ライフサイエンスコーパス: lineage-specific

1 e Poaceae and identifies the Jekyll genes as lineage-specific.

2 ross the angiosperms and, in most cases, are lineage-specific.

3 lox/flox);CAG-CreER) or oligodendrocyte (OL)-lineage specific ablation (Lrp1(flox/flox);Pdgfra-CreER)

4 apes of major and rare cell types, uncovered lineage-specific accessible sites, especially for low-ab

5 nsdifferentiation and show that alary muscle lineage-specific activation of Yorkie plays a key role i

6 ignatures in mucosal and lymphoid sites, and lineage-specific activation states across all sites incl

7 lopmental promoters, poising them for future lineage-specific activation.

8 The molecular basis for ERG lineage-specific activity is unknown.

9 It was found that boosting increased clonal lineage-specific ADCC breadth and potency.

10 We propose that Dmc1 lineage-specific amino acids involved in the stabilizati

11 ull) and find it to be dominated by massive, lineage-specific amplification of testis-expressed gene

12 Lineage-specific analysis of mitochondrial protein evolu

13 led patterns of neuronal diversification are lineage-specific and can differ drastically even among n

14 estimates within Orthoptera, as well as the lineage-specific and dynamic patterns of evolution for h

15 m plastomes was a mixture of locus-specific, lineage-specific and IR-dependent effects.

16 acilitates chromatin binding and function of lineage-specific and oncogenic transcription factors.

17 utic targets for SARS-CoV-2 and reveals SARS lineage-specific and pan-CoV host factors that regulate

18 th additional SNPs that are part of a highly lineage-specific and tumor-acquired super-enhancer that

19 Loci transcribing both lineage-specific annotated and novel lncRNA are adjacent

20 A large proportion of the ISG repertoire is lineage specific; around 40% of protein-coding zebrafish

21 lack cellulases but encode a distinctive and lineage-specific array of mostly intracellular carbohydr

22 overlap between resistant and hypervirulent lineages, specific bacterial and host factors contributi

23 ERG's homeostatic function is lineage-specific, because aberrant ERG expression in can

24 es of the Rad51/RecA family and also reveals lineage-specific behaviors reflecting properties that ar

25 nd the fate of these gene families is highly lineage-specific, being lost in some descendant lineages

26 differentiated cell-state and expression of lineage-specific bHLH/homeobox transcription factors.

27 Lineage-specific cell depletion revealed that Tregs prom

28 in multipotent and give rise to a variety of lineage-specific cells.

29 cluster of related isolates is required, but lineage-specific characteristics call for a more detaile

30 incidence and severity, time to engraftment, lineage-specific chimerism, immune reconstitution, and d

31 how that Satb1 alternative promoters exhibit lineage-specific chromatin accessibility during T-cell d

32 expression regulation, our studies identify lineage-specific chromatin architectures and associated

33 Thus, our data characterize lineage-specific chromatin reconfiguration and a unique

34 toneal macrophages in mice is accompanied by lineage-specific chromatin remodeling in regions enriche

35 -5+ subpopulation and demonstrate the use of lineage-specific CMs for precise drug testing.

36 enriched for the androgen receptor (AR) and lineage-specific cofactors.

37 oci that underpins appropriate CD8(+) T cell lineage-specific commitment and differentiation.

38 the three cell types aggregate and sort into lineage-specific compartments.

39 rgest resistance gene family in plants, with lineage-specific contingents of TNL, CNL and RNL subfami

40 , introduced, and Gulf lineages to determine lineage-specific controls on rhizosphere bacteria.

41 Our findings provide insights into how lineage-specific crosstalk between epithelium and neighb

42 This identification of region- and lineage-specific crosstalk between epithelium and their

43 s, the memory cells are capable of producing lineage specific cytokines much more rapidly than the na

44 osis, and demonstrate that oocyte growth and lineage-specific de novo DNA methylation are separable f

45 In particular, lineage-specific de novo genes are commonly expressed in

46 We found allele-specific and lineage-specific de novo methylation at CG and CH sites

47 arrest in hematopoietic progenitors, myeloid lineage specific deletion of C/EBPalpha resulted in sign

