulates adipose lineage commitment, brown fat and smooth muscle cell for

157 TCF-1 and LEF-1 were dispensable for T cell lineage commitment but instead were required for early t

158 he transcription factor EBF1 promotes B cell lineage commitment by directly repressing expression of

159 asymmetric G-rich loop that controls cardiac lineage commitment by interacting with the transcription

160 at IRF8 regulates granulocyte vs monocyte/DC lineage commitment by oligopotent progenitors.

161 differentiation is not irreversible and that lineage commitment can be overridden following severe ti

162 Cellular diversity within tumors and reduced lineage commitment can undermine targeted therapy by inc

163 ossess enhanced proliferative, survival, and lineage commitment capacity that could account for the e

164 ing development is critical to ensure proper lineage commitment, cell fate determination, and ultimat

165 ne expression can lead to drastic changes in lineage commitment, cellular function, and immunity.

166 During lineage commitment, chromatin accessibility at DORCs pre

167 hematopoietic stem cells undergo a number of lineage commitment decisions that ultimately lead to the

168 These differences permit lineage commitment decisions to be made in different hie

169 ust and broad gene regulation during crucial lineage commitment decisions.

170 tudied proteins, the role of Hb in erythroid lineage commitment, differentiation, and maturation rema

171 in our understanding of the regulation of DC lineage commitment, differentiation, diversification, an

172 ass-restricted binding impacts signaling and lineage commitment, discussing TCR force-driven conforma

173 ocess orchestrated by exquisitely timed cell lineage commitment, divisions, migration, and morphologi

174 ally steer the HPSC differentiation to mimic lineage commitment during gastrulation to ectoderm (earl

175 y, Foxa2, and Sox17 directs proper stem-cell lineage commitment during streak formation.

176 However, the role of lineage commitment factor Bcl11b has been unclear.

177 o block B cell development did not require T lineage commitment factor Bcl11b.

178 Here we show that Bcl11b, known as a T-lineage commitment factor, is essential for proper expre

179 sity may have important consequences for MSC lineage commitment, fetal fat accrual, and offspring obe

180 insights into dynamics of HSPC expansion and lineage commitment following autologous transplantation.

181 scription factors specifying osteoclast (OC) lineage commitment from monocyte/macrophage remains uncl

182 ons at 2 distinct stages to guide eosinophil lineage commitment from the GMP and suppress the neutrop

183 wing Ad5 immunization exhibited impaired Th1 lineage commitment, generating significantly decreased T

184 pG loci within the promoter regions of Th1/2 lineage commitment genes (GATA3, IL-4, IL-4R, STAT4 and

185 cing showed altered expression of fibroblast lineage commitment genes in fibroblasts undergoing MEndo

186 , the expression of p53 and most endothelial lineage commitment genes were upregulated in MEndoT-deri

187 In contrast, exit from pluripotency and lineage commitment have not been studied systematically

188 Because lineage commitment hierarchies differ between embryo and

189 ding facilitating mechanistic studies of MEP lineage commitment, improving approaches for in vitro ex

190 ed with both maintenance of pluripotency and lineage commitment in embryonic stem cells, and TET1 bin

191 xpression markedly increases with eosinophil-lineage commitment in eosinophil progenitors (EoPs), dow

192 the earliest steps between pluripotency and lineage commitment in ESCs and find a critical role for

193 an epigenetic mechanism for maintaining cell lineage commitment in ESCs and iPSCs that can be used to

194 ut its role in self-renewal, pluripotency or lineage commitment in ESCs remains undefined.

195 dulates the balance between self-renewal and lineage commitment in ESCs.

196 tion factor Sp7 (osterix) during mesenchymal lineage commitment in mammalian cells.

197 crucial role for E2A in establishing neural lineage commitment in pluripotent cells.

198 indings provide mechanistic insight into how lineage commitment in progenitor cell differentiation ca

199 ramming and their enhancement of granulocyte lineage commitment in response to E. coli bacteremia.

200 and myeloid differentiation, but its role in lineage commitment in the liver has not been investigate

201 roteins, the key architects of CD4(+)-CD8(+) lineage commitment in the thymus, is critical for CD4(+)

202 ockout of either PKS or GCM revealed spatial lineage commitment in the transition from bilaterality o

203 n driving increased suppressive function and lineage commitment in thymic-derived T(REG) cells and po

204 set that marks the earliest stages of B-cell lineage commitment in utero.

