ライフサイエンスコーパス: linkage

1 ment), and linkage to care (at release or no linkage).

2 ated by stereo-specific head-to-tail overlap linkage.

3 s orientations with respect to the tethering linkage.

4 l toolkit and traces of ancestral bilaterian linkage.

5 that provides a powerful genotype-phenotype linkage.

6 acid, and propylthiouracil) to evaluate this linkage.

7 sult of a failure to form a stable head-tail linkage.

8 els-Alder reactions to form a stable pyrrole linkage.

9 r complex due to the hydrolysis of the ester linkage.

10 icitly model genetic recombination and local linkage.

11 le, benign, and hydrophilic phosphorothioate linkage.

12 al pleiotropic effectors with strong disease linkage.

13 ubgroup membership, increasing likelihood of linkage.

14 evolutionary histories that resolves genetic linkage.

15 pecially with respect to C(sp(2) )-C(sp(3) ) linkages.

16 ng functional materials based on anion-anion linkages.

17 nd are further modulated by the heteroatomic linkages.

18 upon irradiation via photocleavage of ether linkages.

19 carosides and glucosides via ester and amide linkages.

20 provide catechol moieties for the iron cross-linkages.

21 COF powders by temporarily protonating their linkages.

22 ting electrophilic sites at remote sp(2) C-H linkages.

23 to graphite edges though aromatic phenazine linkages.

24 ively show that it cleaves only beta-mannose linkages.

25 its domestic and international supply chain linkages.

26 o an extended, porous framework via covalent linkages.

27 directly impact the global food supply chain linkages.

28 cosifier, organoclay, that has electrostatic linkages.

29 t cleavage of the covalent ring/thread ester linkages.

30 ymers with 1,1-disubstituted alkene backbone linkages.

31 GAX, identify six enzymes that hydrolyze GAX linkages.

32 0) individuals initiated ART within 1 day of linkage, 276 (16.1%, 14.4-17.9) within 1 week, 839 (48.9

33 6) individuals initiated ART within 1 day of linkage, 589 (73.7%, 70.6-76.7) of 799 within 1 week, 67

34 ed 12 - 18 (9.025; 3.314, 2.581) and unknown linkages (6.087; 3.346, 13.848) were at higher risk of b

35 ar answer has emerged because of the complex linkages across multiple trophic levels and the lack of

36 This perturbation impairs sister chromosome linkage, advances the timing of genome replication, and

37 The covalent linkage allowed overcoming solubility problems with the

38 epletion disrupted the cytoskeleton-integrin linkage, allowing for cross-model examination of protein

39 However, the physiological linkages among drought, tree defences, and insect outbre

40 alth that require attention and reveal inter-linkages among the SDGs that should accelerate progress.

41 , covalent labeling provides the most stable linkage, an unrivaled choice of small and highly fluores

42 We concluded that the combination of linkage analyses and WGS to search for disease genes sti

43 ng has allowed researchers to move away from linkage analysis (relying on large pedigrees and/or mult

44 Linkage analysis and complementation tests showed that t

45 alculated using SOLAR (Sequential Oligogenic Linkage Analysis Routines).

46 been identified using four main approaches: linkage analysis, candidate gene sequencing and most rec

47 Methods consisted of genome-wide linkage analysis, exome and Sanger sequencing, clinical

48 ring contigs into pseudomolecules by genetic linkage analysis.

49 Genome-wide linkage and association analysis were conducted on the s

50 Several genes have been implicated using linkage and follow-up sequencing in these families.

51 tal health (EH) studies may be vulnerable to linkage and we investigated, in a case study, whether en

52 atment failures and to identify transmission linkages and associated factors in a cohort of PWID rece

53 aining both 2'-5'- and 3'-5'-internucleotide linkages and their effects on siRNA structure, function,

54 riptomics to identify putative enhancer-gene linkages and transcription factors that regulate human c

55 lity loci through candidate gene, genomewide linkage, and genomewide association studies, relationshi

56 suggest scaling up recommended HIV testing, linkage, and retention interventions can help reduce pre

57 es were more effective than those with (6,1) linkages, and bulk food ingredients were the most effect

58 le information of human mobility, production linkages, and logistics for regional management and plan

59 genes involved in microtubules, cytoskeleton linkages, and motor activity.