48 Notably, lineage-specific deletion of IL-2 in T cells did not red

49 Lineage-specific deletion of layilin on murine CD8+ T ce

50 By lineage-specific deletion of the forkhead box-O 1 (FOXO1

51 undamaged heart, activation of cFAPs through lineage-specific deletion of the gene encoding the quies

52 -responsive cells by generation of mice with lineage-specific deletion of the receptor for IFN-lambda

53 Prostate cancer exhibits a lineage-specific dependence on androgen signaling.

54 Steroid hormones mediate critical lineage-specific developmental and physiologic responses

55 We propose that miRNAs compensate for lineage-specific differences in egl-1 transcriptional ac

56 The results confirm the presence of lineage-specific differential gene expression, linked to

57 However, how BRCA1 deficiency leads to lineage-specific differentiation defect is not clear.

58 In embryonic stem cells, promoters of key lineage-specific differentiation genes are found in a bi

59 We further observe enhanced unbiased lineage-specific differentiation potential of naive hESC

60 latory mechanisms to govern self-renewal and lineage-specific differentiation programs.

61 Efficient lineage-specific differentiation was confirmed by unifor

62 Recent studies indicate that stem cells show lineage-specific differentiation when cultured on substr

63 s possess the capability of self-renewal and lineage-specific differentiation.

64 migration property-specific, in addition to lineage-specific, differentiation programs.

65 whereas most genes are multicopy and/or have lineage-specific distributions for angiosperms.

66 ly over tens of millions of years, promoting lineage-specific diversification regimes under prevailin

67 uring land plant evolution, with evidence of lineage-specific diversification.

68 This situation illuminates multiple lineage-specific diversifications of NOSs and NO/nitrite

69 Our study shows that lineage-specific DNA methylation signatures are stably m

70 lity changes, coupled with stably maintained lineage-specific DNA methylation.

71 induced accessible regions but has different lineage-specific DNA shape features and predicted cofact

72 We discover lineage-specific drug sensitivities based on subcategori

73 We show that when great ape lineage-specific duplications emerge, they preferentiall

74 orthologs in yeast, and many have undergone lineage-specific duplications in one or both lineages.

75 Gene family analyses reveal lineage-specific duplications of genes involved in the t

76 ologs from gene families that have undergone lineage-specific duplications, including those with sing

77 reveal the existence of spatial and temporal lineage-specific dynamics.

78 However, numerous lineage-specific effects were observed, most of greater

79 at the Balance Hypothesis needs to allow for lineage-specific effects, as envisaged in the Phylogenet

80 We propose that lineage-specific elaboration of axoneme structure in T.

81 d in ETPs to establish and maintain a T-cell-lineage-specific enhancer repertoire, including regulato

82 plexes are preferentially targeted to distal lineage specific enhancers and interact with p300 to mod

83 state of the cell through cohesin loading at lineage-specific enhancers and developmental control of

84 on by constraining the activation of dormant lineage-specific enhancers and promoters.

85 es endothelial homeostasis via regulation of lineage-specific enhancers and super-enhancers.

86 is revealed that Jmjd2c is re-distributed to lineage-specific enhancers during ESC priming for differ

87 Single or multi-loci perturbations of lineage-specific enhancers using an enCRISPRi knock-in m

88 hat EBF2 binds and regulates the activity of lineage-specific enhancers.

89 PHIL, a strain with a transgene that directs lineage-specific eosinophil ablation.

90 etic landscape, followed by the emergence of lineage-specific epigenetic patterns during gastrulation

91 Lineage-specific epigenomic changes during human cortico

92 d G. soja, the evolution of FT2c is a G. max lineage specific event.

93 ary conservation of the VNTR reveals a human lineage specific expansion.

94 We find ongoing, lineage-specific expansion and diversification of repres

95 O. sinensis displays considerable lineage-specific expansion of gene families functionally

96 Thus, identifying lineage-specific expansions (LSEs) of nodulation-associa

97 Furthermore, lineage-specific expansions and contractions of UGT grou

98 to a recent whole-genome duplication event, lineage-specific expansions of genes associated with fla

99 re dynamic, with significantly more adaptive lineage-specific expansions, in the more speciose Polyph

100 n had been limited due to highly restricted, lineage-specific expression in vivo.