205 quired for development, differentiation, and lineage commitment in various tissues including the inte

206 n GSCs and is essential for self-renewal and lineage commitment in vitro.

207 propose that CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency w

208 data support a novel paradigm in lymphocyte lineage commitment in which the E2A proteins are necessa

209 This suggests that the adult lineage commitments in the five outgrowths of the hydrop

210 repressive chromatin states during mesoderm lineage commitment, in particular the activation of deve

211 ractomes of three mouse cells of progressive lineage commitment, including pluripotent embryonic stem

212 ive dynamics of cis-regulatory contacts upon lineage commitment, including the acquisition and loss o

213 Lymphoid lineage commitment is an important process in haematopoi

214 controlling progenitor cell self-renewal and lineage commitment is critical for harnessing these cell

215 d activity of cis-regulatory elements during lineage commitment is crucial for understanding developm

216 In ZBTB20-null mice, although lactotrope lineage commitment is normally initiated, somatolactotro

217 These findings reveal that Treg cell lineage commitment is not only controlled by genetic and

218 on, in which the chance loss of cells due to lineage commitment is perfectly compensated by the dupli

219 and function, whereas the early T(reg)-cell-lineage commitment is regulated by the Akt kinase and th

220 ta suggest that the ThPOK-induced CD4 helper lineage commitment is strongly influenced by TCR signal

221 The first mammalian cell lineage commitment is the formation of the trophectoderm

222 Pou5f3 (homologous to mammalian Oct4) drives lineage commitment is unclear.

223 tenance, but whether telomere length affects lineage commitment is unknown.

224 e similar epigenetic mechanisms that prevent lineage commitment is unknown.

225 known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenes

226 Nono deletion impedes neuronal lineage commitment largely due to a failure of up-regula

227 on of HSC required for their maintenance and lineage commitment (Liu et al, 2014).

228 Their stronger lineage commitment makes tTreg cells the safest cells to

229 Here, we provide lineage commitment maps of HSC clones under homeostasis

230 plays critical roles in regulating lymphoid lineage commitment, mature B-cell development, and the G

231 To clarify lineage commitment mechanisms, we followed developing T

232 on (NuRD) complex, which is required for ESC lineage commitment, modulates both transcriptional heter

233 tent progenitor states, with the first major lineage commitment occurring in multipotent progenitors,

234 ome appears to be linked to pluripotency and lineage commitment of a cell.

235 hylation patterns plays an important role in lineage commitment of adult stem cells and that it could

236 ctors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development through

237 tment that contribute to the development and lineage commitment of hematopoietic cells.

238 Molecules that control the lineage commitment of hematopoietic stem cells (HSCs) ma

239 view of promoter interactome dynamics during lineage commitment of human pluripotent cells.

240 Here, we show that Hippo signaling promotes lineage commitment of lung epithelial progenitors by cur

241 ays a pivotal role in cell fate decision and lineage commitment of lymphocytes.

242 l cues play important roles in directing the lineage commitment of mesenchymal stem cells (MSCs).

243 Mechanical cues direct the lineage commitment of mesenchymal stem cells (MSCs).

244 transgene completely restored the CD4 helper lineage commitment of MHCII-specific Thpok (-/-) thymocy

245 al regulator of definitive hematopoiesis and lineage commitment of murine hematopoietic stem and prog

246 deacetylation complex (NuRD) is required for lineage commitment of pluripotent cells; however, the me

247 ression broadly fall into three domains: the lineage commitment of pluripotent stem cells, the approp

248 ZD-selective fashion, enhance the osteogenic lineage commitment of primary mouse and human mesenchyma

249 trol of genes involved in the attraction and lineage commitment of T cell precursors, Foxn1 regulates

250 closely integrated and likely encoded during lineage commitment of T effectors.

251 ession enhanced the suppressive capacity and lineage commitment of these cells in vitro and in vivo.

252 wist1 reprogramming enhanced the endothelial lineage commitment of WJ-MSC and increased the vasculoge

253 defined RNA motif to regulate cardiovascular lineage commitment, opening the door for exploring broad

254 sociated with significant changes in CD4/CD8 lineage commitment or activation profile.