60 xpected predator-prey relationships, trophic linkages, and seasonal shifts across all domains of life

61 the CHKB gene, and that that this regulatory linkage appears to have resulted from an intergenic dele

62 Key proteins in the integrin-cytoskeleton linkage are reduced in haemodialysis patients, suggestin

63 Key proteins in the integrin-cytoskeleton linkage are reduced in MHD patients, suggesting for the

64 sites in both framework Si-O-Al and Si-O-Si linkages are enriched simply on exposure to H(2)(17)O(l)

65 Such physical linkages are interpreted to reflect evidence for stoloni

66 ion waves in a bistable one-dimensional (1D) linkage as a robust mechanism to realize structures that

67 units and cyano substituents at the vinylene linkage as active sites for the evolution of H(2) .

68 h the C16 fatty acids located in acyloxyacyl linkage at the 2' and 3' positions of the diglucosamine

69 Precise assignment of sialylation linkages at the glycopeptide level is of importance in b

70 Here, we tested novel linkage-based droplet digital PCR (ddPCR) assays to stud

71 d hemicelluloses such as xyloglucan or mixed-linkage beta-d-glucan (MLG).

72 plays a major role in evolution by breaking linkage between advantageous and deleterious alleles in

73 A2-ext and a molecule that corresponds to a linkage between an extension and a terminal unit.

74 and culture collections, but also to ensure linkage between bioinformatic databases and the wider re

75 HD conjugate was synthesized via an amide linkage between carboxylic acid group of HA and amine gr

76 ted this observation and showed a consistent linkage between Co and Mn.

77 Despite linkage between coral bleaching and disease, the roles o

78 The linkage between MOF and tumor proliferation suggests tha

79 ific and tunable condensates, while relative linkage between nodes underlies multiphase organization.

80 ntly neglected topic in Animal Cognition-the linkage between ontogeny and cognitive performance.

81 (e.g., externally oriented emotions) of the linkage between perceived unfairness and core components

82 ck to global climate and emphasize the close linkage between soil microbial C and N cycling.

83 nt study is designed to verify this putative linkage between synchrony and cooperation.

84 This database consists of a linkage between the American Association of Medical Coll

85 Cause of death was established using data linkage between the Australian and New Zealand Dialysis

86 However, the inherent linkage between the collective magnetic behavior of part

87 that disruption to the transmembrane protein linkage between the cytoskeleton and the extracellular m

88 Disruption to the transmembrane protein linkage between the cytoskeleton and the extracellular m

89 Our results imply an intimate linkage between the DM-pMHCII interface and peptide-MHCI

90 The linkage between the helices plays an essential role in d

91 ven confer cooperativity, because an ancient linkage between the oxygen binding site and the multimer

92 ur analysis provides a significant molecular linkage between the serum BDNF level and cardiovascular

93 We also found a lack of significant linkage between these two loci, which supports previous

94 ational studies shed light on the allosteric linkage between two anion binding sites that dynamically

95 Little is known about the pathophysiological linkages between altered ceramide profiles in the stratu

96 ement efforts by elucidating the multi-scale linkages between geomorphology and ecology that, in turn

97 like HIV as they have difficulties capturing linkages between infections.

98 Linkages between local fires and climate-driven fuel cha

99 There were 3 transmission linkages between study participants.

100 extended pai-rich alternating carbon-carbon linkages between the rotational electron donors and acce

101 Leveling off between both arms was driven by linkage beyond 12 months in the UC arm.

102 can isomers differentiating from positional, linkage, branching, and anomeric structures is often a p

103 addition of genetic recombination and local linkage brings about significant improvement in the infe

104 cyclization (C2), and a disulfide bond cross-linkage (C3).

105 Sex linkage can affect mutation rates, selection, and drift,

106 We then demonstrate that such bistable linkages can be used as building blocks to realize deplo

107 The cross-linkages can lock the payloads tightly, endowing the cro

108 Genetic linkage causes the fate of new mutations in a population

109 er 407 (P407) via a photo-cleavable coumarin linkage (CM).

