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1 sulfate proteoglycans (CSPGs), aggrecan and link protein.
2 ntracellular scaffolding partner of this tip-link protein.
3 achinery, including the MET channels and tip-link proteins.
4 odon level for five of these six hair bundle link proteins.
5 re found in unique groups of six hair bundle link proteins.
6 ands making multiple contacts with the cross-linked protein.
7 ar cyclization and a high yield of the cross-linked protein.
8 ormed after enzymatic digestion of the cross-linked proteins.
9 multi-pass, or glycosylphosphatidylinositol-linked proteins.
10 dimers in the membrane by analysis of cross-linked proteins.
11 conjugation to visualize and identify cross-linked proteins.
12 oponin and exposed to UV light to form cross-linked proteins.
13 implicated in the processing of other ataxia-linked proteins.
14 n and localization of identified and network-linked proteins.
15 keys, give rise to efficiently processed GPI-linked proteins.
16 g ortholog partners in pairs of functionally linked proteins.
17 luble structure composed of covalently cross-linked proteins.
18 ization, and interaction with itself and ALS-linked proteins.
19 raplakin, as a model actin-microtubule cross-linking protein.
20 hat differ in expression of this actin cross-linking protein.
21 of plasma membrane-actin cytoskeleton cross-linking proteins.
22 band of cortical nodes and bundled by cross-linking proteins.
23 ich is progressively stabilized by the cross-linking proteins.
24 V) and vascular stiffness, in part via cross-linking proteins.
28 inin alpha1, and hyaluronan and proteoglycan link protein 1 (Hapl1) production as well as proliferati
29 , we report that hyaluronan and proteoglycan link protein 1 (HAPLN1) is produced in bone marrow strom
30 oglycan versican/hyaluronan and proteoglycan link protein 1 rich myxoid matrix, which is in direct co
35 inantly of the proteoglycan versican and its linking protein, a vertebrate hyaluronan and proteoglyca
36 ce of unbinding and unfolding of actin cross-linking proteins (ACPs) in the dynamic properties of the
37 n moieties are substituted for the thioester-linked protein acyl-modifications through a sequence of
39 e findings, we propose that 2 mechanisms may link protein aggregation and cardiac function: oligomer-
41 olated raft fractions were enriched in a GPI-linked protein, alkaline phosphatase, and were poor in N
42 king is modulated by the Parkinson's disease-linked protein alpha-synuclein, but the contribution of
43 chizosaccharomyces pombe, in which the cross-linking protein alpha-actinin SpAin1 bundles the actin f
44 tin bundling by interacting with actin-cross-linking protein alpha-actinin-1 and increasing its affin
45 s, regulation of the homodimeric actin cross-linking protein alpha-actinin-4 (ACTN4) during cell migr
47 egment, reminiscent of the Parkinson disease-linked protein, alpha-synuclein, which we show shares a
48 l peptide (LPP) is a proteolytic fragment of link protein, an important cross-linker and stabilizer o
49 We present a robust strategy to covalently link proteins and DNA using HUH-endonuclease domains as
50 M, integrates static and time series data to link proteins and the pathways they regulate in these ne
51 elin (HJV) is a glycosylphosphatidylinositol-linked protein and binds both bone morphogenic proteins
54 family of extracellular matrix receptors and linked proteins and discuss the evidence supporting thes
55 will support the development of novel cross-linked proteins and enable a more rational design proces
57 ope is assembled from transglutaminase cross-linked proteins and lipids in the outermost epidermal la
58 selective identification of dityrosine cross-linked proteins and peptides in complex biological sampl
60 nding this method to the separation of lipid-linked proteins and transmembrane proteins while minimiz
61 l genomic analysis, we identify functionally linked proteins and verify their interaction in vitro by
63 aralog-specific behaviors of different cross-linking proteins and identify a zone of optimal actin-bi
65 tween the density of myosin motors and cross-linking proteins and the rigidity, initial orientation,
66 s a ubiquitously expressed enzyme that cross-links proteins and its overexpression, linked to a drug
69 of receptors, signal transducing kinases and linking proteins, and is responsible for the motile resp
70 ting of actin filaments, alpha-actinin cross-linking proteins, and non-muscle myosin IIA mini-filamen
71 h, the actin cortex, comprising actin, cross-linking proteins, and nonmuscle myosin II (MII), begins
72 aninum produces a family of small, disulfide-linked protein anticoagulants (75-84 amino acid residues
73 n the premise that hair cell stereocilia tip-link proteins are closely coupled with MET, these result
75 ific toxicity, despite the fact that disease-linked proteins are generally ubiquitously expressed.