101 at a promoter-selection system together with lineage-specific expression of accessory factors allows

102 Lineage-specific expression of defense-related genes was

103 structure and regulatory features directing lineage-specific expression of Runx genes, the models of

104 we demonstrate more stringent megakaryocyte lineage-specific expression of the Gp1ba-Cre transgene.

105 Thus, lineage specific factors largely mediate enhancer-promot

106 hallmarks of embryonic development, in that lineage-specific factors can be repurposed upon injury t

107 ption of ribosomal genes and upregulation of lineage-specific factors coordinately controls lineage d

108 at SWI/SNF complexes interact with different lineage-specific factors in NEPC compared to prostate ad

109 ability of genomic regions for activation by lineage-specific factors is regulated in part through dy

110 enhancer module integrating Wnt signals with lineage-specific factors to operate context-dependent tr

111 es are overrepresented, and distributed in a lineage-specific fashion in core and boundary domains of

112 Combined with lineage-specific fate mapping systems, our knockout resu

113 ded here shed new light on the conserved and lineage-specific features of millipedes and centipedes.

114 Collectively, we identify the lineage-specific function of CDC42 in lung tumorigenesis

115 Together, our findings identify a lineage-specific function of NRG1 in SCCs of diverse ana

116 Together, our data reveal novel, lineage-specific functions for E2F-2 and suggest that so

117 d molecular basis of behavior by focusing on lineage-specific functions of the homeodomain transcript

118 yer network was modeled that identified both lineage-specific gene coexpression modules and modules c

119 lmost all the gene families are derived from lineage-specific gene duplications in all three clades,

120 The sHSPs underwent a lineage-specific gene expansion, diversifying early in l

121 Epigenomic regulation and lineage-specific gene expression act in concert to drive

122 dy we examined the role of BRD4 in promoting lineage-specific gene expression and show that BRD4 is e

123 is, chromatin accessibility profiles control lineage-specific gene expression by modulating transcrip

124 Lineage-specific gene expression is modulated by a balan

125 on machinery, are essential for establishing lineage-specific gene expression programs during cell di

126 ct cofactors in feedforward loops to control lineage-specific gene expression programs during progres

127 ific DNA within promoter regions to regulate lineage-specific gene expression, either as activators o

128 factor 2 (EBF2) selectively activates brown lineage-specific gene expression.

129 ction strategies are linked to radiations of lineage-specific gene families.

130 ross 18 species identifies putative adaptive lineage-specific gene family expansions that accompany t

131 on cues, they can activate markedly distinct lineage-specific gene networks while turning off or rewi

132 genes are different between the two groups: lineage-specific gene transpositions are unusual in mamm

133 ntrinsic factor that controlled an iNKT-cell lineage-specific gene-expression program and epigenetic

134 cell cycle progression on the expression of lineage specific genes in precursor cells, and suggests

135 of segmental duplications, we discovered new lineage-specific genes and expanded gene families that a

136 cell types through coordinated expression of lineage-specific genes and modification of complex chrom

137 on and commitment requires the activation of lineage-specific genes and repression of alternative lin

138 Lineage-specific genes are often interpreted as "novel"

139 d provides a simple way of identifying which lineage-specific genes call for special explanations bey

140 to test an alternative null hypothesis: that lineage-specific genes do have homologs outside of the l

141 The super-enhancers (SEs) of lineage-specific genes in B cells are off-target sites o

142 However, we also find that a minority of lineage-specific genes in both clades are not well expla

143 ck of detected homologs of a large number of lineage-specific genes in fungi and insects.

144 esults highlight the potential importance of lineage-specific genes or protein motifs for understandi

145 systematically identifies those orphans and lineage-specific genes that are well-supported to have o

146 enetically related groups of species contain lineage-specific genes that exhibit no sequence similari

147 the recruitment of both highly conserved and lineage-specific genes underlie the convergent evolution

148 ding to Rybp upregulation and suppression of lineage-specific genes via RYBP-dependent ubiquitination

149 Lineage-specific genes were differently expressed betwee

150 tor" is necessary and sufficient to activate lineage-specific genes while restricting the gene expres

151 New genes (or lineage-specific genes) can facilitate functional innova

152 In addition to the bovine-associated lineage-specific genes, including fimbriae, capsule, and

153 sed on their functions and the expression of lineage-specific genes, including those encoding effecto

154 luding changes in the spatial arrangement of lineage-specific genes, nuclear bodies, and heterochroma

155 super-interactive promoters-are enriched for lineage-specific genes, suggesting that interactions at

156 p of evolutionarily related species, called "lineage-specific genes," are pervasive: Essentially ever

157 which reveals 5hmC enrichment in absorptive lineage-specific genes.