110 es including fast kinetics, small and stable linkage, compatibility with low temperature, photocontro

111 Thus, the covalent linkage concept offers several advantages, especially wh

112 ood candidates for umbrella species as these linkages covered only 17% of the corridors for all speci

113 including the anomericity of the glycosidic linkage, demonstrating the power of this tool for glycan

114 genotype and phenotype (dbGaP), which are in linkage disequilibrium (D' = 1) with Exo5 L151P found in

115 We performed linkage disequilibrium (LD) analysis and bioinformatic p

116 nctional in the corresponding tissue, due to linkage disequilibrium (LD) and the correlation of gene

117 D subset with 62 common variants in a single linkage disequilibrium (LD) block in a 350 kb interval h

118 , alpha73, alpha184, beta57) due to complete linkage disequilibrium (LD) of alpha44 with eight such r

119 allows for quick geographic visualization of linkage disequilibrium (LD) patterns between two user-sp

120 Measures of linkage disequilibrium (LD) play a key role in a wide ra

121 sed genes for each of 53 tissues followed by linkage disequilibrium (LD) score-based enrichment testi

122 ltiple datasets, either exploiting different linkage disequilibrium (LD) structures across ancestries

123 S Catalog to identify susceptibility loci in linkage disequilibrium (LD) with a user-provided list of

124 This variant is in linkage disequilibrium (LD) with other 5' risk variants

125 To remove effects of high levels of pairwise linkage disequilibrium (LD), SNPs were also preselected

126 SNPs (fSNP) from disease-associated SNPs in linkage disequilibrium (LD).

127 es from asQTL signals due to complexities in linkage disequilibrium (LD).

128 These two SNPs displayed strong linkage disequilibrium (LD).

129 y do not fully utilize the information [e.g. linkage disequilibrium (LD)] contained in population gen

130 S by utilizing external information, such as linkage disequilibrium and functional annotations.

131 pe I error inflation in this case-only test: linkage disequilibrium and population stratification.

132 y-Weinberg expectations within loci, lack of linkage disequilibrium between distant loci, incongruent

133 w that differences in allele frequencies and linkage disequilibrium between Egyptians and Europeans m

134 We found no significant linkage disequilibrium between MHC-DRB and MHC-DOB, sugg

135 nsitized CPRA categories, with deviations in linkage disequilibrium for Caucasians and the smaller si

136 contamination by measuring the breakdown of linkage disequilibrium in a sequenced individual due to

137 Here, we took advantage of the reduced linkage disequilibrium in African populations to infer g

138 The combination of weak linkage disequilibrium in Africans and functional annota

139 hrinkage (NPS) method can reliably allow for linkage disequilibrium in summary statistics of 5 millio

140 , suggesting that genetic confounding due to linkage disequilibrium is widespread in naive phenome-wi

141 Linkage Disequilibrium Score Regression (LDSR) analyses

142 We applied stratified linkage disequilibrium score regression and evaluated he

143 We used linkage disequilibrium score regression and polygenic ri

144 ity and genetic correlation estimation using linkage disequilibrium score regression.

145 The rate of decay in linkage disequilibrium was fast, and no significant evid

146 ion tests, such assays are not confounded by linkage disequilibrium when loci are independently assay

147 s the top hit (P = 2 x 10(-14)); this was in linkage disequilibrium with HLA-DRB1*10:01 (odds ratio,

148 replication cohorts, multiple SNPs in strong linkage disequilibrium with rs56151658 were associated w

149 n KL variants revealed that only variants in linkage disequilibrium with rs9315202 showed similarly h

150 l of evolutionary constraint), effect sizes, linkage disequilibrium with tagging single nucleotide va

151 candidate genes were identified based on the linkage disequilibrium with these loci, including GRMZM2

152 variants that affect complex traits, due to linkage disequilibrium, and to maximize power while limi

153 raging population differences in patterns of linkage disequilibrium, we achieve improved fine-mapping

154 We identified 58 linkage disequilibrium-independent ADHD-associated loci

155 idates were predicted in the regions of high linkage disequilibrium.