79 of actin filaments, myosin motors, and cross-linking proteins at biologically relevant time and lengt
80 ding with elevated expression of actin-cross-linking proteins at the neuronal growth cone, namely pho
81 n the central hydrophobic core and the cross-linked protein body periphery, respectively, but little
83 tructures contains actin filaments and cross-linking proteins, but the role of cross-linking proteins
87 pha-actinin-4 (Actn4), a dynamic actin cross-linking protein, cause proteinuric disease in humans and
88 to the carboxyl terminus of stereocilia tip-link protein CDH23 +68 (cadherin 23 with expressed exon
89 otein interaction for CNGA3 and a second tip-link protein, CDH23 +68, further suggests possible assoc
91 whole exome sequence we identified two new X-linked protein coding variants that arose de novo in BAL
98 ubstrate pairs into stable, covalently cross-linked protein complexes, thereby facilitating their sub
101 ction of stable secondary and tertiary amine-linked protein conjugates without affecting the structur
103 hology, targeting vimentin or vimentin cross-linking proteins could provide a therapeutic approach to
105 riggered by neuronal production of cartilage link protein Crtl1 (Hapln1), which is up-regulated in th
107 pose that incorporation of BMAA into the ALS-linked protein Cu,Zn superoxide dismutase (SOD1) upon tr
108 of caveolin-3 and filamin (an F-actin cross-linking protein), decreased phosphorylation of caveolin-
109 vel regulators of endoplasmic reticulum (ER)-linked protein degradation and ER function, we determine
110 f proteomic pathway analysis to functionally link proteins differentially expressed in bone and skin
112 ne the rate of cross-link reversal for cross-linked protein-DNA complexes from yeast cell lysate.
114 ases that bind and cleave the target through linked protein domains (e.g. TALENs and zinc-finger nucl
116 codes the glycosylphosphatidylinositol (GPI)-linked protein doppel, which is expressed on the surface
117 tes the phosphorylation of the lissencephaly-linked protein doublecortin (DCX) by cdk5/p35, but the p
118 evation of hydrostatic pressure, the fission-linked protein, Drp-1 was translocated from the cytosol
123 closely related to the membrane-cytoskeleton linking proteins Ezrin, Radixin, and Moesin, and localiz
125 Recent studies showed that the actin cross-linking protein, fascin, undergoes rapid cycling between
126 investigate the behaviors of two actin cross-linking proteins, fascin and alpha-actinin, during the f
127 ll GTPase Rab1A as well as the F-actin cross-linking protein filamin (actin-binding protein 120, abp1
129 esis that interactions between F-actin cross-linking protein filamin A and caveolin-1 facilitate the
130 entified the non-muscle actin filament cross-linking protein filamin A as a novel Gag binding partner
134 ctivation), whereas binding of another actin-linking protein, filamin, to the integrin beta CTs negat
135 ssociated protein AFAP-110 is an actin cross-linking protein first identified as a substrate of the v
139 ly become appreciated as a modification that links protein function to cellular oxidative status.