158 maintain "open" chromatin state for myeloid lineage-specific genes.

159 velopmental process by activating a group of lineage-specific genes.

160 ons in regions of low gene density and maize lineage-specific genes.

161 ignature expressed both CD4+ and CD8+ T cell lineage-specific genes.

162 stages of murine brain development by using lineage-specific genetic ablation of TRF2, an essential

163 Employing conditional lineage-specific genetic ablation studies in mice, we fo

164 t ultimately demonstrates the maintenance of lineage-specific genetic variation among local populatio

165 However, maize, which experienced lineage-specific genome duplication and has a relatively

166 Osteoclast-lineage-specific Gna13 conditional knockout mice have a

167 helial cells and induced erythroblasts using lineage-specific growth factors.

168 Lineage-specific hypomethylated regions are enriched nea

169 The described lineage-specific innovations can be used for future sing

170 type atlas illustrates different examples of lineage-specific innovations within these enigmatic mari

171 e field, highlighting conserved features and lineage-specific innovations.

172 be, the clamp, the bridge helix, and several lineage-specific insertions.

173 ighly diverged chemoreceptor complements and lineage-specific ion channels that are predicted to oper

174 ing function of E proteins is facilitated by lineage-specific isoform expression and by BET-dependent

175 ere, we generated a mouse model with primate-lineage-specific isoforms of C4, human C4A and/or C4B.

176 In contrast, NRF2 activation through cell lineage-specific Keap1 disruption (i.e., in T cells, mye

177 ed in a microRNA (shmiR), allowing erythroid lineage-specific knockdown.

178 Our observations, based on lineage-specific knockout and GFP-tagging of endogenous

179 ChiLS is recruited to these enhancers by lineage-specific LIM-domain proteins that bind to its Ch

180 functional role and molecular mechanism of a lineage-specific Linc-RAM as a regulatory lncRNA require

181 The Vd991 genome harbored several exclusive, lineage-specific (LS) genes within LS regions (LSRs).

182 c genomic compartments originally defined as Lineage-Specific (LS) regions that contain genes involve

183 t on the epigenetics and cellular origins of lineage-specific lung tumours.

184 shown that lncRNAs are expressed in a highly lineage-specific manner and control the differentiation

185 clock gene Bmal1 (also known as Arntl) in a lineage-specific manner to dissect the importance of osc

186 commissioning' phase that is controlled in a lineage-specific manner.

187 nt of multiple Th subsets but functions in a lineage-specific manner.

188 trophectoderm, and identify deeply conserved lineage-specific markers that pre-date the eutherian-mar

189 traits map to enhancers that are co-bound by lineage-specific master transcription factors (MTFs) and

190 Furthermore, lineage-specific mechanisms in compound leaf development

191 quencing revealed thousands of cardiomyocyte lineage-specific MEF2-occupied regulatory elements that

192 ynthesize numerous ecologically specialized, lineage-specific metabolites through biosynthetic gene d

193 specialized metabolism (SM) enzymes produce lineage-specific metabolites with important ecological,

194 General CRF and lineage specific motifs were identified.

195 fy cell-type-specific accessible regions and lineage-specific motifs associated with TF binding there

196 We identified dynamic and lineage-specific MTPTs that have contributed to mitochon

197 nt an approach to treat AML by targeting the lineage-specific myeloid antigen CD33.

198 ype-specific transcription factors can drive lineage-specific neuronal reprogramming, providing a gen

199 F-kappaB p65 binding analyses demonstrated a lineage specific, NF-kappaB-dependent transcriptional pr

200 rearrangement events and species ecology or lineage specific nucleotide substitution rates.