156 ion apart from the exome and regions of high linkage disequilibrium.

157 e rely on well-established genetic models of linkage disequilibrium.

158 polymorphisms (SNPs) are not obvious due to linkage disequilibrium.

159 als, IBDrecomb obtains similar accuracy to a linkage-disequilibrium (LD)-based method applied to 96 i

160 Agglomerative average-linkage distances based on squared error between cluster

161 reby directly influences the consequences of linkage drag.

162 Owing to strong covalent linkages, drilling fluids that were formulated with MSil

163 the higher resistance of galactosyl-fructose linkages during its intestinal degradation.

164 Linkage effects generated by variants that sweep rapidly

165 The covalent protein-ligand linkage enabled structural characterization of these tra

166 ein, we report supramolecular strategy-based linkage engineering to fabricate a versatile 2D hydrazon

167 nding through selection into the program and linkage errors, although analytical approaches have mini

168 ns for several other games we show that such linkage facilitates cooperation.

169 Yet, evidence of such linkage for copepods, the most abundant metazoans in the

170 ridors mapped that, when assembled, provided linkages for up to 27 species.

171 benzazole auxiliary, and tolerance of amide linkage forming conditions constitute the potential appl

172 cificity towards alpha(1,6)-fucose, the only linkage found in human N-glycan core fucosylation.

173 s beta-1,4, beta-1,3 and beta-1,6 glucosidic linkages from non-reducing end of short chain oligosacch

174 rs the distribution of heteroxylan and mixed linkage glucan in cell walls.

175 Different sex-determining loci (linkage group 1, 20 and 23) have been detected in variou

176 controlling fire blight resistance mapped on linkage group 10 (LG10) and explained up to 66% of the p

177 Stereoselective formation of glycosidic linkages has been the prime focus for contemporary carbo

178 To define the final sugar and its linkage, here we identified the glycosyltransferase that

179 l transmission was confirmed by phylogenetic linkage (HIV pol).

180 e 16p12.1-q12.2 with genome-wide significant linkage in a large European Australian family with autos

181 Sialylation and sialic acid linkage in N-glycans are markers of disease but are anal

182 esults argue for the importance of resolving linkage in studies of natural selection.

183 experimental data collection, collation and linkage in the exemplar study and was flexible enough to

184 e that tyrosine can undergo stable, covalent linkages in fibrillar fibronectin under inflammatory con

185 that controlling PS chirality of only two PS linkages in the DNA gap was sufficient to modulate RNase

186 from the varied range of different chemical linkages, including to several amino acid side chains as

187 nd reflex testing outperformed point-of-care linkage indicators.

188 g for genetic recombination effect and local linkage information.

189 BCPE facility-based testing and linkage interventions are undergoing national scale up t

190 topologically connected via robust phenazine linkage into a two-dimensional tetragonal framework that

191 dentified using a health administrative data linkage involving migrants to British Columbia, Canada.

192 led out by the gaze, are linked only if this linkage is pertinent within the prevailing social contex

193 t amino acid modifications and peptide cross-linkages, is presented using solution and solid phase ap

194 oligomannosidic glycan anomers, sialoglycan linkage isomers, and regioisomers of afucosylated and fu

195 Such linkages limit freedom of movement for individual immune

196 the genotype-phenotype association (based on linkage mapping, association mapping or a candidate gene

197 mmon markers and number of unique bins along linkage maps were consistent based on the SNPs genotyped

198 We propose the neural network linkage mediation experiment as an approach to collectin

199 gning synthetic oligos with various base and linkage modifications that can transform into highly sen

200 post-translational modification involving O-linkage of beta-N-acetylglucosamine to Ser/Thr residues

201 a collection, and handles metadata entry and linkage of data.