141 olyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutatio
143 ome underscores the importance of asparagine-linked protein glycosylation for proper functioning of t
144 Our findings underscore the importance of N-linked protein glycosylation for proper functioning of t
164 since the discovery of asparagine-linked (N-linked) protein glycosylation pathways in bacteria, majo
165 llapse radially due to the activity of cross-linking proteins, hence producing conical-shaped filamen
166 oxyl terminus of protocadherin 15 CD3, a tip link protein implicated in mechanosensory transduction.
168 some mothers develop antibodies against a Y-linked protein important in male brain development, and
170 xamined for the first time the expression of link proteins in human brain and malignant gliomas.
171 cently labeled Bacteroides and fluorescently linked proteins in actively growing nanaerobic gut symbi
173 he role of typical Rho GTPases and other Rho-linked proteins in synaptic plasticity and cognitive fun
176 f cellular localization of known actin cross-linking proteins in mouse melanoma B16F1 cells revealed
177 ross-linking proteins, but the role of cross-linking proteins in the initial steps of structure forma
178 ation factor XIIIa (FXIIIa) covalently cross-links proteins in blood and vasculature, such as in bloo
179 of filamin A (FLNa), an actin filament cross-linking protein, in wound contraction and maintenance of
183 d accumulation of polyubiquitinated (K48/K63-linked) proteins into juxtanuclear aggresomes, without a
184 identified filamin A (FLNa), an actin-cross-linking protein involved in cell movement, as a bona fid
185 In addition, microtubule and actin cross-linking protein IQGAP1 localized to fused secretory vesi
187 e; subsequently, DNA together with all cross-linked proteins is isolated by centrifugation under dena
188 osylated, glycosylphosphatidylinositol (GPI)-linked protein, is expressed preferentially by myofiber
190 alpha-actinin and palladin, two actin-cross-linking proteins, is essential for proper bidirectional
193 und to participate in multiprotein complexes linking protein kinase A to the activation of phosphodie
195 that alpha actinin 4 (ACTN4), an actin-cross-linking protein known to coordinate cytoskeletal organiz
197 There is abundant epidemiological evidence linking protein malnutrition to impaired vaccine efficac
199 or a d-amino acid polymer antigen in a cross-linked protein matrix was shown to be sufficient to prod
200 ymer bundles, which also suggests that cross-linking proteins may contribute to the regulation of the
201 tolithographic method for constructing cross-linked protein microstructures, permits one to compartme
202 ggest that CHOP is a fundamental factor that links protein misfolding in the ER to oxidative stress a
207 ases the activity and function of plasticity-linked protein networks in the amygdala that regulate th
208 it is possible that STIM1 represents a nexus linking protein O-GlcNAcylation with Ca(2+)-mediated tra
209 interactions between myosin and actin cross-linking proteins observed in cellular mechanosensation,
212 s lacking glycosylphosphatidylinositol (GPI)-linked proteins on their surface (GPI(neg)) exist alongs
214 lagen biosynthesis as well as collagen cross-linking protein, P4HA1 and PLOD2 were observed along wit
216 t-resistant membrane domains, into which GPI-linked proteins partition, are enriched in cholesterol a
218 immune signaling module downstream of PRRs, linking protein phosphorylation cascades to metabolic re
219 volutionarily conserved actin bundling/cross-linking protein plastin is instrumental for the generati
221 that Ubc13, an E2 enzyme that catalyzes K63-linked protein polyubiquitination, is largely dispensabl
222 Uev1a, specifically mediates lysine 63 (K63)-linked protein polyubiquitylation, a process that does n
223 filament overlap length marked by the cross-linking protein PRC1 decreases during anaphase as chromo
224 identification and characterization of cross-linked proteins presents a significant analytical challe
225 repeat containing 2 (XIRP2), an actin-cross-linking protein previously reported to be specifically e
228 ein-protein interaction between HCN1 and tip-link protein protocadherin 15 CD3, a protein-protein int
229 coupling between HCN1 and stereociliary tip-link protein protocadherin 15 has been described for a t
232 ied by alkaline partial hydrolysis and cross-linked protein residues were identified by mass spectrom
234 denylated RNA, and apply it to recover cross-linked protein-RNA and free protein, or protein-bound RN
235 denaturing washes, the resulting covalently linked protein-RNA complexes are purified with oligo(dT)
237 an intra- and intermolecular cysteine cross-linked protein shell called the chlamydial outer membran
239 to the capability to produce multiple cross-linked protein species and polymeric additions to protei
240 r, we have utilized a genetic selection that links protein stability to antibiotic resistance to isol
241 ssumed that a specific ubiquitin ligase (E3) links protein substrates to polyubiquitin chains contain
244 bsence of other glycosylphosphatidylinositol-linked proteins such as urokinase-type plasminogen activ