201 Here we propose a model, 'lineage-specific ohnologue resolution' (LORe), to addres

202 ess specialized trafficking organelles, some lineage specific, others more widely distributed - the e

203 ts megakaryocyte development by modulating a lineage-specific P-TEFb activation mechanism, revealing

204 ce of many LORe ohnologues with functions in lineage-specific physiological adaptations that potentia

205 Thus, histamine couples lineage-specific physiological demands to intrinsically

206 The avocado lineage experienced 2 lineage-specific polyploidy events during its evolutiona

207 Expression of H3.3K4M in lineage-specific precursor cells depletes H3K4 methylati

208 bly, deletion of the enzymatic SET domain in lineage-specific precursor cells mimics H3.3K4M expressi

209 h embryonic pluripotent cells diversify into lineage-specific precursors that will generate the adult

210 N system and that interferomes are shaped by lineage-specific pressures.

211 Basal lineage-specific profiling and genetic loss-of-function

212 Lineage-specific programming of oligodendrocytes results

213 The combination of a safe-harbor and a lineage-specific promoter establishes a universal correc

214 c annotated and novel lncRNA are adjacent to lineage-specific protein-coding genes in the genome.

215 Lineage-specific proteome differences indicate that vert

216 approaches for testing associations between lineage-specific rates of speciation and phenotypic evol

217 Loss of sexual-lineage-specific RdDM causes mis-splicing of the MPS1 ge

218 t lineage factors and labeled with SA showed lineage specific reduction in the actin turnover shortly

219 to nuclear suppression, highly variable, and lineage-specific, reflecting the diverse biology of euka

220 The coordinate lineage-specific regulation of intricately intertwined D

221 We provide experimental evidence for lineage-specific regulation of nuclear architecture duri

222 Our results reveal that MITF is a lineage-specific regulator of metabolic reprogramming, w

223 ession evolution, our work demonstrated that lineage-specific regulatory elements colocalized with gr

224 Finally, we observed that prostate lineage-specific regulatory elements were strongly assoc

225 c to certain types of tissues or cells, e.g. lineage-specific regulatory elements.

226 ext-specific gene expression program through lineage-specific regulatory elements.

227 s insights into the mechanisms through which lineage-specific regulatory factors achieve divergent fu

228 cells, indicate a role for the trophectoderm-lineage-specific regulatory program during this process,

229 nuclear peripheral heterochromatin undergoes lineage-specific reorganization during cell-fate determi

230 mental trajectories, identified pigment cell-lineage specific responses to TH, and assessed roles for

231 ory function at super-enhancers and a unique lineage-specific role in regulating hESC differentiation

232 de-by-side analyses, we identify ancient and lineage-specific roles for Edn signalling.

233 Using culture-free lineage-specific rRNA-targeted fluorescent in situ hybri

234 e expansions are associated with independent lineage-specific segmental duplications flanking LCR16a

235 at cis-regulation can evolve under polygenic lineage-specific selection in prokaryotes.

236 that genes encoding kinases show evidence of lineage-specific selection on their cis-regulation.

237 However, applying the sign test for lineage-specific selection revealed the polygenic up-reg

238 l-cycle-phase marker, revealed a spatial and lineage-specific separation in cell-cycling behaviour.

239 early programming events with inappropriate lineage-specific signatures apparent with alterations in

240 he subset of their target loci that requires lineage-specific silencing.

241 ined through functional interactions between lineage-specific Sox TFs and beta-catenin/Tcf transcript

242 he AB lineage only, and show that they drive lineage-specific spindle skew and cell reorientation eve

243 tion, yet the functions of most species- and lineage-specific splicing events are not known.

244 We discovered several lineage-specific structures, including novel inter-doubl

245 We identified several independent lineage-specific sublocalization cases with specialized

246 er to delineate cardiac lineages and isolate lineage-specific subpopulations.