202 The linkage of device-measured activity to energy expenditur

203 urvey and tissue staining also confirmed the linkage of ERalpha/miR-141-3p/GSN signaling to the HCC p

204 osomes have been hypothesized to involve the linkage of factors with antagonistic effects on male and

205 rupts oscillations and segmentation, and the linkage of her1 and her7 is essential for the developmen

206 hromosomal stability are demonstrated by the linkage of mutations in helicase genes to hereditary dis

207 In this study, we characterized pathological linkage of OP to OA, and evaluated the effect of knee lo

208 consistent, flexible metadata collection and linkage of related experimental data generated locally b

209 n, and drift, and our results suggest that Z-linkage of SCN4A may make significant contributions to t

210 d their parents was carried out using record linkage of Swedish Population Register, Cancer Registry,

211 s was assessed for the period: 01-12/2018 by linkage of the Liverpool HIV drug interactions and SHCS

212 rove structural resolution because different linkages of glycan units show different stabilities unde

213 o and alpha-hydroxy beta-O-4 type aryl ether linkages of lignin.

214 The monosaccharide compositions and linkages of the detected O-glycans were identified by ex

215 modulation of geometry around the glycosidic linkages of the FPX constituent monosaccharides.

216 re able to break selectively specific glycan linkages on intact glycopeptides and get, to some degree

217 Navigation support is provided for linkage or relinkage to VH or HIV care.

218 ng the ring-closing ester bond with an amide linkage or with a primary ester.

219 e aryl ethers and phenols represent the main linkages or units in lignin biomass, the successes of su

220 The results suggest that the amide linkage plays a key role in the formation of a pai-conju

221 mong 1005 linked SURTAVI trial participants (linkage rate, 60.5%), the trial's primary end point was

222 Among 600 linked HiR participants (linkage rate, 80.0%), the rate of the trial's primary en

223 iant in CYLD (c.2155A>G, p.M719V) within the linkage region as the genetic cause of disease in this f

224 s of polyubiquitylated PCNA are not strictly linkage-selective.

225 g of cyanostar-stabilized anti-electrostatic linkages, shows adhesion strength comparable to commerci

226 distinct structures of anomeric glycans and linkage sialoglycan isomers, alpha2,3 and alpha2,6, were

227 OTULIN, a linear linkage-specific deubiquitinase, is essential for the DN

228 With this strategy, a total of 1236 linkage-specific sialoglycopeptides were successfully id

229 immune defense and extend the importance of linkage specificity beyond mammalian cGAS-STING signalin

230 The data reveal that the length of the linkage strongly influences the viscosity sensitivity, l

231 performed for atrial fibrillation, including linkage studies, genome-wide association studies, and st

232 d as a candidate gene in a previous familial linkage study of SLE and rheumatoid arthritis, but the a

233 ein networks formed from specific functional linkages such as protein complexes and ligand-receptor p

234 groups vary in heterozygosity and levels of linkage, suggesting different recombination histories.

235 2014, were identified using a medical record linkage system that captures virtually all medical care

236 xcellent read-through speed, or a squaramide linkage that is read-through under selective conditions.

237 to its ability to form chains with distinct linkages that can alter the fate of substrate proteins i

238 e range of galactosyl, glucosyl and mannosyl linkages that do not directly reflect cereal root cell w

239 Given linkages that have been established between temperature

240 maintain alleles of multiple genes in tight linkage through suppressed recombination.

241 that are mass tagged to identify the sialyl linkage, thus facilitating the analysis of these charged

242 e 1 (OAS1), which adds AMP residues in 2',5' linkage to a variety of substrates, is observed in many

243 statewide liver clinics resulting in higher linkage to care (86%) than national estimates (~25%).

244 , for all HCV infected or no treatment), and linkage to care (at release or no linkage).

245 tinuum of care: timely diagnosis followed by linkage to care and initiation of antiretroviral therapy

246 ed to describe the uptake of HIV testing and linkage to care and treatment during this programme.

247 CTN0049, a linkage to care randomized clinical trial, enrolled 801

248 helping to establish their prevalence and co-linkage to certain plasmids.

249 opulmonary mortality were identified through linkage to China's Disease Surveillance Point system and

250 Data for all admissions were obtained by linkage to electronic hospital records from the health i

251 present methylome association by predictive linkage to expression (MAPLE), a computational framework

252 and in aging human brains, suggesting their linkage to genetic and age-related factors.