245 Gs), tenascin-R (TN-R), hyaluronan (HA), and link proteins, such as cartilage link protein 1 (Crtll).
246 duces CaMKIIalpha binding to established ASD-linked proteins, such as Shank3 and subunits of l-type c
247 osed of filaments bundled by different cross-linking proteins, such as filopodia (fascin), lamellipod
248 onan (HA) receptor Lyve-1 is a member of the Link protein superfamily most similar to the leukocyte H
249 results suggest general physical mechanisms linking protein symmetry, the lattice architecture of me
250 propose that specialized machinery exists to link protein synthesis with class I peptide ligand gener
254 accurately estimates functional coupling of linked proteins than use individual data sources alone.
257 ocol for the large-scale purification of Ubl-linked proteins that minimizes sample contamination with
258 (CaMKIIalpha) and a network of functionally linked proteins that regulate neural plasticity and glut
259 ) is a complex and dynamic meshwork of cross-linked proteins that supports cell polarization and func
260 10)), encoding plectin, a cytoskeletal cross-linking protein that contributes to integrity of cardiac
261 Filamin A (FlnA) is an important actin cross-linking protein that is required for cellular processes
262 and functions as an actin stress fiber cross-linking protein that promotes the maturation of nascent
265 ave wider implications for other actin cross-linking proteins that share a villin-like headpiece doma
266 ed receptor V1 (adgrv1), another hair bundle link protein, the entry of Cdhr23- and Cdhr15-expressing
267 e 3-deoxythreosone, which modified and cross-linked proteins through the formation of an arginine add
268 anslational modification of the ECM by cross-linking proteins, thus making these proteins resistant t
271 omeostasis, or proteostasis, enables disease-linked proteins to adopt aberrant tertiary structures, a
272 to pairs of non-homologous but functionally linked proteins to find specific regions of the protein
275 how they facilitate expanded functions that link protein translation to other cellular pathways.
283 ytosis of glycosylphosphatidylinositol (GPI)-linked proteins via a specific pathway into GPI-enriched
285 between Capsicum-eIF4E and the viral genome-linked protein (VPg) is required for the viral infection
289 proteolysis assays on this semisynthetic ATP-linked protein, we have obtained unique evidence for an
290 air or with exogenous oxidant, and the cross-linked proteins were reconstituted to assess their funct
292 ce HA synthetic enzymes (HASs), thus HA, and link proteins, which are scaffolding molecules for an or
293 outer membrane containing a network of cross-linked proteins, which together confer cell envelope sta
294 ditions in the absence of any specific cross-linking proteins, which suggests that it is driven by ge
295 re also developed in our laboratory by cross-linking proteins while preserving their native structure
296 se of alpha-synuclein, a Parkinson's disease-linked protein whose monomer exhibits significant disord
297 opropyl)carbodiimide (EDC) was used to cross-link proteins with complementary charged groups in close
298 pping uses gene ontology (GO) information to link proteins with similar biological functions from dif
299 e de novo computational design of multicross-linked proteins with predictable and well-defined folds,
300 microtubules are organized by numerous cross-linking proteins yet the mechanical properties of those