247 We calibrated the divergence times and lineage-specific substitution rates using Bayesian-skyli

248 of a 3D contact domain comprising IGF2 and a lineage-specific super-enhancer, resulting in high-level

249 ed by all subtypes, such as SPRY1, and other lineage-specific super-enhancers, such as SOX2 in brain-

250 tic functions, (3) diversification of novel, lineage-specific symbiosis-induced genes, (4) proliferat

251 We map this increase to lineage-specific symmetrization events of normally asymm

252 y these contributions as they have evolved a lineage-specific TE called LAVA (LINE-AluSz-VNTR-Alu (LI

253 However, contributions of lineage-specific TE insertions to recent regulatory adap

254 ings highlight the importance of considering lineage-specific TEs in studying evolution of gene regul

255 Most lineage specific TFs were stochastically expressed in th

256 an phylogenetic analyses corroborate several lineage-specific TLR gene expansions in urchins and ceph

257 nfarct switch from a MEF2-driven homeostatic lineage-specific to an AP-1-driven injury-induced gene e

258 xtrinsic environmental factors and intrinsic lineage-specific traits related to sexual selection have

259 These lineage-specific trajectories reveal the expression of n

260 SD1 to an altered expression pattern of lung-lineage specific transcription factors and genes, which

261 plexes instruct cellular differentiation and lineage specific transcription.

262 PAX8 is a lineage-specific transcription factor expressed in the F

263 binding partner PAX8 (P = 2x10-10), a known lineage-specific transcription factor in OC.

264 ith increased expression of the myeloid cell lineage-specific transcription factor IRF8 in MDSCs.

265 Paired Box 8 (PAX8) is a lineage-specific transcription factor that has essential

266 cell identity, enabling us to identify a new lineage-specific transcription factor that instructs PN

267 The CD4(+) lineage-specific transcription factor Thpok is required

268 roviding repression capabilities to distinct lineage-specific transcription factor-based regulatory n

269 poiesis suggest that quantitative changes in lineage-specific transcription factors (LS-TFs) underlie

270 We investigated the properties of lineage-specific transcription factors (such as POU2F1 i

271 Tissue development results from lineage-specific transcription factors (TFs) programming

272 The lineage-specific transcription factors Achaete-scute hom

273 egulating these genes, but instead regulates lineage-specific transcription factors that control spat

274 Demonstrating this may be common to lineage-specific transcription factors, estrogen recepto

275 ole in regulating chromatin accessibility to lineage-specific transcription factors.

276 ession of Cebpa and Gata1, myeloid/erythroid lineage-specific transcription factors.

277 s are determined by a distinct repertoire of lineage-specific transcription factors.

278 dynamic changes in the activity of distinct lineage-specific transcription factors.

279 Although the role of lineage-specific transcription regulators has been studi

280 rs from de novo methylation to ensure robust lineage-specific transcription upon differentiation.

281 actors, but competent cells remain devoid of lineage-specific transcription.

282 the establishment of accessible chromatin at lineage-specific transcriptional enhancers and promoters

283 of tissue-specific multipotent progenitors, lineage-specific transcriptional networks are activated

284 ked to genetic and epigenetic alterations at lineage-specific transcriptional regulators in breast ca

285 cell line (VCaP) cells revealed distinctive lineage-specific transcriptome and super-enhancer profil

286 ptome profiling revealed the identity of key lineage-specific transcripts and the clearly distinct ne

287 quences under selective constraint acting on lineage-specific transposable elements (TEs) and a set o

288 ve variation in the amount of DNA gained via lineage-specific transposition, but that DNA loss counte

289 Using hematopoietic- and eosinophil-lineage-specific Trib1 deletion, we found that Trib1 reg

290 important functions fully explains the cell lineage-specific tumorigenesis.

291 A-485 selectively inhibited proliferation in lineage-specific tumour types, including several haemato

292 ed and supervised analyses, led us to detect lineage-specific variants affecting DNA repair genes, in

293 mparative studies can reveal more shared and lineage-specific variation, and improve the investigatio

294 ted proteins (CRISPR-Cas) spacers elucidated lineage-specific virus-host dynamics suggesting active i

295 most all Lamiales (L event), we identified a lineage-specific WGD (D event) that occurred in the earl

296 Our study highlights the role of lineage-specific WGD in species diversification and adap

297 A Myrtales lineage-specific whole-genome duplication event was dete

298 The highest substitution rate was lineage-specific within the araphid 2 taxon Astrosyne ra

299 We examined the lineage-specific Wnt signaling activation, and identifie

300 This evolutionary convergence implies that lineage-specific X-Y coevolution through gene amplificat