255 cell differentiation have focused on initial lineage commitment or proximal differentiation events.

256 C-released factors deflect CHIR99021-induced lineage commitment over time.

257 dominance and lineage bias and uncovered the lineage commitment pathways that lead HSC clones to diff

258 establish an early branch point for separate lineage-commitment pathways from hematopoietic stem cell

259 rtant implications for studies of melanocyte lineage commitment, pigmentation disorders and cell repl

260 re, we show that E4bp4 is required at the NK lineage commitment point when NK progenitors develop fro

261 uired in postselection thymocytes for helper lineage commitment, presumably mediating the maintenance

262 tensively studied, little is known about the lineage commitment process of individual HSC clones.

263 Furthermore, the DP lineage commitment program can be exploited for generati

264 a as the key transcriptional regulator of OC lineage commitment, providing a unique therapeutic targe

265 y results showing that the expression of key lineage commitment regulators, GATA1, GATA2 and PAX5 wer

266 ponents controlling enhancer turnover during lineage commitment remain largely unknown.

267 nderstood, especially since efficient T-cell lineage commitment requires a reduction in Notch signall

268 T lineage commitment requires the coordination of key tran

269 romoter in precursor cells to make Treg cell lineage commitment responsive to a broad range of TCR st

270 ding light on the intricacies underlying ETP lineage commitment, reveal a novel, to our knowledge, fu

271 influence epigenetic changes associated with lineage commitment, specification, and self-renewal.

272 precise signaling pathways that govern their lineage commitment still remain enigmatic.

273 sed' enhancers and at genes involved in HSPC lineage commitment suggest that CD34+ cell subtype heter

274 iptional programs controlling erythropoietic lineage commitment, suggesting a role for O-GlcNAcylatio

275 in culture while maintaining their intrinsic lineage commitment suggests their potential in stem cell

276 ) lineages are essential for inducing T cell lineage commitment, T cell positive selection and the es

277 H3K27me3 and telomere integrity in stem cell lineage commitment that may have implications in aging a

278 , in contrast to TCF1, controls human T-cell lineage commitment through direct regulation of three di

279 Thus Pcid2 controls lymphoid lineage commitment through the regulation of SRCAP remod

280 f kinases that can block the transition from lineage commitment to a differentiating state in myoblas

281 nx proteins and Cbfbeta restrict granulocyte lineage commitment to facilitate multilineage hematopoie

282 Lung stem cells undergo self-renewal or lineage commitment to replenish tissue, depending on cro

283 fate in GMPs, but instead acts downstream of lineage commitment to selectively control neutrophil and

284 cid metabolism within the niche, promote HBC lineage commitment toward two types of respiratory cells

285 el for nucleotide biosynthesis regulates HSC lineage commitment under conditions of metabolic stress.

286 delineate the role of mTORC1 in haemopoietic lineage commitment using knock out (KO) mouse and cell l

287 en mESC differentiation from pluripotency to lineage commitment, using an unbiased single-cell transc

288 study demonstrate that IKKalpha regulates B-lineage commitment via combined canonical and noncanonic

289 we show that T-bet negatively regulates Th17 lineage commitment via direct repression of the transcri

290 role of Raptor (mTORC1) in erythrocyte and B lineage commitment was confirmed in adult Mx1-cre(+)Rapt

291 f focal adhesion formation and osteochondral lineage commitment was observed as a function of both fe

292 In addition, the potential for T lineage commitment was radiation sensitive with aging.

293 m by which transcription factors regulate OC lineage commitment, we mapped the critical cis-regulator

294 ies have elucidated key elements influencing lineage commitment, we still lack a full understanding o

295 Del-1-induced HSC proliferation and myeloid lineage commitment were mediated by beta3 integrin on he

296 CD161 is a marker informative of the NK cell lineage commitment, whereas CD56, CD117, and CD94/NKG2A

297 , were less quiescent and showed accelerated lineage commitment, which resulted in progressive deplet

298 enitor-Like (iPL)" cells, which can maintain lineage commitment while undergoing controlled expansion

299 intrinsic regulators of differentiation and lineage commitment, while cytokine signaling has been sh

300 ATA6 levels regulate the timing and speed of lineage commitment within the ICM.