253 onitoring death registries and by electronic linkage to health registries and health insurance claims

254 in the hospital is beneficial for increasing linkage to HIV care and frequency of visits for PLWH and

255 The TB diagnostic work-up and linkage to HIV care should be strengthened to decrease T

256 t delivery of universal testing, facilitated linkage to HIV care, and universal treatment services.

257 ART in the hospital and its association with linkage to HIV care, frequency of outpatient care visits

258 nificant change was identified in trends for linkage to HIV medical care <=90 days after diagnosis (E

259 nd in newly diagnosed HIV among PWID but not linkage to HIV medical care or referral to prevention se

260 t (Scottish Care Information-Diabetes), with linkage to hospital and mortality data.

261 infant primary care records was maximized by linkage to hospitalization data and death certificates.

262 investigate their genetic position and their linkage to mobile genetic elements.

263 Deaths were identified through linkage to mortality registers.

264 mes were obtained by individual-level record linkage to national electronic records of hospital admis

265 2014 for all-cause and CVD mortality by data linkage to national registries.

266 Using data from a UK cohort study with data linkage to national schooling records, we investigated h

267 s on the beta-carbon, affording the shortest linkage to protein backbone which is essential for advan

268 efforts to increase HIV testing and enhance linkage to services can lead to reductions in HIV transm

269 ortant role in PCa progression, however, its linkage to the DTX resistance remains unclear.

270 ver, the detailed mechanisms, especially its linkage to the gelsolin (GSN)-mediated cell invasion, re

271 ficate underlying or contributing causes, by linkage to the National Death Index through 2015.

272 acyl chain of a specific length for covalent linkage to the protoxin.

273 ecord review and serial National Death Index linkages to enhance mortality findings.

274 tworks in behavior and development and their linkages to neuronal networks.

275 ts are joined substoichiometrically by imine linkages to produce 1D ribbons, termed COF-76, bearing f

276 e it is difficult to establish direct causal linkages to thinly documented historical events, the wet

277 ides, characterized by a glycosidic beta-1,2-linkage, to the pollen surface of Arabidopsis (Arabidops

278 The effectiveness of hepatitis C testing and linkage-to-care (LTC) is poorly characterized in low-res

279 initiated an opt-out VH and HIV testing and linkage-to-care program within our OTP.

280 Hispanic ethnicity was associated with less linkage-to-care, and Manhattan residence was associated

281 attan residence was associated with improved linkage-to-care.

282 (0.91-6.41/100PY); screen acceptance (80%), linkage-to-care/antiretroviral therapy (ART) initiation

283 eed; and (3) examine factors associated with linkage-to-HCV-care.

284 vity, functional connections, and structural linkages together support integrative processing across

285 roperty correlation at the level of chemical linkages, topology, pore size and functionality is neede

286 tagged with ubiquitin chains comprising K63 linkages (UbK63) in a beta-arrestin-dependent manner bef

287 ace that shifts at larger scales; functional linkages vary with scale and are weak, with vein density

288 A linkage was established between the drug dispensing regi

289 e monosaccharide compositions and glycosidic linkages were analyzed by GC-MS, hydrodynamic radius and

290 dimeric lignin model compounds with beta-O-4 linkages were evaporated and ionized using negative ion

291 All transmission linkages were from the same OAT clinic and involved spou

292 aglycones, polyphenols with (2,1) glycosidic linkages were more effective than those with (6,1) linka

293 corresponding mRNA targets showed that 2'-5' linkages were well tolerated in the sense strand, but on

294 to modify the cobalt species via Co-O-SiO(n) linkages, which favor the reactivity of spectroscopicall

295 One-pot ligation gives a urea linkage with excellent read-through speed, or a squarami

296 prevalence of 9 care states over time since linkage with respect to ART initiation, retention in car

297 equently include data that are vulnerable to linkage with voter lists, tax and real estate data, prof

298 can easily be incorporated into more complex linkages with corridors for more charismatic species, th

299 Drug candidates that form covalent linkages with their target proteins have been underexplo

300 The TnT1-tropomyosin linkage yields well-defined molecular crevices.